Benjamin F. Cravatt

80.6k total citations · 22 hit papers
583 papers, 60.0k citations indexed

About

Benjamin F. Cravatt is a scholar working on Pharmacology, Molecular Biology and Organic Chemistry. According to data from OpenAlex, Benjamin F. Cravatt has authored 583 papers receiving a total of 60.0k indexed citations (citations by other indexed papers that have themselves been cited), including 274 papers in Pharmacology, 261 papers in Molecular Biology and 110 papers in Organic Chemistry. Recurrent topics in Benjamin F. Cravatt's work include Cannabis and Cannabinoid Research (258 papers), Click Chemistry and Applications (98 papers) and Pancreatic function and diabetes (77 papers). Benjamin F. Cravatt is often cited by papers focused on Cannabis and Cannabinoid Research (258 papers), Click Chemistry and Applications (98 papers) and Pancreatic function and diabetes (77 papers). Benjamin F. Cravatt collaborates with scholars based in United States, Germany and Italy. Benjamin F. Cravatt's co-authors include Gabriel M. Simon, Aron H. Lichtman, Anna E Speers, Dale L. Boger, Jonathan Z. Long, Matthew P. Patricelli, Jacqueline L. Blankman, Alan Saghatelian, Michele K. McKinney and Daniel K. Nomura and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Benjamin F. Cravatt

576 papers receiving 59.1k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

1996 1.8k citations Benjamin F. Cravatt, Dale L. Boger et al. profile →
Quantitative reactivity profiling predicts functional cysteines in proteomes

2010 1.3k citations Chu Wang, Gabriel M. Simon et al. profile →
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

2001 1.1k citations Benjamin F. Cravatt, Aron H. Lichtman et al. Proceedings of the National Academy of Sciences profile →
Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

2008 995 citations Benjamin F. Cravatt et al. profile →
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines

2007 916 citations Benjamin F. Cravatt et al. profile →
A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2-Arachidonoylglycerol

2007 908 citations Jacqueline L. Blankman, Gabriel M. Simon et al. profile →
Activity-based protein profiling: The serine hydrolases

1999 898 citations Benjamin F. Cravatt et al. Proceedings of the National Academy of Sciences profile →
Activity-Based Protein Profiling in Vivo Using a Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition

2003 830 citations Anna E Speers, Benjamin F. Cravatt et al. profile →
Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

2009 768 citations Daniel K. Nomura, Sherry Niessen et al. Cell profile →
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

2008 745 citations Steven G. Kinsey, Aron H. Lichtman et al. Nature Chemical Biology profile →
Profiling Enzyme Activities In Vivo Using Click Chemistry Methods

2004 652 citations Anna E Speers, Benjamin F. Cravatt profile →
Proteome-wide covalent ligand discovery in native biological systems

2016 636 citations Kenneth M. Lum, Benjamin F. Cravatt et al. profile →
STRUCTURE AND FUNCTION OF FATTY ACID AMIDE HYDROLASE

2005 556 citations Benjamin F. Cravatt et al. profile →
The biological impact of mass-spectrometry-based proteomics

2007 549 citations Benjamin F. Cravatt, Gabriel M. Simon et al. profile →
Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

2011 545 citations Daniel K. Nomura, Jacqueline L. Blankman et al. Science profile →
Chemical Characterization of a Family of Brain Lipids That Induce Sleep

1995 507 citations Benjamin F. Cravatt, Norton B. Gilula et al. Science profile →
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

2010 505 citations Jacqueline L. Blankman, Daniel K. Nomura et al. profile →
Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

2019 324 citations Xiaoyu Zhang, Vincent M. Crowley et al. Nature Chemical Biology profile →
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue

2016 248 citations Benjamin F. Cravatt, Enrique Sáez et al. profile →
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates

2017 237 citations Benjamin F. Cravatt et al. profile →
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

2016 193 citations Benjamin F. Cravatt et al. Cell profile →
LPCAT3 Inhibitors Remodel the Polyunsaturated Phospholipid Content of Human Cells and Protect from Ferroptosis

2022 105 citations Bruno Melillo, Michael A. Schafroth et al. profile →

Peers

Countries citing papers authored by Benjamin F. Cravatt

Since Specialization

Citations

This map shows the geographic impact of Benjamin F. Cravatt's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Benjamin F. Cravatt with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Benjamin F. Cravatt more than expected).

