Alessandra Bigi

1.2k total citations · 1 hit paper
30 papers, 750 citations indexed

About

Alessandra Bigi is a scholar working on Molecular Biology, Physiology and Neurology. According to data from OpenAlex, Alessandra Bigi has authored 30 papers receiving a total of 750 indexed citations (citations by other indexed papers that have themselves been cited), including 18 papers in Molecular Biology, 17 papers in Physiology and 12 papers in Neurology. Recurrent topics in Alessandra Bigi's work include Alzheimer's disease research and treatments (17 papers), Prion Diseases and Protein Misfolding (8 papers) and Parkinson's Disease Mechanisms and Treatments (8 papers). Alessandra Bigi is often cited by papers focused on Alzheimer's disease research and treatments (17 papers), Prion Diseases and Protein Misfolding (8 papers) and Parkinson's Disease Mechanisms and Treatments (8 papers). Alessandra Bigi collaborates with scholars based in Italy, United Kingdom and Spain. Alessandra Bigi's co-authors include Cristina Cecchi, Roberta Cascella, Fabrizio Chiti, Nunilo Cremades, Serene W. Chen, Paola Fusi, Christopher M. Dobson, Catherine K. Xu, José D. Camino and Chiara Pozzi and has published in prestigious journals such as Journal of the American Chemical Society, Nature Communications and The EMBO Journal.

In The Last Decade

Alessandra Bigi

28 papers receiving 746 citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

2021 166 citations Roberta Cascella, Serene W. Chen et al. Nature Communications profile →

Peers

Alessandra Bigi

PHYSI

NEURO

CMN

Francisca Pinheiro Spain

Daniel Little United Kingdom

Dhiman Ghosh Switzerland

Daniel F. Tardiff United States

Surabhi Mehra India

Lise Giehm Denmark

Melissa L. Geddie United States

Dorothea Haasen Germany

Gulay Filiz Australia

Abdullah Sultan United States

Francisca Pinheiro Spain

Alessandra Bigi

336 ×0.9

250 ×0.9

PHYSI

229 ×0.9

NEURO

83 ×0.7

CMN

34 ×0.5

Citations per year, relative to Alessandra Bigi Alessandra Bigi (= 1×) peers Francisca Pinheiro

Countries citing papers authored by Alessandra Bigi

Since Specialization

Citations

This map shows the geographic impact of Alessandra Bigi's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alessandra Bigi with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alessandra Bigi more than expected).

Fields of papers citing papers by Alessandra Bigi

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alessandra Bigi. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alessandra Bigi. The network helps show where Alessandra Bigi may publish in the future.

Co-authorship network of co-authors of Alessandra Bigi

This figure shows the co-authorship network connecting the top 25 collaborators of Alessandra Bigi. A scholar is included among the top collaborators of Alessandra Bigi based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alessandra Bigi. Alessandra Bigi is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Sepe, Sara, Federica Rey, Alessandra Bigi, et al.. (2025). Telomeric DNA damage response mediates neurotoxicity of Aβ42 oligomers in Alzheimer’s disease. The EMBO Journal. 44(21). 6078–6111.

Bigi, Alessandra, Cristina Cecchi, Manuela Sollazzo, et al.. (2025). Human astrocytes from healthy individuals and Alzheimer’s patients respond differently to Aβ1–42 oligomers, triggering distinct paths of reactivity and senescence. Mechanisms of Ageing and Development. 228. 112116–112116.

