Nahum Sonenberg

124.2k total citations · 43 hit papers
673 papers, 97.8k citations indexed

About

Nahum Sonenberg is a scholar working on Molecular Biology, Cardiology and Cardiovascular Medicine and Immunology. According to data from OpenAlex, Nahum Sonenberg has authored 673 papers receiving a total of 97.8k indexed citations (citations by other indexed papers that have themselves been cited), including 570 papers in Molecular Biology, 122 papers in Cardiology and Cardiovascular Medicine and 62 papers in Immunology. Recurrent topics in Nahum Sonenberg's work include RNA and protein synthesis mechanisms (269 papers), RNA Research and Splicing (218 papers) and PI3K/AKT/mTOR signaling in cancer (154 papers). Nahum Sonenberg is often cited by papers focused on RNA and protein synthesis mechanisms (269 papers), RNA Research and Splicing (218 papers) and PI3K/AKT/mTOR signaling in cancer (154 papers). Nahum Sonenberg collaborates with scholars based in Canada, United States and United Kingdom. Nahum Sonenberg's co-authors include Anne‐Claude Gingras, Witold Filipowicz, Nissim Hay, Jerry Pelletier, Brian Raught, Alan G. Hinnebusch, Marc R. Fabian, Suvendra N. Bhattacharyya, Yuri V. Svitkin and Arnim Pause and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Nahum Sonenberg

