Nahum Sonenberg

124.2k total citations · 43 hit papers
673 papers, 97.8k citations indexed

About

Nahum Sonenberg is a scholar working on Molecular Biology, Cardiology and Cardiovascular Medicine and Immunology. According to data from OpenAlex, Nahum Sonenberg has authored 673 papers receiving a total of 97.8k indexed citations (citations by other indexed papers that have themselves been cited), including 570 papers in Molecular Biology, 122 papers in Cardiology and Cardiovascular Medicine and 62 papers in Immunology. Recurrent topics in Nahum Sonenberg's work include RNA and protein synthesis mechanisms (269 papers), RNA Research and Splicing (218 papers) and PI3K/AKT/mTOR signaling in cancer (154 papers). Nahum Sonenberg is often cited by papers focused on RNA and protein synthesis mechanisms (269 papers), RNA Research and Splicing (218 papers) and PI3K/AKT/mTOR signaling in cancer (154 papers). Nahum Sonenberg collaborates with scholars based in Canada, United States and United Kingdom. Nahum Sonenberg's co-authors include Anne‐Claude Gingras, Witold Filipowicz, Nissim Hay, Jerry Pelletier, Brian Raught, Alan G. Hinnebusch, Marc R. Fabian, Suvendra N. Bhattacharyya, Yuri V. Svitkin and Arnim Pause and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Nahum Sonenberg

664 papers receiving 96.2k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

2008 4.2k citations Witold Filipowicz, Nahum Sonenberg et al. profile →
Upstream and downstream of mTOR

2004 3.4k citations Nahum Sonenberg et al. profile →
Regulation of mRNA Translation and Stability by microRNAs

2010 2.5k citations Marc R. Fabian, Nahum Sonenberg et al. profile →
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

2009 2.5k citations Nahum Sonenberg et al. profile →
eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation

1999 1.7k citations Anne‐Claude Gingras, Brian Raught et al. profile →
Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

1988 1.6k citations Jerry Pelletier, Nahum Sonenberg profile →
Regulation of translation initiation by FRAP/mTOR

2001 1.3k citations Anne‐Claude Gingras, Brian Raught et al. profile →
Translational control of gene expression

2000 1.3k citations Nahum Sonenberg, John W.B. Hershey et al. profile →
Translational control in stress and apoptosis

2005 1.1k citations Nahum Sonenberg et al. profile →
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1999 1.1k citations Anne‐Claude Gingras, Brian Raught et al. profile →
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 1.0k citations Anne‐Claude Gingras, Nahum Sonenberg et al. profile →
Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells

2006 881 citations Mahvash Zakikhani, Ryan J.O. Dowling et al. Cancer Research profile →
The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC

2012 802 citations Marc R. Fabian, Nahum Sonenberg profile →
XBP1, Downstream of Blimp-1, Expands the Secretory Apparatus and Other Organelles, and Increases Protein Synthesis in Plasma Cell Differentiation

2004 793 citations Emmanuel Petroulakis, Nahum Sonenberg et al. profile →
Regulation of cap-dependent translation by eIF4E inhibitory proteins

2005 773 citations Nahum Sonenberg et al. profile →
Metformin Inhibits Mammalian Target of Rapamycin–Dependent Translation Initiation in Breast Cancer Cells

2007 770 citations Ryan J.O. Dowling, Mahvash Zakikhani et al. Cancer Research profile →
Translational control by 5′-untranslated regions of eukaryotic mRNAs

2016 760 citations Nahum Sonenberg et al. Science profile →
Translational Control of Long-Lasting Synaptic Plasticity and Memory

2009 750 citations Mauro Costa‐Mattioli, Wayne S. Sossin et al. profile →
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1998 728 citations Anne‐Claude Gingras, Nahum Sonenberg et al. profile →
Hierarchical phosphorylation of the translation inhibitor 4E-BP1

2001 707 citations Anne‐Claude Gingras, Brian Raught et al. profile →
Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus

2000 663 citations Nahum Sonenberg et al. profile →
mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

2013 614 citations Masahiro Morita, Tommy Alain et al. profile →
A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

2001 603 citations Anne‐Claude Gingras, Nahum Sonenberg et al. Proceedings of the National Academy of Sciences profile →
Targeting the translation machinery in cancer

2015 597 citations Mamatha Bhat, Nathaniel Robichaud et al. profile →
PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 594 citations Nahum Sonenberg et al. Science profile →
Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.