Bigi, Alessandra, Devkee M. Vadukul, Fabrizio Chiti, et al.. (2024). A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSF. Alzheimer s Research & Therapy. 16(1). 13–13. 7 indexed citations

Chen, Serene W., Joseph D. Barritt, Roberta Cascella, et al.. (2024). Structure–Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society. 146(15). 10537–10549. 23 indexed citations

Bigi, Alessandra, et al.. (2024). Biophysical characterization of the phase separation of TDP-43 devoid of the C-terminal domain. Cellular & Molecular Biology Letters. 29(1). 104–104. 3 indexed citations

Bigi, Alessandra, Roberta Cascella, & Cristina Cecchi. (2023). α-Synuclein oligomers and fibrils: partners in crime in synucleinopathies. Neural Regeneration Research. 18(11). 2332–2342. 11 indexed citations

Capitini, Claudia, Alessandra Bigi, Marco Emanuele, et al.. (2023). APP and Bace1: Differential effect of cholesterol enrichment on processing and plasma membrane mobility. iScience. 26(5). 106611–106611. 6 indexed citations

Cascella, Roberta, Alessandra Bigi, Maria Cristina Gagliani, et al.. (2022). A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43. Science Advances. 8(30). eabm6376–eabm6376. 16 indexed citations

Cascella, Roberta, Martina Banchelli, Seyyed Abolghasem Ghadami, et al.. (2022). An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature. Annals of Medicine. 55(1). 72–88. 4 indexed citations

10.

Cascella, Roberta, Alessandra Bigi, Nunilo Cremades, & Cristina Cecchi. (2022). Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies. Cellular and Molecular Life Sciences. 79(3). 174–174. 72 indexed citations

11.

Bigi, Alessandra, Roberta Cascella, Caterina Bernacchioni, et al.. (2022). Sphingosine 1‐phosphate attenuates neuronal dysfunction induced by amyloid‐β oligomers through endocytic internalization of NMDA receptors. FEBS Journal. 290(1). 112–133. 5 indexed citations

12.

Bigi, Alessandra, et al.. (2022). Biophysical characterization of full‐length TAR DNA‐binding protein (TDP‐43) phase separation. Protein Science. 31(12). e4509–e4509. 19 indexed citations

13.

Bigi, Alessandra, et al.. (2021). Exploring the Release of Toxic Oligomers from α-Synuclein Fibrils with Antibodies and STED Microscopy. Life. 11(5). 431–431. 21 indexed citations

14.

Cascella, Roberta, Serene W. Chen, Alessandra Bigi, et al.. (2021). The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells. Nature Communications. 12(1). 1814–1814. 166 indexed citations breakdown →

15.

Manna, Sara La, Pasqualina Liana Scognamiglio, Valentina Roviello, et al.. (2019). The acute myeloid leukemia‐associated Nucleophosmin 1 gene mutations dictate amyloidogenicity of the C‐terminal domain. FEBS Journal. 286(12). 2311–2328. 26 indexed citations

16.

Bigi, Alessandra, Elena Beltrami, Mirella Trinei, et al.. (2016). Cyclophilin D counteracts P53-mediated growth arrest and promotes Ras tumorigenesis. Oncogene. 35(39). 5132–5143. 28 indexed citations

17.

Bigi, Alessandra, Cristina Tringali, Matilde Forcella, et al.. (2013). A proline-rich loop mediates specific functions of human sialidase NEU4 in SK-N-BE neuronal differentiation. Glycobiology. 23(12). 1499–1509. 7 indexed citations

18.

Forcella, Matilde, Alessandra Mozzi, Alessandra Bigi, Paolo Parenti, & Paola Fusi. (2012). MOLECULAR CLONING OF SOLUBLE TREHALASE FROM Chironomus riparius LARVAE, ITS HETEROLOGOUS EXPRESSION IN Escherichia coli AND BIOINFORMATIC ANALYSIS. Archives of Insect Biochemistry and Physiology. 81(2). 77–89. 14 indexed citations

19.

Bigi, Alessandra, Lavinia Morosi, Chiara Pozzi, et al.. (2009). Human sialidase NEU4 long and short are extrinsic proteins bound to outer mitochondrial membrane and the endoplasmic reticulum, respectively. Glycobiology. 20(2). 148–157. 48 indexed citations

20.

Pozzi, Chiara, Gabriella Tedeschi, Valentina Pastori, et al.. (2008). Study of subcellular localization and proteolysis of ataxin-3. Neurobiology of Disease. 30(2). 190–200. 51 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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