Kenneth R. Chien

57.0k citations

303 papers · 41.1k indexed · 23 hit papers · h-index 110

Molecular Biology top 0.02%
Cardiology and Cardiovascular Medicine top 0.05%
Surgery top 0.1%
Genetics top 0.2%
Oncology top 0.5%

Co-authors: John Ross John Hunter Masahiko Hoshijima Joan Heller Brown Pilar Ruiz‐Lozano Kirk U. Knowlton Ju Chen Yibin Wang
Topics: Cardiomyopathy and Myosin Studies (94 papers)Congenital heart defects research (87 papers)Tissue Engineering and Regenerative Medicine (41 papers)
Cited by: Cardiology and Cardiovascular Medicine Molecular Biology Cell Biology
Journals: Nature Science New England Journal of Medicine
Partner nations: United States Sweden Japan

In The Last Decade

Kenneth R. Chien

303 papers receiving 40.2k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

1999 1.6k citations Pilar Ruiz‐Lozano, Kenneth R. Chien et al. profile →
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages

2005 978 citations Peter J. Gruber, Kenneth R. Chien et al. profile →
Multipotent Embryonic Isl1+ Progenitor Cells Lead to Cardiac, Smooth Muscle, and Endothelial Cell Diversification

2006 765 citations Kenneth R. Chien et al. Cell profile →
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart

2008 764 citations Sean M. Wu, Ibrahim J. Domian et al. profile →
Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family

1998 723 citations Yibin Wang, Shuang Huang et al. Journal of Biological Chemistry profile →
Signaling Pathways for Cardiac Hypertrophy and Failure

1999 684 citations John Hunter, Kenneth R. Chien profile →
MLP-Deficient Mice Exhibit a Disruption of Cardiac Cytoarchitectural Organization, Dilated Cardiomyopathy, and Heart Failure

1997 672 citations John Hunter, John Ross et al. Cell profile →
ErbB2 is essential in the prevention of dilated cardiomyopathy

2002 668 citations Yusu Gu, Susumu Minamisawa et al. Nature Medicine profile →
Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response

1991 668 citations Kenneth R. Chien et al. profile →
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

2003 647 citations Masahiko Hoshijima, Kenneth R. Chien et al. profile →
Marked differences in differentiation propensity among human embryonic stem cell lines

2008 628 citations Kenneth R. Chien et al. profile →
Enhanced Myocardial Function in Transgenic Mice Overexpressing the β ₂ -Adrenergic Receptor

1994 615 citations Howard A. Rockman, Kenneth R. Chien et al. Science profile →
Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy

1990 553 citations Joan Heller Brown, Kenneth R. Chien et al. Journal of Biological Chemistry profile →
Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress

1999 548 citations Yusu Gu, John Ross et al. Cell profile →
Conduction Slowing and Sudden Arrhythmic Death in Mice With Cardiac-Restricted Inactivation of Connexin43

2001 548 citations Kenneth R. Chien et al. profile →
RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.

1994 522 citations Henry M. Sucov, Kenneth R. Chien et al. profile →
Thymosin β4 induces adult epicardial progenitor mobilization and neovascularization

2006 502 citations Kenneth R. Chien et al. profile →
Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

2013 501 citations Kenneth R. Chien et al. profile →
Fibulin-5/DANCE is essential for elastogenesis in vivo

2002 493 citations Yasuhiro Ikeda, Yoshitaka Iwanaga et al. profile →
Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

1998 405 citations Howard A. Rockman, Kenneth R. Chien et al. profile →
Myocardial ischemia: the pathogenesis of irreversible cell injury in ischemia.

1981 372 citations Kenneth R. Chien et al. profile →
Accelerated phospholipid degradation and associated membrane dysfunction in irreversible, ischemic liver cell injury

1978 358 citations Kenneth R. Chien et al. Journal of Biological Chemistry profile →
Unlocking the promise of mRNA therapeutics

2022 350 citations Ran Yang, Alexander Goedel et al. profile →

Peers

Countries citing papers authored by Kenneth R. Chien

Since Specialization

Citations

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Fields of papers citing papers by Kenneth R. Chien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kenneth R. Chien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kenneth R. Chien. The network helps show where Kenneth R. Chien may publish in the future.

