Arnold Brossi

8.1k citations

255 papers · 6.5k indexed · 2 hit papers · h-index 42

Impact in

Pharmacology top 0.2%
- Cholinesterase and Neurodegenerative Diseases
- Alkaloids: synthesis and pharmacology
Organic Chemistry top 0.5%
- Chemical synthesis and alkaloids
- Synthesis and biological activity
- Asymmetric Synthesis and Catalysis
- Synthesis and Biological Evaluation

Papers in

Organic Chemistry 170
- Chemical synthesis and alkaloids 51
- Synthesis and biological activity 37
- Synthesis and Biological Evaluation 24
- Synthesis and Reactions of Organic Compounds 22
- Asymmetric Synthesis and Catalysis 18
Pharmacology 42
- Cholinesterase and Neurodegenerative Diseases 30
- Alkaloids: synthesis and pharmacology 26
- Plant-based Medicinal Research 21

Co-authors: Nigel H. Greig Harold W. Holloway Qian‐sheng Yu Debomoy K. Lahiri Kuo‐Hsiung Lee Ernest Hamel Kumar Sambamurti Tadanobu Utsuki
Journals: Helvetica Chimica Acta (44 papers)Journal of Medicinal Chemistry (40 papers)The Journal of Organic Chemistry (20 papers)FEBS Letters (9 papers)Bioorganic & Medicinal Chemistry (8 papers)
Partner nations: United States Switzerland Poland

In The Last Decade

Arnold Brossi

249 papers receiving 6.3k citations

Hit Papers

align trajectories log scale

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism 2009 · 502 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2009 Proceedings of the National Academy of Sciences
2005 Proceedings of the National Academy of Sciences

Peers

Countries citing papers authored by Arnold Brossi

Since Specialization

Citations

This map shows the geographic impact of Arnold Brossi's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Arnold Brossi with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Arnold Brossi more than expected).

