Johannes L. Bos

49.1k total citations · 17 hit papers
246 papers, 39.6k citations indexed

About

Johannes L. Bos is a scholar working on Molecular Biology, Oncology and Cell Biology. According to data from OpenAlex, Johannes L. Bos has authored 246 papers receiving a total of 39.6k indexed citations (citations by other indexed papers that have themselves been cited), including 201 papers in Molecular Biology, 61 papers in Oncology and 49 papers in Cell Biology. Recurrent topics in Johannes L. Bos's work include Protein Kinase Regulation and GTPase Signaling (89 papers), Cell Adhesion Molecules Research (31 papers) and Cancer-related Molecular Pathways (28 papers). Johannes L. Bos is often cited by papers focused on Protein Kinase Regulation and GTPase Signaling (89 papers), Cell Adhesion Molecules Research (31 papers) and Cancer-related Molecular Pathways (28 papers). Johannes L. Bos collaborates with scholars based in Netherlands, United Kingdom and Germany. Johannes L. Bos's co-authors include Boudewijn Burgering, Alfred Wittinghofer, Johan de Rooij, Bert Vogelstein, Eric R. Fearon, Stanley R. Hamilton, Holger Rehmann, Alida M.M. Smits, Fried Zwartkruis and René H. Medema and has published in prestigious journals such as Nature, New England Journal of Medicine and Cell.

In The Last Decade

Johannes L. Bos

246 papers receiving 38.7k citations

Hit Papers

Genetic Alterations during Colorectal-Tumor Development 1987 2026 2000 2013 1988 1998 1987 2007 2002 1000 2.0k 3.0k 4.0k 5.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Genetic Alterations during Colorectal-Tumor Development
    1988 5.2k citations Alida M.M. Smits, Johannes L. Bos et al. profile →
  2. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
    1998 1.6k citations Johan de Rooij, Fried Zwartkruis et al. profile →
  3. Prevalence of ras gene mutations in human colorectal cancers
    1987 1.5k citations Johannes L. Bos, Alex J. van der Eb et al. profile →
  4. GEFs and GAPs: Critical Elements in the Control of Small G Proteins
    2007 1.4k citations Johannes L. Bos, Holger Rehmann et al. profile →
  5. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
    2002 1.3k citations Paul J. Coffer, Johannes L. Bos et al. profile →
  6. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    2000 1.2k citations Johannes L. Bos, Boudewijn Burgering et al. profile →
  7. Direct control of the Forkhead transcription factor AFX by protein kinase B
    1999 932 citations Alida M.M. de Vries-Smits, Johannes L. Bos et al. profile →
  8. Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2
    2003 832 citations Fried Zwartkruis, Johannes L. Bos et al. profile →
  9. FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
    2004 658 citations Alida M.M. de Vries-Smits, Johannes L. Bos et al. profile →
  10. The ras gene family and human carcinogenesis
    1988 657 citations Johannes L. Bos profile →
  11. K-rasOncogene Activation as a Prognostic Marker in Adenocarcinoma of the Lung
    1990 643 citations Johannes L. Bos et al. profile →
  12. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
    2002 611 citations Johan de Rooij, Miranda van Triest et al. Nature Cell Biology profile →
  13. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
    2005 590 citations Johannes L. Bos, Fried Zwartkruis et al. profile →
  14. K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.
    1993 546 citations Johannes L. Bos et al. profile →
  15. KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas
    1988 531 citations Alida M.M. Smits, Johannes L. Bos et al. profile →
  16. Rap1 signalling: adhering to new models
    2001 518 citations Johannes L. Bos, Johan de Rooij et al. profile →
  17. Mutational Activation of the K-rasOncogene
    1987 450 citations Johannes L. Bos et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Johannes L. Bos Netherlands 92 25.6k 11.1k 5.2k 5.1k 4.8k 246 39.6k
Paolo M. Comoglio Italy 104 19.9k 0.8× 8.5k 0.8× 4.6k 0.9× 3.2k 0.6× 4.8k 1.0× 403 35.5k
Gérard I. Evan United Kingdom 93 29.9k 1.2× 11.9k 1.1× 5.6k 1.1× 2.5k 0.5× 4.2k 0.9× 245 43.0k
Julian Downward United Kingdom 101 30.1k 1.2× 11.4k 1.0× 4.9k 0.9× 2.3k 0.5× 5.9k 1.2× 292 41.7k
John Blenis United States 101 39.2k 1.5× 8.2k 0.7× 5.6k 1.1× 2.7k 0.5× 6.3k 1.3× 222 51.9k
Pier Giuseppe Pelicci Italy 106 31.6k 1.2× 9.6k 0.9× 3.9k 0.8× 3.8k 0.7× 3.4k 0.7× 532 45.6k
Frank McCormick United States 118 42.8k 1.7× 14.4k 1.3× 5.6k 1.1× 3.0k 0.6× 9.3k 1.9× 381 57.5k
Channing J. Der United States 111 36.2k 1.4× 12.7k 1.1× 6.1k 1.2× 2.3k 0.5× 10.6k 2.2× 406 48.3k
M. Ángela Nieto Spain 66 23.8k 0.9× 13.8k 1.2× 8.0k 1.5× 1.6k 0.3× 4.2k 0.9× 156 35.5k
Mariano Barbacid United States 107 31.1k 1.2× 15.0k 1.3× 5.9k 1.1× 2.9k 0.6× 6.2k 1.3× 266 52.4k
Chu‐Xia Deng United States 119 31.1k 1.2× 9.0k 0.8× 5.5k 1.1× 1.9k 0.4× 4.3k 0.9× 414 47.2k

Countries citing papers authored by Johannes L. Bos

Since Specialization
Citations

This map shows the geographic impact of Johannes L. Bos's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Johannes L. Bos with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Johannes L. Bos more than expected).

