Michael J. Eck

47.3k total citations · 11 hit papers
158 papers, 32.5k citations indexed

About

Michael J. Eck is a scholar working on Molecular Biology, Oncology and Pulmonary and Respiratory Medicine. According to data from OpenAlex, Michael J. Eck has authored 158 papers receiving a total of 32.5k indexed citations (citations by other indexed papers that have themselves been cited), including 104 papers in Molecular Biology, 48 papers in Oncology and 32 papers in Pulmonary and Respiratory Medicine. Recurrent topics in Michael J. Eck's work include Lung Cancer Treatments and Mutations (31 papers), Protein Kinase Regulation and GTPase Signaling (26 papers) and Cancer therapeutics and mechanisms (22 papers). Michael J. Eck is often cited by papers focused on Lung Cancer Treatments and Mutations (31 papers), Protein Kinase Regulation and GTPase Signaling (26 papers) and Cancer therapeutics and mechanisms (22 papers). Michael J. Eck collaborates with scholars based in United States, Germany and South Korea. Michael J. Eck's co-authors include Titus J. Boggon, Matthew Meyerson, Pasi A. Jänne, Heidi Greulich, Bruce E. Johnson, Cai‐Hong Yun, Wenqing Xu, Stephen C. Harrison, Steven E. Shoelson and Stephen R. Sprang and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Michael J. Eck

152 papers receiving 31.8k citations

Hit Papers

EGFR Mutations in Lung Cancer: Correlation with Clinical ... 1995 2026 2005 2015 2004 2005 2008 1997 2007 2.5k 5.0k 7.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
    2004 7.5k citations J. Guillermo Paez, Pasi A. Jänne et al. Science profile →
  2. EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib
    2005 3.2k citations Titus J. Boggon, Pasi A. Jänne et al. profile →
  3. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
    2008 1.6k citations Cai‐Hong Yun, Kristen E. Mengwasser et al. Proceedings of the National Academy of Sciences profile →
  4. Three-dimensional structure of the tyrosine kinase c-Src
    1997 1.2k citations Michael J. Eck et al. profile →
  5. Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity
    2007 904 citations Cai‐Hong Yun, Titus J. Boggon et al. profile →
  6. Catalytic specificity of protein-tyrosine kinases is critical for selective signalling
    1995 805 citations Michael J. Eck, Lewis C. Cantley et al. profile →
  7. Crystal Structure of the Tyrosine Phosphatase SHP-2
    1998 786 citations Michael J. Eck et al. profile →
  8. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
    2009 785 citations Dalia Ercan, Liang Chen et al. profile →
  9. Crystal Structures of c-Src Reveal Features of Its Autoinhibitory Mechanism
    1999 712 citations Michael J. Eck et al. Molecular Cell profile →
  10. Mechanism and Function of Formins in the Control of Actin Assembly
    2007 623 citations Michael J. Eck et al. profile →
  11. Structure and regulation of Src family kinases
    2004 546 citations Titus J. Boggon, Michael J. Eck profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Michael J. Eck United States 76 18.3k 12.5k 11.2k 4.5k 3.9k 158 32.5k
Neal Rosen United States 100 24.7k 1.4× 12.2k 1.0× 5.7k 0.5× 4.2k 0.9× 3.0k 0.8× 255 34.8k
Jeffrey A. Engelman United States 91 21.3k 1.2× 16.0k 1.3× 13.8k 1.2× 6.2k 1.4× 2.0k 0.5× 187 36.0k
Carlos L. Arteaga United States 101 19.8k 1.1× 18.4k 1.5× 7.2k 0.6× 6.4k 1.4× 2.2k 0.6× 432 34.7k
Patricia S. Steeg United States 73 13.2k 0.7× 8.4k 0.7× 5.2k 0.5× 4.3k 1.0× 1.9k 0.5× 200 23.1k
Jeffrey Settleman United States 72 14.0k 0.8× 10.4k 0.8× 7.7k 0.7× 3.8k 0.8× 1.3k 0.3× 158 23.5k
Robert S. Kerbel Canada 99 24.5k 1.3× 16.5k 1.3× 5.8k 0.5× 13.4k 2.9× 5.5k 1.4× 402 41.7k
Nathanael S. Gray United States 104 30.5k 1.7× 10.9k 0.9× 4.9k 0.4× 3.0k 0.7× 3.2k 0.8× 476 42.2k
Julian Downward United Kingdom 101 30.1k 1.6× 11.4k 0.9× 3.1k 0.3× 4.9k 1.1× 5.1k 1.3× 292 41.7k
William C. Hahn United States 101 26.5k 1.5× 11.2k 0.9× 4.9k 0.4× 7.8k 1.7× 4.7k 1.2× 293 40.9k
Charles L. Sawyers United States 99 24.8k 1.4× 12.3k 1.0× 15.9k 1.4× 9.3k 2.0× 3.2k 0.8× 266 53.4k

Countries citing papers authored by Michael J. Eck

Since Specialization
Citations

This map shows the geographic impact of Michael J. Eck's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael J. Eck with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael J. Eck more than expected).

