Xandra O. Breakefield

62.5k total citations · 21 hit papers
285 papers, 38.1k citations indexed

About

Xandra O. Breakefield is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Neurology. According to data from OpenAlex, Xandra O. Breakefield has authored 285 papers receiving a total of 38.1k indexed citations (citations by other indexed papers that have themselves been cited), including 171 papers in Molecular Biology, 102 papers in Cellular and Molecular Neuroscience and 82 papers in Neurology. Recurrent topics in Xandra O. Breakefield's work include Extracellular vesicles in disease (58 papers), Genetic Neurodegenerative Diseases (56 papers) and Neurological disorders and treatments (55 papers). Xandra O. Breakefield is often cited by papers focused on Extracellular vesicles in disease (58 papers), Genetic Neurodegenerative Diseases (56 papers) and Neurological disorders and treatments (55 papers). Xandra O. Breakefield collaborates with scholars based in United States, Germany and Netherlands. Xandra O. Breakefield's co-authors include Samir EL Andaloussi, Johan Skog, Matthew J. A. Wood, Erik R. Abels, Imre Mäger, Anna M. Krichevsky, Ralph Weissleder, Charles Pin‐Kuang Lai, Leonora Balaj and Bob S. Carter and has published in prestigious journals such as Nature, Science and Chemical Reviews.

In The Last Decade

Xandra O. Breakefield

284 papers receiving 37.5k citations

Hit Papers

Glioblastoma microvesicles transport RNA and proteins... 1997 2026 2006 2016 2008 2013 2018 2016 2020 1000 2.0k 3.0k 4.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    2008 4.0k citations Anna M. Krichevsky, Xandra O. Breakefield et al. profile →
  2. Extracellular vesicles: biology and emerging therapeutic opportunities
    2013 2.7k citations Xandra O. Breakefield et al. profile →
  3. New Technologies for Analysis of Extracellular Vesicles
    2018 1.3k citations Xandra O. Breakefield, Ralph Weissleder et al. profile →
  4. Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake
    2016 1.3k citations Erik R. Abels, Xandra O. Breakefield Cellular and Molecular Neurobiology profile →
  5. RNA delivery by extracellular vesicles in mammalian cells and its applications
    2020 1.3k citations Koen Breyne, Xandra O. Breakefield et al. profile →
  6. Extracellular Vesicles: Unique Intercellular Delivery Vehicles
    2016 1.1k citations Sybren L. N. Maas, Xandra O. Breakefield et al. Trends in Cell Biology profile →
  7. Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences
    2011 965 citations Xandra O. Breakefield et al. profile →
  8. Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas
    2000 944 citations Karen S. Aboody, Nikolai G. Rainov et al. Proceedings of the National Academy of Sciences profile →
  9. Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study
    2015 943 citations Xandra O. Breakefield, Charles Pin‐Kuang Lai et al. profile →
