Karien M. Hamer

6.3k total citations · 3 hit papers
22 papers, 3.7k citations indexed

About

Karien M. Hamer is a scholar working on Molecular Biology, Surgery and Genetics. According to data from OpenAlex, Karien M. Hamer has authored 22 papers receiving a total of 3.7k indexed citations (citations by other indexed papers that have themselves been cited), including 20 papers in Molecular Biology, 4 papers in Surgery and 2 papers in Genetics. Recurrent topics in Karien M. Hamer's work include Epigenetics and DNA Methylation (15 papers), Cancer-related gene regulation (15 papers) and RNA modifications and cancer (8 papers). Karien M. Hamer is often cited by papers focused on Epigenetics and DNA Methylation (15 papers), Cancer-related gene regulation (15 papers) and RNA modifications and cancer (8 papers). Karien M. Hamer collaborates with scholars based in Netherlands, United States and France. Karien M. Hamer's co-authors include Arie P. Otte, David Satijn, Hans Clevers, Johan H. van Es, Vivian Li, Toshiro Sato, Robert G. Vries, Sylvia F. Boj, Meritxell Huch and Marc van de Wetering and has published in prestigious journals such as Nature, Cell and Journal of Clinical Investigation.

In The Last Decade

Karien M. Hamer

22 papers receiving 3.6k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

2013 1.1k citations Meritxell Huch, Craig Dorrell et al. Nature profile →
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

2013 535 citations Meritxell Huch, Paola Bonfanti et al. The EMBO Journal profile →
Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis

2023 125 citations Delilah Hendriks, Jos F. Brouwers et al. Nature Biotechnology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Karien M. Hamer Netherlands	19	2.4k	828	766	541	484	22	3.7k
Monique M.A. Verstegen Netherlands	31	1.0k 0.4×	677 0.8×	753 1.0×	459 0.8×	455 0.9×	87	2.8k
Malgorzata Borowiak United States	20	2.0k 0.8×	225 0.3×	1.2k 1.5×	584 1.1×	458 0.9×	40	3.0k
S. Tamir Rashid United Kingdom	20	1.7k 0.7×	198 0.2×	520 0.7×	352 0.7×	289 0.6×	30	2.3k
Wim de Lau Netherlands	15	3.2k 1.3×	1.6k 1.9×	444 0.6×	113 0.2×	837 1.7×	20	4.5k
Alla Danilkovitch‐Miagkova United States	18	1.4k 0.6×	445 0.5×	402 0.5×	446 0.8×	100 0.2×	21	2.9k
Joshua P. Frederick United States	23	2.6k 1.1×	818 1.0×	214 0.3×	245 0.5×	304 0.6×	32	3.6k
Jennifer J. Hofmann United States	18	2.2k 0.9×	331 0.4×	366 0.5×	125 0.2×	164 0.3×	24	3.5k
Yana Zavros United States	21	998 0.4×	606 0.7×	520 0.7×	62 0.1×	251 0.5×	44	1.8k
Mariko Shimokawa Japan	11	1.3k 0.5×	1.8k 2.2×	189 0.2×	127 0.2×	289 0.6×	16	2.8k
Ken-ichiro Kosai Japan	23	1.1k 0.4×	257 0.3×	415 0.5×	147 0.3×	466 1.0×	47	2.2k

Countries citing papers authored by Karien M. Hamer

Since Specialization

Citations

This map shows the geographic impact of Karien M. Hamer's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Karien M. Hamer with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Karien M. Hamer more than expected).

Fields of papers citing papers by Karien M. Hamer

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Karien M. Hamer. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Karien M. Hamer. The network helps show where Karien M. Hamer may publish in the future.

Co-authorship network of co-authors of Karien M. Hamer

This figure shows the co-authorship network connecting the top 25 collaborators of Karien M. Hamer. A scholar is included among the top collaborators of Karien M. Hamer based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Karien M. Hamer. Karien M. Hamer is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Hendriks, Delilah, Jos F. Brouwers, Karien M. Hamer, et al.. (2023). Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis. Nature Biotechnology. 41(11). 1567–1581. 125 indexed citations breakdown →

Gehart, Helmuth, Johan H. van Es, Karien M. Hamer, et al.. (2019). Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping. Cell. 176(5). 1158–1173.e16. 219 indexed citations

Huch, Meritxell, Paola Bonfanti, Sylvia F. Boj, et al.. (2013). Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. The EMBO Journal. 32(20). 2708–2721. 535 indexed citations breakdown →

Huch, Meritxell, Craig Dorrell, Sylvia F. Boj, et al.. (2013). In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature. 494(7436). 247–250. 1149 indexed citations breakdown →

