Mariano Barbacid

66.1k citations

266 papers · 52.4k indexed · 32 hit papers · h-index 107

Molecular Biology top 0.02%
Oncology top 0.05%
Cellular and Molecular Neuroscience top 0.02%
Cell Biology top 0.05%
Cancer Research top 0.1%

Co-authors: Marcos Malumbres Rüdiger Klein Dionisio Martín‐Zanca Fabienne Lamballe Carmen Guerra Eugenio Santos Pierre Dubus Peter Tapley
Topics: Cancer-related Molecular Pathways (52 papers)Nerve injury and regeneration (35 papers)Virus-based gene therapy research (30 papers)
Cited by: Developmental Neuroscience Cellular and Molecular Neuroscience Oncology
Journals: Nature Science Cell
Partner nations: United States Spain Germany

In The Last Decade

Mariano Barbacid

264 papers receiving 50.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

ras GENES

1987 3.4k citations Mariano Barbacid profile →
Cell cycle, CDKs and cancer: a changing paradigm

2009 2.9k citations Marcos Malumbres, Mariano Barbacid profile →
RAS oncogenes: the first 30 years

2003 1.4k citations Marcos Malumbres, Mariano Barbacid profile →
The trk proto-oncogene encodes a receptor for nerve growth factor

1991 1.2k citations Mariano Barbacid et al. profile →
Senescence in premalignant tumours

2005 1.2k citations Carmen Guerra, Mariano Barbacid et al. profile →
The Trk family of neurotrophin receptors

1994 1.1k citations Mariano Barbacid profile →
To cycle or not to cycle: a critical decision in cancer

2001 1.1k citations Marcos Malumbres, Mariano Barbacid profile →
A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

1982 1.1k citations Eugenio Santos, Mariano Barbacid et al. profile →
Renal agenesis and the absence of enteric neurons in mice lacking GDNF

1996 986 citations Mariano Barbacid et al. profile →
Mammalian cyclin-dependent kinases

2005 938 citations Marcos Malumbres, Mariano Barbacid profile →
trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 932 citations Mariano Barbacid et al. profile →
Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice

2007 874 citations Carmen Guerra, Marta Cañamero et al. Cancer Cell profile →
The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1991 823 citations Mariano Barbacid et al. profile →
Cdk1 is sufficient to drive the mammalian cell cycle

2007 806 citations David Santamarı́a, Pierre Dubus et al. profile →
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

1994 799 citations Xosé R. Bustelo, Mariano Barbacid et al. profile →
Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene

1994 792 citations Mariano Barbacid et al. profile →
Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 695 citations Mariano Barbacid et al. profile →
A Pericyte Origin of Spinal Cord Scar Tissue

2011 656 citations Mariano Barbacid et al. profile →
The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 654 citations Mariano Barbacid et al. profile →
A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

1986 639 citations Mariano Barbacid et al. profile →
Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

2003 634 citations Sagrario Ortega, Pierre Dubus et al. profile →
Mammalian Cells Cycle without the D-Type Cyclin-Dependent Kinases Cdk4 and Cdk6

2004 609 citations Marcos Malumbres, Rocı́o Sotillo et al. profile →
Cyclin D-dependent kinases, INK4 inhibitors and cancer

2002 602 citations Sagrario Ortega, Marcos Malumbres et al. profile →
Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations

1983 584 citations Mariano Barbacid et al. profile →
Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia

1999 583 citations Pierre Dubus, Mariano Barbacid et al. profile →
Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death

1993 570 citations Mariano Barbacid et al. profile →
Molecular and biochemical characterization of the human trk proto-oncogene.

1989 540 citations Mariano Barbacid et al. profile →
Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements

1994 525 citations Mariano Barbacid et al. profile →
trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

1989 518 citations Mariano Barbacid et al. profile →
T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes

1982 502 citations Eugenio Santos, Mariano Barbacid et al. profile →
Cell Growth & Differentiation

1992 453 citations Mariano Barbacid et al. profile →
Targeting the MAPK Pathway in KRAS-Driven Tumors

2020 330 citations Matthias Drosten, Mariano Barbacid Cancer Cell profile →

Peers

Countries citing papers authored by Mariano Barbacid

Since Specialization

Citations

This map shows the geographic impact of Mariano Barbacid's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Mariano Barbacid with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Mariano Barbacid more than expected).

Fields of papers citing papers by Mariano Barbacid

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Mariano Barbacid. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Mariano Barbacid. The network helps show where Mariano Barbacid may publish in the future.

