Xosé R. Bustelo

13.8k total citations · 3 hit papers
172 papers, 11.1k citations indexed

About

Xosé R. Bustelo is a scholar working on Molecular Biology, Cell Biology and Oncology. According to data from OpenAlex, Xosé R. Bustelo has authored 172 papers receiving a total of 11.1k indexed citations (citations by other indexed papers that have themselves been cited), including 130 papers in Molecular Biology, 40 papers in Cell Biology and 33 papers in Oncology. Recurrent topics in Xosé R. Bustelo's work include Protein Kinase Regulation and GTPase Signaling (70 papers), PI3K/AKT/mTOR signaling in cancer (19 papers) and Cell Adhesion Molecules Research (18 papers). Xosé R. Bustelo is often cited by papers focused on Protein Kinase Regulation and GTPase Signaling (70 papers), PI3K/AKT/mTOR signaling in cancer (19 papers) and Cell Adhesion Molecules Research (18 papers). Xosé R. Bustelo collaborates with scholars based in Spain, United States and Germany. Xosé R. Bustelo's co-authors include Mariano Barbacid, Kornel E. Schuebel, Vincent Sauzeau, J. Silvio Gutkind, Piero Crespo, Nieves Movilla, Mercedes Dosil, Jorge E. Galán, Li-Mei Chen and Wolf‐Dietrich Hardt and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Xosé R. Bustelo

169 papers receiving 10.9k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

1994 799 citations Xosé R. Bustelo, Mariano Barbacid et al. Molecular and Cellular Biology profile →
Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 679 citations Piero Crespo, Xosé R. Bustelo et al. profile →
S. typhimurium Encodes an Activator of Rho GTPases that Induces Membrane Ruffling and Nuclear Responses in Host Cells

1998 645 citations Xosé R. Bustelo et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Xosé R. Bustelo Spain	57	7.0k	2.8k	2.0k	1.9k	1.2k	172	11.1k
Masato Okada Japan	52	6.2k 0.9×	2.5k 0.9×	1.4k 0.7×	2.6k 1.3×	2.1k 1.8×	226	10.6k
Daniel D. Billadeau United States	69	7.5k 1.1×	4.5k 1.6×	2.9k 1.5×	3.2k 1.6×	1.2k 1.0×	215	14.4k
Mark R. Philips United States	58	8.2k 1.2×	2.0k 0.7×	1.8k 0.9×	2.9k 1.5×	1.2k 1.0×	129	11.5k
Yoshinori Fukui Japan	53	4.7k 0.7×	3.5k 1.2×	1.2k 0.6×	1.5k 0.8×	1.1k 0.9×	174	9.2k
Ivan Gout United Kingdom	52	9.7k 1.4×	2.3k 0.8×	1.7k 0.8×	2.8k 1.4×	660 0.6×	157	12.8k
Wojciech Swat United States	46	4.3k 0.6×	4.2k 1.5×	1.6k 0.8×	992 0.5×	702 0.6×	77	8.4k
Sheila Μ. Thomas United States	35	6.2k 0.9×	1.3k 0.4×	1.4k 0.7×	3.0k 1.5×	2.3k 2.0×	50	9.7k
Gerald Gish Canada	42	5.4k 0.8×	1.2k 0.4×	1.4k 0.7×	1.5k 0.8×	928 0.8×	77	7.8k
J. Justin Hsuan United Kingdom	52	8.0k 1.1×	1.7k 0.6×	1.6k 0.8×	3.1k 1.6×	739 0.6×	97	11.9k
Marcus Thelen Switzerland	52	5.0k 0.7×	5.3k 1.9×	4.0k 2.0×	1.5k 0.8×	1.3k 1.1×	128	11.6k

Countries citing papers authored by Xosé R. Bustelo

Since Specialization

Citations

This map shows the geographic impact of Xosé R. Bustelo's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Xosé R. Bustelo with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Xosé R. Bustelo more than expected).

Fields of papers citing papers by Xosé R. Bustelo

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Xosé R. Bustelo. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Xosé R. Bustelo. The network helps show where Xosé R. Bustelo may publish in the future.

Co-authorship network of co-authors of Xosé R. Bustelo

This figure shows the co-authorship network connecting the top 25 collaborators of Xosé R. Bustelo. A scholar is included among the top collaborators of Xosé R. Bustelo based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Xosé R. Bustelo. Xosé R. Bustelo is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Fernández, Rubén, L. Francisco Lorenzo‐Martín, Vı́ctor Quesada, & Xosé R. Bustelo. (2025). Pan-cancer analyses identify oncogenic drivers, expression signatures, and therapeutic vulnerabilities in RHO GTPase pathway genes. Frontiers in Bioinformatics. 5. 1708800–1708800.

