Christoph Handschin

22.3k total citations · 12 hit papers
141 papers, 17.9k citations indexed

About

Christoph Handschin is a scholar working on Molecular Biology, Physiology and Rehabilitation. According to data from OpenAlex, Christoph Handschin has authored 141 papers receiving a total of 17.9k indexed citations (citations by other indexed papers that have themselves been cited), including 99 papers in Molecular Biology, 92 papers in Physiology and 19 papers in Rehabilitation. Recurrent topics in Christoph Handschin's work include Adipose Tissue and Metabolism (86 papers), Muscle Physiology and Disorders (41 papers) and Peroxisome Proliferator-Activated Receptors (29 papers). Christoph Handschin is often cited by papers focused on Adipose Tissue and Metabolism (86 papers), Muscle Physiology and Disorders (41 papers) and Peroxisome Proliferator-Activated Receptors (29 papers). Christoph Handschin collaborates with scholars based in Switzerland, United States and Italy. Christoph Handschin's co-authors include Bruce M. Spiegelman, Jiandie D. Lin, Julie St‐Pierre, Sibylle Jäger, Urs Meyer, Wenli Yang, James Rhee, Marc Uldry, Sherry Chin and Svenia Schnyder and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Christoph Handschin

136 papers receiving 17.6k citations

Hit Papers

AMP-activated protein kinase (AMPK) action in skeletal mu... 2003 2026 2010 2018 2007 2006 2005 2006 2008 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
    2007 2.0k citations Sibylle Jäger, Christoph Handschin et al. Proceedings of the National Academy of Sciences profile →
  2. Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators
    2006 1.9k citations Julie St‐Pierre, Marc Uldry et al. Cell profile →
  3. Metabolic control through the PGC-1 family of transcription coactivators
    2005 1.7k citations Jiandie D. Lin, Christoph Handschin et al. Cell Metabolism profile →
  4. Peroxisome Proliferator-Activated Receptor γ Coactivator 1 Coactivators, Energy Homeostasis, and Metabolism
    2006 923 citations Christoph Handschin, Bruce M. Spiegelman profile →
  5. The role of exercise and PGC1α in inflammation and chronic disease
    2008 836 citations Christoph Handschin, Bruce M. Spiegelman profile →
  6. PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
    2006 802 citations Jiandie D. Lin, Christoph Handschin et al. Proceedings of the National Academy of Sciences profile →
  7. An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle
    2003 607 citations Christoph Handschin, Jiandie D. Lin et al. Proceedings of the National Academy of Sciences profile →
  8. Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
    2004 572 citations Vamsi K. Mootha, Christoph Handschin et al. Proceedings of the National Academy of Sciences profile →
  9. Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle
    2005 565 citations Zoltàn Arany, Huamei He et al. Cell Metabolism profile →
  10. Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP
    2005 513 citations Jiandie D. Lin, Ruojing Yang et al. Cell profile →
  11. Skeletal Muscle Fiber-type Switching, Exercise Intolerance, and Myopathy in PGC-1α Muscle-specific Knock-out Animals
    2007 511 citations Christoph Handschin, Sherry Chin et al. profile →
  12. The molecular athlete: exercise physiology from mechanisms to medals
    2023 89 citations Regula Furrer, Christoph Handschin et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Christoph Handschin Switzerland 51 11.3k 9.4k 2.6k 1.9k 1.6k 141 17.9k
Zhidan Wu United States 35 11.7k 1.0× 11.0k 1.2× 3.7k 1.4× 1.7k 0.9× 1.0k 0.6× 55 18.1k
Jiandie D. Lin United States 57 12.4k 1.1× 10.1k 1.1× 3.9k 1.5× 3.7k 1.9× 1.3k 0.8× 122 21.2k
Jørgen F. P. Wojtaszewski Denmark 79 11.3k 1.0× 10.2k 1.1× 2.0k 0.8× 3.9k 2.0× 1.6k 1.0× 262 18.4k
Deborah M. Muoio United States 65 8.9k 0.8× 8.2k 0.9× 2.6k 1.0× 2.0k 1.0× 452 0.3× 133 16.1k
Michael F. Hirshman United States 73 14.3k 1.3× 9.3k 1.0× 3.1k 1.2× 2.6k 1.4× 1.2k 0.7× 155 21.3k
Oksana Gavrilova United States 66 9.3k 0.8× 8.0k 0.9× 4.9k 1.9× 1.2k 0.6× 441 0.3× 188 18.6k
Sheila Collins United States 61 6.1k 0.5× 8.0k 0.8× 3.0k 1.2× 1.3k 0.7× 749 0.5× 123 14.0k
Shingo Kajimura United States 57 6.2k 0.5× 15.7k 1.7× 8.2k 3.2× 2.2k 1.1× 3.2k 2.0× 114 20.9k
Dominique Langin France 73 6.2k 0.5× 12.0k 1.3× 5.9k 2.3× 2.0k 1.0× 857 0.5× 294 19.2k

Countries citing papers authored by Christoph Handschin

Since Specialization
Citations

This map shows the geographic impact of Christoph Handschin's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christoph Handschin with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christoph Handschin more than expected).

