Cornelis E. C. A. Hop

7.1k citations

173 papers · 4.9k indexed · h-index 39

Pharmacology top 0.1%
- Pharmacogenetics and Drug Metabolism 45
Spectroscopy top 0.5%
- Mass Spectrometry Techniques and Applications 41
- Analytical Chemistry and Chromatography 36
Oncology top 2%
- Drug Transport and Resistance Mechanisms 38
Computational Theory and Mathematics top 1%
- Computational Drug Discovery Methods 15
Analytical Chemistry top 2%
Atomic and Molecular Physics, and Optics
- Advanced Chemical Physics Studies 14
Pediatrics, Perinatology and Child Health
- Pharmacological Effects and Toxicity Studies 12
Molecular Biology
- Metabolomics and Mass Spectrometry Studies 11

Co-authors: John Holmes Jashvant D. Unadkat David Q. Liu Johan K. Terlouw Zhen Wang Laurent Salphati Matthew Wright S. Cyrus Khojasteh
Cited by: Pharmacology Spectroscopy Oncology
Journals: Journal of the American Chemical Society (8 papers)Nature Materials (1 paper)Journal of Clinical Oncology (1 paper)
Partner nations: United States Canada France

In The Last Decade

Cornelis E. C. A. Hop

171 papers receiving 4.6k citations

Peers

Countries citing papers authored by Cornelis E. C. A. Hop

Since Specialization

Citations

This map shows the geographic impact of Cornelis E. C. A. Hop's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Cornelis E. C. A. Hop with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Cornelis E. C. A. Hop more than expected).

