Alfonso De Simone

9.1k citations

131 papers · 6.1k indexed · 3 hit papers · h-index 39

Impact in

Neurology top 0.5%
- Parkinson's Disease Mechanisms and Treatments
Physiology top 1%
- Alzheimer's disease research and treatments

Papers in

Neurology 23
- Parkinson's Disease Mechanisms and Treatments 23
Physiology 36
- Alzheimer's disease research and treatments 36

Co-authors: Michele Vendruscolo Christopher M. Dobson Giuliana Fusco Carlo Camilloni Frank Biedermann Werner M. Nau Oren A. Scherman Luigi Vitagliano
Journals: Biophysical Journal (14 papers)Journal of the American Chemical Society (8 papers)Scientific Reports (5 papers)Nature Communications (5 papers)Proceedings of the National Academy of Sciences (5 papers)
Partner nations: United Kingdom Italy United States

In The Last Decade

Alfonso De Simone

128 papers receiving 6.1k citations

Hit Papers

align trajectories log scale

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers 2017 · 520 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2017 Science
2013 Proceedings of the National Academy of Sciences
2012 Journal of the American Chemical Society

Peers

Countries citing papers authored by Alfonso De Simone

Since Specialization

Citations

This map shows the geographic impact of Alfonso De Simone's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alfonso De Simone with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alfonso De Simone more than expected).

Fields of papers citing papers by Alfonso De Simone

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alfonso De Simone. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alfonso De Simone. The network helps show where Alfonso De Simone may publish in the future.

