Tinghu Zhang

18.2k total citations · 8 hit papers
81 papers, 6.7k citations indexed

About

Tinghu Zhang is a scholar working on Molecular Biology, Oncology and Organic Chemistry. According to data from OpenAlex, Tinghu Zhang has authored 81 papers receiving a total of 6.7k indexed citations (citations by other indexed papers that have themselves been cited), including 72 papers in Molecular Biology, 31 papers in Oncology and 11 papers in Organic Chemistry. Recurrent topics in Tinghu Zhang's work include Protein Degradation and Inhibitors (46 papers), Ubiquitin and proteasome pathways (27 papers) and Cancer-related Molecular Pathways (13 papers). Tinghu Zhang is often cited by papers focused on Protein Degradation and Inhibitors (46 papers), Ubiquitin and proteasome pathways (27 papers) and Cancer-related Molecular Pathways (13 papers). Tinghu Zhang collaborates with scholars based in United States, Germany and United Kingdom. Tinghu Zhang's co-authors include Nathanael S. Gray, Eric S. Fischer, Nicholas Kwiatkowski, Katherine A. Donovan, Richard A. Young, Yanke Liang, Baishan Jiang, Lyn H. Jones, Radosław P. Nowak and Zhixiang He and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Tinghu Zhang

80 papers receiving 6.6k citations

Hit Papers

Developing Irreversible I... 2013 2026 2017 2021 2013 2014 2018 2017 2015 100 200 300 400 500
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Developing Irreversible Inhibitors of the Protein Kinase Cysteinome
    2013 513 citations Tinghu Zhang, Lyn H. Jones et al. profile →
  2. CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer
    2014 451 citations Edmond Chipumuro, Eugenio Marco et al. Cell profile →
  3. Plasticity in binding confers selectivity in ligand-induced protein degradation
    2018 427 citations Radosław P. Nowak, Zhixiang He et al. Nature Chemical Biology profile →
  4. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation
    2017 402 citations Baishan Jiang, Yanke Liang et al. Nature Chemical Biology profile →
  5. CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer
    2015 347 citations Yubao Wang, Tinghu Zhang et al. Cell profile →
  6. A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging
    2020 260 citations Haopeng Xiao, Mark P. Jedrychowski et al. Cell profile →
  7. Light-induced control of protein destruction by opto-PROTAC
    2020 226 citations Jing Liu, He Chen et al. Science Advances profile →
  8. Rewiring cancer drivers to activate apoptosis
    2023 89 citations Zhengnian Li, Tinghu Zhang et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Tinghu Zhang United States 38 5.3k 2.3k 792 719 653 81 6.7k
Taebo Sim South Korea 31 3.5k 0.7× 1.1k 0.5× 951 1.2× 437 0.6× 438 0.7× 122 5.2k
Alex N. Bullock United Kingdom 49 6.1k 1.1× 2.8k 1.2× 872 1.1× 417 0.6× 756 1.2× 108 8.7k
David J. Bearss United States 34 4.9k 0.9× 1.5k 0.6× 306 0.4× 457 0.6× 367 0.6× 114 6.5k
Zoran Filipovic United States 10 3.9k 0.7× 3.2k 1.4× 608 0.8× 227 0.3× 352 0.5× 17 5.3k
Binh Thanh Vu Vietnam 17 4.2k 0.8× 3.4k 1.5× 742 0.9× 210 0.3× 355 0.5× 48 5.8k
Henrik Daub Germany 35 5.4k 1.0× 1.7k 0.8× 290 0.4× 488 0.7× 403 0.6× 56 7.6k
Nancy E. Kohl United States 42 5.2k 1.0× 2.4k 1.1× 757 1.0× 261 0.4× 511 0.8× 97 8.0k
Lyubomir T. Vassilev United States 36 7.0k 1.3× 5.0k 2.2× 887 1.1× 492 0.7× 670 1.0× 70 9.3k
Judith S. Sebolt–Leopold United States 33 4.9k 0.9× 2.7k 1.2× 573 0.7× 267 0.4× 591 0.9× 67 6.8k
Eric S. Fischer United States 37 6.0k 1.1× 2.3k 1.0× 339 0.4× 1.3k 1.8× 285 0.4× 118 6.7k

Countries citing papers authored by Tinghu Zhang

Since Specialization
Citations

This map shows the geographic impact of Tinghu Zhang's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tinghu Zhang with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tinghu Zhang more than expected).

Fields of papers citing papers by Tinghu Zhang

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tinghu Zhang. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tinghu Zhang. The network helps show where Tinghu Zhang may publish in the future.

