Alan V. Smrcka

11.9k total citations · 3 hit papers
145 papers, 9.1k citations indexed

About

Alan V. Smrcka is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Cell Biology. According to data from OpenAlex, Alan V. Smrcka has authored 145 papers receiving a total of 9.1k indexed citations (citations by other indexed papers that have themselves been cited), including 129 papers in Molecular Biology, 26 papers in Cellular and Molecular Neuroscience and 22 papers in Cell Biology. Recurrent topics in Alan V. Smrcka's work include Protein Kinase Regulation and GTPase Signaling (80 papers), Receptor Mechanisms and Signaling (67 papers) and Neuropeptides and Animal Physiology (19 papers). Alan V. Smrcka is often cited by papers focused on Protein Kinase Regulation and GTPase Signaling (80 papers), Receptor Mechanisms and Signaling (67 papers) and Neuropeptides and Animal Physiology (19 papers). Alan V. Smrcka collaborates with scholars based in United States, China and Spain. Alan V. Smrcka's co-authors include Paul C. Sternweis, John R. Hepler, Dianqing Wu, Huiping Jiang, Sundeep Malik, Wei Xie, Grant G. Kelley, Zhong Li, David M. Lehmann and Burns C. Blaxall and has published in prestigious journals such as Science, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Alan V. Smrcka

141 papers receiving 9.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G _q

1991 757 citations Alan V. Smrcka, Paul C. Sternweis et al. profile →
Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

2000 708 citations Alan V. Smrcka et al. profile →
A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits

1994 504 citations Alan V. Smrcka, Paul C. Sternweis et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Alan V. Smrcka United States	50	7.1k	2.0k	1.6k	1.1k	800	145	9.1k
Tohru Kozasa United States	50	7.9k 1.1×	1.9k 0.9×	1.7k 1.1×	679 0.6×	725 0.9×	107	9.7k
Yehia Daaka United States	45	7.6k 1.1×	3.1k 1.6×	1.2k 0.8×	760 0.7×	1.1k 1.4×	97	10.0k
Peter Gierschik Germany	57	6.9k 1.0×	1.6k 0.8×	1.6k 1.0×	1.4k 1.3×	1.2k 1.5×	173	9.7k
Kazuyasu Chihara Japan	17	5.5k 0.8×	1.3k 0.6×	3.6k 2.3×	575 0.5×	570 0.7×	32	8.4k
Kenji Sobue Japan	47	4.8k 0.7×	1.7k 0.8×	2.7k 1.7×	478 0.5×	600 0.8×	145	7.9k
Masaki Fukata Japan	57	6.6k 0.9×	2.5k 1.3×	4.3k 2.8×	557 0.5×	774 1.0×	104	10.2k
Kendall Blumer United States	47	6.7k 0.9×	1.3k 0.7×	1.5k 1.0×	453 0.4×	522 0.7×	107	8.1k
Seungkirl Ahn United States	43	8.6k 1.2×	4.7k 2.3×	788 0.5×	674 0.6×	1.1k 1.4×	52	10.1k
Matilde Caivano United Kingdom	12	5.0k 0.7×	837 0.4×	858 0.6×	950 0.9×	1.0k 1.3×	16	7.3k
Stephen P. Soltoff United States	43	5.8k 0.8×	981 0.5×	1.1k 0.7×	1.3k 1.2×	1.7k 2.1×	73	8.8k

Countries citing papers authored by Alan V. Smrcka

Since Specialization

Citations

This map shows the geographic impact of Alan V. Smrcka's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alan V. Smrcka with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alan V. Smrcka more than expected).

Fields of papers citing papers by Alan V. Smrcka

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alan V. Smrcka. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alan V. Smrcka. The network helps show where Alan V. Smrcka may publish in the future.

Co-authorship network of co-authors of Alan V. Smrcka

This figure shows the co-authorship network connecting the top 25 collaborators of Alan V. Smrcka. A scholar is included among the top collaborators of Alan V. Smrcka based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alan V. Smrcka. Alan V. Smrcka is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Cunha, Juliana Bragazzi, et al.. (2025). Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening. Atherosclerosis. 403. 119174–119174.