Blokland, Rik van, M. Siep, Karien M. Hamer, et al.. (2010). The Use of a Stringent Selection System Allows the Identification of DNA Elements that Augment Gene Expression. Molecular Biotechnology. 48(1). 19–29. 13 indexed citations

Hamer, Karien M., et al.. (2010). Placing the RPL32 Promoter Upstream of a Second Promoter Results in a Strongly Increased Number of Stably Transfected Mammalian Cell Lines That Display High Protein Expression Levels. SHILAP Revista de lepidopterología. 2011. 1–11. 5 indexed citations

Plath, Kathrin, Dale Talbot, Karien M. Hamer, et al.. (2004). Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome. The Journal of Cell Biology. 167(6). 1025–1035. 109 indexed citations

Sewalt, Richard G. A. B., Ted Kwaks, Karien M. Hamer, & Arie P. Otte. (2003). Biochemical Analysis of Mammalian Polycomb Group Protein Complexes and the Identification of Genetic Elements that Block Polycomb-Mediated Gene Repression. Methods in enzymology on CD-ROM/Methods in enzymology. 377. 282–296. 6 indexed citations

Sewalt, Richard G. A. B., Monika Lachner, Karien M. Hamer, et al.. (2002). Selective Interactions between Vertebrate Polycomb Homologs and the SUV39H1 Histone Lysine Methyltransferase Suggest that Histone H3-K9 Methylation Contributes to Chromosomal Targeting of Polycomb Group Proteins. Molecular and Cellular Biology. 22(15). 5539–5553. 74 indexed citations

10.

Raaphorst, Frank M., Arie P. Otte, Folkert J. van Kemenade, et al.. (2001). Distinct BMI-1 and EZH2 Expression Patterns in Thymocytes and Mature T Cells Suggest a Role for Polycomb Genes in Human T Cell Differentiation. The Journal of Immunology. 166(10). 5925–5934. 62 indexed citations

11.

Gunster, Marco J., Frank M. Raaphorst, Karien M. Hamer, et al.. (2001). Differential expression of human Polycomb group proteins in various tissues and cell types. Journal of Cellular Biochemistry. 81(S36). 129–143. 41 indexed citations

12.

Kemenade, Folkert J. van, Frank M. Raaphorst, Tjasso Blokzijl, et al.. (2001). Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma. Blood. 97(12). 3896–3901. 221 indexed citations

13.

Raaphorst, Frank M., Folkert J. van Kemenade, Elly Fieret, et al.. (2000). Cutting Edge: Polycomb Gene Expression Patterns Reflect Distinct B Cell Differentiation Stages in Human Germinal Centers. The Journal of Immunology. 164(1). 1–4. 82 indexed citations

14.

Raaphorst, Frank M., Folkert J. van Kemenade, Tjasso Blokzijl, et al.. (2000). Coexpression of BMI-1 and EZH2 Polycomb Group Genes in Reed-Sternberg Cells of Hodgkin’s Disease. American Journal Of Pathology. 157(3). 709–715. 138 indexed citations

15.

Sewalt, Richard G. A. B., Johan van der Vlag, Marco J. Gunster, et al.. (1998). Characterization of Interactions between the Mammalian Polycomb-Group Proteins Enx1/EZH2 and EED Suggests the Existence of Different Mammalian Polycomb-Group Protein Complexes. Molecular and Cellular Biology. 18(6). 3586–3595. 196 indexed citations

16.

Satijn, David, Marco J. Gunster, Johan van der Vlag, et al.. (1997). RING1 Is Associated with the Polycomb Group Protein Complex and Acts as a Transcriptional Repressor. Molecular and Cellular Biology. 17(7). 4105–4113. 164 indexed citations

17.

Gunster, Marco J., David Satijn, Karien M. Hamer, et al.. (1997). Identification and Characterization of Interactions between the Vertebrate Polycomb-Group Protein BMI1 and Human Homologs of Polyhomeotic. Molecular and Cellular Biology. 17(4). 2326–2335. 142 indexed citations

18.

Satijn, David, Daniel J. Olson, Johan van der Vlag, et al.. (1997). Interference with the Expression of a Novel Human Polycomb Protein, hPc2, Results in Cellular Transformation and Apoptosis. Molecular and Cellular Biology. 17(10). 6076–6086. 103 indexed citations

19.

Hamer, Karien M., et al.. (1995). Polycomb and bmi-1 homologs are expressed in overlapping patterns in Xenopus embryos and are able to interact with each other. Mechanisms of Development. 53(1). 35–46. 48 indexed citations

20.

Delfau, Marie Hélène, C. Picat, Karien M. Hamer, et al.. (1990). Two different point G to A mutations in exon 10 of the porphobilinogen deaminase gene are responsible for acute intermittent porphyria.. Journal of Clinical Investigation. 86(5). 1511–1516. 65 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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