Manel Esteller

122.9k total citations · 31 hit papers
661 papers, 74.6k citations indexed

About

Manel Esteller is a scholar working on Molecular Biology, Cancer Research and Genetics. According to data from OpenAlex, Manel Esteller has authored 661 papers receiving a total of 74.6k indexed citations (citations by other indexed papers that have themselves been cited), including 513 papers in Molecular Biology, 152 papers in Cancer Research and 120 papers in Genetics. Recurrent topics in Manel Esteller's work include Epigenetics and DNA Methylation (356 papers), RNA modifications and cancer (163 papers) and Cancer-related gene regulation (126 papers). Manel Esteller is often cited by papers focused on Epigenetics and DNA Methylation (356 papers), RNA modifications and cancer (163 papers) and Cancer-related gene regulation (126 papers). Manel Esteller collaborates with scholars based in Spain, United States and Germany. Manel Esteller's co-authors include James G. Herman, Mario F. Fraga, Anna Portela, Stephen B. Baylin, Esteban Ballestar, Santiago Ropero, María Berdasco, Holger Heyn, Marta Kulis and Montse Sánchez‐Céspedes and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Manel Esteller

650 papers receiving 73.5k citations

Hit Papers

Non-coding RNAs in human disease 1997 2026 2006 2016 2011 2008 2010 2000 2005 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Non-coding RNAs in human disease
    2011 3.8k citations Manel Esteller profile →
  2. Epigenetics in Cancer
    2008 2.7k citations Manel Esteller profile →
  3. Epigenetic modifications and human disease
    2010 2.1k citations Manel Esteller et al. profile →
  4. Inactivation of the DNA-Repair GeneMGMTand the Clinical Response of Gliomas to Alkylating Agents
    2000 1.7k citations Manel Esteller et al. profile →
  5. The Polycomb group protein EZH2 directly controls DNA methylation
    2005 1.7k citations Mario F. Fraga, Manel Esteller et al. profile →
  6. A gene hypermethylation profile of human cancer.
    2001 1.7k citations Manel Esteller et al. profile →
  7. Cancer epigenomics: DNA methylomes and histone-modification maps
    2007 1.6k citations Manel Esteller profile →
  8. DNA Methylation and Cancer
    2010 1.1k citations Manel Esteller et al. profile →
  9. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.
    1999 1.0k citations Manel Esteller et al. profile →
  10. CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future
    2002 962 citations Manel Esteller profile →
  11. The transcription factor Slug repressesE-cadherinexpression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors
    2002 929 citations Héctor Peinado, Mario F. Fraga et al. profile →
  12. Cancer epigenetics reaches mainstream oncology
    2011 903 citations Manel Esteller et al. profile →
  13. Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors
    2000 902 citations Manel Esteller profile →
  14. A microRNA DNA methylation signature for human cancer metastasis
    2008 843 citations Amaia Lujambio, Alberto Villanueva et al. profile →
  15. The role of histone deacetylases (HDACs) in human cancer
    2007 791 citations Santiago Ropero, Manel Esteller profile →
  16. Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.
