W. Griffith Humphreys

8.2k total citations · 1 hit paper
129 papers, 5.7k citations indexed

About

W. Griffith Humphreys is a scholar working on Oncology, Molecular Biology and Pharmacology. According to data from OpenAlex, W. Griffith Humphreys has authored 129 papers receiving a total of 5.7k indexed citations (citations by other indexed papers that have themselves been cited), including 50 papers in Oncology, 42 papers in Molecular Biology and 42 papers in Pharmacology. Recurrent topics in W. Griffith Humphreys's work include Drug Transport and Resistance Mechanisms (39 papers), Pharmacogenetics and Drug Metabolism (38 papers) and Pharmacological Effects and Toxicity Studies (19 papers). W. Griffith Humphreys is often cited by papers focused on Drug Transport and Resistance Mechanisms (39 papers), Pharmacogenetics and Drug Metabolism (38 papers) and Pharmacological Effects and Toxicity Studies (19 papers). W. Griffith Humphreys collaborates with scholars based in United States, Germany and Sweden. W. Griffith Humphreys's co-authors include Mingshe Zhu, Donglu Zhang, Haiying Zhang, Li Ma, Yurong Lai, Jinping Gan, Hong Shen, Samuel J. Bonacorsi, Charles Frost and William A. Armstrong and has published in prestigious journals such as Journal of Biological Chemistry, Blood and Analytical Chemistry.

In The Last Decade

W. Griffith Humphreys

128 papers receiving 5.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans

2008 490 citations Nirmala Raghavan, Charles Frost et al. Drug Metabolism and Disposition profile →

Peers

W. Griffith Humphreys

ONCOL

PHARM

PPCH

CCM

Tommy B. Andersson Sweden

Donglu Zhang United States

Youssef Daali Switzerland

Barbara J. Ring United States

Aziz Karim United States

Osamu Okazaki Japan

Katrin Sangkuhl United States

Kyoung‐Ah Kim South Korea

Allan E. Rettie United States

Jiunn H. Lin United States

Tommy B. Andersson Sweden

W. Griffith Humphreys

1.8k ×1.1

1.9k ×1.2

ONCOL

3.1k ×1.9

PHARM

626 ×0.8

PPCH

493 ×0.7

CCM

Citations per year, relative to W. Griffith Humphreys W. Griffith Humphreys (= 1×) peers Tommy B. Andersson

Countries citing papers authored by W. Griffith Humphreys

Since Specialization

Citations

This map shows the geographic impact of W. Griffith Humphreys's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by W. Griffith Humphreys with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites W. Griffith Humphreys more than expected).

Fields of papers citing papers by W. Griffith Humphreys

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by W. Griffith Humphreys. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by W. Griffith Humphreys. The network helps show where W. Griffith Humphreys may publish in the future.

Co-authorship network of co-authors of W. Griffith Humphreys

This figure shows the co-authorship network connecting the top 25 collaborators of W. Griffith Humphreys. A scholar is included among the top collaborators of W. Griffith Humphreys based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with W. Griffith Humphreys. W. Griffith Humphreys is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Zhuo, Xiaoliang, Brett A. Howell, Hong Shen, et al.. (2023). Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator. Toxicological Sciences. 194(2). 235–245. 4 indexed citations

Kumar, Vineet, Kazuya Ishida, Laurent Salphati, et al.. (2020). Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach. Drug Metabolism and Disposition. 49(2). 159–168. 27 indexed citations

Billington, Sarah, Laurent Salphati, Cornelis E. C. A. Hop, et al.. (2019). Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood–Brain Barrier Measured by Quantitative Targeted Proteomics. Clinical Pharmacology & Therapeutics. 106(1). 228–237. 60 indexed citations

Morse, Bridget L., Anthony M. Marino, Yue Zhao, et al.. (2017). Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Clearance and Liver Partitioning of OATP and OCT Substrates in Cynomolgus Monkeys. The AAPS Journal. 19(6). 1878–1889. 11 indexed citations

Shen, Hong, David M. Nelson, Regina V. Oliveira, et al.. (2017). Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys. Drug Metabolism and Disposition. 46(2). 178–188. 38 indexed citations