Fields of papers citing papers by Benjamin F. Cravatt

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Benjamin F. Cravatt. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Benjamin F. Cravatt. The network helps show where Benjamin F. Cravatt may publish in the future.

Co-authorship network of co-authors of Benjamin F. Cravatt

This figure shows the co-authorship network connecting the top 25 collaborators of Benjamin F. Cravatt. A scholar is included among the top collaborators of Benjamin F. Cravatt based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Benjamin F. Cravatt. Benjamin F. Cravatt is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Exploiting the DCAF16–SPIN4 interaction to identify DCAF16 ligands for PROTAC development 2024 ·RSC Medicinal Chemistry ·(unknown), Miguel Campos, Xiao‐Kang Jin, (unknown), Chenlu Zhang, Sara F. Dunne, Benjamin F. Cravatt, Xiaoyu Zhang	2
2	Chemical Proteomic Discovery of Isotype‐Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2 2023 ·Angewandte Chemie International Edition ·Yongfeng Tao, (unknown), Zhongyu Zou, Evert Njomen, Jarrett R. Remsberg, Daisuke Ogasawara, Chang Ye, Bruno Melillo, Stuart L. Schreiber, Chuan He, David Remillard, Benjamin F. Cravatt	40
3	In situ identification of cellular drug targets in mammalian tissue 2022 ·Cell ·Zhengyuan Pang, Michael A. Schafroth, Daisuke Ogasawara, Yu Wang, (unknown), (unknown), Dong Uk Yang, (unknown), (unknown), (unknown), (unknown), Jacqueline L. Blankman, Benjamin F. Cravatt, Li Ye	45
4	Chemical proteomic identification of functional cysteines with atypical electrophile reactivities 2021 ·Tetrahedron Letters ·(unknown), Vincent M. Crowley, Radu M. Suciu, Dale L. Boger, Benjamin F. Cravatt	7
5	ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth 2021 ·Nature Chemical Biology ·Jarrett R. Remsberg, Radu M. Suciu, Noemi A. Zambetti, (unknown), Ari J. Firestone, Anagha Inguva Sheth, (unknown), Nhi Ngo, Kenneth M. Lum, Cassandra L. Henry, Stewart K. Richardson, (unknown), Benjamin J. Huang, Melissa M. Dix, Amy R. Howell, Micah J. Niphakis, Kevin Shannon, Benjamin F. Cravatt	82
6	AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice 2020 ·Journal of Biological Chemistry ·Meric Erikci Ertunc, Bernard P. Kok, William H. Parsons, Justin Wang, Dan Tan, Cynthia J. Donaldson, Antônio F. M. Pinto, Joan Vaughan, Nhi Ngo, Kenneth M. Lum, Cassandra L. Henry, (unknown), Micah J. Niphakis, Benjamin F. Cravatt, Enrique Sáez, Alan Saghatelian	29
7	Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice 2020 ·Blood ·Noemi A. Zambetti, Ari J. Firestone, Jarrett R. Remsberg, Benjamin J. Huang, Jasmine C. Wong, (unknown), (unknown), Radu M. Suciu, Anagha Inguva Sheth, Scott C. Kogan, Kevin M. Haigis, Benjamin F. Cravatt, Kevin Shannon	16
8	Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan 2019 ·Nature Chemical Biology ·(unknown), Kenneth M. Lum, Pablo Lara-González, Daisuke Ogasawara, Armand B. Cognetta, (unknown), William H. Parsons, Gabriel M. Simon, Arshad Desai, Michael Petrascheck, Liron Bar‐Peled, Benjamin F. Cravatt	33
