Mariano Barbacid

66.1k total citations · 32 hit papers
266 papers, 52.4k citations indexed

About

Mariano Barbacid is a scholar working on Molecular Biology, Oncology and Cellular and Molecular Neuroscience. According to data from OpenAlex, Mariano Barbacid has authored 266 papers receiving a total of 52.4k indexed citations (citations by other indexed papers that have themselves been cited), including 171 papers in Molecular Biology, 93 papers in Oncology and 51 papers in Cellular and Molecular Neuroscience. Recurrent topics in Mariano Barbacid's work include Cancer-related Molecular Pathways (52 papers), Nerve injury and regeneration (35 papers) and Virus-based gene therapy research (30 papers). Mariano Barbacid is often cited by papers focused on Cancer-related Molecular Pathways (52 papers), Nerve injury and regeneration (35 papers) and Virus-based gene therapy research (30 papers). Mariano Barbacid collaborates with scholars based in United States, Spain and Germany. Mariano Barbacid's co-authors include Marcos Malumbres, Rüdiger Klein, Dionisio Martín‐Zanca, Fabienne Lamballe, Carmen Guerra, Eugenio Santos, Pierre Dubus, Peter Tapley, Xosé R. Bustelo and Jonas Frisén and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Mariano Barbacid

264 papers receiving 50.6k citations

Hit Papers

ras GENES 1982 2026 1996 2011 1987 2009 2003 1991 2005 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. ras GENES
    1987 3.4k citations Mariano Barbacid profile →
  2. Cell cycle, CDKs and cancer: a changing paradigm
    2009 2.9k citations Marcos Malumbres, Mariano Barbacid profile →
  3. RAS oncogenes: the first 30 years
    2003 1.4k citations Marcos Malumbres, Mariano Barbacid profile →
  4. The trk proto-oncogene encodes a receptor for nerve growth factor
    1991 1.2k citations Mariano Barbacid et al. profile →
  5. Senescence in premalignant tumours
    2005 1.2k citations Manuel Collado, Carmen Guerra et al. profile →
  6. The Trk family of neurotrophin receptors
    1994 1.1k citations Mariano Barbacid profile →
  7. To cycle or not to cycle: a critical decision in cancer
    2001 1.1k citations Marcos Malumbres, Mariano Barbacid profile →
  8. A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene
    1982 1.1k citations Eugenio Santos, Mariano Barbacid et al. profile →
  9. Renal agenesis and the absence of enteric neurons in mice lacking GDNF
    1996 986 citations Mariano Barbacid et al. profile →
  10. Mammalian cyclin-dependent kinases
    2005 938 citations Marcos Malumbres, Mariano Barbacid profile →
  11. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3
    1991 932 citations Mariano Barbacid et al. profile →
  12. Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice
    2007 874 citations Carmen Guerra, Alberto J. Schuhmacher et al. Cancer Cell profile →
  13. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
    1991 823 citations Mariano Barbacid et al. profile →
  14. Cdk1 is sufficient to drive the mammalian cell cycle
    2007 806 citations David Santamarı́a, Pierre Dubus et al. profile →
  15. Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.
    1994 799 citations Xosé R. Bustelo, Mariano Barbacid et al. profile →
  16. Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene
    1994 792 citations Mariano Barbacid et al. profile →
  17. Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats
    1985 695 citations Mariano Barbacid et al. profile →
  18. A Pericyte Origin of Spinal Cord Scar Tissue