Co-authors

The 25 scholars most cited alongside Alfonso De Simone, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Alfonso De Simone Line = papers co-authored together Alfonso De Simone links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Integrating NMR restraints into coarse-grained simulations: toward accurate conformational ensembles of complex protein systems bioRxiv (Cold Spring Harbor Laboratory) ·由貴作, М. П. Исаева, Abd el-Hady Sl, Bogdan-Florin Nae, Davide Mercadante, Alfonso De Simone	2025	0
2	Local Ionic Conditions Modulate the Aggregation Propensity and Influence the Structural Polymorphism of α-Synuclein Journal of the American Chemical Society ·Maria Zacharopoulou, Daniela Escobar, James F. Ross, Amberley D. Stephens, Giuliana Fusco, Thomas M. McCoy, Said moha حاجی میرزایی, Ioanna Mela, Ana Fernández‐Villegas, Anne Martel, Alexander F. Routh, Alfonso De Simone, Jonathan J. Phillips, Gabriele S. Kaminski Schierle	2025	5
3	α-Synuclein and Mitochondria: Probing the Dynamics of Disordered Membrane-protein Regions Using Solid-State Nuclear Magnetic Resonance SHILAP Revista de lepidopterología ·Angelo Gallo, M.P. Medvedev, Priscila Martelli Casarin, Giuliana Fusco, Alfonso De Simone	2024	2
4	Immune responses to oligomeric α-synuclein in Parkinson’s disease peripheral blood mononuclear cells Journal of Neurology ·Ana Florencia Vega-Benedetti, M. A. ESCOBAR, Tommaso Ercoli, Giuliana Fusco, Chiara Burgaletto, 難波博子, М. И. Ткаченко, Zahra Zibaee, Fabrizio Angius, Paolo Solla, Alfonso De Simone, Giuseppina Cantarella, Cesarina Giallongo, Valeria Sogos, Giovanni Defazio, Anna R. Carta	2024	3
5	α-Synuclein and biological membranes: the danger of loving too much Chemical Communications ·M.P. Medvedev, Giuliana Fusco, Alfonso De Simone	2023	5
6	MetalHawk: Enhanced Classification of Metal Coordination Geometries by Artificial Neural Networks Journal of Chemical Information and Modeling ·Fitha NurIzza Qurratul Aini, Mohammad K. Algamdi, Marco Chino, Alfonso De Simone, Angela Lombardi	2023	4
7	Region-specific changes in gene expression are associated with cognitive deficits in the alpha-synuclein-induced model of Parkinson's disease: A transcriptomic profiling study Experimental Neurology ·F.C. Moon, Mauro Pala, Charlie W Lambert, Ashley Will, Andrea Maschio, Н.Х.Абдурахмонова, Augusta Pisanu, 隆夫土井, Gülbin AYŞI ATEŞ, M.P. Medvedev, Ezio Carboni, Giuliana Fusco, Alfonso De Simone, Anna R. Carta	2023	5
8	Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation eLife ·Daniel K. Weber, Michele Zenato, Songlin Wang, Chiara Romeo, Tata Gopinath, Martin Gustavsson, Rǎzvan L. Cornea, David D. Thomas, Alfonso De Simone, Gianluigi Veglia	2021	26
9	A kink in DWORF helical structure controls the activation of the sarcoplasmic reticulum Ca2+-ATPase Structure ·Michele Zenato, Daniel K. Weber, Songlin Wang, Chiara Romeo, Tata Gopinath, Alfonso De Simone, Seth L. Robia, Gianluigi Veglia	2021	13
10	Mechanism of misfolding of the human prion protein revealed by a pathological mutation Proceedings of the National Academy of Sciences ·C. N. Mizyakina, Joseph D. Barritt, Jens Sobek, Simone Hornemann, Adriano Aguzzi, Alfonso De Simone	2021	23
11	Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease Science Advances ·Gabriella T. Heller, Francesco A. Aprile, Thomas C. T. Michaels, Ryan Limbocker, Michele Perni, Francesco Simone Ruggeri, Benedetta Mannini, Thomas Löhr, Massimiliano Bonomi, Carlo Camilloni, Alfonso De Simone, Isabella C. Felli, Roberta Pierattelli, Tuomas P. J. Knowles, Christopher M. Dobson, Michele Vendruscolo	2020	112
12	The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State Scientific Reports ·Yijia Ji, Alfonso De Simone, Michele Vendruscolo, Christopher M. Dobson, Giuliana Fusco	2020	61
13	Probing the dynamic stalk region of the ribosome using solution NMR Scientific Reports ·Maurice G Hansen Hansen, John Kirkpatrick, Hélène Launay, Alfonso De Simone, Daniel Häußinger, Christopher M. Dobson, Michele Vendruscolo, Lisa D. Cabrita, Christopher A. Waudby, John Christodoulou	2019	7
14	Structural differences between toxic and nontoxic HypF-N oligomers Chemical Communications ·Claudia Capitini, Muhand Ali A Asseri, Antonino Natalello, Cristiano D’Andrea, Annalisa Relini, James A. Jarvis, Leila Birolo, 達哉海野, Michele Vendruscolo, Paolo Matteini, Christopher M. Dobson, Alfonso De Simone, Fabrizio Chiti	2018	26
15	Intrinsic structural versatility of the highly conserved 412–423 epitope of the Hepatitis C Virus E2 protein International Journal of Biological Macromolecules ·Nicole Balasco, Daniela Barone, 實梶浦, Annamaria Sandomenico, Alfonso De Simone, Menotti Ruvo, Luigi Vitagliano	2018	7
16	Molecular determinants of the interaction of EGCG with ordered and disordered proteins Biopolymers ·Giuliana Fusco, C. N. Mizyakina, Francesco Simone Ruggeri, Michele Vendruscolo, Christopher M. Dobson, Alfonso De Simone	2018	30
17	Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers Science ·Giuliana Fusco, Serene W. Chen, Philip T. F. Williamson, Roberta Cascella, Michele Perni, James A. Jarvis, Cristina Cecchi, Michele Vendruscolo, Fabrizio Chiti, Nunilo Cremades, Liming Ying, Christopher M. Dobson, Alfonso De Simone Hit paper breakdown →	2017	520
18	Structural basis of synaptic vesicle assembly promoted by α-synuclein Nature Communications ·Giuliana Fusco, Tillmann Pape, Amberley D. Stephens, Pierre Mahou, Ana Rita Costa, Clemens F. Kaminski, Gabriele S. Kaminski Schierle, Michele Vendruscolo, Gianluigi Veglia, Christopher M. Dobson, Alfonso De Simone	2016	199
19	Characterization of the Conformational Fluctuations in the Josephin Domain of Ataxin-3 Biophysical Journal ·Domenico Sanfelice, Alfonso De Simone, Andrea Cavalli, Serena Faggiano, Michele Vendruscolo, Annalisa Pastore	2014	14
20	MD and NMR studies of α-bungarotoxin surface accessibility Biochemical and Biophysical Research Communications ·Vincenzo Venditti, Andrea Bernini, Alfonso De Simone, Ottavia Spiga, Filippo Prischi, Neri Niccolai	2007	14

About Alfonso De Simone

Alfonso De Simone is a scholar working on Neurology, Physiology, Molecular Biology, Molecular Medicine and Spectroscopy, having authored 131 papers that have together received 6.1k indexed citations. Recurring topics across this work include Protein Structure and Dynamics (48 papers), Alzheimer's disease research and treatments (36 papers), Enzyme Structure and Function (25 papers), Parkinson's Disease Mechanisms and Treatments (23 papers), Prion Diseases and Protein Misfolding (15 papers), RNA and protein synthesis mechanisms (13 papers), Advanced NMR Techniques and Applications (8 papers) and Cellular transport and secretion (8 papers). The work is most often cited by research in Neurology (1.4k citations), Physiology (1.8k citations), Spectroscopy (934 citations), Molecular Biology (3.5k citations) and Biomaterials (591 citations). Alfonso De Simone has collaborated with scholars based in United Kingdom, Italy and United States. Frequent co-authors include Michele Vendruscolo, Christopher M. Dobson, Giuliana Fusco, Carlo Camilloni, Frank Biedermann, Werner M. Nau, Oren A. Scherman, Luigi Vitagliano, Gianluigi Veglia and Vanya D. Uzunova. Their work appears in journals such as Biophysical Journal, Journal of the American Chemical Society, Scientific Reports, Nature Communications and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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