9	Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition 2015 ·Proceedings of the National Academy of Sciences ·Daisuke Ogasawara, Hui Deng, Andreu Viader, Marc P. Baggelaar, (unknown), Hans den Dulk, Adrianus M. C. H. van den Nieuwendijk, Marjolein Soethoudt, Tom van der Wel, Juan Zhou, Herman S. Overkleeft, Manuel Sánchez-Alavez, Simone Mori, William Nguyen, Bruno Conti, Xiaojie Liu, Yao Chen, Qing-song Liu, Benjamin F. Cravatt, Mario van der Stelt	118
10	Functional Lysine Modification by an Intrinsically Reactive Primary Glycolytic Metabolite 2013 ·Science ·Raymond E. Moellering, Benjamin F. Cravatt	161
11	In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects 2013 ·British Journal of Pharmacology ·Bogna M. Ignatowska‐Jankowska, Sudeshna Ghosh, Molly S. Crowe, Steven G. Kinsey, Micah J. Niphakis, Rehab A. Abdullah, Tao Qing, (unknown), D. Matthew Walentiny, Jenny L. Wiley, Benjamin F. Cravatt, Aron H. Lichtman	103
12	Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors 2011 ·Proceedings of the National Academy of Sciences ·Daniel A. Bachovchin, Justin T. Mohr, Anna E Speers, Chu Wang, Jacob M. Berlin, Timothy Spicer, Virneliz Fernández-Vega, Peter Chase, Peter Hodder, Stephan C. Schürer, Daniel K. Nomura, Hugh Rosen, Gregory C. Fu, Benjamin F. Cravatt	87
13	Characterization of mice lacking candidate N -acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo 2010 ·Molecular BioSystems ·Gabriel M. Simon, Benjamin F. Cravatt	96
14	RBBP9: A tumor-associated serine hydrolase activity required for pancreatic neoplasia 2009 ·Proceedings of the National Academy of Sciences ·David J. Shields, Sherry Niessen, Eric A. Murphy, Ainhoa Mielgo, Jay S. Desgrosellier, Steven Lau, Leo A. Barnes, Jacqueline Lesperance, Michael Bouvet, David G. Jackson, Benjamin F. Cravatt, David A. Cheresh	52
15	Activity-based probes for proteomic profiling of histone deacetylase complexes 2007 ·Proceedings of the National Academy of Sciences ·Cleo M. Salisbury, Benjamin F. Cravatt	209
16	Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo 2004 ·Proceedings of the National Academy of Sciences ·Nadim Jessani, Mark Humphrey, W. Hayes McDonald, Sherry Niessen, Kim Masuda, Beena Gangadharan, John R. Yates, Barbara M. Mueller, Benjamin F. Cravatt	157
17	Activity-based probes for the proteomic profiling of metalloproteases 2004 ·Proceedings of the National Academy of Sciences ·Alan Saghatelian, Nadim Jessani, (unknown), Mark Humphrey, Benjamin F. Cravatt	369
18	The endogenous cannabinoid system protects against colonic inflammation 2004 ·Journal of Clinical Investigation ·Federico Massa, Giovanni Marsicano, Heike Hermann, Astrid Cannich, Krisztina Monory, Benjamin F. Cravatt, Gian‐Luca Ferri, Andrei Sibaev, Martin Storr, Beat Lutz	341
19	The endogenous cannabinoid system protects against colonic inflammation 2004 ·Journal of Clinical Investigation ·Federico Massa, Giovanni Marsicano, Heike Hermann, Astrid Cannich, Krisztina Monory, Benjamin F. Cravatt, Gian‐Luca Ferri, Andrei Sibaev, Martin Storr, Beat Lutz	369
20	Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system 1997 ·Journal of Neuroscience Research ·Elizabeth A. Thomas, Benjamin F. Cravatt, Patria E. Danielson, Norton B. Gilula, J. Gregor Sutcliffe	138

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