Cornelis E. C. A. Hop

7.1k citations

173 papers · 4.9k indexed · h-index 39

Co-authors: John Holmes Jashvant D. Unadkat David Q. Liu Johan K. Terlouw Zhen Wang Laurent Salphati Matthew Wright S. Cyrus Khojasteh
Topics: Pharmacogenetics and Drug Metabolism (45 papers)Mass Spectrometry Techniques and Applications (41 papers)Drug Transport and Resistance Mechanisms (38 papers)
Cited by: Pharmacology Spectroscopy Oncology
Journals: Journal of the American Chemical Society Nature Materials Journal of Clinical Oncology
Partner nations: United States Canada France

In The Last Decade

Cornelis E. C. A. Hop

171 papers receiving 4.6k citations

Peers

Countries citing papers authored by Cornelis E. C. A. Hop

Since Specialization

Citations

This map shows the geographic impact of Cornelis E. C. A. Hop's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Cornelis E. C. A. Hop with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Cornelis E. C. A. Hop more than expected).

Fields of papers citing papers by Cornelis E. C. A. Hop

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Cornelis E. C. A. Hop. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Cornelis E. C. A. Hop. The network helps show where Cornelis E. C. A. Hop may publish in the future.

Co-authorship network of co-authors of Cornelis E. C. A. Hop

This figure shows the co-authorship network connecting the top 25 collaborators of Cornelis E. C. A. Hop. A scholar is included among the top collaborators of Cornelis E. C. A. Hop based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Cornelis E. C. A. Hop. Cornelis E. C. A. Hop is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Transporter expressions as part of required scaling factor to support in vitro in vivo extrapolation for blood-brain barrier drug permeability 2025 ·European Journal of Pharmaceutical Sciences ·Zubida M. Al‐Majdoub,Jonathan Cheong,(unknown),(unknown),Tom De Bruyn,(unknown),Jingjing Guo,Cornelis E. C. A. Hop,(unknown),Aleksandra Galetin,Kayode Ogungbenro,Amin Rostami‐Hodjegan,Jill Barber	0
2	Using the Dynamic Well-Stirred Model to Extrapolate Hepatic Clearance of Organic Anion-Transporting Polypeptide Transporter Substrates without Assuming Albumin-Mediated Hepatic Drug Uptake 2024 ·Drug Metabolism and Disposition ·Zhengyin Yan,(unknown),(unknown),(unknown),Jane R. Kenny,Cornelis E. C. A. Hop	3
3	Intestinal Excretion, Intestinal Recirculation, and Renal Tubule Reabsorption Are Underappreciated Mechanisms That Drive the Distribution and Pharmacokinetic Behavior of Small Molecule Drugs 2021 ·Journal of Medicinal Chemistry ·Donglu Zhang,Cong Wei,Cornelis E. C. A. Hop,Matthew Wright,Ming Hu,Yurong Lai,S. Cyrus Khojasteh,(unknown)	19
4	Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach 2020 ·Drug Metabolism and Disposition ·Vineet Kumar,(unknown),Kazuya Ishida,Laurent Salphati,Cornelis E. C. A. Hop,Christopher Rowbottom,Guangqing Xiao,Yurong Lai,Anita Mathias,Xiaoyan Chu,W. Griffith Humphreys,Mingxiang Liao,(unknown),(unknown),Scott Heyward,Jashvant D. Unadkat	27
5	Positron Emission Tomography Imaging of [¹¹C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporin A 2019 ·Clinical Pharmacology & Therapeutics ·Sarah Billington,Steven C. Shoner,Scott D. Lee,Kindra Clark‐Snustad,(unknown),David H. Lewis,Mark Muzi,(unknown),Jean Lee,Tot Bui Nguyen,Vineet Kumar,Kazuya Ishida,Laigao Chen,Xiaoyan Chu,Yurong Lai,Laurent Salphati,Cornelis E. C. A. Hop,Guangqing Xiao,Mingxiang Liao,Jashvant D. Unadkat	50
6	Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood–Brain Barrier Measured by Quantitative Targeted Proteomics 2019 ·Clinical Pharmacology & Therapeutics ·Sarah Billington,Laurent Salphati,Cornelis E. C. A. Hop,Xiaoyan Chu,Raymond Evers,(unknown),Christopher Rowbottom,Yurong Lai,Guangqing Xiao,W. Griffith Humphreys,Tot Bui Nguyen,Bhagwat Prasad,Jashvant D. Unadkat	60
7	Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues 2019 ·Drug Metabolism and Disposition ·Donglu Zhang,Peter S. Dragovich,Shang‐Fan Yu,Yong Ma,Thomas H. Pillow,Jack Sadowsky,Dian Su,Wei Wang,Andrew G. Polson,S. Cyrus Khojasteh,Cornelis E. C. A. Hop	24
8	Opportunities and challenges using artificial intelligence in ADME/Tox 2019 ·Nature Materials ·Barun Bhhatarai,W. Patrick Walters,Cornelis E. C. A. Hop,(unknown),Sean Ekins	84
9	Intratumoral Payload Concentration Correlates with the Activity of Antibody–Drug Conjugates 2018 ·Molecular Cancer Therapeutics ·Donglu Zhang,Shang‐Fan Yu,S. Cyrus Khojasteh,Yong Ma,Thomas H. Pillow,Jack Sadowsky,Dian Su,Katherine R. Kozak,Keyang Xu,Andrew G. Polson,Peter S. Dragovich,Cornelis E. C. A. Hop	31
