Kumar Sambamurti

12.7k citations

130 papers · 10.6k indexed · 3 hit papers · h-index 53

Physiology top 0.2%
Molecular Biology top 2%
Pharmacology top 0.1%
Cellular and Molecular Neuroscience top 1%
Computational Theory and Mathematics top 0.2%

Co-authors: Debomoy K. Lahiri Nigel H. Greig Miguel A. Pappolla Lorenzo M. Refolo Harold W. Holloway Arnold Brossi Christopher B. Eckman David Tweedie
Topics: Alzheimer's disease research and treatments (81 papers)Cholinesterase and Neurodegenerative Diseases (33 papers)Computational Drug Discovery Methods (17 papers)
Cited by: Physiology Biological Psychiatry Pharmacology
Journals: Proceedings of the National Academy of Sciences Nucleic Acids Research Journal of Biological Chemistry
Partner nations: United States Germany United Kingdom

In The Last Decade

Kumar Sambamurti

128 papers receiving 10.4k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model

2000 825 citations Lorenzo M. Refolo, Miguel A. Pappolla et al. Neurobiology of Disease profile →
Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent

2005 645 citations Nigel H. Greig, Harold W. Holloway et al. Proceedings of the National Academy of Sciences profile →
GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

2009 502 citations Yazhou Li, Mark S. Kindy et al. Proceedings of the National Academy of Sciences profile →

Peers

Countries citing papers authored by Kumar Sambamurti

Since Specialization

Citations

This map shows the geographic impact of Kumar Sambamurti's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kumar Sambamurti with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kumar Sambamurti more than expected).

Fields of papers citing papers by Kumar Sambamurti

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kumar Sambamurti. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kumar Sambamurti. The network helps show where Kumar Sambamurti may publish in the future.