1996 582 citations Anne‐Claude Gingras, Yuri V. Svitkin et al. profile →
RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation

2007 575 citations Nahum Sonenberg et al. profile →
The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins

1995 569 citations Nahum Sonenberg et al. Molecular and Cellular Biology profile →
The mRNA 5′ cap-binding protein eIF4E and control of cell growth

1998 563 citations Nahum Sonenberg, Anne‐Claude Gingras profile →
Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2α

2002 557 citations Constantinos Koumenis, Marianne Koritzinsky et al. Molecular and Cellular Biology profile →
Translational control in biology and medicine

2007 556 citations Michael B. Mathews, Nahum Sonenberg et al. profile →
Insertion mutagenesis to increase secondary structure within the 5′ noncoding region of a eukaryotic mRNA reduces translational efficiency

1985 555 citations Jerry Pelletier, Nahum Sonenberg profile →
Cocrystal Structure of the Messenger RNA 5′ Cap-Binding Protein (eIF4E) Bound to 7-methyl-GDP

1997 554 citations Anne‐Claude Gingras, Nahum Sonenberg et al. profile →
mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

2010 549 citations Ryan J.O. Dowling, Ivan Topisirović et al. Science profile →
Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.

1990 548 citations William C. Merrick, Nahum Sonenberg et al. Molecular and Cellular Biology profile →
Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A.

1992 543 citations Nahum Sonenberg et al. profile →
Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2

2004 540 citations Nahum Sonenberg et al. Molecular and Cellular Biology profile →
Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.

1995 515 citations Nahum Sonenberg et al. profile →
Pharmacological brake-release of mRNA translation enhances cognitive memory

2013 500 citations Arkady Khoutorsky, Nahum Sonenberg et al. profile →
Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex.

1982 497 citations Nahum Sonenberg, John W.B. Hershey et al. profile →
Fragile X syndrome

2017 466 citations Nahum Sonenberg et al. profile →
La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate

1993 435 citations Yuri V. Svitkin, Nahum Sonenberg et al. profile →
Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

2014 432 citations Nahum Sonenberg et al. profile →

Peers

Countries citing papers authored by Nahum Sonenberg

Since Specialization

Citations

This map shows the geographic impact of Nahum Sonenberg's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Nahum Sonenberg with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Nahum Sonenberg more than expected).

Fields of papers citing papers by Nahum Sonenberg

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Nahum Sonenberg. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Nahum Sonenberg. The network helps show where Nahum Sonenberg may publish in the future.