Co-authorship network of co-authors of Mariano Barbacid

This figure shows the co-authorship network connecting the top 25 collaborators of Mariano Barbacid. A scholar is included among the top collaborators of Mariano Barbacid based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Mariano Barbacid. Mariano Barbacid is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Systemic Kras ablation disrupts myeloid cell homeostasis in adult mice 2025 ·Proceedings of the National Academy of Sciences ·(unknown),(unknown),(unknown),(unknown),(unknown),Isabel Hernández-Porras,Lucía Simón-Carrasco,(unknown),(unknown),(unknown),(unknown),(unknown),Matthias Drosten,Mónica Musteanu,Federico Virga,Eugenio Santos,Francisca Mulero,Eduardo Caleiras,Carmen Guerra,Mariano Barbacid	2
2	Type I interferon signaling pathway enhances immune-checkpoint inhibition in KRAS mutant lung tumors 2024 ·Proceedings of the National Academy of Sciences ·(unknown),Ana Fernández‐Rodríguez,Coral Fustero‐Torre,Elena Piñeiro-Yáñez,Haiyun Wang,Carmen G. Lechuga,Sergio Callejas,(unknown),(unknown),Laura Esteban-Burgos,(unknown),(unknown),Carmen Guerra,Chiara Ambrogio,Matthias Drosten,David Santamarı́a,Fátima Al‐Shahrour,Ana Dopazo,Mariano Barbacid,Mónica Musteanu	9
3	KRAS inhibitors: going noncovalent 2022 ·Molecular Oncology ·Matthias Drosten,Mariano Barbacid	9
4	KSR induces RAS‐independent MAPK pathway activation and modulates the efficacy of KRAS inhibitors 2022 ·Molecular Oncology ·(unknown),Harrys K.C. Jacob,(unknown),Sara García‐Alonso,Carmen G. Lechuga,Tirso Pons,Mónica Musteanu,Carmen Guerra,Matthias Drosten,Mariano Barbacid	22
5	Combined Inhibition of FOSL-1 and YAP Using siRNA-Lipoplexes Reduces the Growth of Pancreatic Tumor 2022 ·Cancers ·(unknown),(unknown),Ana Igea,(unknown),M. Elisabete C.D. Real Oliveira,Andreia C. Gomes,Carmen Guerra,Mariano Barbacid,África González‐Fernández,Rosana Simón‐Vázquez	5
6	Targeting KRAS mutant lung cancer: light at the end of the tunnel 2021 ·Molecular Oncology ·Matthias Drosten,Mariano Barbacid	25
7	Dynamic Regulation of Expression of KRAS and Its Effectors Determines the Ability to Initiate Tumorigenesis in Pancreatic Acinar Cells 2021 ·Cancer Research ·Mohamad Assi,Younès Achouri,Axelle Loriot,Nicolas Dauguet,(unknown),(unknown),(unknown),(unknown),Carmen Guerra,Luc Bouwens,Mariano Barbacid,Frédéric P. Lemaigre,Patrick Jacquemin	12
8	KRAS4A induces metastatic lung adenocarcinomas in vivo in the absence of the KRAS4B isoform 2021 ·Proceedings of the National Academy of Sciences ·(unknown),(unknown),Carmen G. Lechuga,(unknown),Eduardo Zarzuela,Ruth Álvarez,Mónica Musteanu,Carmen Guerra,Eduardo Caleiras,Javier Muñoz,Sagrario Ortega,Matthias Drosten,Mariano Barbacid	12
9	Requirement for epithelial p38α in KRAS-driven lung tumor progression 2020 ·Proceedings of the National Academy of Sciences ·(unknown),Sebastián Real,Nuria Martí Gutiérrez,(unknown),(unknown),Matthias Drosten,Mariano Barbacid,Ángel R. Nebreda	18
10	Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas 2020 ·Proceedings of the National Academy of Sciences ·Laura Esteban-Burgos,Haiyun Wang,(unknown),Jie Zheng,Carmen Blanco‐Aparicio,(unknown),Gonzalo Goméz-López,(unknown),Manuel Sanclemente,Carmen Guerra,Matthias Drosten,(unknown),Eduardo Caleiras,Jorge L. Martínez‐Torrecuadrada,Lluís Fajas,Sheng-Bin Peng,David Santamarı́a,Mónica Musteanu,Mariano Barbacid	15
11	Targeting the MAPK Pathway in KRAS-Driven Tumorsbreakdown → 2020 ·Cancer Cell ·Matthias Drosten,Mariano Barbacid	330
