Kenneth R. Chien

57.0k total citations · 23 hit papers
303 papers, 41.1k citations indexed

About

Kenneth R. Chien is a scholar working on Molecular Biology, Cardiology and Cardiovascular Medicine and Surgery. According to data from OpenAlex, Kenneth R. Chien has authored 303 papers receiving a total of 41.1k indexed citations (citations by other indexed papers that have themselves been cited), including 236 papers in Molecular Biology, 147 papers in Cardiology and Cardiovascular Medicine and 52 papers in Surgery. Recurrent topics in Kenneth R. Chien's work include Cardiomyopathy and Myosin Studies (94 papers), Congenital heart defects research (87 papers) and Tissue Engineering and Regenerative Medicine (41 papers). Kenneth R. Chien is often cited by papers focused on Cardiomyopathy and Myosin Studies (94 papers), Congenital heart defects research (87 papers) and Tissue Engineering and Regenerative Medicine (41 papers). Kenneth R. Chien collaborates with scholars based in United States, Sweden and Japan. Kenneth R. Chien's co-authors include John Ross, John Hunter, Masahiko Hoshijima, Joan Heller Brown, Pilar Ruiz‐Lozano, Kirk U. Knowlton, Ju Chen, Yibin Wang, Ronald M. Evans and Valerie P. Sah and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Kenneth R. Chien

303 papers receiving 40.2k citations

Hit Papers

PPARγ Is Required for Placental, Cardiac, and Ad... 1978 2026 1994 2010 1999 2005 2006 2008 1998 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development
    1999 1.6k citations Pilar Ruiz‐Lozano, Kenneth R. Chien et al. profile →
  2. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages
    2005 978 citations Peter J. Gruber, Kenneth R. Chien et al. profile →
  3. Multipotent Embryonic Isl1+ Progenitor Cells Lead to Cardiac, Smooth Muscle, and Endothelial Cell Diversification
    2006 765 citations Kenneth R. Chien et al. Cell profile →
  4. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
    2008 764 citations Sean M. Wu, Ibrahim J. Domian et al. profile →
  5. Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family
    1998 723 citations Yibin Wang, Shuang Huang et al. Journal of Biological Chemistry profile →
  6. Signaling Pathways for Cardiac Hypertrophy and Failure
    1999 684 citations John Hunter, Kenneth R. Chien profile →
  7. MLP-Deficient Mice Exhibit a Disruption of Cardiac Cytoarchitectural Organization, Dilated Cardiomyopathy, and Heart Failure
    1997 672 citations John Hunter, John Ross et al. Cell profile →
  8. ErbB2 is essential in the prevention of dilated cardiomyopathy
    2002 668 citations Yusu Gu, Susumu Minamisawa et al. Nature Medicine profile →
  9. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response
    1991 668 citations Kenneth R. Chien et al. profile →
  10. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
    2003 647 citations Masahiko Hoshijima, Kenneth R. Chien et al. profile →