    2011 656 citations Mariano Barbacid et al. profile →
  19. The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain
    1990 654 citations Mariano Barbacid et al. profile →
  20. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences
    1986 639 citations Mariano Barbacid et al. profile →
  21. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice
    2003 634 citations Sagrario Ortega, Pierre Dubus et al. profile →
  22. Mammalian Cells Cycle without the D-Type Cyclin-Dependent Kinases Cdk4 and Cdk6
    2004 609 citations Marcos Malumbres, Rocı́o Sotillo et al. profile →
  23. Cyclin D-dependent kinases, INK4 inhibitors and cancer
    2002 602 citations Sagrario Ortega, Marcos Malumbres et al. profile →
  24. Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations
    1983 584 citations Mariano Barbacid et al. profile →
  25. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia
    1999 583 citations Pierre Dubus, Mariano Barbacid et al. profile →
  26. Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death
    1993 570 citations Mariano Barbacid et al. profile →
  27. Molecular and biochemical characterization of the human trk proto-oncogene.
    1989 540 citations Mariano Barbacid et al. profile →
  28. Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements
    1994 525 citations Mariano Barbacid et al. profile →
  29. trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.
    1989 518 citations Mariano Barbacid et al. The EMBO Journal profile →
  30. T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes
    1982 502 citations Eugenio Santos, Mariano Barbacid et al. profile →
  31. Cell Growth & Differentiation
    1992 453 citations Mariano Barbacid et al. profile →
  32. Targeting the MAPK Pathway in KRAS-Driven Tumors
    2020 330 citations Matthias Drosten, Mariano Barbacid Cancer Cell profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Mariano Barbacid United States 107 31.1k 15.0k 12.4k 6.2k 5.9k 266 52.4k
Christer Betsholtz Sweden 100 28.8k 0.9× 7.9k 0.5× 5.3k 0.4× 6.5k 1.1× 6.2k 1.1× 327 52.3k
Tom Curran United States 111 32.0k 1.0× 5.5k 0.4× 14.5k 1.2× 3.7k 0.6× 5.0k 0.8× 276 50.9k
Neal G. Copeland United States 135 42.7k 1.4× 8.0k 0.5× 8.7k 0.7× 8.5k 1.4× 5.2k 0.9× 622 73.1k
Luis F. Parada United States 94 17.4k 0.6× 5.4k 0.4× 9.4k 0.8× 2.5k 0.4× 3.5k 0.6× 231 33.7k
Joachim Herz United States 95 15.9k 0.5× 4.3k 0.3× 5.2k 0.4× 4.8k 0.8× 5.4k 0.9× 284 35.7k
Roel Nusse United States 99 43.6k 1.4× 7.8k 0.5× 4.7k 0.4× 6.3k 1.0× 3.9k 0.7× 208 55.1k
Nancy A. Jenkins United States 120 35.3k 1.1× 6.3k 0.4× 7.7k 0.6× 7.1k 1.1× 4.1k 0.7× 508 60.6k
Michael G. Rosenfeld United States 155 54.8k 1.8× 7.8k 0.5× 10.7k 0.9× 3.3k 0.5× 9.4k 1.6× 389 79.1k
Erwin F. Wagner Austria 115 33.7k 1.1× 14.2k 0.9× 2.9k 0.2× 3.4k 0.6× 8.0k 1.4× 364 50.7k
Janet Rossant Canada 130 49.6k 1.6× 4.6k 0.3× 3.7k 0.3× 7.2k 1.2× 4.3k 0.7× 397 61.8k

Countries citing papers authored by Mariano Barbacid

Since Specialization
Citations

This map shows the geographic impact of Mariano Barbacid's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Mariano Barbacid with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Mariano Barbacid more than expected).

Fields of papers citing papers by Mariano Barbacid

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Mariano Barbacid. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Mariano Barbacid. The network helps show where Mariano Barbacid may publish in the future.