Fields of papers citing papers by Johannes L. Bos

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Johannes L. Bos. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Johannes L. Bos. The network helps show where Johannes L. Bos may publish in the future.

Co-authorship network of co-authors of Johannes L. Bos

This figure shows the co-authorship network connecting the top 25 collaborators of Johannes L. Bos. A scholar is included among the top collaborators of Johannes L. Bos based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Johannes L. Bos. Johannes L. Bos is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Ponsioen, Bas, Ravian L. van Ineveld, Simone Kersten, et al.. (2021). Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling. Nature Cell Biology. 23(4). 377–390. 94 indexed citations
2.
Zwartkruis, Fried, et al.. (2017). A Two-Tiered Mechanism Enables Localized Cdc42 Signaling during Enterocyte Polarization. Molecular and Cellular Biology. 37(7). 11 indexed citations
3.
Chen, Yingxian, Xinmei Zhang, Angela Lai, et al.. (2013). Exchange protein activated by cAMP 1 (Epac1) ‐deficient mice develop β‐cell dysfunction and metabolic syndrome. The FASEB Journal. 27(10). 4122–4135. 50 indexed citations
4.
Meijer, Lars A.T., Houjiang Zhou, Maarten Altelaar, et al.. (2013). Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway. Molecular BioSystems. 9(4). 732–749. 10 indexed citations
5.
Pannekoek, Willem‐Jan, Stephan Huveneers, Jelena R. Linnemann, et al.. (2011). Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control. Cellular Signalling. 23(12). 2056–2064. 60 indexed citations
6.
Epping, Mirjam T., Lars A.T. Meijer, Johannes L. Bos, & René Bernards. (2009). UNC45A Confers Resistance to Histone Deacetylase Inhibitors and Retinoic Acid. Molecular Cancer Research. 7(11). 1861–1870. 22 indexed citations
7.
Pannekoek, Willem‐Jan, Matthijs R.H. Kooistra, Fried Zwartkruis, & Johannes L. Bos. (2008). Cell–cell junction formation: The role of Rap1 and Rap1 guanine nucleotide exchange factors. Biochimica et Biophysica Acta (BBA) - Biomembranes. 1788(4). 790–796. 114 indexed citations
8.
Gringhuis, Sonja I., Jacob M. van Laar, M. Sanders, et al.. (2004). Rap1 Signaling Is Required for Suppression of Ras-Generated Reactive Oxygen Species and Protection Against Oxidative Stress in T Lymphocytes. The Journal of Immunology. 173(2). 920–931. 63 indexed citations
9.
Burgering, Boudewijn, et al.. (2001). Regulation of the Forkhead Transcription Factor AFX by Ral-Dependent Phosphorylation of Threonines 447 and 451. Molecular and Cellular Biology. 21(23). 8225–8235. 82 indexed citations
10.
Spaargaren, Marcel & Johannes L. Bos. (1999). Rab5 Induces Rac-independent Lamellipodia Formation and Cell Migration. Molecular Biology of the Cell. 10(10). 3239–3250. 73 indexed citations
11.
Wolthuis, Rob M.F., Barbara Franke, Miranda van Triest, et al.. (1998). Activation of the Small GTPase Ral in Platelets. Molecular and Cellular Biology. 18(5). 2486–2491. 127 indexed citations
12.
Weering, David H.J. van, Johan de Rooij, Barbara Marte, et al.. (1998). Protein Kinase B Activation and Lamellipodium Formation Are Independent Phosphoinositide 3-Kinase-Mediated Events Differentially Regulated by Endogenous Ras. Molecular and Cellular Biology. 18(4). 1802–1811. 95 indexed citations
13.
Rooij, Johan de & Johannes L. Bos. (1997). Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene. 14(5). 623–625. 424 indexed citations
14.
15.
Vries-Smits, Alida M.M. de, Boudewijn Burgering, & Johannes L. Bos. (1995). [22] Vaccinia virus expression of p21 rasAsn-17. Methods in enzymology on CD-ROM/Methods in enzymology. 255. 221–229. 1 indexed citations
16.
Pronk, Gijsbertus J., et al.. (1995). Shc associates with an unphosphorylated form of the p21ras guanine nucleotide exchange factor mSOS.. Data Archiving and Networked Services (DANS). 10(5). 919–25. 16 indexed citations
17.
Dam, Hans van, Rienk Offringa, Ingeborg Meijer, et al.. (1990). Differential Effects of the Adenovirus E1A Oncogene on Members of the AP-1 Transcription Factor Family. Molecular and Cellular Biology. 10(11). 5857–5864. 78 indexed citations
18.
Burgering, Boudewijn, et al.. (1989). Possible Involvement of Normal p21 H -ras in the Insulin/Insulinlike Growth Factor 1 Signal Transduction Pathway. Molecular and Cellular Biology. 9(10). 4312–4322. 47 indexed citations
19.
Vaessen, R.T.M.J., A.G. Jochemsen, Johannes L. Bos, et al.. (1986). The role of the adenovirus E1a region in transformation and oncogenesis. Cancer Cell. 4. 317–325. 2 indexed citations
20.
Eb, A.J. van der, René Bernards, Peter I. Schrier, et al.. (1983). Altered expression of cellular genes in adenovirus-transformed cells. Cancer Cell. 2. 501–510. 4 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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