Fields of papers citing papers by Cornelis E. C. A. Hop

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Cornelis E. C. A. Hop. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Cornelis E. C. A. Hop. The network helps show where Cornelis E. C. A. Hop may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Cornelis E. C. A. Hop, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Cornelis E. C. A. Hop Line = papers co-authored together Cornelis E. C. A. Hop links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Transporter expressions as part of required scaling factor to support in vitro in vivo extrapolation for blood-brain barrier drug permeability European Journal of Pharmaceutical Sciences ·Zubida M. Al‐Majdoub,Jonathan Cheong,Kunihiko Mizuno,J.C. Hogan,Tom De Bruyn,Anne Kanta,Jingjing Guo,Cornelis E. C. A. Hop,Mike Zientek,Aleksandra Galetin,Kayode Ogungbenro,Amin Rostami‐Hodjegan,Jill Barber	2025	0
2	Using the Dynamic Well-Stirred Model to Extrapolate Hepatic Clearance of Organic Anion-Transporting Polypeptide Transporter Substrates without Assuming Albumin-Mediated Hepatic Drug Uptake Drug Metabolism and Disposition ·Zhengyin Yan,Li Ma,Nicky Hwang,Julie Huang,Jane R. Kenny,Cornelis E. C. A. Hop	2024	3
3	Intestinal Excretion, Intestinal Recirculation, and Renal Tubule Reabsorption Are Underappreciated Mechanisms That Drive the Distribution and Pharmacokinetic Behavior of Small Molecule Drugs Journal of Medicinal Chemistry ·Donglu Zhang,Cong Wei,Cornelis E. C. A. Hop,Matthew Wright,Ming Hu,Yurong Lai,S. Cyrus Khojasteh,W. Griff Humphreys	2021	19
4	Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach Drug Metabolism and Disposition ·Vineet Kumar,Mengyue Yin,Kazuya Ishida,Laurent Salphati,Cornelis E. C. A. Hop,Christopher Rowbottom,Guangqing Xiao,Yurong Lai,Anita Mathias,Xiaoyan Chu,W. Griffith Humphreys,Mingxiang Liao,Zsuzsanna Nerada,Nóra Szilvásy,Scott Heyward,Jashvant D. Unadkat	2020	27
5	Positron Emission Tomography Imaging of [¹¹C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporin A Clinical Pharmacology & Therapeutics ·Sarah Billington,Steven C. Shoner,Scott D. Lee,Kindra Clark‐Snustad,Matthew R. Pennington,David H. Lewis,Mark Muzi,Shirley Rene,Jean Lee,Tot Bui Nguyen,Vineet Kumar,Kazuya Ishida,Laigao Chen,Xiaoyan Chu,Yurong Lai,Laurent Salphati,Cornelis E. C. A. Hop,Guangqing Xiao,Mingxiang Liao,Jashvant D. Unadkat	2019	50
6	Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood–Brain Barrier Measured by Quantitative Targeted Proteomics Clinical Pharmacology & Therapeutics ·Sarah Billington,Laurent Salphati,Cornelis E. C. A. Hop,Xiaoyan Chu,Raymond Evers,Doug Burdette,Christopher Rowbottom,Yurong Lai,Guangqing Xiao,W. Griffith Humphreys,Tot Bui Nguyen,Bhagwat Prasad,Jashvant D. Unadkat	2019	60
7	Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues Drug Metabolism and Disposition ·Donglu Zhang,Peter S. Dragovich,Shang‐Fan Yu,Yong Ma,Thomas H. Pillow,Jack Sadowsky,Dian Su,Wei Wang,Andrew G. Polson,S. Cyrus Khojasteh,Cornelis E. C. A. Hop	2019	24
8	Opportunities and challenges using artificial intelligence in ADME/Tox Nature Materials ·Barun Bhhatarai,W. Patrick Walters,Cornelis E. C. A. Hop,Guido Lanza,Sean Ekins	2019	84
9	Intratumoral Payload Concentration Correlates with the Activity of Antibody–Drug Conjugates Molecular Cancer Therapeutics ·Donglu Zhang,Shang‐Fan Yu,S. Cyrus Khojasteh,Yong Ma,Thomas H. Pillow,Jack Sadowsky,Dian Su,Katherine R. Kozak,Keyang Xu,Andrew G. Polson,Peter S. Dragovich,Cornelis E. C. A. Hop	2018	31
10	Improving Confidence in the Determination of Free Fraction for Highly Bound Drugs Using Bidirectional Equilibrium Dialysis Journal of Pharmaceutical Sciences ·Yi‐Chen Chen,Jane R. Kenny,Matthew Wright,Cornelis E. C. A. Hop,Zhengyin Yan	2018	28
11	Quantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity Relationship Drug Metabolism and Disposition ·Vineet Kumar,Bhagwat Prasad,Gabriela I. Patilea‐Vrana,Anshul Gupta,Laurent Salphati,Raymond Evers,Cornelis E. C. A. Hop,Jashvant D. Unadkat	2014	41
