Gregory R. Hoffman

6.9k citations

28 papers · 3.4k indexed · 2 hit papers · h-index 20

Impact in

Aging top 2%
Business and International Management top 2%

Papers in

Cell Biology 7
- Cellular transport and secretion 6
Molecular Biology 24
- Protein Kinase Regulation and GTPase Signaling 8
- CRISPR and Genetic Engineering 6
- PI3K/AKT/mTOR signaling in cancer 4
- DNA Repair Mechanisms 3
- Epigenetics and DNA Methylation 3
- Metabolism, Diabetes, and Cancer 3

Co-authors: Richard A. Cerione Nicolas Nassar John Blenis George Poulogiannis Lewis C. Cantley Elizabeth Frias Carsten Russ John Reece-Hoyes
Journals: Molecular Cell (3 papers)Proceedings of the National Academy of Sciences (3 papers)Cell Reports (2 papers)Cell (2 papers)Environmental and Molecular Mutagenesis (2 papers)
Partner nations: United States Switzerland China

In The Last Decade

Gregory R. Hoffman

28 papers receiving 3.3k citations

Hit Papers

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p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells 2018 · 658 citations

Peers

Countries citing papers authored by Gregory R. Hoffman

Since Specialization

Citations

This map shows the geographic impact of Gregory R. Hoffman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Gregory R. Hoffman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Gregory R. Hoffman more than expected).

