J. Silvio Gutkind

66.7k total citations · 21 hit papers
582 papers, 52.2k citations indexed

About

J. Silvio Gutkind is a scholar working on Molecular Biology, Oncology and Cell Biology. According to data from OpenAlex, J. Silvio Gutkind has authored 582 papers receiving a total of 52.2k indexed citations (citations by other indexed papers that have themselves been cited), including 438 papers in Molecular Biology, 162 papers in Oncology and 92 papers in Cell Biology. Recurrent topics in J. Silvio Gutkind's work include Protein Kinase Regulation and GTPase Signaling (136 papers), Receptor Mechanisms and Signaling (81 papers) and PI3K/AKT/mTOR signaling in cancer (76 papers). J. Silvio Gutkind is often cited by papers focused on Protein Kinase Regulation and GTPase Signaling (136 papers), Receptor Mechanisms and Signaling (81 papers) and PI3K/AKT/mTOR signaling in cancer (76 papers). J. Silvio Gutkind collaborates with scholars based in United States, Japan and Argentina. J. Silvio Gutkind's co-authors include Vyomesh Patel, Hidemi Teramoto, Omar A. Coso, María Julia Marinissen, Piero Crespo, Julie Gavard, Alfredo Molinolo, M Chiariello, Ningzhi Xu and Robert T. Dorsam and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

J. Silvio Gutkind

573 papers receiving 51.3k citations

Hit Papers

The small GTP-binding proteins Rac1 and Cdc42regulate the... 1994 2026 2004 2015 1995 1996 2007 1995 2006 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway
    1995 1.5k citations M Chiariello, J. Silvio Gutkind et al. profile →
  2. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
    1996 1.3k citations J. Silvio Gutkind et al. profile →
  3. G-protein-coupled receptors and cancer
    2007 1.1k citations Robert T. Dorsam, J. Silvio Gutkind profile →
  4. Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.
    1995 1.0k citations J. Silvio Gutkind et al. profile →
  5. VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin
    2006 823 citations J. Silvio Gutkind et al. profile →
  6. G-protein-coupled receptors and signaling networks: emerging paradigms
    2001 817 citations J. Silvio Gutkind et al. profile →
  7. Prostaglandin E 2 Promotes Colon Cancer Cell Growth Through a G s -Axin-ß-Catenin Signaling Axis
    2005 731 citations J. Silvio Gutkind et al. profile →
  8. Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits
    1994 720 citations J. Silvio Gutkind et al. profile →
  9. The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades
    1998 688 citations J. Silvio Gutkind profile →
  10. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product
    1997 679 citations J. Silvio Gutkind et al. profile →
  11. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator
    1998 677 citations J. Silvio Gutkind et al. profile →
  12. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors.
    1996 662 citations J. Silvio Gutkind et al. profile →
  13. Targeted Killing of Cancer Cellsin Vivoandin Vitrowith EGF-Directed Carbon Nanotube-Based Drug Delivery
    2009 644 citations Vyomesh Patel, Andrius Masedunskas et al. profile →
  14. Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging
    2007 604 citations J. Silvio Gutkind et al. profile →
  15. Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ
    1997 601 citations J. Silvio Gutkind et al. profile →
  16. Carbon Nanotube Amplification Strategies for Highly Sensitive Immunodetection of Cancer Biomarkers
    2006 535 citations Vyomesh Patel, J. Silvio Gutkind et al. profile →
  17. G12-G13–LARG–mediated signaling in vascular smooth muscle is required for salt-induced hypertension
    2007 511 citations J. Silvio Gutkind et al. profile →
  18. Cbl-b regulates the CD28 dependence of T-cell activation
    2000 509 citations J. Silvio Gutkind et al. profile →
  19. The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer
    2013 428 citations J. Silvio Gutkind et al. profile →
  20. Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry
    2014 427 citations Ramiro Iglesias‐Bartolomé, José P. Vaqué et al. profile →
  21. Illuminating G-Protein-Coupling Selectivity of GPCRs
    2019 396 citations Nadia Arang, J. Silvio Gutkind et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
J. Silvio Gutkind United States 121 33.7k 11.5k 7.8k 6.9k 5.8k 582 52.2k
Christer Betsholtz Sweden 100 28.8k 0.9× 7.9k 0.7× 6.5k 0.8× 4.6k 0.7× 6.2k 1.1× 327 52.3k
Carl‐Henrik Heldin Sweden 132 41.7k 1.2× 14.1k 1.2× 6.7k 0.9× 5.9k 0.8× 8.9k 1.5× 494 62.7k
Joan S. Brugge United States 111 25.6k 0.8× 10.2k 0.9× 9.5k 1.2× 5.2k 0.7× 5.1k 0.9× 259 41.9k
Josef Penninger Austria 133 40.9k 1.2× 14.8k 1.3× 3.9k 0.5× 18.0k 2.6× 7.5k 1.3× 582 78.3k
Anne J. Ridley United Kingdom 95 26.0k 0.8× 5.7k 0.5× 16.4k 2.1× 6.3k 0.9× 3.3k 0.6× 304 43.9k
Michael Klagsbrun United States 103 26.1k 0.8× 8.1k 0.7× 8.5k 1.1× 3.8k 0.6× 6.8k 1.2× 272 38.9k
Toshio Suda Japan 120 32.9k 1.0× 17.0k 1.5× 4.0k 0.5× 12.0k 1.7× 7.3k 1.3× 730 59.1k
Elisabetta Dejana Italy 113 22.7k 0.7× 5.6k 0.5× 8.4k 1.1× 7.2k 1.0× 4.6k 0.8× 389 44.0k
Jean Paul Thiery France 108 34.1k 1.0× 19.4k 1.7× 9.5k 1.2× 4.5k 0.7× 11.7k 2.0× 553 55.8k
Shuh Narumiya Japan 125 28.8k 0.9× 6.0k 0.5× 12.0k 1.5× 7.4k 1.1× 3.5k 0.6× 556 60.6k

