James G. Christensen

45.8k citations

189 papers · 18.5k indexed · 8 hit papers · h-index 61

Molecular Biology top 0.5%
Oncology top 0.1%
Pulmonary and Respiratory Medicine top 0.1%
Cancer Research top 0.2%
Hepatology top 0.1%

Co-authors: Pasi A. Jänne John M.L. Ebos Christina R. Lee Robert S. Kerbel Ravi Salgia William Cruz‐Muñoz Georg A. Bjarnason Andrew M. Rogers
Topics: Lung Cancer Treatments and Mutations (49 papers)Liver physiology and pathology (39 papers)PI3K/AKT/mTOR signaling in cancer (35 papers)
Cited by: Hepatology Oncology Cancer Research
Journals: Science New England Journal of Medicine Proceedings of the National Academy of Sciences
Partner nations: United States South Korea Australia

In The Last Decade

James G. Christensen

183 papers receiving 18.1k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling

2007 3.6k citations Jeffrey A. Engelman, Kreshnik Zejnullahu et al. Science profile →
Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

2009 1.4k citations James G. Christensen et al. profile →
Crizotinib inALK-Rearranged Inflammatory Myofibroblastic Tumor

2010 604 citations James E. Butrynski, Marzia Capelletti et al. profile →
An Orally Available Small-Molecule Inhibitor of c-Met, PF-2341066, Exhibits Cytoreductive Antitumor Efficacy through Antiproliferative and Antiangiogenic Mechanisms

2007 593 citations Helen Y. Zou, Qiuhua Li et al. Cancer Research profile →
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma

2007 513 citations James G. Christensen, Helen Y. Zou et al. Molecular Cancer Therapeutics profile →
MET Exon 14 Mutations in Non–Small-Cell Lung Cancer Are Associated With Advanced Age and Stage-Dependent MET Genomic Amplification and c-Met Overexpression

2016 493 citations Pasi A. Jänne, James G. Christensen et al. profile →
Adagrasib with or without Cetuximab in Colorectal Cancer with Mutated KRAS G12C

2022 269 citations James G. Christensen et al. profile →
First-in-Human Phase I/IB Dose-Finding Study of Adagrasib (MRTX849) in Patients With Advanced KRAS^G12C Solid Tumors (KRYSTAL-1)

2022 206 citations Pasi A. Jänne, James G. Christensen et al. profile →

Peers

Countries citing papers authored by James G. Christensen

Since Specialization

Citations

This map shows the geographic impact of James G. Christensen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James G. Christensen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James G. Christensen more than expected).

Fields of papers citing papers by James G. Christensen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James G. Christensen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James G. Christensen. The network helps show where James G. Christensen may publish in the future.