    1999 770 citations Manel Esteller, Montse Sánchez‐Céspedes et al. profile →
  17. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
    2001 769 citations Manel Esteller, Carlos Cordon‐Cardo et al. profile →
  18. Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome
    2011 732 citations Juan Sandoval, Holger Heyn et al. profile →
  19. Genetic Unmasking of an Epigenetically Silenced microRNA in Human Cancer Cells
    2007 729 citations Amaia Lujambio, Santiago Ropero et al. Cancer Research profile →
  20. Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features
    2017 632 citations Manuel Castro de Moura, Manel Esteller et al. profile →
  21. Snail Mediates E-Cadherin Repression by the Recruitment of the Sin3A/Histone Deacetylase 1 (HDAC1)/HDAC2 Complex
    2003 604 citations Héctor Peinado, Esteban Ballestar et al. profile →
  22. DNA methylation profiling in the clinic: applications and challenges
    2012 561 citations Holger Heyn, Manel Esteller profile →
  23. Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours
    2001 557 citations Manel Esteller et al. profile →
  24. Frequent inactivation of PTEN/MMAC1 in primary prostate cancer.
    1997 552 citations Manel Esteller et al. profile →
  25. Epigenetic gene silencing in cancer: the DNA hypermethylome
    2007 533 citations Manel Esteller profile →
  26. Epigenetics and aging: the targets and the marks
    2007 502 citations Mario F. Fraga, Manel Esteller profile →
  27. Validation of a DNA Methylation Microarray for 850,000 CpG Sites of the Human Genome Enriched in Enhancer Sequences
    2015 475 citations Sebastián Morán, Manel Esteller et al. profile →
  28. lncRNAs and microRNAs with a role in cancer development
    2015 434 citations Manel Esteller et al. profile →
  29. DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
    2019 322 citations Manel Esteller et al. Nature Communications profile →
  30. Cancer epigenetics in clinical practice
    2022 162 citations Manel Esteller et al. profile →
  31. Accelerated biological aging in COVID-19 patients
    2022 126 citations Manel Esteller et al. Nature Communications profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Manel Esteller Spain 128 57.8k 20.8k 11.1k 9.3k 5.7k 661 74.6k
James G. Herman United States 119 50.9k 0.9× 13.6k 0.7× 15.1k 1.4× 6.9k 0.7× 7.6k 1.3× 399 65.8k
Stephen B. Baylin United States 131 60.4k 1.0× 13.8k 0.7× 16.0k 1.4× 8.8k 0.9× 6.5k 1.1× 444 77.0k
Pier Paolo Pandolfi United States 139 61.9k 1.1× 22.9k 1.1× 13.1k 1.2× 5.8k 0.6× 5.0k 0.9× 449 80.3k
Benjamin L. Ebert United States 78 46.7k 0.8× 19.4k 0.9× 10.7k 1.0× 5.6k 0.6× 7.3k 1.3× 294 73.5k
Ronald A. DePinho United States 149 56.0k 1.0× 13.7k 0.7× 23.0k 2.1× 6.8k 0.7× 4.4k 0.8× 417 86.1k
Peter A. Jones United States 112 48.9k 0.8× 10.9k 0.5× 8.3k 0.7× 8.9k 1.0× 3.7k 0.6× 352 61.5k
Peter Carmeliet Belgium 151 53.1k 0.9× 27.4k 1.3× 15.0k 1.4× 5.4k 0.6× 9.1k 1.6× 729 100.0k
Raghu Kalluri United States 120 49.4k 0.9× 25.3k 1.2× 21.0k 1.9× 3.9k 0.4× 9.6k 1.7× 321 83.3k
Curtis C. Harris United States 117 41.1k 0.7× 24.8k 1.2× 22.2k 2.0× 4.6k 0.5× 6.9k 1.2× 579 66.9k
William G. Kaelin United States 117 35.6k 0.6× 22.6k 1.1× 14.8k 1.3× 6.0k 0.6× 6.0k 1.0× 246 50.2k

