Sara C. Kozma

22.6k citations

97 papers · 16.5k indexed · 12 hit papers · h-index 54

Molecular Biology top 0.2%
Physiology top 0.5%
Immunology top 1%
Oncology top 1%
Cell Biology top 0.5%

Co-authors: George Thomas Patrick B. Dennis Sung Hee Um Manel Joaquin Melanie Sticker Nick Pullen Stefano Fumagalli Ernst Hafen
Topics: PI3K/AKT/mTOR signaling in cancer (31 papers)Protein Kinase Regulation and GTPase Signaling (19 papers)RNA and protein synthesis mechanisms (13 papers)
Cited by: Aging Molecular Biology Endocrine and Autonomic Systems
Journals: Nature Science Proceedings of the National Academy of Sciences
Partner nations: United States Switzerland Spain

In The Last Decade

Sara C. Kozma

97 papers receiving 16.3k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

2004 1.3k citations Sung Hee Um, Manel Joaquin et al. Nature profile →
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

2008 1.1k citations Andrea Alimonti, George Thomas et al. profile →
The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

2009 1.0k citations Sara C. Kozma et al. profile →
Hypothalamic mTOR Signaling Regulates Food Intake

2006 993 citations Daniela Cota, Karine Proulx et al. Science profile →
Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

2003 832 citations Fried Zwartkruis, Takahiro Nobukuni et al. Molecular Cell profile →
Mammalian TOR: A Homeostatic ATP Sensor

2001 795 citations Patrick B. Dennis, Sara C. Kozma et al. Science profile →
Phosphorylation and Activation of p70 ^s6k by PDK1

1998 728 citations Nick Pullen, Patrick B. Dennis et al. Science profile →
Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

2010 718 citations Anand Selvaraj, Patrick B. Dennis et al. profile →
S6K1 ^−/− / S6K2 ^−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

2004 623 citations Mario Pende, Sung Hee Um et al. Molecular and Cellular Biology profile →
Drosophila S6 Kinase: A Regulator of Cell Size

1999 605 citations Hugo Stocker, Ernst Hafen et al. Science profile →
mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

2010 549 citations Ryan J.O. Dowling, Ivan Topisirović et al. Science profile →
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

1994 534 citations Sara C. Kozma, George Thomas et al. profile →

Peers

Countries citing papers authored by Sara C. Kozma

Since Specialization

Citations

This map shows the geographic impact of Sara C. Kozma's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Sara C. Kozma with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Sara C. Kozma more than expected).

Fields of papers citing papers by Sara C. Kozma

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Sara C. Kozma. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Sara C. Kozma. The network helps show where Sara C. Kozma may publish in the future.