Co-authorship network of co-authors of Nahum Sonenberg

This figure shows the co-authorship network connecting the top 25 collaborators of Nahum Sonenberg. A scholar is included among the top collaborators of Nahum Sonenberg based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Nahum Sonenberg. Nahum Sonenberg is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	The 4EHP-mediated translational repression of cGAS impedes the host immune response against DNA viruses 2024 ·Proceedings of the National Academy of Sciences ·(unknown), Jung‐Hyun Choi, Jun Luo, (unknown), Niaz Mahmood, (unknown), Parisa Naeli, (unknown), (unknown), Huy‐Dung Hoang, Tommy Alain, Jose G. Teodoro, Jianwei Wang, Xu Zhang, Seyed Mehdi Jafarnejad, Nahum Sonenberg	1
2	The ISR downstream target ATF4 represses long-term memory in a cell type–specific manner 2024 ·Proceedings of the National Academy of Sciences ·Niaz Mahmood, Jung‐Hyun Choi, (unknown), Sean W. Dooling, Trent A. Watkins, (unknown), (unknown), (unknown), (unknown), (unknown), Yanis Inglebert, Constantinos Koumenis, Vijendra Sharma, Jean‐Claude Lacaille, Wayne S. Sossin, (unknown), R. Anne McKinney, Mauro Costa‐Mattioli, Nahum Sonenberg	5
3	Dysregulating mTORC1-4E-BP2 signaling in GABAergic interneurons impairs hippocampus-dependent learning and memory 2024 ·Learning & Memory ·(unknown), Shane Wiebe, (unknown), Jung‐Hyun Choi, (unknown), Niaz Mahmood, Arkady Khoutorsky, Jean‐Claude Lacaille, Nahum Sonenberg	2
4	Loss of 4E-BP converts cerebellar long-term depression to long-term potentiation 2022 ·Cell Reports ·(unknown), (unknown), Peng Wang, Sara Bermudez, (unknown), (unknown), Derek Bowie, Nahum Sonenberg, Ellis Cooper, A. Pejmun Haghighi	2
5	High-risk human papillomavirus-18 uses an mRNA sequence to synthesize oncoprotein E6 in tumors 2021 ·Proceedings of the National Academy of Sciences ·Alejandra García, (unknown), (unknown), Yuri V. Svitkin, David Cantú de León, Alejandro Garcı́a-Carrancá, Nahum Sonenberg, Greco Hernández	9
6	BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models 2021 ·Nature Communications ·(unknown), (unknown), Raven Kirschenman, Namrata Patel, Vrajesh Pandya, (unknown), Rachel Montpetit, Lin Zhu, Nahum Sonenberg, Richard P. Fahlman, Nika N. Danial, D. Alan Underhill, Ing Swie Goping	7
7	Elevated V–ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer 2020 ·Molecular Cancer Research ·(unknown), (unknown), Nicholas Bertos, Wissal El-Assaad, (unknown), Harvey W. Smith, Jieyi Yang, (unknown), Isabelle Gamache, (unknown), Bruno Gagnon, Tina Gruosso, Michel L. Tremblay, Nahum Sonenberg, Marie‐Christine Guiot, William J. Muller, Morag Park, Jose G. Teodoro	7
8	eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer 2019 ·JCI Insight ·David C. Muller, (unknown), Théo Goullet de Rugy, Rémi Samain, (unknown), (unknown), (unknown), Julie Guillermet‐Guibert, Christine Jean, Yoshinori Tsukumo, Nahum Sonenberg, Frédéric Marion, Nicolas Guilbaud, Jean‐Sèbastien Hoffmann, Ola Larsson, Corinne Bousquet, Stéphane Pyronnet, Yvan Martineau	25
9	mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction 2018 ·Proceedings of the National Academy of Sciences ·Dong Liu, Adam Stowie, Nuria de Zavalía, Tanya Leise, Salil Saurav Pathak, Lester R. Drewes, Alec J. Davidson, Shimon Amir, Nahum Sonenberg, Ruifeng Cao	39
10	The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer 2018 ·Molecular Cancer Research ·Mei Ding, Theodorus van der Kwast, Ravi N. Vellanki, Warren D. Foltz, Trevor D. McKee, Nahum Sonenberg, Pier Paolo Pandolfi, Marianne Koritzinsky, Bradly G. Wouters	22
11	Cap-binding protein 4EHP effects translation silencing by microRNAs 2017 ·Proceedings of the National Academy of Sciences ·Clément Chapat, Seyed Mehdi Jafarnejad, Edna Matta‐Camacho, Geoffrey G. Hesketh, (unknown), Jan Attig, Christos G. Gkogkas, Tommy Alain, Noam Stern‐Ginossar, Marc R. Fabian, Anne‐Claude Gingras, Thomas F. Duchaîne, Nahum Sonenberg	79
12	eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies 2012 ·Cancer Research ·Tommy Alain, Masahiro Morita, Bruno D. Fonseca, Akiko Yanagiya, Nadeem Siddiqui, Mamatha Bhat, Domenick Zammit, Victoria Marcus, Peter Metrakos, (unknown), Valentina Gandin, Yi Liu, Ivan Topisirović, Nahum Sonenberg	120
13	Protein synthesis and translational control : a subject collection from Cold Spring Harbor perspectives in biology 2012 ·John W.B. Hershey, Nahum Sonenberg, Michael B. Mathews	1
14	eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression 2010 ·Proceedings of the National Academy of Sciences ·Luc Furic, Liwei Rong, Ola Larsson, Ismaël Hervé Koumakpayi, Kaori Yoshida, (unknown), Emmanuel Petroulakis, Nathaniel Robichaud, Michaël Pollak, Louis Gaboury, Pier Paolo Pandolfi, Fred Saad, Nahum Sonenberg	398
15	mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs breakdown → 2010 ·Science ·Ryan J.O. Dowling, Ivan Topisirović, Tommy Alain, Michael Bidinosti, Bruno D. Fonseca, Emmanuel Petroulakis, Xiaoshan Wang, Ola Larsson, Anand Selvaraj, Yi Liu, Sara C. Kozma, George Thomas, Nahum Sonenberg	549
16	MicroRNA Inhibition of Translation Initiation in Vitro by Targeting the Cap-Binding Complex eIF4F 2007 ·Science ·Géraldine Mathonnet, Marc R. Fabian, Yuri V. Svitkin, Armen Parsyan, Laurent Huck, Takayuki Murata, Stefano Biffo, William C. Merrick, Edward Darżynkiewicz, Ramesh S. Pillai, Witold Filipowicz, Thomas F. Duchaîne, Nahum Sonenberg	403
17	Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells breakdown → 2006 ·Cancer Research ·Mahvash Zakikhani, Ryan J.O. Dowling, I. George Fantus, Nahum Sonenberg, Michaël Pollak	881
18	Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation 2005 ·Proceedings of the National Academy of Sciences ·(unknown), James Matthews, (unknown), Lisa Lindqvist, Olivia Novac, Eckhard Jankowsky, Nahum Sonenberg, Peter T. Northcote, Paul Teesdale‐Spittle, Jerry Pelletier	180
19	A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes 2002 ·Journal of Clinical Investigation ·Tania Nikolcheva, Stéphane Pyronnet, (unknown), Nahum Sonenberg, An Song, Carol Clayberger, Alan M. Krensky	43
20	A Novel Functional Human Eukaryotic Translation Initiation Factor 4G 1998 ·Molecular and Cellular Biology ·Alessandra Gradi, Hiroaki Imataka, Yuri V. Svitkin, Eran Rom, Brian Raught, Shigenobu Morino, Nahum Sonenberg	251

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