  10. The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein
    1997 770 citations Laurie J. Ozelius, Jeffrey Hewett et al. profile →
  11. Advances in therapeutic applications of extracellular vesicles
    2019 765 citations Xandra O. Breakefield et al. profile →
  12. Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter
    2014 727 citations Charles Pin‐Kuang Lai, Maria Ericsson et al. profile →
  13. Exosome-based liquid biopsies in cancer: opportunities and challenges
    2021 631 citations Xandra O. Breakefield et al. profile →
  14. Codon-Optimized Gaussia Luciferase cDNA for Mammalian Gene Expression in Culture and in Vivo
    2004 557 citations Bakhos A. Tannous, Ralph Weissleder et al. Molecular Therapy profile →
  15. Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma
    2015 504 citations Xandra O. Breakefield, Ralph Weissleder et al. profile →
  16. Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection
    2018 484 citations Bence György, Xandra O. Breakefield et al. Neuron profile →
  17. Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters
    2015 442 citations Charles Pin‐Kuang Lai, Ralph Weissleder et al. profile →
  18. Multidimensional communication in the microenvirons of glioblastoma
    2018 426 citations Marike L. D. Broekman, Sybren L. N. Maas et al. profile →
  19. Coding and noncoding landscape of extracellular RNA released by human glioma stem cells
    2017 394 citations Xandra O. Breakefield, Anna M. Krichevsky et al. profile →
  20. High levels of AAV vector integration into CRISPR-induced DNA breaks
    2019 289 citations Benjamin P. Kleinstiver, Adrienn Volak et al. profile →
  21. Uptake, functionality, and re-release of extracellular vesicle-encapsulated cargo
    2022 142 citations Xandra O. Breakefield et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Xandra O. Breakefield United States 85 27.1k 12.8k 6.6k 5.4k 3.5k 285 38.1k
Christer Betsholtz Sweden 100 28.8k 1.1× 6.2k 0.5× 5.3k 0.8× 3.0k 0.6× 1.9k 0.5× 327 52.3k
Elisabetta Dejana Italy 113 22.7k 0.8× 4.6k 0.4× 2.1k 0.3× 1.8k 0.3× 1.8k 0.5× 389 44.0k
Carl‐Henrik Heldin Sweden 132 41.7k 1.5× 8.9k 0.7× 2.5k 0.4× 1.4k 0.3× 2.0k 0.6× 494 62.7k
C. Frank Bennett United States 81 23.5k 0.9× 6.1k 0.5× 3.5k 0.5× 3.6k 0.7× 425 0.1× 227 30.1k
Michael Klagsbrun United States 103 26.1k 1.0× 6.8k 0.5× 6.0k 0.9× 903 0.2× 1.1k 0.3× 272 38.9k
Edward H. Oldfield United States 91 7.1k 0.3× 4.2k 0.3× 4.1k 0.6× 6.6k 1.2× 1.1k 0.3× 404 31.8k
Luis F. Parada United States 94 17.4k 0.6× 3.5k 0.3× 9.4k 1.4× 4.5k 0.8× 491 0.1× 231 33.7k
Robert J. Coffey United States 98 16.7k 0.6× 6.4k 0.5× 1.2k 0.2× 3.5k 0.6× 1.0k 0.3× 416 34.1k
Beverly L. Davidson United States 89 19.2k 0.7× 3.3k 0.3× 4.8k 0.7× 1.7k 0.3× 871 0.2× 334 28.1k
Hannes Vogel United States 81 14.1k 0.5× 3.1k 0.2× 2.5k 0.4× 2.3k 0.4× 1.0k 0.3× 352 26.0k