Morse, Bridget L., Hong Cai, Lisa Zhang, et al.. (2015). Rosuvastatin Liver Partitioning in Cynomolgus Monkeys: Measurement In Vivo and Prediction Using In Vitro Monkey Hepatocyte Uptake. Drug Metabolism and Disposition. 43(11). 1788–1794. 22 indexed citations

Yang, Yanou, et al.. (2011). Quantitative estimation of circulating metabolites without synthetic standards by ultra‐high‐performance liquid chromatography/high resolution accurate mass spectrometry in combination with UV correction. Rapid Communications in Mass Spectrometry. 25(21). 3245–3251. 20 indexed citations

Gan, Jinping, Weiqi Chen, Hong Shen, et al.. (2010). Repaglinide‐gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism. British Journal of Clinical Pharmacology. 70(6). 870–880. 34 indexed citations

Zhang, Donglu, Nirmala Raghavan, Lifei Wang, et al.. (2010). Plasma Stability-Dependent Circulation of Acyl Glucuronide Metabolites in Humans: How Circulating Metabolite Profiles of Muraglitazar and Peliglitazar Can Lead to Misleading Risk Assessment. Drug Metabolism and Disposition. 39(1). 123–131. 22 indexed citations

10.

Li, Jun, Stephanie Chen, Brian J. Murphy, et al.. (2008). (d)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: Synthesis and incorporation into the growth hormone secretagogues. Bioorganic & Medicinal Chemistry Letters. 18(14). 4072–4074. 11 indexed citations

11.

Hernández, Andrés S., Mujing Yan, Ramakrishna Seethala, et al.. (2008). Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues. Bioorganic & Medicinal Chemistry Letters. 18(6). 2067–2072. 3 indexed citations

12.

He, Kan, et al.. (2008). Lacteal Secretion, Fetal and Maternal Tissue Distribution of Dasatinib in Rats. Drug Metabolism and Disposition. 36(12). 2564–2570. 43 indexed citations

13.

Fura, Aberra, et al.. (2008). Prediction of human oral pharmacokinetics using nonclinical data: examples involving four proprietary compounds. Biopharmaceutics & Drug Disposition. 29(8). 455–468. 17 indexed citations

14.

Yao, Ming, Li Ma, W. Griffith Humphreys, & Mingshe Zhu. (2008). Rapid screening and characterization of drug metabolites using a multiple ion monitoring–dependent MS/MS acquisition method on a hybrid triple quadrupole‐linear ion trap mass spectrometer. Journal of Mass Spectrometry. 43(10). 1364–1375. 62 indexed citations

15.

Raghavan, Nirmala, Charles Frost, Zhigang Yu, et al.. (2008). Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans. Drug Metabolism and Disposition. 37(1). 74–81. 490 indexed citations breakdown →

16.

Hosagrahara, Vinayak, Gamini Chandrasena, Sang‐Yoon Chang, et al.. (2006). Pharmacokinetics of muraglitazar (BMS-298585), a dual peroxisome proliferator-activated receptors (PPAR) α and γ activator, in mice, rats, dogs, and monkeys. Xenobiotica. 36(12). 1227–1238. 3 indexed citations

17.

Zhang, Donglu, Lifei Wang, Nirmala Raghavan, et al.. (2006). Comparative Metabolism of Radiolabeled Muraglitazar in Animals and Humans by Quantitative and Qualitative Metabolite Profiling. Drug Metabolism and Disposition. 35(1). 150–167. 21 indexed citations

18.

Zhang, Donglu, Theodore J. Chando, Donald W. Everett, et al.. (2005). IN VITRO INHIBITION OF UDP GLUCURONOSYLTRANSFERASES BY ATAZANAVIR AND OTHER HIV PROTEASE INHIBITORS AND THE RELATIONSHIP OF THIS PROPERTY TO IN VIVO BILIRUBIN GLUCURONIDATION. Drug Metabolism and Disposition. 33(11). 1729–1739. 223 indexed citations

19.

Chong, Saeho, Mary T. Obermeier, & W. Griffith Humphreys. (2003). Pharmacokinetics and metabolism of endothelin receptor antagonist: Contribution of kidneys in the overallin vivo N-demethylation. Archives of Pharmacal Research. 26(1). 89–94. 1 indexed citations

20.

Humphreys, W. Griffith & T G Parks. (1975). Crohn’s disease in northern Ireland — A retrospective survey of 159 cases. Irish Journal of Medical Science (1971 -). 144(1). 437–446. 15 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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