Countries citing papers authored by J. Silvio Gutkind

Since Specialization
Citations

This map shows the geographic impact of J. Silvio Gutkind's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by J. Silvio Gutkind with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites J. Silvio Gutkind more than expected).

Fields of papers citing papers by J. Silvio Gutkind

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by J. Silvio Gutkind. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by J. Silvio Gutkind. The network helps show where J. Silvio Gutkind may publish in the future.

Co-authorship network of co-authors of J. Silvio Gutkind

This figure shows the co-authorship network connecting the top 25 collaborators of J. Silvio Gutkind. A scholar is included among the top collaborators of J. Silvio Gutkind based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with J. Silvio Gutkind. J. Silvio Gutkind is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Sato, Kuniaki, Farhoud Faraji, Rodolfo Daniel Cervantes‐Villagrana, et al.. (2025). Targeting YAP/TAZ-TEAD signaling as a therapeutic approach in head and neck squamous cell carcinoma. Cancer Letters. 612. 217467–217467. 6 indexed citations
2.
Arang, Nadia, et al.. (2024). Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation. npj Systems Biology and Applications. 10(1). 75–75. 2 indexed citations
3.
Gilardi, Mara, Robert Saddawi‐Konefka, Victoria H. Wu, et al.. (2022). Microneedle-mediated Intratumoral Delivery of Anti-CTLA-4 Promotes cDC1-dependent Eradication of Oral Squamous Cell Carcinoma with Limited irAEs. Molecular Cancer Therapeutics. 21(4). 616–624. 34 indexed citations
4.
Kim, Sangwoo S., Sarek Shen, Sayuri Miyauchi, et al.. (2020). B Cells Improve Overall Survival in HPV-Associated Squamous Cell Carcinomas and Are Activated by Radiation and PD-1 Blockade. Clinical Cancer Research. 26(13). 3345–3359. 141 indexed citations
5.
Izumi, Hiroki, Zhiyong Wang, Yusuke Goto, et al.. (2020). Pathway-Specific Genome Editing of PI3K/mTOR Tumor Suppressor Genes Reveals that PTEN Loss Contributes to Cetuximab Resistance in Head and Neck Cancer. Molecular Cancer Therapeutics. 19(7). 1562–1571. 24 indexed citations
6.
Liu, Chao, Koji Ebisumoto, Akihiro Sakai, et al.. (2020). Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation. Clinical Cancer Research. 26(11). 2693–2703. 47 indexed citations
7.
Miyauchi, Sayuri, P. Dominick Sanders, Sangwoo S. Kim, et al.. (2019). HPV16 E5 Mediates Resistance to PD-L1 Blockade and Can Be Targeted with Rimantadine in Head and Neck Cancer. Cancer Research. 80(4). 732–746. 46 indexed citations
8.
Wu, Xingyu, Huwate Yeerna, Yusuke Goto, et al.. (2019). Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells. Cancer Research. 79(17). 4360–4370. 43 indexed citations
9.