12	Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties 2018 ·Cancer Discovery ·Yijun Gao,Matthew T. Chang,Daniel J. McKay,Na Na,Bing Zhou,Rona Yaeger,Neilawattie M. Torres,(unknown),Matthias Drosten,Mariano Barbacid,Giordano Caponigro,Darrin D. Stuart,Henrik Moebitz,David B. Solit,Omar Abdel‐Wahab,Barry S. Taylor,Zhan Yao,Neal Rosen	87
13	Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma 2017 ·Genes & Development ·Lucía Simón-Carrasco,Osvaldo Graña‐Castro,(unknown),Harrys K.C. Jacob,Alejandro Gutiérrez,Gerardo Jiménez,Matthias Drosten,Mariano Barbacid	38
14	A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer 2017 ·PLoS Genetics ·(unknown),Lucía Simón-Carrasco,Leiore Ajuria,Núria Samper,Sergio González‐Crespo,Matthias Drosten,Mariano Barbacid,Gerardo Jiménez	45
15	H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences 2016 ·Cancer Research ·Matthias Drosten,Lucía Simón-Carrasco,Isabel Hernández-Porras,Carmen G. Lechuga,Maria Blasco,Harrys K.C. Jacob,Salvatore Fabbiano,Nicoletta Potenza,Xosé R. Bustelo,Carmen Guerra,Mariano Barbacid	19
16	Modeling Lung Cancer Evolution and Preclinical Response by Orthotopic Mouse Allografts 2014 ·Cancer Research ·Chiara Ambrogio,Francisco javier García Carmona,August Vidal,Mattia Falcone,(unknown),Octavio A. Romero,Sara Puertas,Miguel Vizoso,Ernest Nadal,Teresa Poggio,Montse Sánchez‐Céspedes,Manel Esteller,Francisca Mulero,Claudia Voena,Roberto Chiarle,Mariano Barbacid,David Santamarı́a,Alberto Villanueva	18
17	Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome 2011 ·Proceedings of the National Academy of Sciences ·Jelena Urosevic,Vincent Sauzeau,María Luisa Soto‐Montenegro,Santiago Reig,Manuel Desco,(unknown),Marta Cañamero,Francisca Mulero,Sagrario Ortega,Xosé R. Bustelo,Mariano Barbacid	59
18	Spontaneous and UV Radiation–Induced Multiple Metastatic Melanomas in Cdk4R24C/R24C/TPras Mice 2006 ·Cancer Research ·Elke Hacker,H. Konrad Muller,(unknown),Brian Gabrielli,Douglas Lincoln,Sandra Pavey,Marianne Broome Powell,Marcos Malumbres,Mariano Barbacid,Nicholas K. Hayward,Graeme J. Walker	41
19	Cooperation between Cdk4 and p27kip1 in Tumor Development: A Preclinical Model to Evaluate Cell Cycle Inhibitors with Therapeutic Activity 2005 ·Cancer Research ·Rocı́o Sotillo,Oliver Renner,Pierre Dubus,Jesús Ruı́z-Cabello,(unknown),Mariano Barbacid,Amancio Carnero,Marcos Malumbres	38
20	The combined effects of trkB and trkC mutations on the innervation of the inner ear 1998 ·International Journal of Developmental Neuroscience ·Bernd Fritzsch,Mariano Barbacid,I. Silos-Santiago	50

About Mariano Barbacid

Mariano Barbacid is a scholar working on Developmental Neuroscience, Oncology and Cellular and Molecular Neuroscience, having authored 266 papers that have together received 52.4k indexed citations. Recurring topics across this work include Cancer-related Molecular Pathways (52 papers), Nerve injury and regeneration (35 papers) and Virus-based gene therapy research (30 papers). The work is most often cited by research in Developmental Neuroscience (5.4k citations), Cellular and Molecular Neuroscience (12.4k citations) and Oncology (15.0k citations). Mariano Barbacid has collaborated with scholars based in United States, Spain and Germany. Frequent co-authors include Marcos Malumbres, Rüdiger Klein, Dionisio Martín‐Zanca, Fabienne Lamballe, Carmen Guerra, Eugenio Santos, Pierre Dubus, Peter Tapley, Xosé R. Bustelo and Jonas Frisén. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact