Alfred Wittinghofer

39.2k total citations · 7 hit papers
296 papers, 31.2k citations indexed

About

Alfred Wittinghofer is a scholar working on Molecular Biology, Cell Biology and Materials Chemistry. According to data from OpenAlex, Alfred Wittinghofer has authored 296 papers receiving a total of 31.2k indexed citations (citations by other indexed papers that have themselves been cited), including 256 papers in Molecular Biology, 84 papers in Cell Biology and 58 papers in Materials Chemistry. Recurrent topics in Alfred Wittinghofer's work include Protein Kinase Regulation and GTPase Signaling (120 papers), Enzyme Structure and Function (57 papers) and Cellular transport and secretion (49 papers). Alfred Wittinghofer is often cited by papers focused on Protein Kinase Regulation and GTPase Signaling (120 papers), Enzyme Structure and Function (57 papers) and Cellular transport and secretion (49 papers). Alfred Wittinghofer collaborates with scholars based in Germany, Netherlands and United States. Alfred Wittinghofer's co-authors include Ingrid R. Vetter, Johannes L. Bos, Holger Rehmann, Mohammad Reza Ahmadian, Christian Herrmann, Roger S. Goody, Klaus Scheffzek, Robbert H. Cool, Wolfgang Kabsch and Johan de Rooij and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Alfred Wittinghofer

293 papers receiving 30.8k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 1.6k citations Alfred Wittinghofer et al. profile →
GEFs and GAPs: Critical Elements in the Control of Small G Proteins

2007 1.4k citations Holger Rehmann, Alfred Wittinghofer et al. Cell profile →
The Guanine Nucleotide-Binding Switch in Three Dimensions

2001 1.4k citations Ingrid R. Vetter, Alfred Wittinghofer Science profile →
The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

1997 1.2k citations Alfred Wittinghofer et al. Science profile →
Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 758 citations E.F. Pai, Alfred Wittinghofer et al. profile →
An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms

2005 672 citations Oliver Rocks, Martin Kahms et al. Science profile →
Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

2013 474 citations Gunther Zimmermann, Bjoern Papke et al. profile →

Peers

Countries citing papers authored by Alfred Wittinghofer

Since Specialization

Citations

This map shows the geographic impact of Alfred Wittinghofer's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alfred Wittinghofer with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alfred Wittinghofer more than expected).

Fields of papers citing papers by Alfred Wittinghofer

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alfred Wittinghofer. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alfred Wittinghofer. The network helps show where Alfred Wittinghofer may publish in the future.

