Karien M. Hamer

6.3k citations

22 papers · 3.7k indexed · 3 hit papers · h-index 19

Molecular Biology top 5%
Oncology top 5%
Surgery top 5%
Hepatology top 1%
Genetics top 5%

Co-authors: Arie P. Otte David Satijn Hans Clevers Johan H. van Es Robert G. Vries Toshiro Sato Meritxell Huch Marc van de Wetering
Topics: Epigenetics and DNA Methylation (15 papers)Cancer-related gene regulation (15 papers)RNA modifications and cancer (8 papers)
Cited by: Hepatology Molecular Biology Oncology
Journals: Nature Cell Journal of Clinical Investigation
Partner nations: Netherlands United States Austria

In The Last Decade

Karien M. Hamer

22 papers receiving 3.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

2013 1.1k citations Meritxell Huch, Craig Dorrell et al. Nature profile →
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

2013 535 citations Meritxell Huch, Paola Bonfanti et al. The EMBO Journal profile →
Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis

2023 125 citations Delilah Hendriks, Jos F. Brouwers et al. Nature Biotechnology profile →

Peers

Countries citing papers authored by Karien M. Hamer

Since Specialization

Citations

This map shows the geographic impact of Karien M. Hamer's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Karien M. Hamer with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Karien M. Hamer more than expected).

Fields of papers citing papers by Karien M. Hamer

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Karien M. Hamer. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Karien M. Hamer. The network helps show where Karien M. Hamer may publish in the future.