Co-authorship network of co-authors of Mariano Barbacid

This figure shows the co-authorship network connecting the top 25 collaborators of Mariano Barbacid. A scholar is included among the top collaborators of Mariano Barbacid based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Mariano Barbacid. Mariano Barbacid is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Drosten, Matthias & Mariano Barbacid. (2025). The rapidly growing landscape of RAS inhibitors: from selective allele blockade to broad inhibition strategies. Molecular Oncology. 19(11). 2991–2995. 1 indexed citations
2.
Sevilla, David Fernández de, Alberto Fernández‐Medarde, Eugenio Santos, et al.. (2025). Different Ras isoforms regulate synaptic plasticity in opposite directions. The EMBO Journal. 44(7). 2106–2133.
3.
Hernández-Porras, Isabel, Lucía Simón-Carrasco, Matthias Drosten, et al.. (2025). Systemic Kras ablation disrupts myeloid cell homeostasis in adult mice. Proceedings of the National Academy of Sciences. 122(34). e2512404122–e2512404122. 2 indexed citations
4.
Drosten, Matthias & Mariano Barbacid. (2022). KRAS inhibitors: going noncovalent. Molecular Oncology. 16(22). 3911–3915. 9 indexed citations
5.
Drosten, Matthias & Mariano Barbacid. (2021). Targeting KRAS mutant lung cancer: light at the end of the tunnel. Molecular Oncology. 16(5). 1057–1071. 25 indexed citations
6.
Assi, Mohamad, Younès Achouri, Axelle Loriot, et al.. (2021). Dynamic Regulation of Expression of KRAS and Its Effectors Determines the Ability to Initiate Tumorigenesis in Pancreatic Acinar Cells. Cancer Research. 81(10). 2679–2689. 12 indexed citations
7.
Lechuga, Carmen G., Eduardo Zarzuela, Ruth Álvarez, et al.. (2021). KRAS4A induces metastatic lung adenocarcinomas in vivo in the absence of the KRAS4B isoform. Proceedings of the National Academy of Sciences. 118(30). 12 indexed citations
8.
Esteban-Burgos, Laura, Haiyun Wang, Jie Zheng, et al.. (2020). Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas. Proceedings of the National Academy of Sciences. 117(39). 24415–24426. 15 indexed citations
9.
Gao, Yijun, Matthew T. Chang, Daniel J. McKay, et al.. (2018). Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties. Cancer Discovery. 8(5). 648–661. 87 indexed citations
10.
Simón-Carrasco, Lucía, Gerardo Jiménez, Mariano Barbacid, & Matthias Drosten. (2018). The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer. Cell Cycle. 17(6). 702–711. 35 indexed citations
11.
Simón-Carrasco, Lucía, Osvaldo Graña‐Castro, Harrys K.C. Jacob, et al.. (2017). Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma. Genes & Development. 31(14). 1456–1468. 38 indexed citations
12.
Drosten, Matthias, Lucía Simón-Carrasco, Isabel Hernández-Porras, et al.. (2016). H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences. Cancer Research. 77(3). 707–718. 19 indexed citations
13.
Ambrogio, Chiara, Francisco javier García Carmona, August Vidal, et al.. (2014). Modeling Lung Cancer Evolution and Preclinical Response by Orthotopic Mouse Allografts. Cancer Research. 74(21). 5978–5988. 18 indexed citations
14.
Urosevic, Jelena, Vincent Sauzeau, María Luisa Soto‐Montenegro, et al.. (2011). Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome. Proceedings of the National Academy of Sciences. 108(12). 5015–5020. 59 indexed citations
15.
Guerra, Carmen, Manuel Collado, Carolina Navas, et al.. (2011). Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence. Cancer Cell. 19(6). 728–739. 380 indexed citations
16.
Hacker, Elke, H. Konrad Muller, Brian Gabrielli, et al.. (2006). Spontaneous and UV Radiation–Induced Multiple Metastatic Melanomas in Cdk4R24C/R24C/TPras Mice. Cancer Research. 66(6). 2946–2952. 41 indexed citations
17.
Hacker, Elke, H. Konrad Muller, Brian Gabrielli, et al.. (2006). Spontaneous and UVR-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice. Faculty of Health. 1 indexed citations
18.
Sotillo, Rocı́o, Oliver Renner, Pierre Dubus, et al.. (2005). Cooperation between Cdk4 and p27kip1 in Tumor Development: A Preclinical Model to Evaluate Cell Cycle Inhibitors with Therapeutic Activity. Cancer Research. 65(9). 3846–3852. 38 indexed citations
19.
Fritzsch, Bernd, Mariano Barbacid, & I. Silos-Santiago. (1998). The combined effects of trkB and trkC mutations on the innervation of the inner ear. International Journal of Developmental Neuroscience. 16(6). 493–505. 50 indexed citations
20.
Barbacid, Mariano. (1995). Neurotrophic factors and their receptors. Current Opinion in Cell Biology. 7(2). 148–155. 492 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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