Matthias Frech

6.3k total citations · 2 hit papers
33 papers, 4.9k citations indexed

About

Matthias Frech is a scholar working on Molecular Biology, Oncology and Cell Biology. According to data from OpenAlex, Matthias Frech has authored 33 papers receiving a total of 4.9k indexed citations (citations by other indexed papers that have themselves been cited), including 24 papers in Molecular Biology, 6 papers in Oncology and 5 papers in Cell Biology. Recurrent topics in Matthias Frech's work include Protein Kinase Regulation and GTPase Signaling (10 papers), Heat shock proteins research (8 papers) and Protein Structure and Dynamics (5 papers). Matthias Frech is often cited by papers focused on Protein Kinase Regulation and GTPase Signaling (10 papers), Heat shock proteins research (8 papers) and Protein Structure and Dynamics (5 papers). Matthias Frech collaborates with scholars based in Germany, France and United Kingdom. Matthias Frech's co-authors include Thilo Stehle, Simon L. Goodman, M. Amin Arnaout, A. Joachimiak, Jian-Ping Xiong, Rongguang Zhang, Brian A. Hemmings, Alfred Wittinghofer, Mirjana Andjelković and Roger Meier and has published in prestigious journals such as Science, Cell and Journal of Biological Chemistry.

In The Last Decade

Matthias Frech

32 papers receiving 4.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand

2002 1.3k citations Matthias Frech et al. profile →
Role of Translocation in the Activation and Function of Protein Kinase B

1997 886 citations Mirjana Andjelković, Dario R. Alessi et al. Journal of Biological Chemistry profile →

Peers

Countries citing papers authored by Matthias Frech

Since Specialization

Citations

This map shows the geographic impact of Matthias Frech's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Matthias Frech with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Matthias Frech more than expected).

Fields of papers citing papers by Matthias Frech

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Matthias Frech. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Matthias Frech. The network helps show where Matthias Frech may publish in the future.