Co-authorship network of co-authors of Sara C. Kozma

This figure shows the co-authorship network connecting the top 25 collaborators of Sara C. Kozma. A scholar is included among the top collaborators of Sara C. Kozma based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Sara C. Kozma. Sara C. Kozma is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis 2022 ·JCI Insight ·(unknown),Sónia R. Veiga,Jèssica Latorre,José María Moreno‐Navarrete,Núria Bonifaci,(unknown),You Zhou,Marcus Höring,Gerhard Liebisch,Vesa M. Olkkonen,David Llobet‐Navàs,George Thomas,Ruth Rodríguez‐Barrueco,José Manuel Fernández‐Real,Sara C. Kozma,Francisco Ortega	6
2	Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death 2021 ·Blood ·(unknown),Suresh Peddigari,Carol A. Mercer,(unknown),(unknown),(unknown),Virginia Amador,Sarah T. Diepstraten,Gemma L. Kelly,Ramón Salazar,Sara C. Kozma,Eric Kusnadi,Jian Kang,Antonio Gentilella,Richard B. Pearson,George Thomas,Joffrey Pelletier	17
3	Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage 2020 ·The EMBO Journal ·Joffrey Pelletier,(unknown),Eugènia Almacellas,Caroline Mauvezin,Sara Samino,(unknown),(unknown),(unknown),(unknown),Ramón Salazar,Constanza Cortés,Ricard Marcos,Albert Tauler,Óscar Yanes,Neus Agell,Sara C. Kozma,Antonio Gentilella,George Thomas	28
4	Oncogenic MYC Induces the Impaired Ribosome Biogenesis Checkpoint and Stabilizes p53 Independent of Increased Ribosome Content 2019 ·Cancer Research ·(unknown),(unknown),(unknown),Albert Tauler,Sara C. Kozma,George Thomas,Antonio Gentilella	28
5	Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR 2018 ·Clinical Cancer Research ·Sónia R. Veiga,Xuemei Ge,Carol A. Mercer,María Isabel Hernández‐Álvarez,Hala Elnakat Thomas,Javier Hernández‐Losa,Santiago Ramón y Cajal,António Zorzano,George Thomas,Sara C. Kozma	36
6	EPRS is a critical mTORC1–S6K1 effector that influences adiposity in mice 2017 ·Nature ·Abul Arif,Fulvia Terenzi,Alka A. Potdar,Jie Jia,Jessica Sacks,Arnab China,Dalia Halawani,K.I. Vasu,Xiaoxia Li,J. Mark Brown,Jie Chen,Sara C. Kozma,George Thomas,Paul L. Fox	98
7	Differential Expression of S6K2 Dictates Tissue-Specific Requirement for S6K1 in Mediating Aberrant mTORC1 Signaling and Tumorigenesis 2011 ·Cancer Research ·Caterina Nardella,Andrea Lunardi,Giuseppe Fedele,John G. Clohessy,Andrea Alimonti,Sara C. Kozma,George Thomas,Massimo Loda,Pier Paolo Pandolfi	17
8	mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPsbreakdown → 2010 ·Science ·Ryan J.O. Dowling,Ivan Topisirović,Tommy Alain,Michael Bidinosti,Bruno D. Fonseca,Emmanuel Petroulakis,Xiaoshan Wang,Ola Larsson,Anand Selvaraj,Yi Liu,Sara C. Kozma,George Thomas,Nahum Sonenberg	549
9	Differences in Wound Healing in Mice with Deficiency of IL-6 versus IL-6 Receptor 2010 ·The Journal of Immunology ·Molly M. McFarland-Mancini,(unknown),Andrew M. Paluch,Mingfu Zhou,Premkumar Vummidi Giridhar,Carol A. Mercer,Sara C. Kozma,Angela F. Drew	209
10	Interferon-Dependent Engagement of Eukaryotic Initiation Factor 4B via S6 Kinase (S6K)- and Ribosomal Protein S6K-Mediated Signals 2009 ·Molecular and Cellular Biology ·Barbara Kroczyńska,Surinder Kaur,Efstratios Katsoulidis,Beata Majchrzak-Kita,Antonella Sassano,Sara C. Kozma,Eleanor N. Fish,Leonidas C. Platanias	62
11	Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors 2008 ·Molecular Cancer Therapeutics ·Gunnar Johansson,Yonatan Y. Mahller,Margaret H. Collins,Mi‐Ok Kim,Takahiro Nobukuni,John P. Perentesis,Timothy P. Cripe,Heidi A. Lane,Sara C. Kozma,George Thomas,Nancy Ratner	104
12	Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity 2008 ·Learning & Memory ·Marcia D. Antion,Maayan Merhav,Charles A. Hoeffer,Gerald F. Reis,Sara C. Kozma,George Thomas,Erin M. Schuman,Kobi Rosenblum,Eric Klann	115
13	17 Translational Control in Metabolic Diseases: The Role of mTOR Signaling in Obesity and Diabetes 2007 ·Cold Spring Harbor Monograph Archive ·Sara C. Kozma,Sung Hee Um,George Thomas	1
14	Hypothalamic mTOR Signaling Regulates Food Intakebreakdown → 2006 ·Science ·Daniela Cota,Karine Proulx,(unknown),Sara C. Kozma,George Thomas,Stephen C. Woods,Randy J. Seeley	993
15	S6K1 ^−/− / S6K2 ^−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathwaybreakdown → 2004 ·Molecular and Cellular Biology ·Mario Pende,Sung Hee Um,Virginie Mieulet,Melanie Sticker,Valerie L. Goss,Jürgen Mestan,Matthias Mueller,Stefano Fumagalli,Sara C. Kozma,George Thomas	623
16	Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2breakdown → 2003 ·Molecular Cell ·(unknown),Fried Zwartkruis,Takahiro Nobukuni,Manel Joaquin,Marta Roccio,Hugo Stocker,Sara C. Kozma,Ernst Hafen,Johannes L. Bos,George Thomas	832
17	p70 ^S6K Controls Selective mRNA Translation during Oocyte Maturation and Early Embryogenesis in Xenopus laevis 1999 ·Molecular and Cellular Biology ·Markus S. Schwab,Sang Ho Kim,Naohiro Terada,(unknown),Sara C. Kozma,George Thomas,James L. Maller	51
18	Dual Requirement for a Newly Identified Phosphorylation Site in p70 ^s6k 1997 ·Molecular and Cellular Biology ·Bettina A. Moser,Patrick B. Dennis,Nick Pullen,Richard B. Pearson,Nicholas A. Williamson,Richard E.H. Wettenhall,Sara C. Kozma,George Thomas	89
19	Serine/threonine kinases in the propagation of the early mitogenic response 1992 ·Reviews of physiology, biochemistry and pharmacology ·Sara C. Kozma,George Thomas	25
20	Unmasking a growth factor/oncogene-activated S6 phosphorylation cascade 1989 ·Cellular Signalling ·Sara C. Kozma,Stefano Ferrari,George Thomas	59

About Sara C. Kozma

Sara C. Kozma is a scholar working on Molecular Biology, Oncology and Cell Biology, having authored 97 papers that have together received 16.5k indexed citations. Recurring topics across this work include PI3K/AKT/mTOR signaling in cancer (31 papers), Protein Kinase Regulation and GTPase Signaling (19 papers) and RNA and protein synthesis mechanisms (13 papers). The work is most often cited by research in Aging (409 citations), Molecular Biology (12.0k citations) and Endocrine and Autonomic Systems (792 citations). Sara C. Kozma has collaborated with scholars based in United States, Switzerland and Spain. Frequent co-authors include George Thomas, Patrick B. Dennis, George Thomas, Sung Hee Um, Manel Joaquin, Melanie Sticker, Nick Pullen, Stefano Fumagalli, Ernst Hafen and Hugo Stocker. Their work appears in journals such as Nature, Science and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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