Countries citing papers authored by Xandra O. Breakefield

Since Specialization
Citations

This map shows the geographic impact of Xandra O. Breakefield's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Xandra O. Breakefield with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Xandra O. Breakefield more than expected).

Fields of papers citing papers by Xandra O. Breakefield

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Xandra O. Breakefield. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Xandra O. Breakefield. The network helps show where Xandra O. Breakefield may publish in the future.

Co-authorship network of co-authors of Xandra O. Breakefield

This figure shows the co-authorship network connecting the top 25 collaborators of Xandra O. Breakefield. A scholar is included among the top collaborators of Xandra O. Breakefield based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Xandra O. Breakefield. Xandra O. Breakefield is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Leandro, Kevin, David Rufino‐Ramos, Koen Breyne, et al.. (2024). Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads. Advanced Drug Delivery Reviews. 211. 115346–115346. 13 indexed citations
2.
Nieland, Lisa, et al.. (2023). EXTH-55. ALL-IN-ONE GENETIC CONSTRUCT TO KNOCKDOWN MIR-21 REDUCES GLIOMA PROLIFERATION IN VITRO. Neuro-Oncology. 25(Supplement_5). v236–v237. 1 indexed citations
3.
Maas, Sybren L. N., Erik R. Abels, Xuan Zhang, et al.. (2020). Glioblastoma hijacks microglial gene expression to support tumor growth. Journal of Neuroinflammation. 17(1). 120–120. 81 indexed citations
4.
György, Bence, Cyrille Sage, Artur A. Indzhykulian, et al.. (2017). Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV. Molecular Therapy. 25(2). 379–391. 182 indexed citations
5.
Ricklefs, Franz, Marco Mineo, Arun K. Rooj, et al.. (2016). Extracellular Vesicles from High-Grade Glioma Exchange Diverse Pro-oncogenic Signals That Maintain Intratumoral Heterogeneity. Cancer Research. 76(10). 2876–2881. 81 indexed citations
6.
Pucci, Ferdinando, Christopher Garris, Charles Pin‐Kuang Lai, et al.. (2016). SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions. Science. 352(6282). 242–246. 258 indexed citations
7.
Maas, Sybren L. N., Xandra O. Breakefield, & Alissa M. Weaver. (2016). Extracellular Vesicles: Unique Intercellular Delivery Vehicles. Trends in Cell Biology. 27(3). 172–188. 1115 indexed citations breakdown →
8.
Zhang, Xuan, Erik R. Abels, Jasmina S. Redzic, et al.. (2016). Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington’s Disease: Background and Evaluation in Cell Culture. Cellular and Molecular Neurobiology. 36(3). 459–470. 80 indexed citations
9.
Lai, Charles Pin‐Kuang, Bakhos A. Tannous, & Xandra O. Breakefield. (2013). Noninvasive In Vivo Monitoring of Extracellular Vesicles. Methods in molecular biology. 1098. 249–258. 43 indexed citations
10.
Prabhakar, Shilpa, Davide Gianni, Thomas J. Conlon, et al.. (2012). Regression of Schwannomas Induced by Adeno-Associated Virus-Mediated Delivery of Caspase-1. Human Gene Therapy. 24(2). 152–162. 23 indexed citations
11.
Saydam, Okay, Ozlem Senol, Thomas Würdinger, et al.. (2010). miRNA-7 Attenuation in Schwannoma Tumors Stimulates Growth by Upregulating Three Oncogenic Signaling Pathways. Cancer Research. 71(3). 852–861. 129 indexed citations
12.
Breakefield, Xandra O. & Miguel Sena‐Esteves. (2010). Healing Genes in the Nervous System. Neuron. 68(2). 178–181. 4 indexed citations
13.
Bragg, D. Cristopher, et al.. (2010). Molecular pathways in dystonia. Neurobiology of Disease. 42(2). 136–147. 63 indexed citations
14.
Hewett, Jeffrey, Brian Niland, Pei Ge, et al.. (2008). siRNA knock-down of mutant torsinA restores processing through secretory pathway in DYT1 dystonia cells. Human Molecular Genetics. 17(10). 1436–1445. 51 indexed citations
15.
Yoshimura, Shinichi, Tetsuyuki Teramoto, Michael J. Whalen, et al.. (2003). FGF-2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice. Journal of Clinical Investigation. 112(8). 1202–1210. 145 indexed citations
16.
Opal, Puneet, Ron Tintner, Joseph Jankovic, et al.. (2002). Intrafamilial phenotypic variability of the DYT1 dystonia: From asymptomatic TOR1A gene carrier status to dystonic storm. Movement Disorders. 17(2). 339–345. 88 indexed citations
17.
Aboody, Karen S., Nikolai G. Rainov, Shaoxiong Liu, et al.. (2000). Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas. Proceedings of the National Academy of Sciences. 97(23). 12846–12851. 944 indexed citations breakdown →
18.
Rosenberg, William S., et al.. (1992). Authentic and artifactual detection of the E. coli lacZ gene product in the rat brain by histochemical methods. Molecular Brain Research. 16(3-4). 311–315. 29 indexed citations
19.
Seizinger, Bernd R. & Xandra O. Breakefield. (1990). The role of ‘tumor suppressor’ genes in neural tumors. Trends in Neurosciences. 13(1). 3–6. 18 indexed citations
20.
Kramer, Patricia L., Deborah de Leon, Laurie J. Ozelius, et al.. (1990). Dystonia gene in Ashkenazi Jewish population is located on chromosome 9q32–34. Annals of Neurology. 27(2). 114–120. 109 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Christer Betsholtz Breakdown of academic impact, for papers by Elisabetta Dejana Breakdown of academic impact, for papers by Carl‐Henrik Heldin Breakdown of academic impact, for papers by C. Frank Bennett Breakdown of academic impact, for papers by Michael Klagsbrun Breakdown of academic impact, for papers by Edward H. Oldfield Breakdown of academic impact, for papers by Luis F. Parada Breakdown of academic impact, for papers by Robert J. Coffey Breakdown of academic impact, for papers by Beverly L. Davidson Breakdown of academic impact, for papers by Hannes Vogel
Rankless by CCL
2026