Serene W. Chen

3.1k total citations · 3 hit papers
23 papers, 2.0k citations indexed

About

Serene W. Chen is a scholar working on Neurology, Physiology and Molecular Biology. According to data from OpenAlex, Serene W. Chen has authored 23 papers receiving a total of 2.0k indexed citations (citations by other indexed papers that have themselves been cited), including 15 papers in Neurology, 14 papers in Physiology and 10 papers in Molecular Biology. Recurrent topics in Serene W. Chen's work include Parkinson's Disease Mechanisms and Treatments (15 papers), Alzheimer's disease research and treatments (14 papers) and Monoclonal and Polyclonal Antibodies Research (6 papers). Serene W. Chen is often cited by papers focused on Parkinson's Disease Mechanisms and Treatments (15 papers), Alzheimer's disease research and treatments (14 papers) and Monoclonal and Polyclonal Antibodies Research (6 papers). Serene W. Chen collaborates with scholars based in United Kingdom, Spain and Italy. Serene W. Chen's co-authors include Christopher M. Dobson, Nunilo Cremades, Cristina Cecchi, Roberta Cascella, Fabrizio Chiti, Giuliana Fusco, Alfonso De Simone, Michele Vendruscolo, Michele Perni and David Klenerman and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

Serene W. Chen

23 papers receiving 2.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

2017 520 citations Giuliana Fusco, Serene W. Chen et al. Science profile →
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

2015 368 citations Serene W. Chen, Srdja Drakulić et al. Proceedings of the National Academy of Sciences profile →
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

2021 166 citations Roberta Cascella, Serene W. Chen et al. Nature Communications profile →

Peers

Serene W. Chen

PHYSI

NEURO

CMN

Mathew H. Horrocks United Kingdom

Giuliana Fusco United Kingdom

Larissa A. Munishkina United States

Yue‐De Yang China

Ashutosh Kumar India

Ghiam Yamin United States

David R. Boyer United States

Silvia Campioni Switzerland

Dmitry Cherny Germany

Pradeep K. Singh India

Mathew H. Horrocks United Kingdom

Serene W. Chen

997 ×0.9

PHYSI

847 ×0.8

NEURO

1.5k ×1.7

457 ×1.4

CMN

289 ×1.4

Citations per year, relative to Serene W. Chen Serene W. Chen (= 1×) peers Mathew H. Horrocks

Countries citing papers authored by Serene W. Chen

Since Specialization

Citations

This map shows the geographic impact of Serene W. Chen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Serene W. Chen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Serene W. Chen more than expected).

Fields of papers citing papers by Serene W. Chen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Serene W. Chen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Serene W. Chen. The network helps show where Serene W. Chen may publish in the future.

Co-authorship network of co-authors of Serene W. Chen

This figure shows the co-authorship network connecting the top 25 collaborators of Serene W. Chen. A scholar is included among the top collaborators of Serene W. Chen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Serene W. Chen. Serene W. Chen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Chen, Serene W., Joseph D. Barritt, Roberta Cascella, et al.. (2024). Structure–Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society. 146(15). 10537–10549. 23 indexed citations

Chen, Serene W., Yuansheng Yang, Masahiro Ogino, et al.. (2023). Leveraging an advanced simulated moving bed approach to achieve 3-component separation for enhanced impurity removal in a non-affinity cation exchange capture step. PLoS ONE. 18(1). e0280760–e0280760. 3 indexed citations

Chen, Serene W., Yu‐Han Huang, Jianxin Huo, et al.. (2023). Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies. mAbs. 15(1). 2231129–2231129. 9 indexed citations

Chen, Serene W., et al.. (2022). Effective flow-through polishing strategies for knob-into-hole bispecific antibodies. Bioresources and Bioprocessing. 9(1). 98–98. 7 indexed citations

Chen, Serene W., et al.. (2022). Excellent removal of knob-into-hole bispecific antibody byproducts and impurities in a single-capture chromatography. Bioresources and Bioprocessing. 9(1). 72–72. 10 indexed citations

Xu, Catherine K., Serene W. Chen, Georg Meisl, et al.. (2022). The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity. Molecules. 27(4). 1293–1293. 9 indexed citations

Bigi, Alessandra, et al.. (2021). Exploring the Release of Toxic Oligomers from α-Synuclein Fibrils with Antibodies and STED Microscopy. Life. 11(5). 431–431. 21 indexed citations

Cascella, Roberta, Serene W. Chen, Alessandra Bigi, et al.. (2021). The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells. Nature Communications. 12(1). 1814–1814. 166 indexed citations breakdown →

Chen, Serene W. & Wei Zhang. (2021). Current trends and challenges in the downstream purification of bispecific antibodies. PubMed. 4(2). 73–88. 59 indexed citations

10.

Camino, José D., Pablo Gracia, Serene W. Chen, et al.. (2020). The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel β-sheet α-synuclein aggregates. Chemical Science. 11(43). 11902–11914. 37 indexed citations

11.

Froula, Jessica M., José D. Camino, Serene W. Chen, et al.. (2019). Defining α-synuclein species responsible for Parkinson’s disease phenotypes in mice. Journal of Biological Chemistry. 294(27). 10392–10406. 97 indexed citations

12.

Vivoli, Mirella, Roberta Cascella, Serene W. Chen, et al.. (2019). The Toxicity of Misfolded Protein Oligomers Is Independent of Their Secondary Structure. ACS Chemical Biology. 14(7). 1593–1600. 43 indexed citations

13.

Chen, Serene W. & Nunilo Cremades. (2018). Preparation of α-Synuclein Amyloid Assemblies for Toxicity Experiments. Methods in molecular biology. 1779. 45–60. 13 indexed citations

14.

Fusco, Giuliana, Serene W. Chen, Philip T. F. Williamson, et al.. (2017). Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers. Science. 358(6369). 1440–1443. 520 indexed citations breakdown →

15.

Aprile, Francesco A., Paolo Arosio, Giuliana Fusco, et al.. (2017). Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species. Biochemistry. 56(9). 1177–1180. 43 indexed citations

16.

Pedersen, Jeppe T., Serene W. Chen, Justyna M.C. Bahl, et al.. (2016). Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing. Journal of the American Chemical Society. 138(12). 3966–3969. 69 indexed citations

17.

Cremades, Nunilo, Serene W. Chen, & Christopher M. Dobson. (2016). Structural Characteristics of α-Synuclein Oligomers. International review of cell and molecular biology. 329. 79–143. 101 indexed citations

18.

Horrocks, Mathew H., Steven F. Lee, Sonia Gandhi, et al.. (2016). Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids. ACS Chemical Neuroscience. 7(3). 399–406. 93 indexed citations

19.

Chen, Serene W., Srdja Drakulić, Emma Deas, et al.. (2015). Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation. Proceedings of the National Academy of Sciences. 112(16). E1994–2003. 368 indexed citations breakdown →

20.

Deas, Emma, Nunilo Cremades, Plamena R. Angelova, et al.. (2015). Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease. Antioxidants and Redox Signaling. 24(7). 376–391. 285 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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