Co-authorship network of co-authors of Kenneth R. Chien

This figure shows the co-authorship network connecting the top 25 collaborators of Kenneth R. Chien. A scholar is included among the top collaborators of Kenneth R. Chien based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kenneth R. Chien. Kenneth R. Chien is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Endovascular transplantation of mRNA-enhanced mesenchymal stromal cells results in superior therapeutic protein expression in swine heart 2024 ·Molecular Therapy — Methods & Clinical Development ·Jonathan Al‐Saadi,(unknown),(unknown),(unknown),(unknown),(unknown),Agneta Andersson,Mattias Carlsten,Kenneth R. Chien,Johan Lundberg,Nevin Witman,Staffan Holmin	2
2	Single-cell analysis of embryoids reveals lineage diversification roadmaps of early human development 2022 ·Cell stem cell ·Yi Zheng,(unknown),(unknown),Mutsumi Kobayashi,Lifeng Xiang,Ran Yang,Alexander Goedel,Yu Kang,Xufeng Xue,Sajedeh Nasr Esfahani,Yue Liu,(unknown),(unknown),(unknown),Weizhi Ji,Yuyu Niu,Kenneth R. Chien,Tianqing Li,Toshi Shioda,Jianping Fu	36
3	Sequencing of a Chinese tetralogy of Fallot cohort reveals clustering mutations in myogenic heart progenitors 2021 ·JCI Insight ·Clara Sze-Man Tang,(unknown),(unknown),Sheng Chih Jin,Xuehan Zhuang,María-Mercé García-Barceló,(unknown),Yujia Yang,Makoto Sahara,Elif Eroğlu,Kenneth R. Chien,Haifa Hong,Paul Kwong Hang Tam,Peter J. Gruber	11
4	Amnion signals are essential for mesoderm formation in primates 2021 ·Nature Communications ·Ran Yang,Alexander Goedel,Yu Kang,Chenyang Si,Chu Chu,Yi Zheng,Zhenzhen Chen,Peter J. Gruber,Yao Xiao,Chikai Zhou,Nevin Witman,Elif Eroğlu,(unknown),Yongchang Chen,Jianping Fu,Weizhi Ji,Fredrik Lanner,Yuyu Niu,Kenneth R. Chien	73
5	BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways 2021 ·Communications Biology ·(unknown),Huichuan Duan,Liang Xu,Nevin Witman,Bingqian Yan,Zheyuan Yu,Huijing Wang,Yao Tan,(unknown),(unknown),(unknown),Regina Fritsche‐Danielson,Jie Yuan,Kenneth R. Chien,Min Wei,Wei Fu	78
6	Generation of Functional Ventricular Heart Muscle from Mouse Ventricular Progenitor Cells 2009 ·Science ·Ibrahim J. Domian,Murali Chiravuri,Peter van der Meer,Adam W. Feinberg,Xi Shi,Ying Shao,Sean M. Wu,Kevin Kit Parker,Kenneth R. Chien	151
7	Committed Ventricular Progenitors in the Islet-1 Lineage Expand and Assemble Into Functional Ventricular Heart Muscle 2009 ·Data Archiving and Networked Services (DANS) ·Peter van der Meer,Ibrahim J. Domian,Murali Chiravuri,(unknown),Sean M. Wu,Kevin Kit Parker,Kenneth R. Chien	2
8	Origins and Fates of Cardiovascular Progenitor Cells 2008 ·Cell ·Sean M. Wu,Kenneth R. Chien,Christine L. Mummery	143
9	Longevity and Lineages: Toward the Integrative Biology of Degenerative Diseases in Heart, Muscle, and Bone 2005 ·Cell ·Kenneth R. Chien,Gérard Karsenty	117
10	Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats 2004 ·Journal of Clinical Investigation ·Yoshitaka Iwanaga,Masahiko Hoshijima,Yusu Gu,Mitsuo Iwatate,Thomas Dieterle,Yasuhiro Ikeda,Motoo Date,Jacqueline Chrast,Masunori Matsuzaki,Kirk L. Peterson,Kenneth R. Chien,John Ross	12
11	Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats 2004 ·Journal of Clinical Investigation ·Yoshitaka Iwanaga,Masahiko Hoshijima,Yusu Gu,Mitsuo Iwatate,Thomas Dieterle,Yasuhiro Ikeda,Motoo Date,Jacqueline Chrast,Masunori Matsuzaki,Kirk L. Peterson,Kenneth R. Chien,John Ross	140