664 papers receiving 96.2k citations

Hit Papers

Mechanisms of post-transc... 1982 2026 1996 2011 2008 2004 2010 2009 1999 1000 2.0k 3.0k 4.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
    2008 4.2k citations Witold Filipowicz, Nahum Sonenberg et al. profile →
  2. Upstream and downstream of mTOR
    2004 3.4k citations Nahum Sonenberg et al. profile →
  3. Regulation of mRNA Translation and Stability by microRNAs
    2010 2.5k citations Marc R. Fabian, Nahum Sonenberg et al. profile →
  4. Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
    2009 2.5k citations Nahum Sonenberg et al. profile →
  5. eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation
    1999 1.7k citations Anne‐Claude Gingras, Brian Raught et al. profile →
  6. Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA
    1988 1.6k citations Jerry Pelletier, Nahum Sonenberg profile →
  7. Regulation of translation initiation by FRAP/mTOR
    2001 1.3k citations Anne‐Claude Gingras, Brian Raught et al. profile →
  8. Translational control of gene expression
    2000 1.3k citations Nahum Sonenberg et al. profile →
  9. Translational control in stress and apoptosis
    2005 1.1k citations Nahum Sonenberg et al. profile →
  10. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
    1999 1.1k citations Anne‐Claude Gingras, Brian Raught et al. profile →
  11. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function
    1994 1.0k citations Anne‐Claude Gingras, Nahum Sonenberg et al. profile →
  12. Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells
    2006 881 citations Mahvash Zakikhani, Ryan J.O. Dowling et al. Cancer Research profile →
  13. The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC
    2012 802 citations Marc R. Fabian, Nahum Sonenberg profile →
  14. XBP1, Downstream of Blimp-1, Expands the Secretory Apparatus and Other Organelles, and Increases Protein Synthesis in Plasma Cell Differentiation
    2004 793 citations Emmanuel Petroulakis, Nahum Sonenberg et al. profile →
  15. Regulation of cap-dependent translation by eIF4E inhibitory proteins
    2005 773 citations Nahum Sonenberg et al. profile →
  16. Metformin Inhibits Mammalian Target of Rapamycin–Dependent Translation Initiation in Breast Cancer Cells
    2007 770 citations Ryan J.O. Dowling, Mahvash Zakikhani et al. Cancer Research profile →
  17. Translational control by 5′-untranslated regions of eukaryotic mRNAs
    2016 760 citations Nahum Sonenberg et al. Science profile →
  18. Translational Control of Long-Lasting Synaptic Plasticity and Memory
    2009 750 citations Mauro Costa‐Mattioli, Wayne S. Sossin et al. profile →
  19. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway
    1998 728 citations Anne‐Claude Gingras, Nahum Sonenberg et al. profile →
  20. Hierarchical phosphorylation of the translation inhibitor 4E-BP1
    2001 707 citations Anne‐Claude Gingras, Brian Raught et al. profile →
  21. Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus
    2000 663 citations Nahum Sonenberg et al. profile →
  22. mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation
    2013 614 citations Masahiro Morita, Tommy Alain et al. profile →
  23. A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus
    2001 603 citations Anne‐Claude Gingras, Nahum Sonenberg et al. Proceedings of the National Academy of Sciences profile →
  24. Targeting the translation machinery in cancer
    2015 597 citations Mamatha Bhat, Nathaniel Robichaud et al. profile →
  25. PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation
    1994 594 citations Nahum Sonenberg et al. Science profile →
  26. Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.
    1996 582 citations Anne‐Claude Gingras, Yuri V. Svitkin et al. profile →
  27. RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation
    2007 575 citations Nahum Sonenberg et al. profile →
  28. The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins
    1995 569 citations Nahum Sonenberg et al. Molecular and Cellular Biology profile →
  29. The mRNA 5′ cap-binding protein eIF4E and control of cell growth
    1998 563 citations Nahum Sonenberg, Anne‐Claude Gingras profile →
  30. Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2α
    2002 557 citations Constantinos Koumenis, Marianne Koritzinsky et al. Molecular and Cellular Biology profile →
  31. Translational control in biology and medicine
    2007 556 citations Nahum Sonenberg et al. profile →
  32. Insertion mutagenesis to increase secondary structure within the 5′ noncoding region of a eukaryotic mRNA reduces translational efficiency
    1985 555 citations Jerry Pelletier, Nahum Sonenberg profile →
  33. Cocrystal Structure of the Messenger RNA 5′ Cap-Binding Protein (eIF4E) Bound to 7-methyl-GDP
    1997 554 citations Anne‐Claude Gingras, Nahum Sonenberg et al. profile →
  34. mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs
    2010 549 citations Ryan J.O. Dowling, Ivan Topisirović et al. Science profile →
  35. Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.
    1990 548 citations William C. Merrick, Nahum Sonenberg et al. Molecular and Cellular Biology profile →
  36. Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A.
    1992 543 citations Nahum Sonenberg et al. profile →
  37. Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2
    2004 540 citations Nahum Sonenberg et al. Molecular and Cellular Biology profile →
  38. Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.
    1995 515 citations Nahum Sonenberg et al. profile →
  39. Pharmacological brake-release of mRNA translation enhances cognitive memory
    2013 500 citations Arkady Khoutorsky, Nahum Sonenberg et al. profile →
  40. Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex.
    1982 497 citations Nahum Sonenberg et al. profile →
  41. Fragile X syndrome
    2017 466 citations Nahum Sonenberg et al. profile →
  42. La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate
    1993 435 citations Yuri V. Svitkin, Nahum Sonenberg et al. profile →
  43. Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch
    2014 432 citations Alaji Bah, Robert M. Vernon et al. profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
Nahum Sonenberg 77.5k 12.8k 10.2k 9.1k 8.7k 673 97.8k
Peter Carmeliet 53.1k 0.7× 27.4k 2.1× 5.8k 0.6× 11.7k 1.3× 5.4k 0.6× 729 100.0k
Eric N. Olson 109.1k 1.4× 24.0k 1.9× 20.7k 2.0× 6.8k 0.7× 15.5k 1.8× 761 135.3k
George D. Yancopoulos 55.1k 0.7× 11.9k 0.9× 6.8k 0.7× 16.0k 1.8× 6.1k 0.7× 430 103.1k
Josef Penninger 40.9k 0.5× 7.5k 0.6× 8.0k 0.8× 18.0k 2.0× 3.9k 0.5× 582 78.3k
Harvey F. Lodish 49.1k 0.6× 11.2k 0.9× 3.9k 0.4× 8.7k 1.0× 6.7k 0.8× 646 82.0k
John C. Reed 73.3k 0.9× 12.2k 1.0× 2.6k 0.3× 20.4k 2.2× 6.1k 0.7× 799 107.5k
Simon C. Watkins 28.3k 0.4× 5.3k 0.4× 3.9k 0.4× 12.9k 1.4× 4.6k 0.5× 788 59.2k
Christopher K. Glass 61.4k 0.8× 12.2k 1.0× 2.4k 0.2× 19.3k 2.1× 17.9k 2.1× 375 96.6k
Steven P. Gygi 88.4k 1.1× 11.7k 0.9× 2.4k 0.2× 7.9k 0.9× 7.6k 0.9× 695 121.5k
Paul Tempst 62.1k 0.8× 7.6k 0.6× 1.6k 0.2× 9.0k 1.0× 6.6k 0.8× 320 80.8k

Countries citing papers authored by Nahum Sonenberg

Since Specialization
Citations

This map shows the geographic impact of Nahum Sonenberg's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Nahum Sonenberg with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Nahum Sonenberg more than expected).

Fields of papers citing papers by Nahum Sonenberg

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Nahum Sonenberg. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Nahum Sonenberg. The network helps show where Nahum Sonenberg may publish in the future.