Co-authorship network of co-authors of Kumar Sambamurti

This figure shows the co-authorship network connecting the top 25 collaborators of Kumar Sambamurti. A scholar is included among the top collaborators of Kumar Sambamurti based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kumar Sambamurti. Kumar Sambamurti is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Sulfur amino acids, metabolic health and beyond: Recent advances, translational implications, and future research considerations 2025 ·Analytical Biochemistry ·Thomas Olsén,Amany Elshorbagy,Jay E. Johnson,Sailendra N. Nichenametla,Zhen Dong,Kumar Sambamurti,John P. Richie,Kathrine J. Vinknes	0
2	Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity 2025 ·Cancer Research ·(unknown),(unknown),Natalia V. Oleinik,(unknown),(unknown),(unknown),(unknown),Paramita Chakraborty,(unknown),(unknown),Silvia G. Vaena,Kalyani Sonawane,Ashish A. Deshmukh,Narayan R. Bhat,Kumar Sambamurti,Önder Albayram,Özgür Şahin,Shikhar Mehrotra,Besim Öğretmen	1
3	DPP-4 inhibitors sitagliptin and PF-00734,200 mitigate dopaminergic neurodegeneration, neuroinflammation and behavioral impairment in the rat 6-OHDA model of Parkinson’s disease 2024 ·GeroScience ·Seong‐Jin Yu,Yun Wang,Hui Shen,Eun-Kyung Bae,Yazhou Li,Kumar Sambamurti,Michael A. Tones,Margaret M. Zaleska,Barry J. Hoffer,Nigel H. Greig	16
4	Nitric Oxide as a Determinant of Human Longevity and Health Span 2023 ·International Journal of Molecular Sciences ·Burkhard Pöeggeler,Sandeep Kumar Singh,Kumar Sambamurti,Miguel A. Pappolla	6
5	Mitigating chronic neuroinflammation in Alzheimer mice by novel immunomodulatory imide drugs (IMiDs) conserves neuroplasticity and cognitive function and also alleviates neurodegeneration‐behavioral impairments in TBI‐challenged mice 2023 ·Alzheimer s & Dementia ·Nigel H. Greig,Daniela Lecca,Shih‐Chang Hsueh,David Tweedie,Michael T. Scerba,Barry J. Hoffer,Jia‐Yi Wang,Kumar Sambamurti,Debomoy K. Lahiri,Dong Seok Kim	1
6	Incretin mimetics as pharmacological tools to elucidate and as a new drug strategy to treat traumatic brain injury 2014 ·PMC ·Nigel H. Greig,David Tweedie,Lital Rachmany,Yazhou Li,Vardit Rubovitch,Shaul Schreiber,Yung‐Hsiao Chiang,Barry J. Hoffer,Jonathan P. Miller,Debomoy K. Lahiri,Kumar Sambamurti,Robert E. Becker,Chaim G. Pick	25
7	Major Carboxyl Terminal Fragments Generated by γ-Secretase Processing of the Alzheimer Amyloid Precursor Are 50 and 51 Amino Acids Long 2013 ·American Journal of Geriatric Psychiatry ·Inga Pinnix,Jorge Ghiso,Miguel A. Pappolla,Kumar Sambamurti	11
8	GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonismbreakdown → 2009 ·Proceedings of the National Academy of Sciences ·Yazhou Li,(unknown),Mark S. Kindy,Brandon K. Harvey,David Tweedie,Harold W. Holloway,Kathleen Powers,Hui Shen,Josephine M. Egan,Kumar Sambamurti,Arnold Brossi,Debomoy K. Lahiri,Mark P. Mattson,Barry J. Hoffer,Yun Wang,Nigel H. Greig	502
9	An Increase in Aβ42 in the Prefrontal Cortex is Associated with a Reversal-Learning Impairment in Alzheimers Disease Model Tg2576 APPsw Mice 2008 ·Current Alzheimer Research ·(unknown),A. Prakasam,Melissa E. Murray,(unknown),Mark G. Baxter,Kumar Sambamurti,Michelle M. Nicolle	25
10	Amyloid Precursor Protein Metabolism in Retinal Degeneration 2007 ·Investigative Ophthalmology & Visual Science ·Kumar Sambamurti,Chitra Venugopal,Anitha Suram,Miguel A. Pappolla,Bäerbel Rohrer,(unknown)	1
11	A Partial Failure of Membrane Protein Turnover May Cause Alzheimers Disease: A New Hypothesis 2006 ·Current Alzheimer Research ·Kumar Sambamurti,Anitha Suram,Chitra Venugopal,A. Prakasam,Yan Zhou,Debomoy K. Lahiri,Nigel H. Greig	49
12	Differential Expression of Cholesterol Hydroxylases in Alzheimer's Disease 2004 ·Journal of Biological Chemistry ·James A. Brown,Catherine Theisler,Simone Silberman,Debra J. Magnuson,Numa R. Gottardi-Littell,John M. Lee,Debra Yager,(unknown),Kumar Sambamurti,Mohammad Mizanur Rahman,Allison B. Reiss,Christopher B. Eckman,Benjamin Wolozin	230
13	Glucagon‐like peptide‐1 decreases endogenous amyloid‐β peptide (Aβ) levels and protects hippocampal neurons from death induced by Aβ and iron 2003 ·Journal of Neuroscience Research ·(unknown),Debomoy K. Lahiri,Kumar Sambamurti,De‐Mao Chen,Mark P. Mattson,Josephine M. Egan,Nigel H. Greig	300
14	A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor 2001 ·Journal of Biological Chemistry ·Inga Pinnix,(unknown),Han W. Tun,Arati Sridharan,Todd E. Golde,Christopher B. Eckman,Chewki Ziani‐Cherif,Luisa Onstead,Kumar Sambamurti	126
15	Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Modelbreakdown → 2000 ·Neurobiology of Disease ·Lorenzo M. Refolo,Miguel A. Pappolla,Brian Malester,John J. LaFrancois,Tara Bryant‐Thomas,Rong Wang,G S Tint,Kumar Sambamurti,Karen Duff	825
16	Glycosylphosphatidylinositol-anchored Proteins Play an Important Role in the Biogenesis of the Alzheimer's Amyloid β-Protein 1999 ·Journal of Biological Chemistry ·Kumar Sambamurti,Daniel Sevlever,(unknown),Lawrence M. Refolo,Inga Pinnix,(unknown),Luisa Onstead,Linda H. Younkin,(unknown),Debra Yager,Yasumasa Ohyagi,Christopher B. Eckman,Terrone L. Rosenberry,Steven G. Younkin	45
17	The effect of tacrine and leupeptin on the secretion of the beta-amyloid precursor protein in HeLa cells 1997 ·Life Sciences ·Debomoy K. Lahiri,Martin R. Farlow,Kumar Sambamurti,C. Nall	10
18	Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization 1995 ·Journal of Neuroscience Research ·Lorenzo M. Refolo,Kumar Sambamurti,Spiros Efthimiopoulos,Miguel A. Pappolla,Nikolaos K. Robakis	51
19	Study of the phorbol ester effect on Alzheimer amyloid precursor processing: Sequence requirements and involvement of a Cholera toxin sensitive protein 1994 ·Journal of Neuroscience Research ·Spiros Efthimiopoulos,Kevin M. Felsenstein,Kumar Sambamurti,Nikolaos K. Robakis,Lorenzo M. Refolo	29
20	Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells 1991 ·Neuroscience Letters ·John P. Anderson,Fred Esch,Pamela S. Keim,Kumar Sambamurti,Ivan Lieberburg,Nikolaos K. Robakis	173

About Kumar Sambamurti

Kumar Sambamurti is a scholar working on Physiology, Biological Psychiatry and Pharmacology, having authored 130 papers that have together received 10.6k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (81 papers), Cholinesterase and Neurodegenerative Diseases (33 papers) and Computational Drug Discovery Methods (17 papers). The work is most often cited by research in Physiology (5.2k citations), Biological Psychiatry (497 citations) and Pharmacology (2.6k citations). Kumar Sambamurti has collaborated with scholars based in United States, Germany and United Kingdom. Frequent co-authors include Debomoy K. Lahiri, Nigel H. Greig, Miguel A. Pappolla, Lorenzo M. Refolo, Harold W. Holloway, Arnold Brossi, Christopher B. Eckman, David Tweedie, A. Prakasam and Mark P. Mattson. Their work appears in journals such as Proceedings of the National Academy of Sciences, Nucleic Acids Research and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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