Joan Heller Brown

26.3k citations

228 papers · 21.7k indexed · 3 hit papers · h-index 88

Impact in

Cardiology and Cardiovascular Medicine top 0.1%
- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- Cardiac Fibrosis and Remodeling
Molecular Biology top 0.1%
- Ion channel regulation and function
- Protein Kinase Regulation and GTPase Signaling
- Receptor Mechanisms and Signaling
- Signaling Pathways in Disease

Papers in

Cardiology and Cardiovascular Medicine 77
- Cardiac electrophysiology and arrhythmias 55
- Cardiomyopathy and Myosin Studies 25
Molecular Biology 189
- Protein Kinase Regulation and GTPase Signaling 74
- Receptor Mechanisms and Signaling 61
- Ion channel regulation and function 57
- Signaling Pathways in Disease 19
- Mitochondrial Function and Pathology 17
- Sphingolipid Metabolism and Signaling 14

Co-authors: Shigeki Miyamoto Kenneth R. Chien Valerie P. Sah Donald M. Bers Tammy M. Seasholtz Yibin Wang John Ross Lars S. Maier
Journals: Journal of Biological Chemistry (48 papers)Circulation Research (20 papers)Molecular Pharmacology (14 papers)Journal of Clinical Investigation (13 papers)Journal of Molecular and Cellular Cardiology (12 papers)
Partner nations: United States Germany Netherlands

In The Last Decade

Joan Heller Brown

228 papers receiving 21.2k citations

Hit Papers

align trajectories log scale

Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca ²⁺ /Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling 2018 · 231 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2018 Circulation
1998 Journal of Biological Chemistry
1990 Journal of Biological Chemistry

Peers

Countries citing papers authored by Joan Heller Brown

Since Specialization

Citations

This map shows the geographic impact of Joan Heller Brown's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Joan Heller Brown with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Joan Heller Brown more than expected).

Fields of papers citing papers by Joan Heller Brown

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Joan Heller Brown. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Joan Heller Brown. The network helps show where Joan Heller Brown may publish in the future.