  11. Marked differences in differentiation propensity among human embryonic stem cell lines
    2008 628 citations Kenneth R. Chien et al. profile →
  12. Enhanced Myocardial Function in Transgenic Mice Overexpressing the β 2 -Adrenergic Receptor
    1994 615 citations Howard A. Rockman, Kenneth R. Chien et al. Science profile →
  13. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy
    1990 553 citations Joan Heller Brown, Kenneth R. Chien et al. Journal of Biological Chemistry profile →
  14. Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress
    1999 548 citations Yusu Gu, John Ross et al. Cell profile →
  15. Conduction Slowing and Sudden Arrhythmic Death in Mice With Cardiac-Restricted Inactivation of Connexin43
    2001 548 citations Kenneth R. Chien et al. profile →
  16. RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.
    1994 522 citations Henry M. Sucov, Kenneth R. Chien et al. profile →
  17. Thymosin β4 induces adult epicardial progenitor mobilization and neovascularization
    2006 502 citations Kenneth R. Chien et al. profile →
  18. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction
    2013 501 citations Kenneth R. Chien et al. profile →
  19. Fibulin-5/DANCE is essential for elastogenesis in vivo
    2002 493 citations Yasuhiro Ikeda, Yoshitaka Iwanaga et al. profile →
  20. Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice
    1998 405 citations Howard A. Rockman, Kenneth R. Chien et al. profile →
  21. Myocardial ischemia: the pathogenesis of irreversible cell injury in ischemia.
    1981 372 citations Kenneth R. Chien et al. profile →
  22. Accelerated phospholipid degradation and associated membrane dysfunction in irreversible, ischemic liver cell injury
    1978 358 citations Kenneth R. Chien et al. Journal of Biological Chemistry profile →
  23. Unlocking the promise of mRNA therapeutics
    2022 350 citations Ran Yang, Alexander Goedel et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Kenneth R. Chien United States 110 29.4k 15.0k 6.9k 4.0k 3.4k 303 41.1k
Jeffery D. Molkentin United States 124 39.3k 1.3× 19.7k 1.3× 7.5k 1.1× 2.9k 0.7× 4.0k 1.2× 430 54.9k
Joseph A. Hill United States 95 23.3k 0.8× 10.5k 0.7× 5.2k 0.8× 2.0k 0.5× 2.1k 0.6× 352 39.8k
Roger J. Hajjar United States 90 17.5k 0.6× 14.6k 1.0× 4.3k 0.6× 3.0k 0.8× 1.5k 0.5× 500 28.9k
Yoshio Yazaki Japan 93 17.8k 0.6× 10.2k 0.7× 4.5k 0.7× 2.4k 0.6× 2.4k 0.7× 442 35.5k
Walter J. Koch United States 97 22.1k 0.8× 13.0k 0.9× 2.7k 0.4× 1.7k 0.4× 1.6k 0.5× 507 32.3k
Christine E. Seidman United States 109 24.1k 0.8× 28.1k 1.9× 4.0k 0.6× 4.2k 1.1× 1.3k 0.4× 416 45.6k
Richard P. Lifton United States 92 20.6k 0.7× 4.9k 0.3× 4.2k 0.6× 5.6k 1.4× 2.1k 0.6× 276 35.1k
Seigo Izumo United States 82 15.6k 0.5× 10.4k 0.7× 3.0k 0.4× 1.8k 0.4× 1.3k 0.4× 161 24.1k
Piero Anversa United States 94 20.4k 0.7× 15.2k 1.0× 15.9k 2.3× 1.0k 0.3× 2.0k 0.6× 331 40.7k
Michael Schneider United States 79 15.0k 0.5× 5.8k 0.4× 4.0k 0.6× 1.4k 0.3× 2.0k 0.6× 233 22.5k