Co-authorship network of co-authors of Nahum Sonenberg

This figure shows the co-authorship network connecting the top 25 collaborators of Nahum Sonenberg. A scholar is included among the top collaborators of Nahum Sonenberg based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Nahum Sonenberg. Nahum Sonenberg is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Choi, Jung‐Hyun, Jun Luo, Niaz Mahmood, et al.. (2024). The 4EHP-mediated translational repression of cGAS impedes the host immune response against DNA viruses. Proceedings of the National Academy of Sciences. 121(48). e2413018121–e2413018121. 1 indexed citations
2.
Mahmood, Niaz, Jung‐Hyun Choi, Sean W. Dooling, et al.. (2024). The ISR downstream target ATF4 represses long-term memory in a cell type–specific manner. Proceedings of the National Academy of Sciences. 121(31). e2407472121–e2407472121. 5 indexed citations
3.
Wiebe, Shane, Jung‐Hyun Choi, Niaz Mahmood, et al.. (2024). Dysregulating mTORC1-4E-BP2 signaling in GABAergic interneurons impairs hippocampus-dependent learning and memory. Learning & Memory. 31(10-11). a054018–a054018. 2 indexed citations
4.
García, Alejandra, Yuri V. Svitkin, David Cantú de León, et al.. (2021). High-risk human papillomavirus-18 uses an mRNA sequence to synthesize oncoprotein E6 in tumors. Proceedings of the National Academy of Sciences. 118(41). 9 indexed citations
5.
Pearl, Dana, Sakie Katsumura, Mehdi Amiri, et al.. (2020). 4E-BP–Dependent Translational Control of Irf8 Mediates Adipose Tissue Macrophage Inflammatory Response. The Journal of Immunology. 204(9). 2392–2400. 13 indexed citations
6.
Dawson, Jennifer E., Alaji Bah, Zhenfu Zhang, et al.. (2020). Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition. Nature Communications. 11(1). 3146–3146. 19 indexed citations
7.
Muller, David C., Théo Goullet de Rugy, Rémi Samain, et al.. (2019). eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer. JCI Insight. 4(21). 25 indexed citations
8.
Liu, Dong, Adam Stowie, Nuria de Zavalía, et al.. (2018). mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction. Proceedings of the National Academy of Sciences. 115(14). E3296–E3304. 39 indexed citations
9.
Ding, Mei, Theodorus van der Kwast, Ravi N. Vellanki, et al.. (2018). The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer. Molecular Cancer Research. 16(4). 682–695. 22 indexed citations
10.
Ratcliffe, Colin D.H., Nadeem Siddiqui, Paula P. Coelho, et al.. (2018). HGF-induced migration depends on the PI(3,4,5)P3-binding microexon-spliced variant of the Arf6 exchange factor cytohesin-1. The Journal of Cell Biology. 218(1). 285–298. 21 indexed citations
11.
Chapat, Clément, Seyed Mehdi Jafarnejad, Edna Matta‐Camacho, et al.. (2017). Cap-binding protein 4EHP effects translation silencing by microRNAs. Proceedings of the National Academy of Sciences. 114(21). 5425–5430. 79 indexed citations
12.
Alain, Tommy, Masahiro Morita, Bruno D. Fonseca, et al.. (2012). eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies. Cancer Research. 72(24). 6468–6476. 120 indexed citations
13.
Furic, Luc, Liwei Rong, Ola Larsson, et al.. (2010). eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proceedings of the National Academy of Sciences. 107(32). 14134–14139. 398 indexed citations
14.
Dowling, Ryan J.O., Ivan Topisirović, Tommy Alain, et al.. (2010). mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs. Science. 328(5982). 1172–1176. 549 indexed citations breakdown →
15.
Yanagiya, Akiko, et al.. (2008). Requirement of RNA Binding of Mammalian Eukaryotic Translation Initiation Factor 4GI (eIF4GI) for Efficient Interaction of eIF4E with the mRNA Cap. Molecular and Cellular Biology. 29(6). 1661–1669. 88 indexed citations
16.
Mathonnet, Géraldine, Marc R. Fabian, Yuri V. Svitkin, et al.. (2007). MicroRNA Inhibition of Translation Initiation in Vitro by Targeting the Cap-Binding Complex eIF4F. Science. 317(5845). 1764–1767. 403 indexed citations
17.
Zakikhani, Mahvash, Ryan J.O. Dowling, I. George Fantus, Nahum Sonenberg, & Michaël Pollak. (2006). Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells. Cancer Research. 66(21). 10269–10273. 881 indexed citations breakdown →
18.
Matthews, James, Lisa Lindqvist, Olivia Novac, et al.. (2005). Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Proceedings of the National Academy of Sciences. 102(30). 10460–10465. 180 indexed citations
19.
Nikolcheva, Tania, Stéphane Pyronnet, Nahum Sonenberg, et al.. (2002). A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes. Journal of Clinical Investigation. 110(1). 119–126. 43 indexed citations
20.
Gradi, Alessandra, Hiroaki Imataka, Yuri V. Svitkin, et al.. (1998). A Novel Functional Human Eukaryotic Translation Initiation Factor 4G. Molecular and Cellular Biology. 18(1). 334–342. 251 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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