Nicolas Nassar

4.2k citations

42 papers · 3.4k indexed · 2 hit papers · h-index 26

Impact in

Cell Biology top 1%
- Cellular transport and secretion
Molecular Biology top 2%
- Protein Kinase Regulation and GTPase Signaling
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Protein Structure and Dynamics
- Melanoma and MAPK Pathways
- RNA Research and Splicing

Papers in

Molecular Biology 34
- Protein Kinase Regulation and GTPase Signaling 18
- Protein Tyrosine Phosphatases 4
- Melanoma and MAPK Pathways 3
Hematology 5
- Acute Myeloid Leukemia Research 3

Co-authors: Richard A. Cerione Gregory R. Hoffman Christian Herrmann Gudrun Horn R. Leberman C. Berthet-Colominas S. Cusack Michael Härtlein
Journals: Journal of Biological Chemistry (6 papers)Biochemistry (5 papers)Nature (3 papers)Leukemia (2 papers)PLoS ONE (2 papers)
Partner nations: United States Germany France

In The Last Decade

Nicolas Nassar

41 papers receiving 3.4k citations

Hit Papers

align trajectories log scale

The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue 1995 · 551 citations

Peers

Countries citing papers authored by Nicolas Nassar

Since Specialization

Citations

This map shows the geographic impact of Nicolas Nassar's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Nicolas Nassar with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Nicolas Nassar more than expected).

Fields of papers citing papers by Nicolas Nassar

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Nicolas Nassar. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Nicolas Nassar. The network helps show where Nicolas Nassar may publish in the future.