Co-authorship network of co-authors of James G. Christensen

This figure shows the co-authorship network connecting the top 25 collaborators of James G. Christensen. A scholar is included among the top collaborators of James G. Christensen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with James G. Christensen. James G. Christensen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition 2013 ·Clinical Cancer Research ·Ying Zhang,(unknown),Yanzhi Yang,Fadila Guessous,Charles G. diPierro,Valerie Calvert,Jianghong Deng,David Schiff,Wenjun Xin,Jae K. Lee,Benjamin Purow,James G. Christensen,Emanuel F. Petricoin,Roger Abounader	29
2	Activation of IL-6R/JAK1/STAT3 Signaling Induces De Novo Resistance to Irreversible EGFR Inhibitors in Non–Small Cell Lung Cancer with T790M Resistance Mutation 2012 ·Molecular Cancer Therapeutics ·Sun Mi Kim,Oh-Joon Kwon,Yun Hong,Joo Hang Kim,Flavio Solca,Sang‐Jun Ha,Ross A. Soo,James G. Christensen,Ji Hyun Lee,Byoung Chul Cho	172
3	Suppression of Tumor Invasion and Metastasis by Concurrent Inhibition of c-Met and VEGF Signaling in Pancreatic Neuroendocrine Tumors 2012 ·Cancer Discovery ·Barbara Sennino,Toshina Ishiguro‐Oonuma,Ying Wei,Ryan M. Naylor,Casey W. Williamson,Vikash Bhagwandin,Sébastien P. Tabruyn,Weon‐Kyoo You,Harold A. Chapman,James G. Christensen,Dana T. Aftab,Donald M. McDonald	325
4	An Integrated Genomic Approach to Identify Predictive Biomarkers of Response to the Aurora Kinase Inhibitor PF-03814735 2012 ·Molecular Cancer Therapeutics ·Kenneth E. Hook,(unknown),Maruja E. Lira,Keith A. Ching,Nathan V. Lee,Joan Cao,Jing Yuan,Jingjing Ye,Mark Ozeck,Stephanie T. Shi,Xianxian Zheng,Paul A. Rejto,Julie L.C. Kan,James G. Christensen,Adam Pavlı́c̀ek	77
5	Biomarker and Pharmacologic Evaluation of the γ-Secretase Inhibitor PF-03084014 in Breast Cancer Models 2012 ·Clinical Cancer Research ·Cathy C. Zhang,Adam Pavlı́c̀ek,Qin Zhang,Maruja E. Lira,Cory L. Painter,Zhengming Yan,Xianxian Zheng,Nathan V. Lee,Mark Ozeck,Ming Qiu,(unknown),Patrick B. Lappin,Anthony Wong,Paul A. Rejto,Tod Smeal,James G. Christensen	53
6	Multiple Mutations and Bypass Mechanisms Can Contribute to Development of Acquired Resistance to MET Inhibitors 2011 ·Cancer Research ·Jie Qi,Michele McTigue,Andrew M. Rogers,Eugene Lifshits,James G. Christensen,Pasi A. Jänne,Jeffrey A. Engelman	168
7	Antitumor Activity of SNX-2112, a Synthetic Heat Shock Protein-90 Inhibitor, in MET -Amplified Tumor Cells with or without Resistance to Selective MET Inhibition 2011 ·Clinical Cancer Research ·Thomas Bachleitner‐Hofmann,Mark Y. Sun,Chin‐Tung Chen,David Liska,Zhaoshi Zeng,Agnès Viale,Adam B. Olshen,Martina Mittlboeck,James G. Christensen,Neal Rosen,David B. Solit,Martin R. Weiser	33
8	Evaluation of the Antitumor Effects and Mechanisms of PF00299804, a Pan-HER Inhibitor, Alone or in Combination with Chemotherapy or Targeted Agents in Gastric Cancer 2011 ·Molecular Cancer Therapeutics ·(unknown),Keith A. Ching,Julie L.C. Kan,Hwang-Phill Kim,Sae‐Won Han,Seock‐Ah Im,Tae‐You Kim,James G. Christensen,Do‐Youn Oh,Yung‐Jue Bang	58
9	[18F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells 2011 ·Clinical Cancer Research ·Cathy C. Zhang,Zhengming Yan,Wenlin Li,Kyle Kuszpit,Cory L. Painter,Qin Zhang,Patrick B. Lappin,Tim Nichols,Maruja E. Lira,Timothy Affolter,(unknown),Carleen Cullinane,Mary E. Spilker,Kenneth Zasadny,Peter J. O’Brien,(unknown),Anthony Wong,James G. Christensen	62
10	In Vivo Activity of Combined PI3K/mTOR and MEK Inhibition in a KrasG12D ; Pten Deletion Mouse Model of Ovarian Cancer 2011 ·Molecular Cancer Therapeutics ·Kathryn M. Kinross,Daniel V. Brown,Margarete Kleinschmidt,Susan Jackson,James G. Christensen,Carleen Cullinane,Rodney J. Hicks,Ricky W. Johnstone,Grant A. McArthur	62
11	PF-03732010: A Fully Human Monoclonal Antibody against P-Cadherin with Antitumor and Antimetastatic Activity 2010 ·Clinical Cancer Research ·Cathy C. Zhang,Zhengming Yan,Qin Zhang,Kyle Kuszpit,Kenneth Zasadny,Ming Qiu,Cory L. Painter,Anthony Wong,Eugenia Kraynov,Maria E. Arango,Pramod P. Mehta,Ian Popoff,Gerald F. Casperson,Gerrit Los,Steve Bender,Kenna Anderes,James G. Christensen,Todd VanArsdale	58
