Frank J. Gonzalez

149.8k total citations · 42 hit papers
1.3k papers, 119.2k citations indexed

About

Frank J. Gonzalez is a scholar working on Molecular Biology, Pharmacology and Oncology. According to data from OpenAlex, Frank J. Gonzalez has authored 1.3k papers receiving a total of 119.2k indexed citations (citations by other indexed papers that have themselves been cited), including 725 papers in Molecular Biology, 431 papers in Pharmacology and 352 papers in Oncology. Recurrent topics in Frank J. Gonzalez's work include Pharmacogenetics and Drug Metabolism (379 papers), Peroxisome Proliferator-Activated Receptors (322 papers) and Drug Transport and Resistance Mechanisms (306 papers). Frank J. Gonzalez is often cited by papers focused on Pharmacogenetics and Drug Metabolism (379 papers), Peroxisome Proliferator-Activated Receptors (322 papers) and Drug Transport and Resistance Mechanisms (306 papers). Frank J. Gonzalez collaborates with scholars based in United States, Japan and China. Frank J. Gonzalez's co-authors include Daniel W. Nebert, Jeffrey M. Peters, Kristopher W. Krausz, Jerrold M. Ward, Harry V. Gelboin, Pedro M. Fernández‐Salguero, Shioko Kimura, Jeffrey R. Idle, Yatrik M. Shah and Andrew D. Patterson and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Frank J. Gonzalez