12	Dose-dependent exposure and metabolism of GNE-892, a β-secretase inhibitor, in monkeys: contributions by P450, AO, and P-gp European Journal of Drug Metabolism and Pharmacokinetics ·Ryan Takahashi,Shuguang Ma,Qin Yue,Heasook Kim‐Kang,Yijun Yi,Joseph P. Lyssikatos,Kelly Regal,Kevin W. Hunt,Nicholas C. Kallan,Michael Siu,Cornelis E. C. A. Hop,Xingrong Liu,S. Cyrus Khojasteh	2014	2
13	Mechanistic Pharmacokinetic-Pharmacodynamic Modeling of BACE1 Inhibition in Monkeys: Development of a Predictive Model for Amyloid Precursor Protein Processing Drug Metabolism and Disposition ·Xingrong Liu,Harvey Wong,Kimberly Scearce‐Levie,Ryan J. Watts,Melis Coraggio,Young G. Shin,Kun Peng,Kristin R. Wildsmith,Jasvinder K. Atwal,Jason Mango,Stephen Schauer,Kelly Regal,Kevin W. Hunt,Allen A. Thomas,Michael Siu,Joseph P. Lyssikatos,Gauri Deshmukh,Cornelis E. C. A. Hop	2013	17
14	Antitumor Activity of Targeted and Cytotoxic Agents in Murine Subcutaneous Tumor Models Correlates with Clinical Response Clinical Cancer Research ·Harvey Wong,Edna F. Choo,Bruno Alicke,Xiao Ding,Hank La,Erin McNamara,Frank‐Peter Theil,Jay Tibbitts,Lori S. Friedman,Cornelis E. C. A. Hop,Stephen E. Gould	2012	96
15	Do We Need to Optimize Plasma Protein and Tissue Binding in Drug Discovery? Current Topics in Medicinal Chemistry ·Xingrong Liu,Cuiping Chen,Cornelis E. C. A. Hop	2011	31
16	Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling Drug Metabolism and Disposition ·Harvey Wong,Frank‐Peter Theil,Yong Cui,James C. Marsters,S. Cyrus Khojasteh,Laurent Vernillet,Hank La,Xi‐Ling Song,Hong Wang,Eric J. Morinello,Yuzhong Deng,Cornelis E. C. A. Hop	2010	17
17	BIOACTIVATION OF THE NONTRICYCLIC ANTIDEPRESSANT NEFAZODONE TO A REACTIVE QUINONE-IMINE SPECIES IN HUMAN LIVER MICROSOMES AND RECOMBINANT CYTOCHROME P450 3A4 Drug Metabolism and Disposition ·Amit S. Kalgutkar,Alfin D. N. Vaz,Mary E. Lame,Kirk R. Henne,John R. Soglia,Sabrina X. Zhao,Yuri A. Abramov,Franco Lombardo,Claire Collin,Zachary S. Hendsch,Cornelis E. C. A. Hop	2004	102
18	Identification of Metabolites of a Substance P (Neurokinin 1 Receptor) Antagonist in Rat Hepatocytes and Rat Plasma Drug Metabolism and Disposition ·Cornelis E. C. A. Hop,Yanfeng Wang,Sanjeev Kumar,Maria Victoria Silva Elipe,Conrad E. Raab,Dennis Dean,Grace K. Poon,Carol-Ann Keohane,John R. Strauss,Shuet‐Hing Lee Chiu,Neil R. Curtis,Jason Elliott,Ute Gerhard,Karen L Locker,Denise Morrison,Russell J. Mortishire‐Smith,Steven R. Thomas,Alan P. Watt,David C. Evans	2002	6
19	Homocysteine thiolactone and protein homocysteinylation: mechanistic studies with model peptides and proteins Rapid Communications in Mass Spectrometry ·Cornelis E. C. A. Hop,Ray Bakhtiar	2002	28
20	Determination ofin vitro permeability of drug candidates through a Caco-2 cell monolayer by liquid chromatography/tandem mass spectrometry Journal of Mass Spectrometry ·Zhen Wang,Cornelis E. C. A. Hop,Kwan Leung,Jianmei Pang	2000	81

About Cornelis E. C. A. Hop

Cornelis E. C. A. Hop is a scholar working on Pharmacology, Spectroscopy and Oncology, having authored 173 papers that have together received 4.9k indexed citations. Recurring topics across this work include Pharmacogenetics and Drug Metabolism (45 papers), Mass Spectrometry Techniques and Applications (41 papers), Drug Transport and Resistance Mechanisms (38 papers), Analytical Chemistry and Chromatography (36 papers), Computational Drug Discovery Methods (15 papers), Advanced Chemical Physics Studies (14 papers), Pharmacological Effects and Toxicity Studies (12 papers) and Metabolomics and Mass Spectrometry Studies (11 papers). The work is most often cited by research in Pharmacology (1.3k citations), Spectroscopy (1.2k citations) and Oncology (1.4k citations). Cornelis E. C. A. Hop has collaborated with scholars based in United States, Canada and France. Frequent co-authors include John Holmes, Jashvant D. Unadkat, David Q. Liu, Johan K. Terlouw, Zhen Wang, Laurent Salphati, Matthew Wright, S. Cyrus Khojasteh, Jane R. Kenny and Raymond Evers. Their work appears in journals such as Journal of the American Chemical Society, Nature Materials and Journal of Clinical Oncology.

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