Calleja, E., Clara L. Oeste, I. Reig Rincón de Arellano, et al.. (2025). Antigen receptor ITAMs provide tonic signaling by acting as guanine nucleotide exchange factors to directly activate R-RAS2. Science Signaling. 18(871). eadk4204–eadk4204. 1 indexed citations

Fernández‐Pisonero, Isabel, L. Francisco Lorenzo‐Martín, Matthias Drosten, et al.. (2025). Active R-RAS2/TC21 prevents cell cycle arrest and morphological alterations in mouse embryonic fibroblasts lacking RAS proteins. Oncogene. 44(24). 1905–1921. 1 indexed citations

Lorenzo‐Martín, L. Francisco, et al.. (2024). VAV2 orchestrates the interplay between regenerative proliferation and ribogenesis in both keratinocytes and oral squamous cell carcinoma. Scientific Reports. 14(1). 4060–4060. 2 indexed citations

Conde, Javier, Isabel Fernández‐Pisonero, L. Francisco Lorenzo‐Martín, et al.. (2024). The mevalonate pathway contributes to breast primary tumorigenesis and lung metastasis. Molecular Oncology. 19(1). 56–80. 4 indexed citations

Prieto, Cristina, et al.. (2023). Mice Overexpressing Wild-Type RRAS2 Are a Novel Model for Preclinical Testing of Anti-Chronic Lymphocytic Leukemia Therapies. Cancers. 15(24). 5817–5817.

Alcoceba, Miguel, et al.. (2023). An Optimized Single Nucleotide Polymorphism-Based Detection Method Suggests That Allelic Variants in the 3’ Untranslated Region of RRAS2 Correlate with Treatment Response in Chronic Lymphocytic Leukemia Patients. Cancers. 15(3). 644–644. 3 indexed citations

Robles‐Valero, Javier, L. Francisco Lorenzo‐Martín, Myriam Cuadrado, et al.. (2021). Cancer‐associated mutations in VAV1 trigger variegated signaling outputs and T‐cell lymphomagenesis. The EMBO Journal. 40(22). e108125–e108125. 17 indexed citations

Clavaín, Laura, et al.. (2021). Efficient fractionation and analysis of ribosome assembly intermediates in human cells. RNA Biology. 18(sup1). 182–197. 7 indexed citations

10.

Conde, Javier, Isabel Fernández‐Pisonero, Myriam Cuadrado, et al.. (2021). Distinct Roles of Vav Family Members in Adaptive and Innate Immune Models of Arthritis. Biomedicines. 9(6). 695–695. 4 indexed citations

11.

Cortázar, Ana R., Verónica Torrano, Natalia Martín-Martín, et al.. (2018). CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets. Cancer Research. 78(21). 6320–6328. 63 indexed citations

12.

Mendoza, Pilar, Núria Martínez, Diana Reyes-Garau, et al.. (2018). R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes. Science Signaling. 11(532). 26 indexed citations

13.

Cárcer, Guillermo de, Sara Martínez‐Martínez, Jorge Oller, et al.. (2017). Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis. Nature Medicine. 23(8). 964–974. 43 indexed citations

14.

Drosten, Matthias, Lucía Simón-Carrasco, Isabel Hernández-Porras, et al.. (2016). H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences. Cancer Research. 77(3). 707–718. 19 indexed citations

15.

Urosevic, Jelena, Vincent Sauzeau, María Luisa Soto‐Montenegro, et al.. (2011). Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome. Proceedings of the National Academy of Sciences. 108(12). 5015–5020. 59 indexed citations

16.

Ruiz, Sergio, Eugenio Santos, & Xosé R. Bustelo. (2007). RasGRF2, a Guanosine Nucleotide Exchange Factor for Ras GTPases, Participates in T-Cell Signaling Responses. Molecular and Cellular Biology. 27(23). 8127–8142. 46 indexed citations

17.

Bartolomé, Rubén A., et al.. (2006). Activation of Vav/Rho GTPase Signaling by CXCL12 Controls Membrane-Type Matrix Metalloproteinase–Dependent Melanoma Cell Invasion. Cancer Research. 66(1). 248–258. 109 indexed citations

18.

Sánchez-Martı́n, Lorena, Noelia Sánchez‐Sánchez, María Dolores Gutiérrez‐López, et al.. (2004). Signaling through the Leukocyte Integrin LFA-1 in T Cells Induces a Transient Activation of Rac-1 That Is Regulated by Vav and PI3K/Akt-1. Journal of Biological Chemistry. 279(16). 16194–16205. 59 indexed citations

19.

López-Barahona, M, Xosé R. Bustelo, & Mariano Barbacid. (1996). The TC21 oncoprotein interacts with the Ral guanosine nucleotide dissociation factor.. PubMed. 12(3). 463–70. 26 indexed citations

20.

Bustelo, Xosé R., et al.. (1991). Cytochrome c oxidase subunit II mRNA levels during T-lymphocyte proliferation and liver regeneration. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1092(2). 184–187. 5 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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