1.3k papers receiving 116.5k citations

Hit Papers

Targeted Disruption of th... 1987 2026 2000 2013 2000 1995 1993 1999 1987 400 800 1.2k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
    2000 1.5k citations Frank J. Gonzalez et al. profile →
  2. Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators
    1995 1.4k citations Frank J. Gonzalez et al. profile →
  3. The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature
    1993 1.4k citations Frank J. Gonzalez et al. DNA and Cell Biology profile →
  4. Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
    1999 1.4k citations Jeffrey M. Peters, Frank J. Gonzalez et al. profile →
  5. P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION
    1987 1.3k citations Frank J. Gonzalez et al. profile →
  6. C/EBPα induces adipogenesis through PPARγ: a unified pathway
    2002 1.2k citations Frank J. Gonzalez et al. profile →
  7. The molecular biology of cytochrome P450s.
    1988 1.1k citations Frank J. Gonzalez profile →
  8. The PPARα–leukotriene B4 pathway to inflammation control
    1996 1.1k citations Jeffrey M. Peters, Frank J. Gonzalez et al. profile →
  9. Role of Aryl Hydrocarbon Receptor-mediated Induction of the CYP1 Enzymes in Environmental Toxicity and Cancer
    2004 953 citations Frank J. Gonzalez et al. profile →
  10. The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.
    1996 945 citations Frank J. Gonzalez et al. profile →
  11. Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1
    1999 936 citations Jeffrey M. Peters, Frank J. Gonzalez et al. profile →
  12. Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis
    2001 915 citations Frank J. Gonzalez et al. profile →
  13. The P450 Superfamily: Update on New Sequences, Gene Mapping, and Recommended Nomenclature
    1991 904 citations Frank J. Gonzalez et al. DNA and Cell Biology profile →
  14. Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin-Binding Ah Receptor
    1995 898 citations Frank J. Gonzalez et al. profile →
  15. International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors
    2006 813 citations Frank J. Gonzalez et al. profile →
  16. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
    2006 786 citations Frank J. Gonzalez et al. Proceedings of the National Academy of Sciences profile →
  17. Altered Constitutive Expression of Fatty Acid-metabolizing Enzymes in Mice Lacking the Peroxisome Proliferator-activated Receptor α (PPARα)
    1998 767 citations Jeffrey M. Peters, Frank J. Gonzalez et al. profile →
  18. Aryl-hydrocarbon Receptor-Deficient Mice Are Resistant to 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Toxicity
    1996 706 citations Frank J. Gonzalez et al. profile →
  19. Liver Peroxisome Proliferator-activated Receptor γ Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass
    2003 665 citations Frank J. Gonzalez et al. profile →
  20. The P450 Gene Superfamily: Recommended Nomenclature
    1987 657 citations Frank J. Gonzalez et al. profile →
  21. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
    2000 636 citations Frank J. Gonzalez et al. profile →
  22. Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
    2013 587 citations Fei Li, Changtao Jiang et al. profile →
  23. Adipocyte-specific Gene Expression and Adipogenic Steatosis in the Mouse Liver Due to Peroxisome Proliferator-activated Receptor γ1 (PPARγ1) Overexpression
    2002 551 citations Frank J. Gonzalez et al. profile →
  24. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism
    1988 548 citations Frank J. Gonzalez et al. profile →
  25. Growth, Adipose, Brain, and Skin Alterations Resulting from Targeted Disruption of the Mouse Peroxisome Proliferator-Activated Receptor β(δ)
    2000 547 citations Jeffrey M. Peters, Frank J. Gonzalez et al. profile →
  26. Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
    2014 541 citations Changtao Jiang, Cen Xie et al. profile →
  27. Role of CYP2E1 in the Hepatotoxicity of Acetaminophen
    1996 539 citations Frank J. Gonzalez et al. profile →
  28. The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci
    1989 521 citations Frank J. Gonzalez et al. profile →
  29. Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis
    2022 512 citations Lulu Sun, Frank J. Gonzalez et al. profile →
  30. Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota
    2017 510 citations Cen Xie, Kristopher W. Krausz et al. Cell Metabolism profile →
  31. Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue
    2011 509 citations Frank J. Gonzalez et al. profile →
  32. Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions
    1992 494 citations Frank J. Gonzalez et al. profile →
  33. Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.
    1989 481 citations Frank J. Gonzalez et al. profile →
  34. Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
    2015 455 citations Changtao Jiang, Cen Xie et al. profile →
  35. Cytochrome P-450 hPCN3, a Novel Cytochrome P-450 IIIA Gene Product That Is Differentially Expressed in Adult Human Liver
    1989 434 citations Frank J. Gonzalez et al. profile →
  36. Intestine farnesoid X receptor agonist and the gut microbiota activate G‐protein bile acid receptor‐1 signaling to improve metabolism
    2018 410 citations Cen Xie, Kristopher W. Krausz et al. Hepatology profile →
  37. PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice
    2020 391 citations Frank J. Gonzalez et al. profile →
  38. Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis
    2017 356 citations Haiping Hao, Changtao Jiang et al. Cell Metabolism profile →
  39. The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer
    2021 288 citations Lulu Sun, Frank J. Gonzalez et al. profile →
  40. Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice
    2023 125 citations Manyun Dai, Frank J. Gonzalez et al. profile →
  41. Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal
    2022 116 citations Yuhong Luo, Frank J. Gonzalez et al. profile →
  42. A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage
    2024 76 citations Frank J. Gonzalez et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Frank J. Gonzalez United States 171 56.6k 31.3k 27.1k 19.1k 16.8k 1.3k 119.2k
Steven A. Kliewer United States 102 33.0k 0.6× 8.0k 0.3× 14.4k 0.5× 7.8k 0.4× 9.1k 0.5× 168 56.3k
Timothy M. Willson United States 97 31.4k 0.6× 7.3k 0.2× 14.0k 0.5× 7.0k 0.4× 8.9k 0.5× 230 54.1k
Ronald M. Evans United States 187 96.0k 1.7× 5.6k 0.2× 17.0k 0.6× 11.6k 0.6× 20.1k 1.2× 629 148.1k
Michael Karin United States 229 113.1k 2.0× 5.2k 0.2× 45.8k 1.7× 23.0k 1.2× 14.0k 0.8× 652 212.6k
Bart Staels France 147 41.5k 0.7× 2.5k 0.1× 10.3k 0.4× 18.4k 1.0× 18.2k 1.1× 789 78.9k
David J. Mangelsdorf United States 120 40.1k 0.7× 3.0k 0.1× 17.8k 0.7× 8.6k 0.4× 7.3k 0.4× 223 70.2k
Johan Auwerx Switzerland 157 51.3k 0.9× 1.9k 0.1× 13.2k 0.5× 19.7k 1.0× 29.9k 1.8× 638 96.6k
Jan-Ακε Gustafsson Sweden 138 33.6k 0.6× 5.7k 0.2× 13.5k 0.5× 3.4k 0.2× 6.0k 0.4× 1.2k 85.2k
Masayuki Yamamoto Japan 169 85.7k 1.5× 3.5k 0.1× 5.1k 0.2× 9.2k 0.5× 10.4k 0.6× 1.4k 119.9k
Barry Halliwell United Kingdom 176 45.3k 0.8× 5.9k 0.2× 4.2k 0.2× 4.3k 0.2× 20.5k 1.2× 736 138.6k

Countries citing papers authored by Frank J. Gonzalez

Since Specialization
Citations

This map shows the geographic impact of Frank J. Gonzalez's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Frank J. Gonzalez with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Frank J. Gonzalez more than expected).

Fields of papers citing papers by Frank J. Gonzalez

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Frank J. Gonzalez. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Frank J. Gonzalez. The network helps show where Frank J. Gonzalez may publish in the future.