Countries citing papers authored by Kenneth R. Chien

Since Specialization
Citations

This map shows the geographic impact of Kenneth R. Chien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kenneth R. Chien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kenneth R. Chien more than expected).

Fields of papers citing papers by Kenneth R. Chien

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kenneth R. Chien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kenneth R. Chien. The network helps show where Kenneth R. Chien may publish in the future.

Co-authorship network of co-authors of Kenneth R. Chien

This figure shows the co-authorship network connecting the top 25 collaborators of Kenneth R. Chien. A scholar is included among the top collaborators of Kenneth R. Chien based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kenneth R. Chien. Kenneth R. Chien is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Al‐Saadi, Jonathan, Agneta Andersson, Mattias Carlsten, et al.. (2024). Endovascular transplantation of mRNA-enhanced mesenchymal stromal cells results in superior therapeutic protein expression in swine heart. Molecular Therapy — Methods & Clinical Development. 32(2). 101225–101225. 2 indexed citations
2.
Zheng, Yi, Mutsumi Kobayashi, Lifeng Xiang, et al.. (2022). Single-cell analysis of embryoids reveals lineage diversification roadmaps of early human development. Cell stem cell. 29(9). 1402–1419.e8. 36 indexed citations
3.
Yang, Ran, Alexander Goedel, Yu Kang, et al.. (2021). Amnion signals are essential for mesoderm formation in primates. Nature Communications. 12(1). 73 indexed citations
4.
Duan, Huichuan, Liang Xu, Nevin Witman, et al.. (2021). BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways. Communications Biology. 4(1). 82–82. 78 indexed citations
5.
Tang, Clara Sze-Man, Sheng Chih Jin, Xuehan Zhuang, et al.. (2021). Sequencing of a Chinese tetralogy of Fallot cohort reveals clustering mutations in myogenic heart progenitors. JCI Insight. 7(2). 11 indexed citations
6.
Sahara, Makoto, Federica Santoro, & Kenneth R. Chien. (2015). Programming and reprogramming a human heart cell. The EMBO Journal. 34(6). 710–738. 60 indexed citations
7.
Domian, Ibrahim J., Murali Chiravuri, Peter van der Meer, et al.. (2009). Generation of Functional Ventricular Heart Muscle from Mouse Ventricular Progenitor Cells. Science. 326(5951). 426–429. 151 indexed citations
8.
Meer, Peter van der, Ibrahim J. Domian, Murali Chiravuri, et al.. (2009). Committed Ventricular Progenitors in the Islet-1 Lineage Expand and Assemble Into Functional Ventricular Heart Muscle. Data Archiving and Networked Services (DANS). 2 indexed citations
9.
Wu, Sean M., Kenneth R. Chien, & Christine L. Mummery. (2008). Origins and Fates of Cardiovascular Progenitor Cells. Cell. 132(4). 537–543. 143 indexed citations
10.
Chien, Kenneth R. & Gérard Karsenty. (2005). Longevity and Lineages: Toward the Integrative Biology of Degenerative Diseases in Heart, Muscle, and Bone. Cell. 120(4). 533–544. 117 indexed citations
11.
Iwanaga, Yoshitaka, Masahiko Hoshijima, Yusu Gu, et al.. (2004). Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats. Journal of Clinical Investigation. 113(5). 727–736. 12 indexed citations
12.
Iwanaga, Yoshitaka, Masahiko Hoshijima, Yusu Gu, et al.. (2004). Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats. Journal of Clinical Investigation. 113(5). 727–736. 140 indexed citations
13.
Hoshijima, Masahiko, Yasuhiro Ikeda, Yoshitaka Iwanaga, et al.. (2002). Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nature Medicine. 8(8). 864–871. 288 indexed citations
14.
Wang, Yibin, Shuang Huang, Valerie P. Sah, et al.. (1998). Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family. Journal of Biological Chemistry. 273(4). 2161–2168. 723 indexed citations breakdown →
15.
Hongo, Minoru, Nobuaki Tanaka, Lan Mao, et al.. (1998). Angiotensin II blockade followed by growth hormone as adjunctive therapy after experimental myocardial infarction. Journal of Cardiac Failure. 4(3). 213–224. 14 indexed citations
16.
Ruiz‐Lozano, Pilar, Pieter A. Doevendans, Anne B. Brown, Peter J. Gruber, & Kenneth R. Chien. (1997). Developmental expression of the murine spliceosome-associated protein mSAP49. Developmental Dynamics. 208(4). 482–490. 20 indexed citations
17.
Gruber, Peter J., S. Kubalak, Tomáš Pexieder, et al.. (1996). RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice.. Journal of Clinical Investigation. 98(6). 1332–1343. 157 indexed citations
18.
Lembo, Giuseppe, Howard A. Rockman, John Hunter, et al.. (1996). Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency.. Journal of Clinical Investigation. 98(11). 2648–2655. 112 indexed citations
19.
Lee, Kevin J., Reed Hickey, Hong Zhu, & Kenneth R. Chien. (1994). Positive Regulatory Elements (HF-1a and HF-1b) and a Novel Negative Regulatory Element (HF-3) Mediate Ventricular Muscle-Specific Expression of Myosin Light-Chain 2-Luciferase Fusion Genes in Transgenic Mice. Molecular and Cellular Biology. 14(2). 1220–1229. 56 indexed citations
20.
Chien, Kenneth R., et al.. (1977). Prevention by chlorpromazine of ischemic liver cell death.. Munich Personal RePEc Archive (Ludwig Maximilian University of Munich). 88(3). 539–57. 157 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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