W. Griffith Humphreys

8.2k citations

129 papers · 5.7k indexed · 1 hit paper · h-index 44

Molecular Biology top 5%
Oncology top 2%
Pharmacology top 0.05%
Pediatrics, Perinatology and Child Health top 1%
Cardiology and Cardiovascular Medicine top 2%

Co-authors: Mingshe Zhu Donglu Zhang Haiying Zhang Li Ma Yurong Lai Jinping Gan Hong Shen Samuel J. Bonacorsi
Topics: Drug Transport and Resistance Mechanisms (39 papers)Pharmacogenetics and Drug Metabolism (38 papers)Pharmacological Effects and Toxicity Studies (19 papers)
Cited by: Pharmacology Internal Medicine Oncology
Journals: Journal of Biological Chemistry Blood Analytical Chemistry
Partner nations: United States Germany Sweden

In The Last Decade

W. Griffith Humphreys

128 papers receiving 5.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans

2008 490 citations Nirmala Raghavan, Charles Frost et al. Drug Metabolism and Disposition profile →

Peers

Countries citing papers authored by W. Griffith Humphreys

Since Specialization

Citations

This map shows the geographic impact of W. Griffith Humphreys's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by W. Griffith Humphreys with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites W. Griffith Humphreys more than expected).

Fields of papers citing papers by W. Griffith Humphreys

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by W. Griffith Humphreys. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by W. Griffith Humphreys. The network helps show where W. Griffith Humphreys may publish in the future.