Countries citing papers authored by Manel Esteller

Since Specialization
Citations

This map shows the geographic impact of Manel Esteller's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Manel Esteller with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Manel Esteller more than expected).

Fields of papers citing papers by Manel Esteller

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Manel Esteller. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Manel Esteller. The network helps show where Manel Esteller may publish in the future.

Co-authorship network of co-authors of Manel Esteller

This figure shows the co-authorship network connecting the top 25 collaborators of Manel Esteller. A scholar is included among the top collaborators of Manel Esteller based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Manel Esteller. Manel Esteller is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Jiménez-Baladó, Joan, Cristina Gallego-Fábrega, Uxue Lazcano, et al.. (2024). DNA methylation and stroke prognosis: an epigenome-wide association study. Clinical Epigenetics. 16(1). 75–75. 8 indexed citations
2.
Mereu, Elisabetta, Neus Prats, Mònica Aguilera, et al.. (2023). Targeting lymphoid-derived IL-17 signaling to delay skin aging. Nature Aging. 3(6). 688–704. 43 indexed citations
3.
Oliveira-Mateos, Cristina, Marta Soler, David Piñeyro, et al.. (2019). The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition. Nature Communications. 10(1). 3979–3979. 45 indexed citations
4.
Bosch‐Presegué, Laia, Anna Marazuela-Duque, Carolina de la Torre, et al.. (2018). SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway. Nature Communications. 9(1). 101–101. 49 indexed citations
5.
Wei, Yongyue, Ruyang Zhang, Yichen Guo, et al.. (2018). Epigenetic modifications in KDM lysine demethylases associate with survival of early-stage NSCLC. Clinical Epigenetics. 10(1). 41–41. 5 indexed citations
6.
Remacha, Laura, Iñaki Comino‐Méndez, Susan Richter, et al.. (2017). Targeted Exome Sequencing of Krebs Cycle Genes Reveals Candidate Cancer–Predisposing Mutations in Pheochromocytomas and Paragangliomas. Clinical Cancer Research. 23(20). 6315–6324. 62 indexed citations
7.
Aznar, M. Ángela, Sara Labiano, Ángel Díaz‐Lagares, et al.. (2017). CD137 (4-1BB) Costimulation Modifies DNA Methylation in CD8+ T Cell–Relevant Genes. Cancer Immunology Research. 6(1). 69–78. 35 indexed citations
8.
Giménez‐Xavier, Pol, Eva Pros, Sebastián Morán, et al.. (2017). Genomic and Molecular Screenings Identify Different Mechanisms for Acquired Resistance to MET Inhibitors in Lung Cancer Cells. Molecular Cancer Therapeutics. 16(7). 1366–1376. 24 indexed citations
9.
Díaz‐Lagares, Ángel, Jesús Méndez‐González, David Hervás, et al.. (2016). A Novel Epigenetic Signature for Early Diagnosis in Lung Cancer. Clinical Cancer Research. 22(13). 3361–3371. 103 indexed citations
10.
Silva-Diz, Victoria da, Adrià Bernat‐Peguera, Jana de Sostoa, et al.. (2016). Cancer Stem-like Cells Act via Distinct Signaling Pathways in Promoting Late Stages of Malignant Progression. Cancer Research. 76(5). 1245–1259. 24 indexed citations
11.
Adams, Brian D., Eleni Anastasiadou, Manel Esteller, Lin He, & Frank J. Slack. (2015). The Inescapable Influence of Noncoding RNAs in Cancer. Cancer Research. 75(24). 5206–5210. 42 indexed citations
12.
Carmona, F. Javier, Daniel Azuara, Antonio Berenguer, et al.. (2013). DNA Methylation Biomarkers for Noninvasive Diagnosis of Colorectal Cancer. Cancer Prevention Research. 6(7). 656–665. 102 indexed citations
13.
Javierre, Biola M., Javier Rodríguez‐Ubreva, Fátima Al‐Shahrour, et al.. (2011). Long-Range Epigenetic Silencing Associates with Deregulation of Ikaros Targets in Colorectal Cancer Cells. Molecular Cancer Research. 9(8). 1139–1151. 45 indexed citations
14.
Guerrero‐Preston, Rafael, Julio Acero, Luis Alberto Moreno López, et al.. (2011). NID2 and HOXA9 Promoter Hypermethylation as Biomarkers for Prevention and Early Detection in Oral Cavity Squamous Cell Carcinoma Tissues and Saliva. Cancer Prevention Research. 4(7). 1061–1072. 106 indexed citations
15.
Cebrián, Virginia, Virginia López, Esteban Orenes‐Piñero, et al.. (2008). Identification of PMF1 Methylation in Association with Bladder Cancer Progression. Clinical Cancer Research. 14(24). 8236–8243. 29 indexed citations
16.
Lujambio, Amaia, Santiago Ropero, Esteban Ballestar, et al.. (2007). Genetic Unmasking of an Epigenetically Silenced microRNA in Human Cancer Cells. Cancer Research. 67(4). 1424–1429. 729 indexed citations breakdown →
17.
Jacinto, Filipe V., Esteban Ballestar, Santiago Ropero, & Manel Esteller. (2007). Discovery of Epigenetically Silenced Genes by Methylated DNA Immunoprecipitation in Colon Cancer Cells. Cancer Research. 67(24). 11481–11486. 77 indexed citations
18.
Fraga, Mario F., Michel Herranz, Jesús Espada, et al.. (2004). A Mouse Skin Multistage Carcinogenesis Model Reflects the Aberrant DNA Methylation Patterns of Human Tumors. Cancer Research. 64(16). 5527–5534. 157 indexed citations
19.
Pellisé, María, Antoni Castells, Àngels Ginès, et al.. (2004). Detection of Lymph Node Micrometastases by Gene Promoter Hypermethylation in Samples Obtained by Endosonography- Guided Fine-Needle Aspiration Biopsy. Clinical Cancer Research. 10(13). 4444–4449. 51 indexed citations
20.
Esteller, Manel, et al.. (1995). High rate of MDR‐1 and heterogeneous pattern of MRP expression without gene amplification in endometrial cancer. International Journal of Cancer. 63(6). 798–803. 18 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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