Christoph Handschin

22.3k citations

141 papers · 17.9k indexed · 12 hit papers · h-index 51

Molecular Biology top 0.2%
Physiology top 0.05%
Epidemiology top 0.5%
Cell Biology top 0.5%
Rehabilitation top 0.1%

Co-authors: Bruce M. Spiegelman Jiandie D. Lin Julie St‐Pierre Sibylle Jäger Urs Meyer Wenli Yang James Rhee Marc Uldry
Topics: Adipose Tissue and Metabolism (86 papers)Muscle Physiology and Disorders (41 papers)Peroxisome Proliferator-Activated Receptors (29 papers)
Cited by: Physiology Geriatrics and Gerontology Rehabilitation
Journals: Nature Cell Proceedings of the National Academy of Sciences
Partner nations: Switzerland United States Italy

In The Last Decade

Christoph Handschin

136 papers receiving 17.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

2007 2.0k citations Sibylle Jäger, Christoph Handschin et al. Proceedings of the National Academy of Sciences profile →
Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

2006 1.9k citations Julie St‐Pierre, Marc Uldry et al. Cell profile →
Metabolic control through the PGC-1 family of transcription coactivators

2005 1.7k citations Jiandie D. Lin, Christoph Handschin et al. profile →
Peroxisome Proliferator-Activated Receptor γ Coactivator 1 Coactivators, Energy Homeostasis, and Metabolism

2006 923 citations Christoph Handschin, Bruce M. Spiegelman profile →
The role of exercise and PGC1α in inflammation and chronic disease

2008 836 citations Christoph Handschin, Bruce M. Spiegelman profile →
PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

2006 802 citations Jiandie D. Lin, Christoph Handschin et al. Proceedings of the National Academy of Sciences profile →
An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle

2003 607 citations Christoph Handschin, James Rhee et al. Proceedings of the National Academy of Sciences profile →
Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

2004 572 citations Vamsi K. Mootha, Christoph Handschin et al. Proceedings of the National Academy of Sciences profile →
Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle

2005 565 citations Jiandie D. Lin, Christoph Handschin et al. profile →
Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP

2005 513 citations Jiandie D. Lin, Ruojing Yang et al. Cell profile →
Skeletal Muscle Fiber-type Switching, Exercise Intolerance, and Myopathy in PGC-1α Muscle-specific Knock-out Animals

2007 511 citations Christoph Handschin, Sherry Chin et al. profile →
The molecular athlete: exercise physiology from mechanisms to medals

2023 89 citations Regula Furrer, Christoph Handschin et al. profile →

Peers

Countries citing papers authored by Christoph Handschin

Since Specialization

Citations

This map shows the geographic impact of Christoph Handschin's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christoph Handschin with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christoph Handschin more than expected).

Fields of papers citing papers by Christoph Handschin

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christoph Handschin. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christoph Handschin. The network helps show where Christoph Handschin may publish in the future.