Co-authorship network of co-authors of W. Griffith Humphreys

This figure shows the co-authorship network connecting the top 25 collaborators of W. Griffith Humphreys. A scholar is included among the top collaborators of W. Griffith Humphreys based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with W. Griffith Humphreys. W. Griffith Humphreys is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator 2023 ·Toxicological Sciences ·Xiaoliang Zhuo,Brett A. Howell,Hong Shen,Jeffrey L. Woodhead,Kathy Mosure,Yueping Zhang,Renato J. Scialis,Ramaswamy A. Iyer,Yongnian Sun,(unknown),Kimberley A. Lentz,Rex Denton,Matthew G. Soars,Benjamin M. Johnson,W. Griffith Humphreys	4
2	Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach 2020 ·Drug Metabolism and Disposition ·Vineet Kumar,(unknown),Kazuya Ishida,Laurent Salphati,Cornelis E. C. A. Hop,Christopher Rowbottom,Guangqing Xiao,Yurong Lai,Anita Mathias,Xiaoyan Chu,W. Griffith Humphreys,Mingxiang Liao,(unknown),(unknown),Scott Heyward,Jashvant D. Unadkat	27
3	Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood–Brain Barrier Measured by Quantitative Targeted Proteomics 2019 ·Clinical Pharmacology & Therapeutics ·Sarah Billington,Laurent Salphati,Cornelis E. C. A. Hop,Xiaoyan Chu,Raymond Evers,(unknown),Christopher Rowbottom,Yurong Lai,Guangqing Xiao,W. Griffith Humphreys,Tot Bui Nguyen,Bhagwat Prasad,Jashvant D. Unadkat	60
4	Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Clearance and Liver Partitioning of OATP and OCT Substrates in Cynomolgus Monkeys 2017 ·The AAPS Journal ·Bridget L. Morse,(unknown),Anthony M. Marino,Yue Zhao,(unknown),Yueping Zhang,Hong Shen,W. Griffith Humphreys,Punit Marathe,Yurong Lai	11
5	Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys 2017 ·Drug Metabolism and Disposition ·Hong Shen,David M. Nelson,Regina V. Oliveira,Yueping Zhang,(unknown),Xiaomei Gu,Weiqi Chen,(unknown),Michael D. Reily,Petia Shipkova,Jinping Gan,Yurong Lai,Punit Marathe,W. Griffith Humphreys	38
6	Rosuvastatin Liver Partitioning in Cynomolgus Monkeys: Measurement In Vivo and Prediction Using In Vitro Monkey Hepatocyte Uptake 2015 ·Drug Metabolism and Disposition ·Bridget L. Morse,Hong Cai,(unknown),(unknown),Lisa Zhang,Yueping Zhang,Xiaomei Gu,Hong Shen,Elizabeth A. Dierks,Hong Su,(unknown),Punit Marathe,Yue‐Zhong Shu,W. Griffith Humphreys,Yurong Lai	22
7	Quantitative estimation of circulating metabolites without synthetic standards by ultra‐high‐performance liquid chromatography/high resolution accurate mass spectrometry in combination with UV correction 2011 ·Rapid Communications in Mass Spectrometry ·Yanou Yang,Mary F. Grubb,(unknown),W. Griffith Humphreys,Jonathan L. Josephs	20
8	Repaglinide‐gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism 2010 ·British Journal of Clinical Pharmacology ·Jinping Gan,Weiqi Chen,Hong Shen,Ling Gao,(unknown),Yuan Tian,Wenying Li,Yueping Zhang,(unknown),Hongjian Zhang,W. Griffith Humphreys,A. David Rodrigues	34
9	Plasma Stability-Dependent Circulation of Acyl Glucuronide Metabolites in Humans: How Circulating Metabolite Profiles of Muraglitazar and Peliglitazar Can Lead to Misleading Risk Assessment 2010 ·Drug Metabolism and Disposition ·Donglu Zhang,Nirmala Raghavan,Lifei Wang,Yongjun Xue,Mary T. Obermeier,Stephanie Chen,Shiwei Tao,Hao Zhang,Peter T. W. Cheng,Wenying Li,Ragu Ramanathan,Yang Zheng,W. Griffith Humphreys	22
10	(d)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: Synthesis and incorporation into the growth hormone secretagogues 2008 ·Bioorganic & Medicinal Chemistry Letters ·Jun Li,Stephanie Chen,Brian J. Murphy,Neil Flynn,Ramakrishna Seethala,(unknown),Mujing Yan,Paul G. Sleph,(unknown),W. Griffith Humphreys,William R. Ewing,Jeffrey A. Robl,David Gordon,Joseph A. Tino	11
11	Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues 2008 ·Bioorganic & Medicinal Chemistry Letters ·Andrés S. Hernández,(unknown),(unknown),Mujing Yan,Ramakrishna Seethala,Paul G. Sleph,Gary J. Grover,Kenneth E.J. Dickinson,(unknown),Timothy W. Harper,W. Griffith Humphreys,Daniel Angelo Longhi,Neil Flynn,Brian J. Murphy,David A. Gordon,Scott A. Biller,Jeffrey A. Robl,Joseph A. Tino	3
12	Lacteal Secretion, Fetal and Maternal Tissue Distribution of Dasatinib in Rats 2008 ·Drug Metabolism and Disposition ·Kan He,Michael W. Lago,Ramaswamy A. Iyer,(unknown),W. Griffith Humphreys,Lisa J. Christopher	43
13	Prediction of human oral pharmacokinetics using nonclinical data: examples involving four proprietary compounds 2008 ·Biopharmaceutics & Drug Disposition ·Aberra Fura,Viral Vyas,W. Griffith Humphreys,(unknown),David Rodrigues	17
14	Rapid screening and characterization of drug metabolites using a multiple ion monitoring–dependent MS/MS acquisition method on a hybrid triple quadrupole‐linear ion trap mass spectrometer 2008 ·Journal of Mass Spectrometry ·Ming Yao,Li Ma,W. Griffith Humphreys,Mingshe Zhu	62
15	Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humansbreakdown → 2008 ·Drug Metabolism and Disposition ·Nirmala Raghavan,Charles Frost,Zhigang Yu,Kan He,Haiying Zhang,W. Griffith Humphreys,Donald Pinto,Shiang-Yuan Chen,Samuel J. Bonacorsi,Pancras C. Wong,Donglu Zhang	490
16	Pharmacokinetics of muraglitazar (BMS-298585), a dual peroxisome proliferator-activated receptors (PPAR) α and γ activator, in mice, rats, dogs, and monkeys 2006 ·Xenobiotica ·Vinayak Hosagrahara,Gamini Chandrasena,Sang‐Yoon Chang,Barry Koplowitz,Narayanan Hariharan,Peter T. W. Cheng,W. Griffith Humphreys	3
17	Comparative Metabolism of Radiolabeled Muraglitazar in Animals and Humans by Quantitative and Qualitative Metabolite Profiling 2006 ·Drug Metabolism and Disposition ·Donglu Zhang,Lifei Wang,Nirmala Raghavan,Haiying Zhang,Wenying Li,Peter T. W. Cheng,Ming Yao,Litao Zhang,Mingshe Zhu,Samuel J. Bonacorsi,Suresh Yeola,James Mitroka,Narayanan Hariharan,Vinayak Hosagrahara,Gamini Chandrasena,Wen Chyi Shyu,W. Griffith Humphreys	21
18	IN VITRO INHIBITION OF UDP GLUCURONOSYLTRANSFERASES BY ATAZANAVIR AND OTHER HIV PROTEASE INHIBITORS AND THE RELATIONSHIP OF THIS PROPERTY TO IN VIVO BILIRUBIN GLUCURONIDATION 2005 ·Drug Metabolism and Disposition ·Donglu Zhang,Theodore J. Chando,Donald W. Everett,Christopher Patten,Shangara S. Dehal,W. Griffith Humphreys	223
19	Pharmacokinetics and metabolism of endothelin receptor antagonist: Contribution of kidneys in the overallin vivo N-demethylation 2003 ·Archives of Pharmacal Research ·Saeho Chong,Mary T. Obermeier,W. Griffith Humphreys	1
20	Crohn’s disease in northern Ireland — A retrospective survey of 159 cases 1975 ·Irish Journal of Medical Science (1971 -) ·W. Griffith Humphreys,T G Parks	15

About W. Griffith Humphreys

W. Griffith Humphreys is a scholar working on Pharmacology, Oncology and Biochemistry, having authored 129 papers that have together received 5.7k indexed citations. Recurring topics across this work include Drug Transport and Resistance Mechanisms (39 papers), Pharmacogenetics and Drug Metabolism (38 papers) and Pharmacological Effects and Toxicity Studies (19 papers). The work is most often cited by research in Pharmacology (1.6k citations), Internal Medicine (443 citations) and Oncology (1.6k citations). W. Griffith Humphreys has collaborated with scholars based in United States, Germany and Sweden. Frequent co-authors include Mingshe Zhu, Donglu Zhang, Haiying Zhang, Li Ma, Yurong Lai, Jinping Gan, Hong Shen, Samuel J. Bonacorsi, Charles Frost and William A. Armstrong. Their work appears in journals such as Journal of Biological Chemistry, Blood and Analytical Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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