Francesco A. Aprile

5.2k total citations · 3 hit papers
60 papers, 3.5k citations indexed

About

Francesco A. Aprile is a scholar working on Molecular Biology, Physiology and Neurology. According to data from OpenAlex, Francesco A. Aprile has authored 60 papers receiving a total of 3.5k indexed citations (citations by other indexed papers that have themselves been cited), including 41 papers in Molecular Biology, 21 papers in Physiology and 11 papers in Neurology. Recurrent topics in Francesco A. Aprile's work include Alzheimer's disease research and treatments (20 papers), Protein Structure and Dynamics (17 papers) and Parkinson's Disease Mechanisms and Treatments (10 papers). Francesco A. Aprile is often cited by papers focused on Alzheimer's disease research and treatments (20 papers), Protein Structure and Dynamics (17 papers) and Parkinson's Disease Mechanisms and Treatments (10 papers). Francesco A. Aprile collaborates with scholars based in United Kingdom, Italy and United States. Francesco A. Aprile's co-authors include Michele Vendruscolo, Pietro Sormanni, Christopher M. Dobson, Tuomas P. J. Knowles, David Klenerman, Nunilo Cremades, Emma Deas, Nicholas Wood, Andrey Y. Abramov and Samuel I. A. Cohen and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

Francesco A. Aprile

58 papers receiving 3.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

2012 709 citations Nunilo Cremades, Emma Deas et al. profile →
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

2019 387 citations Suman De, David C. Wirthensohn et al. Nature Communications profile →
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

2015 368 citations Serene W. Chen, Srdja Drakulić et al. Proceedings of the National Academy of Sciences profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Francesco A. Aprile United Kingdom	24	2.0k	1.4k	824	377	341	60	3.5k
Nunilo Cremades Spain	35	2.2k 1.1×	2.2k 1.5×	2.1k 2.5×	187 0.5×	469 1.4×	49	4.8k
Wenjuan Zhang China	20	2.0k 1.0×	2.1k 1.5×	454 0.6×	127 0.3×	270 0.8×	53	3.4k
Janet R. Kumita United Kingdom	37	3.0k 1.5×	1.6k 1.1×	660 0.8×	140 0.4×	445 1.3×	90	4.8k
Anthony W. P. Fitzpatrick United States	19	2.5k 1.2×	2.2k 1.5×	358 0.4×	118 0.3×	310 0.9×	28	4.2k
Magdalena I. Ivanova United States	23	3.2k 1.6×	2.3k 1.6×	453 0.5×	114 0.3×	341 1.0×	50	4.4k
Hisashi Yagi Japan	33	1.8k 0.9×	1.6k 1.1×	507 0.6×	102 0.3×	144 0.4×	78	2.9k
Bente Vestergaard Denmark	31	2.2k 1.1×	656 0.5×	321 0.4×	208 0.6×	171 0.5×	68	3.2k
Georg Meisl United Kingdom	38	3.4k 1.7×	3.6k 2.5×	1.1k 1.4×	157 0.4×	439 1.3×	104	5.9k
Sarah Meehan United Kingdom	23	2.6k 1.3×	1.6k 1.1×	269 0.3×	124 0.3×	555 1.6×	31	3.7k
Thomas C. T. Michaels United Kingdom	36	3.1k 1.5×	2.7k 1.9×	696 0.8×	98 0.3×	405 1.2×	95	5.1k

Countries citing papers authored by Francesco A. Aprile

Since Specialization

Citations

This map shows the geographic impact of Francesco A. Aprile's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Francesco A. Aprile with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Francesco A. Aprile more than expected).

Fields of papers citing papers by Francesco A. Aprile

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Francesco A. Aprile. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Francesco A. Aprile. The network helps show where Francesco A. Aprile may publish in the future.