12	Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery 2002 ·Nature Medicine ·Masahiko Hoshijima,Yasuhiro Ikeda,Yoshitaka Iwanaga,Susumu Minamisawa,Motoo Date,Yusu Gu,Mitsuo Iwatate,Manxiang Li,Lili Wang,James M. Wilson,Yibin Wang,John Ross,Kenneth R. Chien	288
13	Angiotensin II blockade followed by growth hormone as adjunctive therapy after experimental myocardial infarction 1998 ·Journal of Cardiac Failure ·Minoru Hongo,(unknown),Nobuaki Tanaka,Lan Mao,M. Dan McKirnan,Ross Clark,Wesley Won,Kenneth R. Chien,John Ross	14
14	Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Familybreakdown → 1998 ·Journal of Biological Chemistry ·Yibin Wang,Shuang Huang,Valerie P. Sah,John Ross,Joan Heller Brown,Jiahuai Han,Kenneth R. Chien	723
15	Developmental expression of the murine spliceosome-associated protein mSAP49 1997 ·Developmental Dynamics ·Pilar Ruiz‐Lozano,Pieter A. Doevendans,Anne B. Brown,Peter J. Gruber,Kenneth R. Chien	20
16	Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. 1996 ·Journal of Clinical Investigation ·Giuseppe Lembo,Howard A. Rockman,John Hunter,Helmuth Steinmetz,Walter J. Koch,Ligeng Ma,(unknown),John Ross,Kenneth R. Chien,Lyn Powell-Braxton	112
17	RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice. 1996 ·Journal of Clinical Investigation ·Peter J. Gruber,S. Kubalak,Tomáš Pexieder,Henry M. Sucov,Ronald M. Evans,Kenneth R. Chien	157
18	Positive Regulatory Elements (HF-1a and HF-1b) and a Novel Negative Regulatory Element (HF-3) Mediate Ventricular Muscle-Specific Expression of Myosin Light-Chain 2-Luciferase Fusion Genes in Transgenic Mice 1994 ·Molecular and Cellular Biology ·Kevin J. Lee,Reed Hickey,Hong Zhu,Kenneth R. Chien	56
19	A Novel, Tissue-Restricted Zinc Finger Protein (HF-1b) Binds to the Cardiac Regulatory Element (HF-1b/MEF-2) in the Rat Myosin Light-Chain 2 Gene 1993 ·Molecular and Cellular Biology ·Hong Zhu,Van Trung Nguyen,Anne B. Brown,(unknown),Arnold Garcia,Marc van Bilsen,Kenneth R. Chien	73
20	Prevention by chlorpromazine of ischemic liver cell death. 1977 ·Munich Personal RePEc Archive (Ludwig Maximilian University of Munich) ·Kenneth R. Chien,(unknown),Richard Pfau,John L. Farber	157

About Kenneth R. Chien

Kenneth R. Chien is a scholar working on Cardiology and Cardiovascular Medicine, Molecular Biology and Aging, having authored 303 papers that have together received 41.1k indexed citations. Recurring topics across this work include Cardiomyopathy and Myosin Studies (94 papers), Congenital heart defects research (87 papers) and Tissue Engineering and Regenerative Medicine (41 papers). The work is most often cited by research in Cardiology and Cardiovascular Medicine (15.0k citations), Molecular Biology (29.4k citations) and Cell Biology (2.7k citations). Kenneth R. Chien has collaborated with scholars based in United States, Sweden and Japan. Frequent co-authors include John Ross, John Hunter, Masahiko Hoshijima, Joan Heller Brown, Pilar Ruiz‐Lozano, Kirk U. Knowlton, Ju Chen, Yibin Wang, Ronald M. Evans and Valerie P. Sah. Their work appears in journals such as Nature, Science and New England Journal of Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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