Co-authors

The 25 scholars most cited alongside Joan Heller Brown, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Joan Heller Brown Line = papers co-authored together Joan Heller Brown links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Nitric Oxide Modulates Ca ²⁺ Leak and Arrhythmias via S-Nitrosylation of CaMKII Circulation Research ·Amelia Power, Esther Udo Asamudo, Luke P. I. Worthington, Chidera C. Alim, Raquel E. Parackal, Rachel S. Wallace, Obialunanma V. Ebenebe, Joan Heller Brown, Mark J. Kohr, Donald M. Bers, Jeffrey R. Erickson	2023	11
2	SiglecF(HI) Marks Late‐Stage Neutrophils of the Infarcted Heart: A Single‐Cell Transcriptomic Analysis of Neutrophil Diversification Journal of the American Heart Association ·David Calcagno, Claire Zhang, Avinash Toomu, Kenneth Huang, Van K. Ninh, Shigeki Miyamoto, Aaron D. Aguirre, Zhenxing Fu, Joan Heller Brown, Kevin R. King	2021	59
3	ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ International Journal of Molecular Sciences ·Mario Pávez, Pablo Sánchez-Aguilera, Nils Bömer, Shigeki Miyamoto, Harmen G. Booij, Paula Giraldo, Silke U. Oberdorf‐Maass, Kirsten T. Nijholt, Salva R. Yurista, Hendrik Milting, Peter van der Meer, Rudolf A. de Boer, Joan Heller Brown, Herman W. H. Sillje, B. Daan Westenbrink	2021	10
4	Spatiotemporal restriction of endothelial cell calcium signaling is required during leukocyte transmigration The Journal of Experimental Medicine ·Prarthana Dalal, David P. Sullivan, Evan W. Weber, David B. Sacks, Matthias Gunzer, Isabella M. Grumbach, Joan Heller Brown, William A. Müller	2020	17
5	Reductions in the Cardiac Transient Outward K+ Current Ito Caused by Chronic β-Adrenergic Receptor Stimulation Are Partly Rescued by Inhibition of Nuclear Factor κB Journal of Biological Chemistry ·Brian K. Panama, Adam Korogyi, Roozbeh Aschar‐Sobbi, Yena Oh, Charles B.B. Gray, Hongying Gang, Joan Heller Brown, Lorrie A. Kirshenbaum, Peter H. Backx	2016	17
6	Abstract 18574: Mitochondrial Reprogramming By Camkiiδ Underlies Gq-induced Cardiomyopathy Circulation ·B. Daan Westenbrink, Haiyun Ling, Shigeki Miyamoto, Kirk L. Peterson, Ajit S. Divakaruni, Scott J. Matkovich, Gerald W. Dorn, Joan Heller Brown	2012	1
7	Abstract 18536: Camkii-{delta} Splice Variants Exert Differential Effects on Heart Failure Development and Myocardial Ischemia / Reperfusion Injury Circulation ·B. Daan Westenbrink, Charlie B Gray, Sunny Xiang, Shika Mishra, Jan Shilling, Hemal H. Patel, Joan Heller Brown	2012	3
8	βAr-Stimulation Causes EADs but not DADs in Pre-Failure CAMKIIδC Transgenic Myocytes Biophysical Journal ·Andrew G. Edwards, Johan Hake, Joan Heller Brown, Andrew D. McCulloch	2012	2
9	Abstract 14642: Calcium Calmodulin Dependent Protein Kinase II Overexpression Predisposes Myocytes to Isoproterenol-Induced Early Afterdepolarizations Before the Onset of Heart Failure Circulation ·Andrew G. Edwards, Johan Hake, Joan Heller Brown, Andrew D. McCulloch	2011	1
10	RhoA protects the mouse heart against ischemia/reperfusion injury Journal of Clinical Investigation ·Sunny Xiang, Davy Vanhoutte, Dominic P. Del Re, Nicole H. Purcell, Haiyun Ling, Indroneal Banerjee, Julie Bossuyt, Richard A. Lang, Yi Zheng, Scot J. Matkovich, Shigeki Miyamoto, Jeffery D. Molkentin, Gerald W. Dorn, Joan Heller Brown	2011	80
11	Crossing signals: relationships between β-adrenergic stimulation and CaMKII activation Heart Rhythm ·Michael Grimm, Haiyun Ling, Joan Heller Brown	2011	14
12	CaMKII Negatively Regulates Calcineurin–NFAT Signaling in Cardiac Myocytes Circulation Research ·Scott M. MacDonnell, Jutta Weisser-Thomas, Hajime Kubo, Marie Hanscome, (unknown), Naser Jaleel, Remus M. Berretta, Xiongwen Chen, Joan Heller Brown, Abdel-Karim Sabri, Jeffery D. Molkentin, Steven R. Houser	2009	116
13	Utilization of discrete event simulation in the prospective determination of optimal cardiovascular lab processes Winter Simulation Conference ·John Pirolo, Abhijit Ray, Matt Gadzinski, Mario Manese, Brannon Garvert, George Scoville, Howard T. Walpole, Robert C. Amland, Rebecca Boos, Ian Mamminga, Joan Heller Brown, Kipp Donion	2009	3
14	Focal Adhesion Kinase as a RhoA-activable Signaling Scaffold Mediating Akt Activation and Cardiomyocyte Protection Journal of Biological Chemistry ·Dominic P. Del Re, Shigeki Miyamoto, Joan Heller Brown	2008	95
15	Phospholipase Cε is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation Proceedings of the National Academy of Sciences ·Simona Citro, Sundeep Malik, Emily A. Oestreich, Julie Radeff‐Huang, Grant G. Kelley, Alan V. Smrcka, Joan Heller Brown	2007	62
16	Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels Journal of Clinical Investigation ·Stefan Wagner, Nataliya Dybkova, Eva Rasenack, Claudius Jacobshagen, Larissa Fabritz, Paulus Kirchhof, Sebastian K.G. Maier, Tong Zhang, Gerd Hasenfuß, Joan Heller Brown, Donald M. Bers, Lars S. Maier	2006	400
17	Marked Perinatal Lethality and Cellular Signaling Deficits in Mice Null for the Two Sphingosine 1-Phosphate (S1P) Receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3 Journal of Biological Chemistry ·Isao Ishii, Xiaoqin Ye, Beth Friedman, Shuji Kawamura, James J. A. Contos, Marcy A. Kingsbury, Amy H. Yang, Guangfa Zhang, Joan Heller Brown, Jerold Chun	2002	213
18	Pertussis Toxin-Sensitive and -Insensitive Thrombin Stimulation of Shc Phosphorylation and Mitogenesis Are Mediated through Distinct Pathways Molecular Endocrinology ·William A. Ricketts, Joan Heller Brown, Jerrold M. Olefsky	1999	16
19	Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family Journal of Biological Chemistry ·Yibin Wang, Shuang Huang, Valerie P. Sah, John Ross, Joan Heller Brown, Jiahuai Han, Kenneth R. Chien Hit paper breakdown →	1998	723
20	Rho Is Required for Gαq and α1-Adrenergic Receptor Signaling in Cardiomyocytes Journal of Biological Chemistry ·Valerie P. Sah, Masahiko Hoshijima, Kenneth R. Chien, Joan Heller Brown	1996	204

About Joan Heller Brown

Joan Heller Brown is a scholar working on Cardiology and Cardiovascular Medicine, Molecular Biology, Cell Biology, Cellular and Molecular Neuroscience and Immunology and Allergy, having authored 228 papers that have together received 21.7k indexed citations. Recurring topics across this work include Protein Kinase Regulation and GTPase Signaling (74 papers), Receptor Mechanisms and Signaling (61 papers), Ion channel regulation and function (57 papers), Cardiac electrophysiology and arrhythmias (55 papers), Cardiomyopathy and Myosin Studies (25 papers), Signaling Pathways in Disease (19 papers), Mitochondrial Function and Pathology (17 papers) and Sphingolipid Metabolism and Signaling (14 papers). The work is most often cited by research in Cardiology and Cardiovascular Medicine (7.8k citations), Molecular Biology (16.5k citations), Cellular and Molecular Neuroscience (3.1k citations), Cell Biology (2.5k citations) and Physiology (441 citations). Joan Heller Brown has collaborated with scholars based in United States, Germany and Netherlands. Frequent co-authors include Shigeki Miyamoto, Kenneth R. Chien, Valerie P. Sah, Donald M. Bers, Tammy M. Seasholtz, Yibin Wang, John Ross, Lars S. Maier, Tong Zhang and Kirk U. Knowlton. Their work appears in journals such as Journal of Biological Chemistry, Circulation Research, Molecular Pharmacology, Journal of Clinical Investigation and Journal of Molecular and Cellular Cardiology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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