Co-authorship network of co-authors of Francesco A. Aprile

This figure shows the co-authorship network connecting the top 25 collaborators of Francesco A. Aprile. A scholar is included among the top collaborators of Francesco A. Aprile based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Francesco A. Aprile. Francesco A. Aprile is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Vadukul, Devkee M., Nicoló Paracini, Valérie Laux, et al.. (2025). Membrane Charge Drives the Aggregation of TDP-43 Pathological Fragments. Journal of the American Chemical Society. 147(16). 13577–13591. 2 indexed citations

Bigi, Alessandra, Devkee M. Vadukul, Fabrizio Chiti, et al.. (2024). A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSF. Alzheimer s Research & Therapy. 16(1). 13–13. 7 indexed citations

García‐Revilla, Juan, Antonio Boza‐Serrano, Devkee M. Vadukul, et al.. (2023). Galectin-3 shapes toxic alpha-synuclein strains in Parkinson’s disease. Acta Neuropathologica. 146(1). 51–75. 18 indexed citations

Vadukul, Devkee M., et al.. (2023). α-Synuclein Aggregation Is Triggered by Oligomeric Amyloid-β 42 via Heterogeneous Primary Nucleation. Journal of the American Chemical Society. 145(33). 18276–18285. 21 indexed citations

Raguseo, Federica, Yiran Wang, Jessica Li, et al.. (2023). The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes. Nature Communications. 14(1). 8272–8272. 30 indexed citations

Ge, Ying, et al.. (2023). Site-Specific ⁶⁸Ga Radiolabeling of Trastuzumab Fab via Methionine for ImmunoPET Imaging. Bioconjugate Chemistry. 34(10). 1802–1810. 8 indexed citations

Morse, Sophie V., Michelle Simon, Helena Watts, et al.. (2021). Modulation of amyloid-β aggregation by metal complexes with a dual binding mode and their delivery across the blood–brain barrier using focused ultrasound. Chemical Science. 12(27). 9485–9493. 22 indexed citations

Houben, Bert, Francesco A. Aprile, Renée I. Seinstra, et al.. (2021). The cellular modifier MOAG‐4/SERF drives amyloid formation through charge complementation. The EMBO Journal. 40(21). e107568–e107568. 15 indexed citations

Ikenoue, Tatsuya, Francesco A. Aprile, Pietro Sormanni, & Michele Vendruscolo. (2021). Rationally Designed Bicyclic Peptides Prevent the Conversion of Aβ42 Assemblies Into Fibrillar Structures. Frontiers in Neuroscience. 15. 623097–623097. 6 indexed citations

10.

Aprile, Francesco A., et al.. (2020). Systematic Activity Maturation of a Single-Domain Antibody with Non-canonical Amino Acids through Chemical Mutagenesis. Cell chemical biology. 28(1). 70–77.e5. 13 indexed citations

11.

Heller, Gabriella T., Francesco A. Aprile, Thomas C. T. Michaels, et al.. (2020). Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease. Science Advances. 6(45). 112 indexed citations

12.

Ikenoue, Tatsuya, Francesco A. Aprile, Pietro Sormanni, et al.. (2020). A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer’s disease. Scientific Reports. 10(1). 15280–15280. 17 indexed citations

13.

De, Suman, David C. Wirthensohn, Patrick Flagmeier, et al.. (2019). Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms. Nature Communications. 10(1). 1541–1541. 387 indexed citations breakdown →

14.

Raimondi, Sara, Loredana Marchese, Frederick A. Partridge, et al.. (2019). C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis. Scientific Reports. 9(1). 19960–19960. 12 indexed citations

15.

Giorgetti, Sofia, Claudio Greco, Paolo Tortora, & Francesco A. Aprile. (2018). Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms. International Journal of Molecular Sciences. 19(9). 2677–2677. 117 indexed citations

16.

Heller, Gabriella T., Francesco A. Aprile, & Michele Vendruscolo. (2017). Methods of probing the interactions between small molecules and disordered proteins. Cellular and Molecular Life Sciences. 74(17). 3225–3243. 52 indexed citations

17.

Heller, Gabriella T., Francesco A. Aprile, Massimiliano Bonomi, et al.. (2017). Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide. Journal of Molecular Biology. 429(18). 2772–2779. 52 indexed citations

18.

Perni, Michele, Francesco A. Aprile, Benedetta Mannini, et al.. (2017). Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles. Scientific Reports. 7(1). 15045–15045. 18 indexed citations

19.

Bardaro, Michael F., et al.. (2016). Structure of a low-population binding intermediate in protein-RNA recognition. Proceedings of the National Academy of Sciences. 113(26). 7171–7176. 53 indexed citations

20.

Chen, Serene W., Srdja Drakulić, Emma Deas, et al.. (2015). Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation. Proceedings of the National Academy of Sciences. 112(16). E1994–2003. 368 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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