Smrcka, Alan V., et al.. (2024). Internalized β2-Adrenergic Receptors Oppose PLC-Dependent Hypertrophic Signaling. Circulation Research. 135(2). e24–e38. 6 indexed citations

Krumm, B., Nicholas J. Kapolka, W.H. Ludlam, et al.. (2024). A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state. Nature Communications. 15(1). 6643–6643. 5 indexed citations

SenGupta, Shuvasree, et al.. (2022). A network of Gα _i signaling partners is revealed by proximity labeling proteomics analysis and includes PDZ-RhoGEF. Science Signaling. 15(717). eabi9869–eabi9869. 11 indexed citations

Mohan, Ramkumar, Xiaohuan Chen, Mounir Bendahmane, et al.. (2022). PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells. The Journal of General Physiology. 155(2). 5 indexed citations

Jutkiewicz, Emily M., et al.. (2022). Coincident Regulation of PLCβ Signaling by Gq-Coupled and μ-Opioid Receptors Opposes Opioid-Mediated Antinociception. Molecular Pharmacology. 102(6). 269–279. 9 indexed citations

Cash, Jennifer N., et al.. (2020). Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1–Dependent Functions in Neutrophils. Molecular Pharmacology. 97(3). 226–236. 15 indexed citations

Ransom, Richard F., et al.. (2018). Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production. Science Signaling. 11(547). 33 indexed citations

Stoveken, Hannah M., et al.. (2016). Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein–Coupled Receptor Antagonist. Molecular Pharmacology. 90(3). 214–224. 44 indexed citations

10.

Xiang, Sunny, Kunfu Ouyang, Bryan S. Yung, et al.. (2013). PLCε, PKD1, and SSH1L Transduce RhoA Signaling to Protect Mitochondria from Oxidative Stress in the Heart. Science Signaling. 6(306). ra108–ra108. 58 indexed citations

11.

Dzhura, Igor, Oleg G. Chepurny, Colin A. Leech, et al.. (2011). Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans. Islets. 3(3). 121–128. 62 indexed citations

12.

Zhang, Lianghui, Sundeep Malik, Grant G. Kelley, Michael S. Kapiloff, & Alan V. Smrcka. (2011). Phospholipase C∈ Scaffolds to Muscle-specific A Kinase Anchoring Protein (mAKAPβ) and Integrates Multiple Hypertrophic Stimuli in Cardiac Myocytes. Journal of Biological Chemistry. 286(26). 23012–23021. 78 indexed citations

13.

Smrcka, Alan V., Nessim Kichik, Teresa Tarragó, et al.. (2009). NMR analysis of G-protein βγ subunit complexes reveals a dynamic Gα-Gβγ subunit interface and multiple protein recognition modes. Proceedings of the National Academy of Sciences. 107(2). 639–644. 18 indexed citations

14.

Bianchi, Enrica, Monica Norcini, Alan V. Smrcka, & Carla Ghelardini. (2009). Supraspinal Gβγ‐dependent stimulation of PLCβ₃originating from G inhibitory protein‐μ opioid receptor‐coupling is necessary for morphine induced acute hyperalgesia. Journal of Neurochemistry. 111(1). 171–180. 34 indexed citations

15.

Citro, Simona, Sundeep Malik, Emily A. Oestreich, et al.. (2007). Phospholipase Cε is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation. Proceedings of the National Academy of Sciences. 104(39). 15543–15548. 62 indexed citations

16.

Sato, Motohiko, Mary J. Cismowski, Eiji Toyota, et al.. (2006). Identification of a receptor-independent activator of G protein signaling (AGS8) in ischemic heart and its interaction with Gβγ. Proceedings of the National Academy of Sciences. 103(3). 797–802. 52 indexed citations

17.

Kelley, Grant G., et al.. (2005). G-protein-coupled Receptor Agonists Activate Endogenous Phospholipase Cϵ and Phospholipase Cβ3 in a Temporally Distinct Manner. Journal of Biological Chemistry. 281(5). 2639–2648. 70 indexed citations

18.

Smrcka, Alan V.. (2003). G Protein Signaling. Humana Press eBooks.

19.

Pang, Iok-Hou, Alan V. Smrcka, & Paul C. Sternweis. (1994). [13] Synthesis and applications of affinity matrix containing immobilized βγ subunits of G proteins. Methods in enzymology on CD-ROM/Methods in enzymology. 237. 164–174. 7 indexed citations

20.

Sternweis, Paul C., Alan V. Smrcka, & Stephen Gutowski. (1992). Hormone signalling via G-protein: regulation of phosphatidylinositol 4,5-bisphosphate hydrolysis by Gq. Philosophical Transactions of the Royal Society B Biological Sciences. 336(1276). 35–42. 21 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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