Co-authorship network of co-authors of Alfred Wittinghofer

This figure shows the co-authorship network connecting the top 25 collaborators of Alfred Wittinghofer. A scholar is included among the top collaborators of Alfred Wittinghofer based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alfred Wittinghofer. Alfred Wittinghofer is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Identification of pyrazolopyridazinones as PDEδ inhibitors 2016 ·Nature Communications ·Bjoern Papke, Sandip Murarka, (unknown), Pablo Martín‐Gago, Marija Kovačević, Dina C. Truxius, Eyad K. Fansa, Shehab Ismail, Gunther Zimmermann, (unknown), Carsten Schultz‐Fademrecht, (unknown), Matthias Baumann, Peter Nußbaumer, Alfred Wittinghofer, Herbert Waldmann, Philippe I. H. Bastiaens	131
2	The Structure of an Arf-ArfGAP Complex Reveals a Ca2+ Regulatory Mechanism 2010 ·Cell ·Shehab Ismail, Ingrid R. Vetter, Begoña Sot, Alfred Wittinghofer	2
3	RPGR and RP2: targets for the treatment of X-linked retinitis pigmentosa? 2009 ·Expert Opinion on Therapeutic Targets ·Stefan Veltel, Alfred Wittinghofer	16
4	RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP‐binding proteins and mediate Rap2‐specific nucleotide exchange 2009 ·FEBS Journal ·(unknown), Raphael Gasper, (unknown), Alfred Wittinghofer, Uygar Halis Tazebay	26
5	Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway 2009 ·FEBS Letters ·(unknown), Matthias Weiwad, Reinhard Wetzker, Gunter Fischer, Alfred Wittinghofer, Ignacio Rubio	40
6	The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy 2008 ·Proceedings of the National Academy of Sciences ·Carsten Kötting, (unknown), (unknown), Alfred Wittinghofer, Klaus Gerwert	102
7	Specificity of Interactions between mDia Isoforms and Rho Proteins 2008 ·Journal of Biological Chemistry ·Michael Lammers, Simon F. De Meyer, (unknown), Alfred Wittinghofer	96
8	Crystal Structures of the Conserved tRNA-Modifying Enzyme GidA: Implications for Its Interaction with MnmE and Substrate 2008 ·Journal of Molecular Biology ·Simon F. De Meyer, Andrea Scrima, Wim Versées, Alfred Wittinghofer	45
9	Structure of a 14-3-3 Coordinated Hexamer of the Plant Plasma Membrane H+-ATPase by Combining X-Ray Crystallography and Electron Cryomicroscopy 2007 ·Molecular Cell ·Christian Ottmann, Sergio Marco, Nina Jaspert, Caroline Marcon, Nicolas Schauer, Michael Weyand, (unknown), Geoffrey Duby, Marc Boutry, Alfred Wittinghofer, Jean‐Louis Rigaud, Claudia Oecking	209
10	A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein 2006 ·Proceedings of the National Academy of Sciences ·Carsten Kötting, (unknown), (unknown), Roger S. Goody, Alfred Wittinghofer, Klaus Gerwert	65
11	Characterization of the GbpD-activated Rap1 Pathway Regulating Adhesion and Cell Polarity in Dictyostelium discoideum 2006 ·Journal of Biological Chemistry ·Arjan Kortholt, Holger Rehmann, (unknown), Leonard Bosgraaf, Ineke Keizer‐Gunnink, Gerald Weeks, Alfred Wittinghofer, Peter J.M. Van Haastert	48
12	An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms breakdown → 2005 ·Science ·Oliver Rocks, (unknown), Martin Kahms, Peter J. Verveer, (unknown), María Lumbierres, Jürgen Kuhlmann, Herbert Waldmann, Alfred Wittinghofer, Philippe I. H. Bastiaens	672
13	Properties of the Interaction of Arf-like Protein 2 with PDEδ 2005 ·Journal of Molecular Biology ·Michael Hanzal‐Bayer, Marco Linari, Alfred Wittinghofer	24
14	The Core FH2 Domain of Diaphanous-Related Formins Is an Elongated Actin Binding Protein that Inhibits Polymerization 2004 ·Molecular Cell ·Atsushi Shimada, Miklós Nyitrai, Ingrid R. Vetter, (unknown), Beáta Bugyi, Shuh Narumiya, Michael A. Geeves, Alfred Wittinghofer	123
15	Ras – ein molekularer Schalter bei der Tumorentstehung 2000 ·Angewandte Chemie ·Alfred Wittinghofer, Herbert Waldmann	66
16	Model of the Ran-RCC1 Interaction using Biochemical and Docking Experiments 1999 ·Journal of Molecular Biology ·Yoshiaki Azuma, Louis Renault, Juan A. G. Ranea, Alfonso Valencia, Takeharu Nishimoto, Alfred Wittinghofer	42
17	Signaling mechanistics: Aluminum fluoride for molecule of the year 1997 ·Current Biology ·Alfred Wittinghofer	107
18	Ras/Rap effector specificity determined by charge reversal 1996 ·Nature Structural & Molecular Biology ·Nicolas Nassar, Gudrun Horn, Christian Herrmann, Christoph Block, Ralf Janknecht, Alfred Wittinghofer	179
19	Time-resolved crystallography on H-ras p21 1992 ·Philosophical Transactions of the Royal Society of London Series A Physical and Engineering Sciences ·Axel J. Scheidig, E.F. Pai, Ilme Schlichting, John E. T. Corrie, G. Reid, Alfred Wittinghofer, Roger S. Goody	12
20	Spectroscopic and hydrodynamic studies reveal structural differences in normal and transforming H-ras gene products 1988 ·Biochemistry ·Alfred Pingoud, (unknown), Uwe Pieper, (unknown), Claus Urbanke, Juergen Alves, (unknown), Alfred Wittinghofer	17

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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