Co-authorship network of co-authors of Frank J. Gonzalez

This figure shows the co-authorship network connecting the top 25 collaborators of Frank J. Gonzalez. A scholar is included among the top collaborators of Frank J. Gonzalez based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Frank J. Gonzalez. Frank J. Gonzalez is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
López‐Sandoval, R., et al.. (2024). Oxidative calcination of brewery bagasse and in-situ preparation of activated carbon-PEDOT composite for hybrid supercapacitor application. Synthetic Metals. 309. 117735–117735. 5 indexed citations
2.
Gonzalez, Frank J., et al.. (2024). Molecular targets of PXR-dependent ethanol-induced hepatotoxicity in female mice. Biochemical Pharmacology. 228. 116416–116416. 2 indexed citations
3.
Xia, Yangliu, Yang Zhang, Nana Yan, et al.. (2024). Intestinal stearoyl-coenzyme A desaturase-inhibition improves obesity-associated metabolic disorders. Acta Pharmaceutica Sinica B. 15(2). 892–908. 4 indexed citations
4.
Zhu, Junjie, Jianhua Li, Jie Lu, et al.. (2021). Targeting Xenobiotic Nuclear Receptors PXR and CAR to Prevent Cobicistat Hepatotoxicity. Toxicological Sciences. 181(1). 58–67. 14 indexed citations
5.
Mu, Xiyan, Kun Liu, Xinyu Hao, et al.. (2019). Non-targeted metabolomics reveals diagnostic biomarker in the tongue coating of patients with chronic gastritis. Journal of Pharmaceutical and Biomedical Analysis. 174. 541–551. 16 indexed citations
6.
Yang, Xiaonan, Xuemei Liu, Xiu‐Wei Yang, et al.. (2018). PPARα Mediates the Hepatoprotective Effects of Nutmeg. Journal of Proteome Research. 17(5). 1887–1897. 25 indexed citations
7.
Lin, Kaifeng, Danny Bruce, Stephanie A. Montgomery, et al.. (2017). T-cell expression of AhR inhibits the maintenance of pTreg cells in the gastrointestinal tract in acute GVHD. Blood. 130(3). 348–359. 22 indexed citations
8.
Wang, Wei, Mingjiang Xu, Yan Cai, et al.. (2017). Inflammation is independent of steatosis in a murine model of steatohepatitis. Hepatology. 66(1). 108–123. 59 indexed citations
9.
Jiang, Changtao, Kim Cheng, Rebecca Stokes, et al.. (2017). Hepatic Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) regulates metabolism in mice. PLoS ONE. 12(11). e0186543–e0186543. 5 indexed citations
10.
Patel, Dhaval, Matthew D. Thompson, Soumen Manna, et al.. (2017). Unique and Novel Urinary Metabolomic Features in Malignant versus Benign Adrenal Neoplasms. Clinical Cancer Research. 23(17). 5302–5310. 17 indexed citations
11.
Gao, Xiaoxia, Cen Xie, Yuanyuan Wang, et al.. (2016). The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4. Biochemical Pharmacology. 119. 93–104. 24 indexed citations
12.
Ramakrishnan, Sadeesh K., Huabing Zhang, Shogo Takahashi, et al.. (2016). HIF2 α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling. Cell Metabolism. 23(3). 505–516. 43 indexed citations
13.
Cook, John A., Gadisetti V.R. Chandramouli, Miriam R. Anver, et al.. (2016). Mass Spectrometry–Based Metabolomics Identifies Longitudinal Urinary Metabolite Profiles Predictive of Radiation-Induced Cancer. Cancer Research. 76(6). 1569–1577. 13 indexed citations
14.
Song, Danjun, Manyun Dai, Shizhong Bu, et al.. (2016). PPARα-dependent increase of mouse urine output by gemfibrozil and fenofibrate. Canadian Journal of Physiology and Pharmacology. 95(2). 199–205. 1 indexed citations
15.
Qu, Aijuan, Matthew J. Taylor, Xiang Xue, et al.. (2011). Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis. Hepatology. 54(2). 472–483. 152 indexed citations
16.
Nakajima, Miki, et al.. (2008). Regulation of insulin-like growth factor binding protein-1 and lipoprotein lipase by the aryl hydrocarbon receptor. The Journal of Toxicological Sciences. 33(4). 405–413. 15 indexed citations
17.
Shah, Yatrik M., Shinji Ito, Keiichirou Morimura, et al.. (2008). Hypoxia-Inducible Factor Augments Experimental Colitis Through an MIF–Dependent Inflammatory Signaling Cascade. Gastroenterology. 134(7). 2036–2048.e3. 152 indexed citations
18.
Lee, Chih‐Hao, Peter Olson, Andrea L. Hevener, et al.. (2006). PPARδ regulates glucose metabolism and insulin sensitivity. Proceedings of the National Academy of Sciences. 103(9). 3444–3449. 402 indexed citations
19.
Wagner, Martin, Peter Fickert, Gernot Zollner, et al.. (2003). Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice. Gastroenterology. 125(3). 825–838. 216 indexed citations
20.
Liu, Suyan & Frank J. Gonzalez. (1995). Role of the Liver-Enriched Transcription Factor HNF-1α in Expression of the CYP2E1 Gene. DNA and Cell Biology. 14(4). 285–293. 83 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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