Fields of papers citing papers by Christoph Handschin

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christoph Handschin. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christoph Handschin. The network helps show where Christoph Handschin may publish in the future.

Co-authorship network of co-authors of Christoph Handschin

This figure shows the co-authorship network connecting the top 25 collaborators of Christoph Handschin. A scholar is included among the top collaborators of Christoph Handschin based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christoph Handschin. Christoph Handschin is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Delezie, Julien, Pål O. Westermark, Danilo Ritz, et al.. (2024). More than the clock: distinct regulation of muscle function and metabolism by PER2 and RORα. The Journal of Physiology. 602(23). 6373–6402. 4 indexed citations
2.
Ritz, Danilo, et al.. (2023). Effects of high‐resistance wheel running on hallmarks of endurance and resistance training adaptations in mice. Physiological Reports. 11(11). e15701–e15701. 8 indexed citations
3.
Börsch, Anastasiya, et al.. (2023). Impaired age-associated mitochondrial translation is mitigated by exercise and PGC-1α. Proceedings of the National Academy of Sciences. 120(36). e2302360120–e2302360120. 24 indexed citations
4.
Furrer, Regula, et al.. (2022). Interleukin‐6 potentiates endurance training adaptation and improves functional capacity in old mice. Journal of Cachexia Sarcopenia and Muscle. 13(2). 1164–1176. 18 indexed citations
5.
Ham, Daniel J., Anastasiya Börsch, Shuo Lin, et al.. (2022). Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle. Nature Communications. 13(1). 2025–2025. 58 indexed citations
6.
Pérez‐Schindler, Joaquín, Bastian Kohl, Carlos Henríquez‐Olguín, et al.. (2021). RNA-bound PGC-1α controls gene expression in liquid-like nuclear condensates. Proceedings of the National Academy of Sciences. 118(36). 16 indexed citations
7.
8.
Svensson, Kristoffer, Svenia Schnyder, Bettina Cardel, & Christoph Handschin. (2016). Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice. PLoS ONE. 11(7). e0158716–e0158716. 22 indexed citations
9.
Summermatter, Serge, Gesa Santos, Joaquín Pérez‐Schindler, & Christoph Handschin. (2013). Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A. Proceedings of the National Academy of Sciences. 110(21). 8738–8743. 121 indexed citations
10.
Pérez‐Schindler, Joaquín, Serge Summermatter, Silvia Salatino, et al.. (2012). The Corepressor NCoR1 Antagonizes PGC-1 α and Estrogen-Related Receptor α in the Regulation of Skeletal Muscle Function and Oxidative Metabolism. Molecular and Cellular Biology. 32(24). 4913–4924. 73 indexed citations
11.
Choi, Cheol Soo, Douglas E. Befroy, Roberto Codella, et al.. (2008). Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proceedings of the National Academy of Sciences. 105(50). 19926–19931. 228 indexed citations
12.
Jäger, Sibylle, Christoph Handschin, Julie St‐Pierre, & Bruce M. Spiegelman. (2007). AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α. Proceedings of the National Academy of Sciences. 104(29). 12017–12022. 1984 indexed citations breakdown →
13.
Handschin, Christoph, Cheol Soo Choi, Sherry Chin, et al.. (2007). Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk. Journal of Clinical Investigation. 117(11). 3463–3474. 285 indexed citations
14.
Gnerre, Carmela, Gertrud U. Schuster, Adrian Roth, et al.. (2005). LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver. Journal of Lipid Research. 46(8). 1633–1642. 25 indexed citations
15.
Lin, Jiandie D., Ruojing Yang, Paul T. Tarr, et al.. (2005). Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP. Cell. 120(2). 261–273. 513 indexed citations breakdown →
16.
Arany, Zoltàn, Huamei He, Jiandie D. Lin, et al.. (2005). Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle. Cell Metabolism. 1(4). 259–271. 565 indexed citations breakdown →
17.
Fan, Melina, James A. Van Rhee, Julie St‐Pierre, et al.. (2004). Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α: modulation by p38 MAPK. Genes & Development. 18(3). 278–289. 250 indexed citations
18.
Mootha, Vamsi K., Christoph Handschin, Xiaohui Xie, et al.. (2004). Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proceedings of the National Academy of Sciences. 101(17). 6570–6575. 572 indexed citations breakdown →
19.
Handschin, Christoph & Urs Meyer. (2004). Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Archives of Biochemistry and Biophysics. 433(2). 387–396. 134 indexed citations
20.
Handschin, Christoph. (1993). Offene Kommunikation mit Spediteuren.. Electronic Markets. 3. 6. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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