Fields of papers citing papers by Michael J. Eck

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael J. Eck. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael J. Eck. The network helps show where Michael J. Eck may publish in the future.

Co-authorship network of co-authors of Michael J. Eck

This figure shows the co-authorship network connecting the top 25 collaborators of Michael J. Eck. A scholar is included among the top collaborators of Michael J. Eck based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Michael J. Eck. Michael J. Eck is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Latorre‐Muro, Pedro, Katherine Zhang, Jonathan M. Palozzi, et al.. (2025). Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity. Nature Cell Biology. 27(1). 130–140. 1 indexed citations
2.
Ha, Byung Hak, et al.. (2025). Characterization and inhibitor sensitivity of ARAF, BRAF, and CRAF kinases. Journal of Biological Chemistry. 301(12). 110800–110800.
3.
4.
Li, Zhengnian, Wenchao Lu, Tyler S. Beyett, et al.. (2024). ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases. Journal of Medicinal Chemistry. 67(4). 2837–2848. 2 indexed citations
5.
Beyett, Tyler S., Ciric To, David E. Heppner, et al.. (2022). Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors. Nature Communications. 13(1). 2530–2530. 56 indexed citations
6.
To, Ciric, Jaebong Jang, Ting Chen, et al.. (2019). Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor. Cancer Discovery. 9(7). 926–943. 250 indexed citations
7.
Jang, Jaebong, Jieun Son, Eunyoung Park, et al.. (2018). Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor. Angewandte Chemie International Edition. 57(36). 11629–11633. 23 indexed citations
8.
Ercan, Dalia, Hwan Geun Choi, Cai‐Hong Yun, et al.. (2015). EGFR Mutations and Resistance to Irreversible Pyrimidine-Based EGFR Inhibitors. Clinical Cancer Research. 21(17). 3913–3923. 291 indexed citations
9.
Hu, Yiduo, Sarah A. Petit, Scott B. Ficarro, et al.. (2014). PARP1-Driven Poly-ADP-Ribosylation Regulates BRCA1 Function in Homologous Recombination–Mediated DNA Repair. Cancer Discovery. 4(12). 1430–1447. 136 indexed citations
10.
Cho, Jeonghee, Liang Chen, Naveen F. Sangji, et al.. (2013). Cetuximab Response of Lung Cancer–Derived EGF Receptor Mutants Is Associated with Asymmetric Dimerization. Cancer Research. 73(22). 6770–6779. 86 indexed citations
11.
Ni, Jing, Qingsong Liu, Shaozhen Xie, et al.. (2012). Functional Characterization of an Isoform-Selective Inhibitor of PI3K-p110β as a Potential Anticancer Agent. Cancer Discovery. 2(5). 425–433. 125 indexed citations
12.
He, Mai, Marzia Capelletti, Khédoudja Nafa, et al.. (2011). EGFR Exon 19 Insertions: A New Family of Sensitizing EGFR Mutations in Lung Adenocarcinoma. Clinical Cancer Research. 18(6). 1790–1797. 109 indexed citations
13.
Sasaki, Takaaki, Katsuhiro Okuda, Wei Zheng, et al.. (2010). The Neuroblastoma-Associated F1174L ALK Mutation Causes Resistance to an ALK Kinase Inhibitor in ALK-Translocated Cancers. Cancer Research. 70(24). 10038–10043. 254 indexed citations
14.
Yun, Cai‐Hong, Kristen E. Mengwasser, Angela V. Toms, et al.. (2008). The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proceedings of the National Academy of Sciences. 105(6). 2070–2075. 1564 indexed citations breakdown →
15.
Swanson, Kenneth D., Yong Tang, Derek F. Ceccarelli, et al.. (2008). The Skap-hom Dimerization and PH Domains Comprise a 3′-Phosphoinositide-Gated Molecular Switch. Molecular Cell. 32(4). 564–575. 37 indexed citations
16.
Paez, J. Guillermo, Pasi A. Jänne, Jeffrey C. Lee, et al.. (2004). EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy. Science. 304(5676). 1497–1500. 7539 indexed citations breakdown →
17.
Kim, Peter W., Zhenyu Sun, Stephen C. Blacklow, Gerhard Wagner, & Michael J. Eck. (2003). A Zinc Clasp Structure Tethers Lck to T Cell Coreceptors CD4 and CD8. Science. 301(5640). 1725–1728. 209 indexed citations
18.
Wang, Jia‐Huai & Michael J. Eck. (2003). Assembling atomic resolution views of the immunological synapse. Current Opinion in Immunology. 15(3). 286–293. 3 indexed citations
19.
Morra, Massimo, Marı́a Simarro, Margarita Martı́n, et al.. (2001). Characterization of SH2D1A Missense Mutations Identified in X-linked Lymphoproliferative Disease Patients. Journal of Biological Chemistry. 276(39). 36809–36816. 76 indexed citations
20.
Poy, Florence, Michael B. Yaffe, Joan Sayós, et al.. (1999). Crystal Structures of the XLP Protein SAP Reveal a Class of SH2 Domains with Extended, Phosphotyrosine-Independent Sequence Recognition. Molecular Cell. 4(4). 555–561. 206 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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