Co-authorship network of co-authors of Karien M. Hamer

This figure shows the co-authorship network connecting the top 25 collaborators of Karien M. Hamer. A scholar is included among the top collaborators of Karien M. Hamer based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Karien M. Hamer. Karien M. Hamer is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosisbreakdown → 2023 ·Nature Biotechnology ·Delilah Hendriks,Jos F. Brouwers,Karien M. Hamer,Maarten H. Geurts,(unknown),(unknown),Carmen López‐Iglesias,Peter J. Peters,Maria J. Rodríguez Colman,Susana M. Chuva de Sousa Lopes,Benedetta Artegiani,Hans Clevers	125
2	Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping 2019 ·Cell ·Helmuth Gehart,Johan H. van Es,Karien M. Hamer,Joep Beumer,Kai Kretzschmar,Johanna F. Dekkers,Anne C. Rios,Hans Clevers	219
3	Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axisbreakdown → 2013 ·The EMBO Journal ·Meritxell Huch,Paola Bonfanti,Sylvia F. Boj,Toshiro Sato,Cindy J.M. Loomans,Marc van de Wetering,Mozhdeh Sojoodi,Vivian Li,Jurian Schuijers,Ana Gudelj Gračanin,Femke Ringnalda,Harry Begthel,Karien M. Hamer,Jan Mulder,Johan H. van Es,Eelco J.P. de Koning,Robert G. Vries,Harry Heimberg,Hans Clevers	535
4	In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regenerationbreakdown → 2013 ·Nature ·Meritxell Huch,Craig Dorrell,Sylvia F. Boj,Johan H. van Es,Vivian Li,Marc van de Wetering,Toshiro Sato,Karien M. Hamer,Nobuo Sasaki,Milton J. Finegold,Annelise Haft,Robert G. Vries,Markus Grompe,Hans Clevers	1149
5	The Use of a Stringent Selection System Allows the Identification of DNA Elements that Augment Gene Expression 2010 ·Molecular Biotechnology ·(unknown),Rik van Blokland,M. Siep,Karien M. Hamer,Tjalling Siersma,Jan den Blaauwen,John Verhees,Arie P. Otte	13
6	Placing the RPL32 Promoter Upstream of a Second Promoter Results in a Strongly Increased Number of Stably Transfected Mammalian Cell Lines That Display High Protein Expression Levels 2010 ·SHILAP Revista de lepidopterología ·(unknown),Karien M. Hamer,M. Siep,John Verhees,Arie P. Otte	5
7	Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome 2004 ·The Journal of Cell Biology ·Kathrin Plath,Dale Talbot,Karien M. Hamer,Arie P. Otte,Thomas P. Yang,Rudolf Jaenisch,Barbara Panning	109
8	Biochemical Analysis of Mammalian Polycomb Group Protein Complexes and the Identification of Genetic Elements that Block Polycomb-Mediated Gene Repression 2003 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Richard G. A. B. Sewalt,Ted Kwaks,Karien M. Hamer,Arie P. Otte	6
9	Selective Interactions between Vertebrate Polycomb Homologs and the SUV39H1 Histone Lysine Methyltransferase Suggest that Histone H3-K9 Methylation Contributes to Chromosomal Targeting of Polycomb Group Proteins 2002 ·Molecular and Cellular Biology ·Richard G. A. B. Sewalt,Monika Lachner,(unknown),Karien M. Hamer,Jan L. den Blaauwen,(unknown),Martin Melcher,Dieter Schweizer,Thomas Jenuwein,Arie P. Otte	74
10	Distinct BMI-1 and EZH2 Expression Patterns in Thymocytes and Mature T Cells Suggest a Role for Polycomb Genes in Human T Cell Differentiation 2001 ·The Journal of Immunology ·Frank M. Raaphorst,Arie P. Otte,Folkert J. van Kemenade,Tjasso Blokzijl,Elly Fieret,Karien M. Hamer,David Satijn,Chris J.L.M. Meijer	62
11	Differential expression of human Polycomb group proteins in various tissues and cell types 2001 ·Journal of Cellular Biochemistry ·Marco J. Gunster,Frank M. Raaphorst,Karien M. Hamer,Jan L. den Blaauwen,Elly Fieret,Chris J.L.M. Meijer,Arie P. Otte	41
12	Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma 2001 ·Blood ·Folkert J. van Kemenade,Frank M. Raaphorst,Tjasso Blokzijl,Elly Fieret,Karien M. Hamer,David Satijn,Arie P. Otte,Chris J.L.M. Meijer	221
13	Cutting Edge: Polycomb Gene Expression Patterns Reflect Distinct B Cell Differentiation Stages in Human Germinal Centers 2000 ·The Journal of Immunology ·Frank M. Raaphorst,Folkert J. van Kemenade,Elly Fieret,Karien M. Hamer,David Satijn,Arie P. Otte,Chris J.L.M. Meijer	82
14	Coexpression of BMI-1 and EZH2 Polycomb Group Genes in Reed-Sternberg Cells of Hodgkin’s Disease 2000 ·American Journal Of Pathology ·Frank M. Raaphorst,Folkert J. van Kemenade,Tjasso Blokzijl,Elly Fieret,Karien M. Hamer,David Satijn,Arie P. Otte,Chris J.L.M. Meijer	138
15	Characterization of Interactions between the Mammalian Polycomb-Group Proteins Enx1/EZH2 and EED Suggests the Existence of Different Mammalian Polycomb-Group Protein Complexes 1998 ·Molecular and Cellular Biology ·Richard G. A. B. Sewalt,Johan van der Vlag,Marco J. Gunster,Karien M. Hamer,Jan L. den Blaauwen,David Satijn,(unknown),Roel van Driel,Arie P. Otte	196
16	RING1 Is Associated with the Polycomb Group Protein Complex and Acts as a Transcriptional Repressor 1997 ·Molecular and Cellular Biology ·David Satijn,Marco J. Gunster,Johan van der Vlag,Karien M. Hamer,Wouter Schul,Mark J. Alkema,Andrew J. Saurin,Paul S. Freemont,Roel van Driel,Arie P. Otte	164
17	Interference with the Expression of a Novel Human Polycomb Protein, hPc2, Results in Cellular Transformation and Apoptosis 1997 ·Molecular and Cellular Biology ·David Satijn,Daniel J. Olson,Johan van der Vlag,Karien M. Hamer,(unknown),(unknown),Marco J. Gunster,Richard G. A. B. Sewalt,Roel van Driel,Arie P. Otte	103
18	Identification and Characterization of Interactions between the Vertebrate Polycomb-Group Protein BMI1 and Human Homologs of Polyhomeotic 1997 ·Molecular and Cellular Biology ·Marco J. Gunster,David Satijn,Karien M. Hamer,Jan L. den Blaauwen,Diederik de Bruijn,Mark J. Alkema,Maarten van Lohuizen,Roel van Driel,Arie P. Otte	142
19	Polycomb and bmi-1 homologs are expressed in overlapping patterns in Xenopus embryos and are able to interact with each other 1995 ·Mechanisms of Development ·(unknown),Karien M. Hamer,Jan L. den Blaauwen,(unknown),(unknown),Roel van Driel,Arie P. Otte	48
20	Two different point G to A mutations in exon 10 of the porphobilinogen deaminase gene are responsible for acute intermittent porphyria. 1990 ·Journal of Clinical Investigation ·Marie Hélène Delfau,C. Picat,(unknown),Karien M. Hamer,M. Bogard,J. H. P. Wilson,Jean‐Charles Deybach,Y Nordmann,Bernard Grandchamp	65

About Karien M. Hamer

Karien M. Hamer is a scholar working on Molecular Biology, Biochemistry and Hepatology, having authored 22 papers that have together received 3.7k indexed citations. Recurring topics across this work include Epigenetics and DNA Methylation (15 papers), Cancer-related gene regulation (15 papers) and RNA modifications and cancer (8 papers). The work is most often cited by research in Hepatology (541 citations), Molecular Biology (2.4k citations) and Oncology (828 citations). Karien M. Hamer has collaborated with scholars based in Netherlands, United States and Austria. Frequent co-authors include Arie P. Otte, David Satijn, Hans Clevers, Johan H. van Es, Robert G. Vries, Toshiro Sato, Meritxell Huch, Marc van de Wetering, Vivian Li and Sylvia F. Boj. Their work appears in journals such as Nature, Cell and Journal of Clinical Investigation.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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