Lubrano, Simone, Andrea Marranci, Federica Gemignani, et al.. (2018). Development of a yeast-based system to identify new hBRAFV600E functional interactors. Oncogene. 38(8). 1355–1366. 7 indexed citations
10.
Guo, Theresa, Akihiro Sakai, Bahman Afsari, et al.. (2017). A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers. Cancer Research. 77(19). 5248–5258. 33 indexed citations
11.
Doçi, Colleen L., Constantinos M. Mikelis, Michail S. Lionakis, Alfredo Molinolo, & J. Silvio Gutkind. (2015). Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma. Cancer Research. 75(14). 2937–2948. 36 indexed citations
12.
Amornphimoltham, Panomwat, Jamie Thompson, Andrius Masedunskas, et al.. (2013). Rab25 Regulates Invasion and Metastasis in Head and Neck Cancer. Clinical Cancer Research. 19(6). 1375–1388. 61 indexed citations
13.
Molinolo, Alfredo, Christina A. Marsh, Mohamed El Dinali, et al.. (2012). mTOR as a Molecular Target in HPV-Associated Oral and Cervical Squamous Carcinomas. Clinical Cancer Research. 18(9). 2558–2568. 138 indexed citations
14.
Tamburrino, Anna, Alfredo Molinolo, Paolo Salerno, et al.. (2012). Activation of the mTOR Pathway in Primary Medullary Thyroid Carcinoma and Lymph Node Metastases. Clinical Cancer Research. 18(13). 3532–3540. 60 indexed citations
15.
Giulianelli, Sebastián, José P. Vaqué, Rocío Soldati, et al.. (2012). Estrogen Receptor Alpha Mediates Progestin-Induced Mammary Tumor Growth by Interacting with Progesterone Receptors at the Cyclin D1/MYC Promoters. Cancer Research. 72(9). 2416–2427. 79 indexed citations
16.
Patel, Vyomesh, Christina A. Marsh, Robert T. Dorsam, et al.. (2011). Decreased Lymphangiogenesis and Lymph Node Metastasis by mTOR Inhibition in Head and Neck Cancer. Cancer Research. 71(22). 7103–7112. 116 indexed citations
17.
Bian, Yansong, Anita Terse, Juan Du, et al.. (2009). Progressive Tumor Formation in Mice with Conditional Deletion of TGF-β Signaling in Head and Neck Epithelia Is Associated with Activation of the PI3K/Akt Pathway. Cancer Research. 69(14). 5918–5926. 75 indexed citations
18.
Raimondi, Ana R., Alfredo Molinolo, & J. Silvio Gutkind. (2009). Rapamycin Prevents Early Onset of Tumorigenesis in an Oral-Specific K- ras and p53 Two-Hit Carcinogenesis Model. Cancer Research. 69(10). 4159–4166. 68 indexed citations
19.
Amornphimoltham, Panomwat, Kantima Leelahavanichkul, Alfredo Molinolo, Vyomesh Patel, & J. Silvio Gutkind. (2008). Inhibition of Mammalian Target of Rapamycin by Rapamycin Causes the Regression of Carcinogen-Induced Skin Tumor Lesions. Clinical Cancer Research. 14(24). 8094–8101. 54 indexed citations
20.
Miyazaki, Hiroshi, Vyomesh Patel, Ahmad Waseem, et al.. (2008). Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility. Molecular Cancer Therapeutics. 7(9). 2894–2903. 72 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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