Co-authors

The 25 scholars most cited alongside Nicolas Nassar, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Nicolas Nassar Line = papers co-authored together Nicolas Nassar links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Reclassification of ATM Missense Variants of Uncertain Significance by Integrating Results from Systematic Functional Assays into an ACMG Points–Based Framework Clinical Cancer Research ·Helmut Hanenberg, Fan Zhang, Nikita Malev, Constanze Wiek, Brett Klamer, Nicolas Nassar, Tyler Hesselbrock, Judith H. Hanenberg, Amber M. Aeilts, Julia Hentschel, Ulrike Faust, Andrea Gehrig, Christoph Engel, Jan Hauke, Dieter Niederacher, Amanda E. Toland, Paul R. Andreassen	2025	0
2	Merlin tumor suppressor function is regulated by PIP2-mediated dimerization PLoS ONE ·Robert F. Hennigan, Craig S. Thomson, Kye Stachowski, Nicolas Nassar, Nancy Ratner	2023	3
3	Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia Leukemia ·Shailaja Hegde, Anjelika Gasilina, Mark Wunderlich, Yuan Lin, Marcel Buchholzer, Oliver H.F. Krumbach, Mohammad Akbarzadeh, Mohammad Reza Ahmadian, William Seibel, Yi Zheng, John P. Perentesis, Benjamin Mizukawa, Lisa M. Privette Vinnedge, José A. Cancelas, Nicolas Nassar	2021	9
4	VPS4A Mutations in Humans Cause Syndromic Congenital Dyserythropoietic Anemia due to Cytokinesis and Trafficking Defects The American Journal of Human Genetics ·Katie Seu, Lisa Trump, Sana Emberesh, Robert B. Lorsbach, Clarissa E. Johnson, Jessica Meznarich, Hunter R. Underhill, Stella T. Chou, Haripriya Sakthivel, Nicolas Nassar, Kalani J. Seu, Kalani J. Seu, Lionel Blanc, Wenying Zhang, Carolyn Lutzko, Theodosia A. Kalfa	2020	19
5	Real-time genomic profiling of histiocytoses identifies early-kinase domain BRAF alterations while improving treatment outcomes JCI Insight ·Lynn Lee, Anjelika Gasilina, Jayeeta Roychoudhury, Jason Clark, Francis X. McCormack, Joseph G. Pressey, Michael Grimley, Robert B. Lorsbach, Siraj Ali, Mark Bailey, Philip Stephens, Jeffrey S. Ross, Vincent A. Miller, Nicolas Nassar, Ashish Kumar	2017	61
6	UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO Leukemia ·Susumu Goyama, Janet Schibler, Anjelika Gasilina, Mahesh Shrestha, Shan Lin, Kevin A. Link, Jianjun Chen, Susan P. Whitman, Clara D. Bloomfield, Deedra Nicolet, Salam A. Assi, Anetta Ptasinska, Olaf Heidenreich, Constanze Bonifer, Toshio Kitamura, Nicolas Nassar, James C. Mulloy	2015	38
7	BREAST CANCER-ASSOCIATED MISSENSE MUTANTS OF THE PALB2 WD40 DOMAIN, WHICH DIRECTLY BINDS RAD51C, RAD51 AND BRCA2, DISRUPT DNA REPAIR PMC ·Jung‐Young Park, Thiyam Ramsing Singh, Nicolas Nassar, Fan Zhang, Marcel Freund, Helmut Hanenberg, Amom Ruhikanta Meetei, Paul R. Andreassen	2014	3
8	Sts-2 Is a Phosphatase That Negatively Regulates Zeta-associated Protein (ZAP)-70 and T Cell Receptor Signaling Pathways Journal of Biological Chemistry ·Boris San Luis, Ben Sondgeroth, Nicolas Nassar, Nick Carpino	2011	64
9	The 1.35 Å resolution structure of the phosphatase domain of the suppressor of T-cell receptor signaling protein in complex with sulfate Acta Crystallographica Section F Structural Biology and Crystallization Communications ·Jean Jakoncic, Benjamin Sondgeroth, Nick Carpino, Nicolas Nassar	2010	1
10	A Phosphatase Activity of Sts-1 Contributes to the Suppression of TCR Signaling Molecular Cell ·Anatoly Mikhailik, Bradley Ford, James Keller, Yunting Chen, Nicolas Nassar, Nick Carpino	2007	94
11	Structure of a Transient Intermediate for GTP Hydrolysis by Ras Structure ·Bradley Ford, Viktor Horn̆ák, Holly Kleinman, Nicolas Nassar	2006	47
12	Structure-Function Based Design of Small Molecule Inhibitors Targeting Rho Family GTPases Current Topics in Medicinal Chemistry ·Nicolas Nassar, José A. Cancelas, Jie Zheng, David A. Williams, Yi Zheng	2006	72
13	The Crystal Structure of Cdc42 in Complex with Collybistin II, a Gephyrin-interacting Guanine Nucleotide Exchange Factor Journal of Molecular Biology ·Song Xiang, Eun Young Kim, Jessica J. Connelly, Nicolas Nassar, Joachim Kirsch, Jan Winking, Günter Schwarz, Hermann Schindelin	2006	59
14	Structure of the G60A Mutant of Ras Journal of Biological Chemistry ·Bradley Ford, Karlheinz Skowronek, Sean Boykevisch, Dafna Bar‐Sagi, Nicolas Nassar	2005	67
15	Crystallization and initial crystal characterization of the N-terminal DH/PH domain of Trio Acta Crystallographica Section D Biological Crystallography ·Karlheinz Skowronek, Mohammed Ghumman, Yi Zheng, Nicolas Nassar	2003	2
16	Crystallization and preliminary X-ray analysis of human RCC1, the regulator of chromosome condensation Acta Crystallographica Section D Biological Crystallography ·Louis Renault, Nicolas Nassar, Alfred Wittinghofer, M. Roth, Ingrid R. Vetter	1999	6
17	The 1.7 Å crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller Nature ·Louis Renault, Nicolas Nassar, Ingrid R. Vetter, Jörg D. Becker, Christian Klebe, M. Roth, Alfred Wittinghofer	1998	244
18	Ras and its effectors Progress in Biophysics and Molecular Biology ·Christian Herrmann, Nicolas Nassar	1996	52
19	Ras/Rap effector specificity determined by charge reversal Nature Structural & Molecular Biology ·Nicolas Nassar, Gudrun Horn, Christian Herrmann, Christoph Block, Ralf Janknecht, Alfred Wittinghofer	1996	179
20	A second class of synthetase structure revealed by X-ray analysis of Escherichia coli seryl-tRNA synthetase at 2.5 Å Nature ·S. Cusack, C. Berthet-Colominas, Michael Härtlein, Nicolas Nassar, R. Leberman Hit paper breakdown →	1990	544

About Nicolas Nassar

Nicolas Nassar is a scholar working on Molecular Biology, Hematology, Cell Biology, Immunology and Toxicology, having authored 42 papers that have together received 3.4k indexed citations. Recurring topics across this work include Protein Kinase Regulation and GTPase Signaling (18 papers), Enzyme Structure and Function (12 papers), Cellular transport and secretion (6 papers), Galectins and Cancer Biology (4 papers), Protein Tyrosine Phosphatases (4 papers), Cytokine Signaling Pathways and Interactions (3 papers), Melanoma and MAPK Pathways (3 papers) and Acute Myeloid Leukemia Research (3 papers). The work is most often cited by research in Cell Biology (818 citations), Molecular Biology (2.9k citations), Immunology and Allergy (131 citations), Immunology (328 citations) and Oncology (314 citations). Nicolas Nassar has collaborated with scholars based in United States, Germany and France. Frequent co-authors include Richard A. Cerione, Gregory R. Hoffman, Christian Herrmann, Gudrun Horn, R. Leberman, C. Berthet-Colominas, S. Cusack, Michael Härtlein, Anna Scherer and Frank McCormick. Their work appears in journals such as Journal of Biological Chemistry, Biochemistry, Nature, Leukemia and PLoS ONE.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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