12	HGF/c-Met Acts as an Alternative Angiogenic Pathway in Sunitinib-Resistant Tumors 2010 ·Cancer Research ·Farbod Shojaei,Joseph H. Lee,Brett H. Simmons,Anthony Wong,(unknown),(unknown),Junli Feng,Albert Stewart,Dana D. Hu‐Lowe,James G. Christensen	267
13	The Neuroblastoma-Associated F1174L ALK Mutation Causes Resistance to an ALK Kinase Inhibitor in ALK-Translocated Cancers 2010 ·Cancer Research ·Takaaki Sasaki,Katsuhiro Okuda,Wei Zheng,James E. Butrynski,Marzia Capelletti,Liping Wang,Nathanael S. Gray,Keith D. Wilner,James G. Christensen,George D. Demetri,Geoffrey I. Shapiro,Scott J. Rodig,Michael J. Eck,Pasi A. Jänne	254
14	Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth 2010 ·Proceedings of the National Academy of Sciences ·Brion W. Murray,Chuangxing Guo,Joseph Piraino,John Westwick,Cathy Zhang,Jane E. Lamerdin,Eleanor Dagostino,(unknown),Cho‐Ming Loi,Michael Zager,Eugenia Kraynov,Ian Popoff,James G. Christensen,(unknown),Susan E. Kephart,Joseph Marakovits,(unknown),Simon Bergqvist,Tod Smeal	253
15	Acquired Resistance of Non–Small Cell Lung Cancer Cells to MET Kinase Inhibition Is Mediated by a Switch to Epidermal Growth Factor Receptor Dependency 2010 ·Cancer Research ·Ultan McDermott,Raju V. Pusapati,James G. Christensen,Nathanael S. Gray,Jeff Settleman	129
16	PF-00477736 Mediates Checkpoint Kinase 1 Signaling Pathway and Potentiates Docetaxel-Induced Efficacy in Xenografts 2009 ·Clinical Cancer Research ·Cathy Zhang,Zhengming Yan,Cory L. Painter,Qin Zhang,Enhong Chen,Maria E. Arango,Kyle Kuszpit,Kenneth Zasadny,Max Hallin,Jill Hallin,Anthony Wong,(unknown),Guizhen Sun,Ming Qiu,Kenna Anderes,James G. Christensen	45
17	An Orally Available Small-Molecule Inhibitor of c-Met, PF-2341066, Exhibits Cytoreductive Antitumor Efficacy through Antiproliferative and Antiangiogenic Mechanismsbreakdown → 2007 ·Cancer Research ·Helen Y. Zou,Qiuhua Li,Joseph H. Lee,Maria E. Arango,Scott R. McDonnell,Shinji Yamazaki,Tatiana Koudriakova,Gordon Alton,Jingrong Jean Cui,(unknown),Mitchell D. Nambu,Gerrit Los,Steven L. Bender,Barbara Mroczkowski,James G. Christensen	593
18	MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signalingbreakdown → 2007 ·Science ·Jeffrey A. Engelman,Kreshnik Zejnullahu,Tetsuya Mitsudomi,Youngchul Song,Courtney Hyland,Joon Oh Park,Neal I. Lindeman,(unknown),Xiao‐Jun Zhao,James G. Christensen,Takayuki Kosaka,Alison J. Holmes,Andrew M. Rogers,Federico Cappuzzo,Tony Mok,Charles Lee,Bruce E. Johnson,Lewis C. Cantley,Pasi A. Jänne	3570
19	Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphomabreakdown → 2007 ·Molecular Cancer Therapeutics ·James G. Christensen,Helen Y. Zou,Maria E. Arango,Qiuhua Li,Joseph H. Lee,Scott R. McDonnell,Shinji Yamazaki,Gordon Alton,Barbara Mroczkowski,Gerrit Los	513
20	Functional Expression and Mutations of c-Met and Its Therapeutic Inhibition with SU11274 and Small Interfering RNA in Non–Small Cell Lung Cancer 2005 ·Cancer Research ·C. Patrick,Ramasamy Jagadeeswaran,Simha Jagadeesh,Maria Tretiakova,Vidya Nallasura,Edward A. Fox,Mark Berner Hansen,Erik Schaefer,Katsuhiko Naoki,Alan S. Lader,William G. Richards,David J. Sugarbaker,Aliya N. Husain,James G. Christensen,Ravi Salgia	467

About James G. Christensen

James G. Christensen is a scholar working on Hepatology, Oncology and Pulmonary and Respiratory Medicine, having authored 189 papers that have together received 18.5k indexed citations. Recurring topics across this work include Lung Cancer Treatments and Mutations (49 papers), Liver physiology and pathology (39 papers) and PI3K/AKT/mTOR signaling in cancer (35 papers). The work is most often cited by research in Hepatology (3.3k citations), Oncology (9.0k citations) and Cancer Research (3.7k citations). James G. Christensen has collaborated with scholars based in United States, South Korea and Australia. Frequent co-authors include Pasi A. Jänne, John M.L. Ebos, Christina R. Lee, Robert S. Kerbel, Ravi Salgia, William Cruz‐Muñoz, Georg A. Bjarnason, Andrew M. Rogers, Jeffrey A. Engelman and Kreshnik Zejnullahu. Their work appears in journals such as Science, New England Journal of Medicine and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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