Fields of papers citing papers by Arnold Brossi

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Arnold Brossi. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Arnold Brossi. The network helps show where Arnold Brossi may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Arnold Brossi, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Arnold Brossi Line = papers co-authored together Arnold Brossi links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Design, synthesis and biological assessment of novel N-substituted 3-(phthalimidin-2-yl)-2,6-dioxopiperidines and 3-substituted 2,6-dioxopiperidines for TNF-α inhibitory activity Bioorganic & Medicinal Chemistry ·Weiming Luo, Qian-sheng Yu, Yusuf Evren Aykac, Harold W. Holloway, Debomoy K. Lahiri, Arnold Brossi, David Tweedie, Nigel H. Greig	2011	20
2	GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism Proceedings of the National Academy of Sciences ·Yazhou Li, 안철현, Mark S. Kindy, Brandon K. Harvey, David Tweedie, Harold W. Holloway, Kathleen Powers, Hui Shen, Josephine M. Egan, Kumar Sambamurti, Arnold Brossi, Debomoy K. Lahiri, Mark P. Mattson, Barry J. Hoffer, Yun Wang, Nigel H. Greig Hit paper breakdown →	2009	502
3	A cellular model of inflammation for identifying TNF-α synthesis inhibitors Journal of Neuroscience Methods ·David Tweedie, Weiming Luo, Ryan G. Short, Arnold Brossi, Harold W. Holloway, Yazhou Li, Qian‐sheng Yu, Nigel H. Greig	2009	45
4	Antitumor Agents 252. Application of validated QSAR models to database mining: discovery of novel tylophorine derivatives as potential anticancer agents Journal of Computer-Aided Molecular Design ·Kathy Hickman, Linyi Wei, 亮斎藤, Weifan Zheng, Arnold Brossi, Kuo‐Hsiung Lee, Alexander Tropsha	2007	67
5	Racemic N1-Norphenserine and Its Enantiomers: Unpredicted Inhibition of Human Acetyl- and Butyrylcholinesterase and β-Amyloid Precursor Protein in vitro Heterocycles ·Nigel H. Greig, Qian‐sheng Yu, Weiming Luo, Harold W. Holloway, Tada Utsuki, Tracy Ann Perry, Debomoy K. Lahiri, Arnold Brossi	2003	13
6	Mapping the Binding Site of Colchicinoids on β-Tubulin Journal of Biological Chemistry ·Ruoli Bai, David G. Covell, Xue‐Feng Pei, Nurys B. de Armas Rojas, Nga Y. Nguyen, Arnold Brossi, Ernest Hamel	2000	82
7	Anti-AIDS agents Part 41 Bioorganic & Medicinal Chemistry Letters ·Zheng-Yu Yang, Xia Yi, Peng Xia, Arnold Brossi, L.Mark Cosentino, A.F. Osikoya	2000	21
8	Antitumor agents. Part 186:11For part 185, see ref. [1]. Synthesis and biological evaluation of demethylcolchiceinamide analogues as cytotoxic DNA topoisomerase II inhibitors Bioorganic & Medicinal Chemistry ·Jian Guan, Luciana de Carvalho Tavares, Yoko Tachibana, Kenneth F. Bastow, Arnold Brossi, Ernest Hamel, Kuo‐Hsiung Lee	1998	6
9	Phenserine and ring C hetero‐analogues: Drug candidates for the treatment of Alzheimer's disease Medicinal Research Reviews ·Nigel H. Greig, Xue‐Feng Pei, Timothy T. Soncrant, Donald K. Ingram, Arnold Brossi	1995	169
10	The nitrogen of the acetamido group of colchicine modulates P-glycoprotein-mediated multidrug resistance Biochemistry ·David F. Tang‐Wai, Arnold Brossi, Lee D. Arnold, Piet Gros	1993	48
11	The long-acting cholinesterase inhibitor heptyl-physostigmine attenuates the scopolamine-induced learning impairment of rats in a 14-unit T-maze Neuroscience Letters ·Akhsholphan Byekyet, Nigel H. Greig, Paolo Garofalo, Edward L. Spangler, Rehab Abd El-Moneim Abou Shaheen, Arnold Brossi, Donald K. Ingram	1992	12
12	Oxoaporphine Alkaloids: Conversion of Lysicamine into Liriodendronine and its 2‐O‐Methyl Ether, and Antifungal Activity Archiv der Pharmazie ·نرجس قيصر بولس ميخائيل, Maria D. Rozwadowska, Arnold Brossi, Alice M. Clark, Charles D. Hufford, Clifford George, J.L. Flippen-Anderson	1991	8
13	Fluorinated colchicinoids: antitubulin and cytotoxic properties Journal of Medicinal Chemistry ·Israel Ringel, Dena H. Jaffe, A Montoya, Keith Ck Lai, Dionysios Siamidis, Arnold Brossi	1991	28
14	Chemistry of colchine Pharmacology & Therapeutics ·Dionysios Siamidis, Arnold Brossi	1991	13
15	Partial Synthesis and Antitubulin Activity of Minor Colchicum Alkaloids: N-Acetoacetyl-deacetylcolchicine and 2-Demethylspeciosine (Speciocolchine) Journal of Natural Products ·Dionysios Siamidis, Arnold Brossi, Ernest Hamel	1990	4
16	Comparison of mass spectral techniques using organic peroxides related to artemisinin Analytical Chemistry ·Henry M. Fales, Edward A. Sokoloski, Lewis K. Pannell, Lynn D. Pearlman, Daniel L. Klayman, Lin Ai, Arnold Brossi, James A. Kelley	1990	18
17	Geneserine and Geneseroline Revisited: Acid-Base Catalyzed Equilibria of Hexahydropyrrolo-[2,3-b]-indole N-oxides with Hexahydro-1 ,2-oxazino-[ 5 , 6- b]-indoles Journal of Natural Products ·Qian-sheng Yu, Herman J. C. Yeh, Arnold Brossi, J.L. Flippen-Anderson	1989	10
18	Carbamate analogues of (−)‐physostigmine: In vitro inhibition of acetyl‐ and butyrylcholinesterase FEBS Letters ·Qian‐sheng Yu, John Atack, Stanley I. Rapoport, Arnold Brossi	1988	18
19	MPTP metabolites inhibit rat brain glutathione S-transferases Neuroscience Letters ·W. F. Almeida, Shivendra V. Singh, Evi Irawati, Creed W. Abell, Wieslaw Gessner, Arnold Brossi	1987	9
20	Structure, Chemistry, and Antimalarial Properties of Mefloquineaziridine Heterocycles ·Arnold Brossi, J. V. Silverton, Manfred Rösner	1981	8

About Arnold Brossi

Arnold Brossi is a scholar working on Organic Chemistry, Pharmacology, Pharmacology, Toxicology and Biochemistry, having authored 255 papers that have together received 6.5k indexed citations. Recurring topics across this work include Chemical synthesis and alkaloids (51 papers), Synthesis and biological activity (37 papers), Cholinesterase and Neurodegenerative Diseases (30 papers), Alkaloids: synthesis and pharmacology (26 papers), Synthesis and Biological Evaluation (24 papers), Synthesis and Reactions of Organic Compounds (22 papers), Plant-based Medicinal Research (21 papers) and Asymmetric Synthesis and Catalysis (18 papers). The work is most often cited by research in Pharmacology (2.0k citations), Organic Chemistry (3.1k citations), Pharmacology (563 citations), Computational Theory and Mathematics (894 citations) and Toxicology (165 citations). Arnold Brossi has collaborated with scholars based in United States, Switzerland and Poland. Frequent co-authors include Nigel H. Greig, Harold W. Holloway, Qian‐sheng Yu, Debomoy K. Lahiri, Kuo‐Hsiung Lee, Ernest Hamel, Kumar Sambamurti, Tadanobu Utsuki, S. Teitel and Donald K. Ingram. Their work appears in journals such as Helvetica Chimica Acta, Journal of Medicinal Chemistry, The Journal of Organic Chemistry, FEBS Letters and Bioorganic & Medicinal Chemistry.

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