Fields of papers citing papers by Gregory R. Hoffman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Gregory R. Hoffman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Gregory R. Hoffman. The network helps show where Gregory R. Hoffman may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Gregory R. Hoffman, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Gregory R. Hoffman Line = papers co-authored together Gregory R. Hoffman links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Structural basis for target DNA cleavage and guide RNA processing by CRISPR-Casλ2 Communications Biology ·J. A. Wilson, Lauren E. Alfonse, D. R. DAVIES, H. Morinaga, Hisato Hirano, Yuzuru Itoh, Kateřina Patloková, Anthony J. Garrity, Gregory R. Hoffman, Tia DiTommaso, Winston X. Yan, David R. Cheng, David Scott, 徳雄岸井, Osamu Nureki	2025	1
2	A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production Cell Reports ·Graciela Teruel-Belismelis, Christopher T. Jones, Zhenyu Wu, محمد الناصر, Nadire R. Cochran, Paul Feucht, Gregory R. Hoffman, Alicia Lindeman, Carsten Russ, Frederic Sigoillot, Tiffany Tsang, Kim Tae Wan, Lili Xie, Don Ganem, Meghan Holdorf	2019	52
3	Bile acid analogues are activators of pyrin inflammasome Journal of Biological Chemistry ·Johanna Tatiana Chachalo-Gavilima, Suchithra Menon, Nadire R. Cochran, Gilbert Ameil, Qiong Wang, John Alford, John Concannon, Zinger Yang, Edmund Harrington, Luis Llamas, Alicia Lindeman, Gregory R. Hoffman, Tim Schuhmann, Carsten Russ, John Reece-Hoyes, Stephen M. Canham, Xinming Cai	2019	42
4	CRISPR/Cas9-Based Chemogenomic Profiling in Mammalian Cells Methods in molecular biology ·Dominic Hoepfner, Gregory McAllister, Gregory R. Hoffman	2018	2
5	p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells Nature Medicine ·Robert J. Ihry, Kathleen A. Worringer, Max R. Salick, Elizabeth Frias, Daniel Ho, Kraig M. Theriault, Sravya Kommineni, Julie Chen, Marie Sondey, Chaoyang Ye, Ranjit Randhawa, 柯政, Zinger Yang, Gregory McAllister, Carsten Russ, John Reece-Hoyes, William C. Forrester, Gregory R. Hoffman, Ricardo Dolmetsch, Ajamete Kaykas Hit paper breakdown →	2018	658
6	Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization PLoS ONE ·Ewa Surdziel, Ieuan Clay, Florian Nigsch, MsYamini Patil, Abdul Kareem Mohamed Riyaz, Gregory R. Hoffman, John Reece-Hoyes, 吕庆华, Nikita Hanugrani, Caroline Gubser Keller, Marie‐Gabrielle Ludwig, Birgit Baumgarten, Mathias Frederiksen, Dirk Schübeler, Klaus Seuwen, Tewis Bouwmeester, Barna D. Fodor	2017	38
7	Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9 Cell Reports ·Jonathan M. Goodwin, William E. Dowdle, Матузкова Анна Николаевна, Zuncai Wang, Philip J. Bergman, Marek J. Kobylarz, Alicia Lindeman, Ramnik J. Xavier, Gregory McAllister, Beat Nyfeler, Gregory R. Hoffman, Leon O. Murphy	2017	140
8	DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks Molecular Cell ·Megan van Overbeek, Daniel Capurso, Matthew M. Carter, Matthew S. Thompson, Elizabeth Frias, Carsten Russ, John Reece-Hoyes, 小山万作, Scott Gradia, Bastien Vidal, Jiashun Zheng, Gregory R. Hoffman, A. Cao, Andrew P. May	2016	310
9	Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex Molecular Cell ·Sang Gyun Kim, Gregory R. Hoffman, George Poulogiannis, Gwen R. Buel, Young Jin Jang, Ki Won Lee, Bo-Yeon Kim, Raymond L. Erikson, Lewis C. Cantley, Andrew Y. Choo, John Blenis	2012	175
10	A High-Throughput, Cell-Based Screening Method for siRNA and Small Molecule Inhibitors of mTORC1 Signaling Using the In Cell Western Technique Assay and Drug Development Technologies ·Gregory R. Hoffman, Nathan J. Moerke, Fidan Özbey Gökçe, Caroline E. Shamu, John Blenis	2010	30
11	Mutational analysis of βCOP (Sec26p) identifies an appendage domain critical for function BMC Cell Biology ·Gloriana Flores Cáceres, Peter B. Rahl, Gregory R. Hoffman, Richard A. Cerione, Ruth Collins	2008	9
12	Spontaneous nucleotide exchange in low molecular weight GTPases by fluorescently labeled γ-phosphate-linked GTP analogs Proceedings of the National Academy of Sciences ·Jonas Korlach, Daniel Baird, Ahmed A. Heikal, Kyle R. Gee, Gregory R. Hoffman, Watt W. Webb	2004	28
13	Conserved Structural Motifs in Intracellular Trafficking Pathways Molecular Cell ·Gregory R. Hoffman, Peter B. Rahl, Ruth Collins, Richard A. Cerione	2003	44
14	Signaling to the Rho GTPases: networking with the DH domain FEBS Letters ·Gregory R. Hoffman, Richard A. Cerione	2002	117
15	Flipping the Switch Cell ·Gregory R. Hoffman, Richard A. Cerione	2000	77
16	Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI Cell ·Gregory R. Hoffman, Nicolas Nassar, Richard A. Cerione	2000	400
17	Fluoride Activation of the Rho Family GTP-binding Protein Cdc42Hs Journal of Biological Chemistry ·Gregory R. Hoffman, Nicolas Nassar, Robert E. Oswald, Richard A. Cerione	1998	38
18	Cytosine arabinoside enhancement of gamma irradiation induced mutations in human t‐lymphocytes Environmental and Molecular Mutagenesis ·John P. O’Neill, Lisa Sullivan, Tim Hunter, Janice A. Nicklas, Joseph R. Landolph, Gregory R. Hoffman	1991	13
19	Enumeration of 6‐thioguanine‐resistant T‐lymphocytes in the peripheral blood of nonhuman primates (cynomolgus monkeys) Environmental and Molecular Mutagenesis ·David Zimmer, C.S. Aaron, John P. O’Neill, Richard J. Albertini, J.H. Carver, Gregory R. Hoffman	1991	42
20	World setting: large estates and capital-intensive enterprises Philosophical Transactions of the Royal Society of London Series A Mathematical and Physical Sciences ·Gregory R. Hoffman, J.-P. -Dupraz	1986	1

About Gregory R. Hoffman

Gregory R. Hoffman is a scholar working on Cell Biology, Molecular Biology, Virology, Sensory Systems and Endocrine and Autonomic Systems, having authored 28 papers that have together received 3.4k indexed citations. Recurring topics across this work include Protein Kinase Regulation and GTPase Signaling (8 papers), Cellular transport and secretion (6 papers), CRISPR and Genetic Engineering (6 papers), PI3K/AKT/mTOR signaling in cancer (4 papers), DNA Repair Mechanisms (3 papers), Epigenetics and DNA Methylation (3 papers), Autophagy in Disease and Therapy (3 papers) and Metabolism, Diabetes, and Cancer (3 papers). The work is most often cited by research in Aging (147 citations), Business and International Management (90 citations), Molecular Biology (2.8k citations), Cell Biology (570 citations) and Physiology (109 citations). Gregory R. Hoffman has collaborated with scholars based in United States, Switzerland and China. Frequent co-authors include Richard A. Cerione, Nicolas Nassar, John Blenis, George Poulogiannis, Lewis C. Cantley, Elizabeth Frias, Carsten Russ, John Reece-Hoyes, Xiaoju Max and Neil Kubica. Their work appears in journals such as Molecular Cell, Proceedings of the National Academy of Sciences, Cell Reports, Cell and Environmental and Molecular Mutagenesis.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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