Co-authorship network of co-authors of Christoph Handschin

This figure shows the co-authorship network connecting the top 25 collaborators of Christoph Handschin. A scholar is included among the top collaborators of Christoph Handschin based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christoph Handschin. Christoph Handschin is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	More than the clock: distinct regulation of muscle function and metabolism by PER2 and RORα 2024 ·The Journal of Physiology ·(unknown),(unknown),Julien Delezie,Pål O. Westermark,Danilo Ritz,Wandrille Duchemin,Gesa Santos,(unknown),Stefan Steurer,Urs Albrecht,Christoph Handschin	4
2	Effects of high‐resistance wheel running on hallmarks of endurance and resistance training adaptations in mice 2023 ·Physiological Reports ·(unknown),(unknown),Danilo Ritz,Christoph Handschin	8
3	Impaired age-associated mitochondrial translation is mitigated by exercise and PGC-1α 2023 ·Proceedings of the National Academy of Sciences ·(unknown),Anastasiya Börsch,(unknown),Jonathan F. Gill,Danilo Ritz,Mihaela Zavolan,Christoph Handschin	24
4	Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle 2022 ·Nature Communications ·Daniel J. Ham,Anastasiya Börsch,(unknown),Shuo Lin,(unknown),(unknown),(unknown),Julien Delezie,Regula Furrer,Dominik Bürri,Michael Sinnreich,Christoph Handschin,Lionel Tintignac,Mihaela Zavolan,Nitish Mittal,Markus A. Rüegg	58
5	Interleukin‐6 potentiates endurance training adaptation and improves functional capacity in old mice 2022 ·Journal of Cachexia Sarcopenia and Muscle ·(unknown),Regula Furrer,Stefan Steurer,(unknown),(unknown),Yves Sagot,Christoph Handschin	18
6	RNA-bound PGC-1α controls gene expression in liquid-like nuclear condensates 2021 ·Proceedings of the National Academy of Sciences ·Joaquín Pérez‐Schindler,Bastian Kohl,(unknown),(unknown),Carlos Henríquez‐Olguín,(unknown),(unknown),Julien Delezie,Thomas Sakoparnig,(unknown),(unknown),Danilo Ritz,Alexander Schmidt,Maria Hondele,Thomas E. Jensen,Sebastian Hiller,Christoph Handschin	16
7	Peroxisome proliferator‐activated receptor γ coactivator 1α regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging 2019 ·Aging Cell ·Jonathan F. Gill,Julien Delezie,Gesa Santos,Shawn McGuirk,Svenia Schnyder,Stephan Frank,Martin Rausch,Julie St‐Pierre,Christoph Handschin	29
8	Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A 2013 ·Proceedings of the National Academy of Sciences ·Serge Summermatter,Gesa Santos,Joaquín Pérez‐Schindler,Christoph Handschin	121
9	The Corepressor NCoR1 Antagonizes PGC-1 α and Estrogen-Related Receptor α in the Regulation of Skeletal Muscle Function and Oxidative Metabolism 2012 ·Molecular and Cellular Biology ·Joaquín Pérez‐Schindler,Serge Summermatter,Silvia Salatino,Francesco Zorzato,(unknown),Piotr J. Balwierz,Erik van Nimwegen,Jérôme N. Feige,Johan Auwerx,Christoph Handschin	73
10	Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism 2008 ·Proceedings of the National Academy of Sciences ·Cheol Soo Choi,Douglas E. Befroy,Roberto Codella,Sheene Kim,(unknown),Yu-Jin Hwang,Zhenxiang Liu,Hui‐Young Lee,Alberto Distefano,Varman T. Samuel,Dongyan Zhang,Gary W. Cline,Christoph Handschin,Jiandie D. Lin,Kitt Falk Petersen,Bruce M. Spiegelman,Gerald I. Shulman	228
11	AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1αbreakdown → 2007 ·Proceedings of the National Academy of Sciences ·Sibylle Jäger,Christoph Handschin,Julie St‐Pierre,Bruce M. Spiegelman	1984
12	Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk 2007 ·Journal of Clinical Investigation ·Christoph Handschin,Cheol Soo Choi,Sherry Chin,Sheene Kim,Dan Kawamori,(unknown),(unknown),Jiang Hu,Vamsi K. Mootha,Young‐Bum Kim,Rohit Kulkarni,Gerald I. Shulman,Bruce M. Spiegelman	285
13	PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy 2007 ·Genes & Development ·Christoph Handschin,Yvonne M. Kobayashi,Sherry Chin,Patrick Seale,Kevin P. Campbell,Bruce M. Spiegelman	289
14	LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver 2005 ·Journal of Lipid Research ·Carmela Gnerre,Gertrud U. Schuster,Adrian Roth,Christoph Handschin,Lisen Johansson,Renate Looser,Paolo Parini,Michael Podvinec,(unknown),Jan-Åke Gustafsson,Urs Meyer	25
15	Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBPbreakdown → 2005 ·Cell ·Jiandie D. Lin,Ruojing Yang,Paul T. Tarr,Pei-Hsuan Wu,Christoph Handschin,Siming Li,Wenli Yang,Liming Pei,Marc Uldry,Peter Tontonoz,Christopher B. Newgard,Bruce M. Spiegelman	513
16	Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α 2005 ·Cell ·Christoph Handschin,Jiandie D. Lin,James Rhee,(unknown),Sherry Chin,Pei-Hsuan Wu,Urs Meyer,Bruce M. Spiegelman	283
17	Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α: modulation by p38 MAPK 2004 ·Genes & Development ·Melina Fan,James A. Van Rhee,Julie St‐Pierre,Christoph Handschin,Pere Puigserver,Jiandie D. Lin,(unknown),Hediye Erdjument‐Bromage,Paul Tempst,Bruce M. Spiegelman	250
18	Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR 2004 ·Archives of Biochemistry and Biophysics ·Christoph Handschin,Urs Meyer	134
19	Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic musclebreakdown → 2004 ·Proceedings of the National Academy of Sciences ·Vamsi K. Mootha,Christoph Handschin,(unknown),Xiaohui Xie,Julie St‐Pierre,Smita Sihag,Wenli Yang,David Altshuler,Pere Puigserver,Nick Patterson,(unknown),Ira G. Schulman,Richard A. Heyman,Eric S. Lander,Bruce M. Spiegelman	572
20	Offene Kommunikation mit Spediteuren. 1993 ·Electronic Markets ·Christoph Handschin	1

About Christoph Handschin

Christoph Handschin is a scholar working on Physiology, Aging and Rehabilitation, having authored 141 papers that have together received 17.9k indexed citations. Recurring topics across this work include Adipose Tissue and Metabolism (86 papers), Muscle Physiology and Disorders (41 papers) and Peroxisome Proliferator-Activated Receptors (29 papers). The work is most often cited by research in Physiology (9.4k citations), Geriatrics and Gerontology (1.4k citations) and Rehabilitation (1.6k citations). Christoph Handschin has collaborated with scholars based in Switzerland, United States and Italy. Frequent co-authors include Bruce M. Spiegelman, Jiandie D. Lin, Julie St‐Pierre, Sibylle Jäger, Urs Meyer, Wenli Yang, James Rhee, Marc Uldry, Sherry Chin and Svenia Schnyder. Their work appears in journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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