Co-authorship network of co-authors of Tinghu Zhang

This figure shows the co-authorship network connecting the top 25 collaborators of Tinghu Zhang. A scholar is included among the top collaborators of Tinghu Zhang based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Tinghu Zhang. Tinghu Zhang is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Liu, Han‐Yuan, Zhengnian Li, Zhixiang He, et al.. (2024). Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism. Nature Communications. 15(1). 5179–5179. 11 indexed citations
2.
Li, Zhengnian, Wenchao Lu, Tyler S. Beyett, et al.. (2024). ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases. Journal of Medicinal Chemistry. 67(4). 2837–2848. 2 indexed citations
3.
Li, Zhengnian, Jie Jiang, Scott B. Ficarro, et al.. (2024). Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality. ACS Central Science. 10(6). 1156–1166. 5 indexed citations
4.
Du, Guangyan, Jie Jiang, Wenchao Lu, et al.. (2024). Discovery of bivalent small molecule degraders of cyclin-dependent kinase 7 (CDK7). European Journal of Medicinal Chemistry. 276. 116613–116613. 1 indexed citations
5.
Doctor, Zainab M., Annan Yang, Mingfeng Hao, et al.. (2023). Development and Characterization of Selective FAK Inhibitors and PROTACs with In Vivo Activity. ChemBioChem. 24(19). e202300141–e202300141. 8 indexed citations
6.
Hsu, Austin, Qiming Duan, Daniel S. Day, et al.. (2022). Targeting transcription in heart failure via CDK7/12/13 inhibition. Nature Communications. 13(1). 4345–4345. 8 indexed citations
7.
Huang, Chun‐Hao, Francisco J. Sánchez‐Rivera, Margaret C. Kennedy, et al.. (2022). A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets. Proceedings of the National Academy of Sciences. 119(17). e2110557119–e2110557119. 8 indexed citations
8.
Teng, Mingxing, Wenchao Lu, Katherine A. Donovan, et al.. (2021). Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. Journal of Medicinal Chemistry. 65(1). 747–756. 34 indexed citations
9.
Lu, Wenchao, Milka Kostić, Tinghu Zhang, et al.. (2021). Fragment-based covalent ligand discovery. RSC Chemical Biology. 2(2). 354–367. 80 indexed citations
10.
Jiang, Baishan, Yang Gao, Jianwei Che, et al.. (2021). Discovery and resistance mechanism of a selective CDK12 degrader. Nature Chemical Biology. 17(6). 675–683. 96 indexed citations
11.
Du, Guangyan, Jie Jiang, Qibiao Wu, et al.. (2021). Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2. Angewandte Chemie International Edition. 60(29). 15905–15911. 48 indexed citations
12.
Liu, Jing, He Chen, Leina Ma, et al.. (2020). Light-induced control of protein destruction by opto-PROTAC. Science Advances. 6(8). eaay5154–eaay5154. 226 indexed citations breakdown →
13.
Manz, Theresa, Fleur M. Ferguson, Tinghu Zhang, et al.. (2020). Discovery and Structure–Activity Relationship Study of ( Z )-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. Journal of Medicinal Chemistry. 63(9). 4880–4895. 18 indexed citations
14.
Xiao, Haopeng, Mark P. Jedrychowski, Devin K. Schweppe, et al.. (2020). A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 180(5). 968–983.e24. 260 indexed citations breakdown →
15.
Manz, Theresa, Adam Yasgar, Matthew D. Hall, et al.. (2019). Structure–Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. ACS Medicinal Chemistry Letters. 11(3). 346–352. 13 indexed citations
16.
Du, Lili, Sandra S. Ojeda, Tran Nguyen, et al.. (2019). JNK2 Is Required for the Tumorigenic Properties of Melanoma Cells. ACS Chemical Biology. 14(7). 1426–1435. 12 indexed citations
17.
Silva, M. Catarina, Fleur M. Ferguson, Quan-Ying Cai, et al.. (2019). Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. eLife. 8. 203 indexed citations
18.
Zarei, Mahsa, Heng Du, Amin H. Nassar, et al.. (2019). Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion. The Journal of Experimental Medicine. 216(11). 2635–2652. 17 indexed citations
19.
Chipumuro, Edmond, Eugenio Marco, Camilla L. Christensen, et al.. (2014). CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer. DSpace@MIT (Massachusetts Institute of Technology). 1 indexed citations
20.
Liu, Wujun, et al.. (2010). Construction of a long-lenth cDNA library for Xinji Fine-wool Sheep skin tissue by use of SMART technique.. Journal of Northwest A&F University. 38(5). 46–55. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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