Co-authorship network of co-authors of Matthias Frech

This figure shows the co-authorship network connecting the top 25 collaborators of Matthias Frech. A scholar is included among the top collaborators of Matthias Frech based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Matthias Frech. Matthias Frech is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Visualizing the transiently populated closed-state of human HSP90 ATP binding domain 2022 ·Nature Communications ·(unknown), (unknown), Adrien Favier, Pavel Macek, Elodie Crublet, (unknown), Bernhard Brutscher, Matthias Frech, Pierre Gans, Claire Loison, Jérôme Boisbouvier	15
2	NMR assignment of human HSP90 N-terminal domain bound to a long residence time resorcinol ligand 2022 ·Biomolecular NMR Assignments ·(unknown), Elodie Crublet, Matthias Frech, Jérôme Boisbouvier	1
3	Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2 2021 ·Cell chemical biology ·Benedict‐Tilman Berger, Marta Amaral, Daria B. Kokh, Ariane Nunes‐Alves, Djordje Müsil, Timo Heinrich, Martin Schröder, (unknown), Jing Wang, Iva Navrátilová, Joerg Bomke, Jonathan M. Elkins, Susanne Müller, Matthias Frech, Rebecca C. Wade, Stefan Knapp	50
4	Estimation of Drug-Target Residence Times by τ-Random Acceleration Molecular Dynamics Simulations 2018 ·Journal of Chemical Theory and Computation ·Daria B. Kokh, Marta Amaral, Joerg Bomke, Ulrich Grädler, Djordje Müsil, Hans‐Peter Buchstaller, Matthias Dreyer, Matthias Frech, Maryse Lowinski, François Vallée, Marc Bianciotto, Alexey Rak, Rebecca C. Wade	183
5	Protein conformational flexibility modulates kinetics and thermodynamics of drug binding 2017 ·Nature Communications ·Marta Amaral, Daria B. Kokh, Jörg Bomke, Ansgar Wegener, Hans‐Peter Buchstaller, Hans‐Michael Eggenweiler, Pedro M. Matias, Christian Sirrenberg, Rebecca C. Wade, Matthias Frech	196
6	Structural and Biophysical Characterization of the Syk Activation Switch 2012 ·Journal of Molecular Biology ·Ulrich Grädler, Dániel Schwarz, (unknown), Djordje Müsil, Jörg Bomke, Matthias Frech, Hartmut E. Greiner, Stefan Jäkel, (unknown), (unknown), Ansgar Wegener	64
7	Structure of the Leech Protein Saratin and Characterization of Its Binding to Collagen 2008 ·Journal of Molecular Biology ·Wolfram Gronwald, Jörg Bomke, Till Maurer, (unknown), Fritz Huber, Frank Schumann, Werner Kremer, (unknown), (unknown), Matthias Frech, Hans Robert Kalbitzer	37
8	Features of the Env leader protein and the N-terminal Gag domain of feline foamy virus important for virus morphogenesis 2003 ·Virology ·(unknown), Astrid Schwantes, (unknown), Matthias Frech, Martin Löchelt	35
9	PH Domain of Serine-Threonine Protein Kinase 6 (RAC–PKB): Expression and Binding Assay for Phosphoinositides and lnositol Phosphates 2003 ·Humana Press eBooks ·Matthias Frech, Brian A. Hemmings	0
10	Production and Characterization of Saratin, an Inhibitor of von Willebrand Factor-Dependent Platelet Adhesion to Collagen 2001 ·Seminars in Thrombosis and Hemostasis ·Christopher S. Barnes, (unknown), Matthias Frech, (unknown), (unknown), Ulrike Dahlems, Gerd Gellissen, Marc Hoylaerts	49
11	Specific Interaction of a Novel Foamy Virus Env Leader Protein with the N-Terminal Gag Domain 2001 ·Journal of Virology ·Thomas Wilk, (unknown), Matthias Frech, Stephen D. Fuller, Rolf M. Flügel, Martin Löchelt	61
12	Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex 1999 ·Current Biology ·Wolfgang Ziegler, (unknown), J. Ann Le Good, Richard D. H. Whelan, (unknown), Matthias Frech, Brian A. Hemmings, Peter J. Parker	92
13	Nerve growth factor promotes activation of the α, β and γ isoforms of protein kinase B in PC12 pheochromocytoma cells 1998 ·European Journal of Biochemistry ·Mirjana Andjelković, Hana S. Suidan, Roger Meier, Matthias Frech, Dario R. Alessi, Brian A. Hemmings	58
14	High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity 1997 ·Journal of Biological Chemistry ·Matthias Frech, Mirjana Andjelković, Evan Ingley, K. Kishta Reddy, John R. Falck, Brian A. Hemmings	363
15	Role of Translocation in the Activation and Function of Protein Kinase B breakdown → 1997 ·Journal of Biological Chemistry ·Mirjana Andjelković, Dario R. Alessi, Roger Meier, Anne Fernandez, Ned Lamb, Matthias Frech, Peter Cron, Philip Cohen, John M. Lucocq, Brian A. Hemmings	886
16	Role of Glutamine-61 in the Hydrolysis of GTP by p21H-ras: An Experimental and Theoretical Study 1994 ·Biochemistry ·Matthias Frech, Tom Darden, Lee G. Pedersen, C. K. Foley, Paul S. Charifson, M W Anderson, A. Wittinghofer	112
17	Crystallization and preliminary X-ray structure analysis of thermally unstable p21H−ras guanosine complexes 1994 ·Acta Crystallographica Section D Biological Crystallography ·Klaus Scheffzek, Wolfgang Kabsch, Ilme Schlichting, E.F. Pai, Alfred Lautwein, Matthias Frech, (unknown), Roger S. Goody	8
18	Binding of the h-ras p21 GTPase activating protein by the activated epidermal growth factor receptor leads to inhibition of the p21 GTPase activity in vitro 1992 ·Biochemistry ·Jürgen Serth, Wolfgang Weber, Matthias Frech, A. Wittinghofer, Alfred Pingoud	23
19	Three-dimensional structures of H-ras p21 mutants: Molecular basis for their inability to function as signal switch molecules 1990 ·Cell ·Ute Krengel, Ilme Schlichting, Anna Scherer, (unknown), Matthias Frech, Jacob John, Wolfgang Kabsch, E.F. Pai, Alfred Wittinghofer	333
20	Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction. 1988 ·Journal of Biological Chemistry ·Jacob John, Matthias Frech, Alfred Wittinghofer	174

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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