10	Improving Confidence in the Determination of Free Fraction for Highly Bound Drugs Using Bidirectional Equilibrium Dialysis 2018 ·Journal of Pharmaceutical Sciences ·Yi‐Chen Chen,Jane R. Kenny,Matthew Wright,Cornelis E. C. A. Hop,Zhengyin Yan	28
11	Quantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity Relationship 2014 ·Drug Metabolism and Disposition ·Vineet Kumar,Bhagwat Prasad,Gabriela I. Patilea‐Vrana,Anshul Gupta,Laurent Salphati,Raymond Evers,Cornelis E. C. A. Hop,Jashvant D. Unadkat	41
12	Dose-dependent exposure and metabolism of GNE-892, a β-secretase inhibitor, in monkeys: contributions by P450, AO, and P-gp 2014 ·European Journal of Drug Metabolism and Pharmacokinetics ·Ryan Takahashi,Shuguang Ma,Qin Yue,(unknown),Yijun Yi,Joseph P. Lyssikatos,Kelly Regal,Kevin W. Hunt,Nicholas C. Kallan,Michael Siu,Cornelis E. C. A. Hop,Xingrong Liu,S. Cyrus Khojasteh	2
13	Mechanistic Pharmacokinetic-Pharmacodynamic Modeling of BACE1 Inhibition in Monkeys: Development of a Predictive Model for Amyloid Precursor Protein Processing 2013 ·Drug Metabolism and Disposition ·Xingrong Liu,Harvey Wong,Kimberly Scearce‐Levie,Ryan J. Watts,Melis Coraggio,Young G. Shin,Kun Peng,Kristin R. Wildsmith,Jasvinder K. Atwal,(unknown),Stephen Schauer,Kelly Regal,Kevin W. Hunt,Allen A. Thomas,Michael Siu,Joseph P. Lyssikatos,Gauri Deshmukh,Cornelis E. C. A. Hop	17
14	Antitumor Activity of Targeted and Cytotoxic Agents in Murine Subcutaneous Tumor Models Correlates with Clinical Response 2012 ·Clinical Cancer Research ·Harvey Wong,Edna F. Choo,Bruno Alicke,Xiao Ding,Hank La,Erin McNamara,Frank‐Peter Theil,Jay Tibbitts,Lori S. Friedman,Cornelis E. C. A. Hop,Stephen E. Gould	96
15	Do We Need to Optimize Plasma Protein and Tissue Binding in Drug Discovery? 2011 ·Current Topics in Medicinal Chemistry ·Xingrong Liu,Cuiping Chen,Cornelis E. C. A. Hop	31
16	Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling 2010 ·Drug Metabolism and Disposition ·Harvey Wong,Frank‐Peter Theil,Yong Cui,James C. Marsters,S. Cyrus Khojasteh,Laurent Vernillet,Hank La,(unknown),Hong Wang,Eric J. Morinello,Yuzhong Deng,Cornelis E. C. A. Hop	17
17	BIOACTIVATION OF THE NONTRICYCLIC ANTIDEPRESSANT NEFAZODONE TO A REACTIVE QUINONE-IMINE SPECIES IN HUMAN LIVER MICROSOMES AND RECOMBINANT CYTOCHROME P450 3A4 2004 ·Drug Metabolism and Disposition ·Amit S. Kalgutkar,Alfin D. N. Vaz,Mary E. Lame,Kirk R. Henne,John R. Soglia,Sabrina X. Zhao,Yuri A. Abramov,Franco Lombardo,(unknown),Zachary S. Hendsch,Cornelis E. C. A. Hop	102
18	Identification of Metabolites of a Substance P (Neurokinin 1 Receptor) Antagonist in Rat Hepatocytes and Rat Plasma 2002 ·Drug Metabolism and Disposition ·Cornelis E. C. A. Hop,Yanfeng Wang,Sanjeev Kumar,Maria Victoria Silva Elipe,Conrad E. Raab,Dennis Dean,Grace K. Poon,(unknown),John R. Strauss,Shuet‐Hing Lee Chiu,Neil R. Curtis,Jason Elliott,Ute Gerhard,Karen L Locker,Denise Morrison,Russell J. Mortishire‐Smith,Steven R. Thomas,Alan P. Watt,David C. Evans	6
19	Homocysteine thiolactone and protein homocysteinylation: mechanistic studies with model peptides and proteins 2002 ·Rapid Communications in Mass Spectrometry ·Cornelis E. C. A. Hop,Ray Bakhtiar	28
20	Determination ofin vitro permeability of drug candidates through a Caco-2 cell monolayer by liquid chromatography/tandem mass spectrometry 2000 ·Journal of Mass Spectrometry ·Zhen Wang,Cornelis E. C. A. Hop,Kwan Leung,Jianmei Pang	81

About Cornelis E. C. A. Hop

Cornelis E. C. A. Hop is a scholar working on Pharmacology, Spectroscopy and Oncology, having authored 173 papers that have together received 4.9k indexed citations. Recurring topics across this work include Pharmacogenetics and Drug Metabolism (45 papers), Mass Spectrometry Techniques and Applications (41 papers) and Drug Transport and Resistance Mechanisms (38 papers). The work is most often cited by research in Pharmacology (1.3k citations), Spectroscopy (1.2k citations) and Oncology (1.4k citations). Cornelis E. C. A. Hop has collaborated with scholars based in United States, Canada and France. Frequent co-authors include John Holmes, Jashvant D. Unadkat, David Q. Liu, Johan K. Terlouw, Zhen Wang, Laurent Salphati, Matthew Wright, S. Cyrus Khojasteh, Jane R. Kenny and Raymond Evers. Their work appears in journals such as Journal of the American Chemical Society, Nature Materials and Journal of Clinical Oncology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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