Alfred Wittinghofer

39.8k citations
304 papers · 32.8k · 8 hit papers · h-index 97

Impact in

  • Cell Biology top 0.02%
    • Cellular transport and secretion
    • Microtubule and mitosis dynamics
    • Protein Kinase Regulation and GTPase Signaling
    • Protein Structure and Dynamics
    • RNA and protein synthesis mechanisms
    • RNA Research and Splicing
    • Receptor Mechanisms and Signaling

Papers in

    • Protein Kinase Regulation and GTPase Signaling 124
    • RNA and protein synthesis mechanisms 37
    • Cell death mechanisms and regulation 24
    • Protein Structure and Dynamics 21
    • Biochemical and Molecular Research 20
    • Cellular transport and secretion 52

Alfred Wittinghofer

301 papers receiving 32.3k citations

Alfred Wittinghofer's Hit Papers

Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling 2013 · 506 citations
5060+12+24Years since publication50010001.5k

Peers

Alfred Wittinghofer
Comparison fields: 5 of 165
  • Cell Biology 8.5k
  • Molecular Biology 26.8k
  • Physiology 658
  • Immunology and Allergy 798
  • Aging 239
Replace Susan S. Taylor with:
Susan S. Taylor United States
Peter J. Parker United Kingdom
Richard A. Cerione United States
Mark A. Lemmon United States
Jack E. Dixon United States
Mitsuhiko Ikura Canada
Michael D. Waterfield United Kingdom
Kevan M. Shokat United States
William S. Lane United States
Dafna Bar‐Sagi United States
Alfred Wittinghofer relative to Susan S. Taylor United States Susan S. Taylor's profile →
Citations per field
00.5×1.5×
Susan S. Taylor · 1×
Citations per year

Countries citing papers authored by Alfred Wittinghofer

Since Specialization
Citations

This map shows the geographic impact of Alfred Wittinghofer's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alfred Wittinghofer with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alfred Wittinghofer more than expected).

Fields of papers citing papers by Alfred Wittinghofer

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alfred Wittinghofer. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alfred Wittinghofer. The network helps show where Alfred Wittinghofer may publish in the future.

Co-authors

The 25 scholars most cited alongside Alfred Wittinghofer, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Alfred Wittinghofer Line = papers co-authored together Alfred Wittinghofer links everyone, so they are left out of the graph.

All Works

20 of 20 papers shown

Showing the 20 most-cited of 304 papers — load more, or switch the sort, to bring in the rest.

#Work
1
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
Hit paper breakdown →
19981704
2
GEFs and GAPs: Critical Elements in the Control of Small G Proteins
Hit paper breakdown →
20071512
3
The Guanine Nucleotide-Binding Switch in Three Dimensions
Hit paper breakdown →
20011501
4
The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants
Hit paper breakdown →
19971274
5
Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation
Hit paper breakdown →
1989798
6
An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms
Hit paper breakdown →
2005706
7
The ras protein family: evolutionary tree and role of conserved amino acids
Hit paper breakdown →
1991507
8
Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling
Hit paper breakdown →
2013506
9 1994460
10 1990425
11 1990377
12 2011370
13 2007360
14 1998360
15 1990349
16 2000334
17 1995318
18 2003303
19 1999303
20 1996294

About Alfred Wittinghofer

Alfred Wittinghofer is a scholar working on Molecular Biology, Cell Biology, Materials Chemistry, Oncology and Genetics, having authored 304 papers that have together received 32.8k indexed citations. Recurring topics across this work include Protein Kinase Regulation and GTPase Signaling (124 papers), Enzyme Structure and Function (62 papers), Cellular transport and secretion (52 papers), RNA and protein synthesis mechanisms (37 papers), Cancer-related Molecular Pathways (31 papers), Cell death mechanisms and regulation (24 papers), Protein Structure and Dynamics (21 papers) and Biochemical and Molecular Research (20 papers). The work is most often cited by research in Cell Biology (8.5k citations), Molecular Biology (26.8k citations), Physiology (658 citations), Immunology and Allergy (798 citations) and Aging (239 citations). Alfred Wittinghofer has collaborated with scholars based in Germany, Netherlands and United States. Frequent co-authors include Ingrid R. Vetter, Johannes L. Bos, Holger Rehmann, Mohammad Reza Ahmadian, Christian Herrmann, Roger S. Goody, Klaus Scheffzek, Wolfgang Kabsch, Robbert H. Cool and Johan de Rooij. Their work appears in journals such as Journal of Biological Chemistry, Biochemistry, Journal of Molecular Biology, Nature and The EMBO Journal.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact