Robbert H. Cool

7.1k citations

84 papers · 5.7k indexed · 2 hit papers · h-index 37

Impact in

Molecular Biology top 1%
- Protein Kinase Regulation and GTPase Signaling
- Bacterial biofilms and quorum sensing
- Receptor Mechanisms and Signaling
- Cell death mechanisms and regulation
- Phosphodiesterase function and regulation
Molecular Medicine top 1%
- Antibiotic Resistance in Bacteria

Papers in

Molecular Medicine 6
Molecular Biology 62
- Protein Kinase Regulation and GTPase Signaling 19
- Cell death mechanisms and regulation 13
- RNA and protein synthesis mechanisms 10
- RNA Interference and Gene Delivery 8
- Bacterial biofilms and quorum sensing 6

Co-authors: Alfred Wittinghofer Johannes L. Bos Johan de Rooij Wim J. Quax Sebastian Nijman Fried Zwartkruis Mark H. G. Verheijen Gudrun Koch
Journals: Journal of Biological Chemistry (12 papers)Biochemistry (7 papers)European Journal of Biochemistry (4 papers)FEBS Journal (3 papers)Journal of Medicinal Chemistry (3 papers)
Partner nations: Netherlands Germany France

In The Last Decade

Robbert H. Cool

84 papers receiving 5.7k citations

Hit Papers

align trajectories log scale

The Multiple Signaling Systems Regulating Virulence in Pseudomonas aeruginosa 2012 · 551 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2012 Microbiology and Molecular Biology Reviews
1998 Nature

Peers

Countries citing papers authored by Robbert H. Cool

Since Specialization

Citations

This map shows the geographic impact of Robbert H. Cool's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Robbert H. Cool with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Robbert H. Cool more than expected).

Fields of papers citing papers by Robbert H. Cool

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Robbert H. Cool. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Robbert H. Cool. The network helps show where Robbert H. Cool may publish in the future.

Co-authors

The 25 scholars most cited alongside Robbert H. Cool, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Robbert H. Cool Line = papers co-authored together Robbert H. Cool links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos Journal of Medicinal Chemistry ·Deng Chen, Angelina Osipyan, Jeaunice Adriana, Mohammed Abdul Kader, Maxim Gureev, Catharina W. J. Knol, Marie‐Cathérine Sigmund, Zhangping Xiao, Petra E. van der Wouden, Robbert H. Cool, Gerrit J. Poelarends, Frank J. Dekker	2023	6
2	Proteolysis Targeting Chimera (PROTAC) for Macrophage Migration Inhibitory Factor (MIF) Has Anti‐Proliferative Activity in Lung Cancer Cells Angewandte Chemie ·Zhangping Xiao, Shanshan Song, Deng Chen, Ronald van Merkerk, Petra E. van der Wouden, Robbert H. Cool, Wim J. Quax, Gerrit J. Poelarends, Barbro N. Melgert, Frank J. Dekker	2021	3
3	Proteolysis Targeting Chimera (PROTAC) for Macrophage Migration Inhibitory Factor (MIF) Has Anti‐Proliferative Activity in Lung Cancer Cells Angewandte Chemie International Edition ·Zhangping Xiao, Shanshan Song, Deng Chen, Ronald van Merkerk, Petra E. van der Wouden, Robbert H. Cool, Wim J. Quax, Gerrit J. Poelarends, Barbro N. Melgert, Frank J. Dekker	2021	37
4	Small-molecule inhibitors of macrophage migration inhibitory factor (MIF) as an emerging class of therapeutics for immune disorders Drug Discovery Today ·Tjie Kok, Anna A. Wasiel, Robbert H. Cool, Barbro N. Melgert, Gerrit J. Poelarends, Frank J. Dekker	2018	48
5	Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity Oncogene ·Lynda O’Leary, Almer M. van der Sloot, Carlos R. Reis, Shane Deegan, Aideen E. Ryan, Sukhraj Pal Singh Dhami, Laura S. Murillo, Robbert H. Cool, Pedro Corrêa de Sampaio, Kerry Thompson, Gillian Murphy, Wim J. Quax, Luís Serrano, Afshin Samali, Éva Szegezdi	2015	51
6	Assessing Pseudomonas Virulence with Nonmammalian Host: Galleria mellonella Methods in molecular biology ·Gudrun Koch, Pol Nadal‐Jimenez, Robbert H. Cool, Wim J. Quax	2014	36
7	The Multiple Signaling Systems Regulating Virulence in Pseudomonas aeruginosa Microbiology and Molecular Biology Reviews ·Pol Nadal‐Jimenez, Gudrun Koch, Jessica A. Thompson, Karina B. Xavier, Robbert H. Cool, Wim J. Quax Hit paper breakdown →	2012	551
8	Targeting AML through DR4 with a novel variant of rhTRAIL Journal of Cellular and Molecular Medicine ·Éva Szegezdi, Carlos R. Reis, Almer M. van der Sloot, Alessandro Natoni, A. O’Reilly, Janice LV Reeve, Robbert H. Cool, Michael O’Dwyer, Steven Knapper, Luís Serrano, Wim J. Quax, Afshin Samali	2010	19
9	Enhanced Antitumor Efficacy of a DR5-Specific TRAIL Variant over Recombinant Human TRAIL in a Bioluminescent Ovarian Cancer Xenograft Model Clinical Cancer Research ·Evelien W. Duiker, Elisabeth G.E. de Vries, Devalingam Mahalingam, Gert Jan Meersma, Wytske Boersma-van Ek, Harry Hollema, Marjolijn N. Lub-de Hooge, Go M. van Dam, Robbert H. Cool, Wim J. Quax, Afshin Samali, Ate G.J. van der Zee, Steven de Jong	2009	41
10	Role of PvdQ in Pseudomonas aeruginosa virulence under iron-limiting conditions Microbiology ·Pol Nadal‐Jimenez, Gudrun Koch, Evelina Papaioannou, Mariana Wahjudi, Joanna Krzeslak, Tom Coenye, Robbert H. Cool, Wim J. Quax	2009	83
11	Quorum Quenching by an N -Acyl-Homoserine Lactone Acylase from Pseudomonas aeruginosa PAO1 Infection and Immunity ·Charles F. Sio, Linda G. Otten, Robbert H. Cool, Stephen P. Diggle, Peter Braun, Rein Bos, Mavis Daykin, Miguel Cámara, Paul Williams, Wim J. Quax	2006	244
12	Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor Proceedings of the National Academy of Sciences ·Almer M. van der Sloot, Vicente Tur, Éva Szegezdi, Margaret M. Mullally, Robbert H. Cool, Afshin Samali, Luís Serrano, Wim J. Quax	2006	136
13	S‐Decyl‐glutathione nonspecifically stimulates the ATPase activity of the nucleotide‐binding domains of the human multidrug resistance‐associated protein, MRP1 (ABCC1) European Journal of Biochemistry ·Robbert H. Cool, Marloes Veenstra, Jack van de Vossenberg, René I. R. Heyne, Michael Müller, Elisabeth G.E. de Vries, Hendrik W. van Veen, Wil N. Konings	2002	8
14	Activation of hypoxia-inducible factor-1 is modulated by Rac1 in endothelial cells Circulation ·Agnes Görlach, Isabel Diebold, Robbert H. Cool, H. Acker, Joachim Fandrey, Thomas Kietzmann, Rudi Busse	2000	1
15	Mechanism of Regulation of the Epac Family of cAMP-dependent RapGEFs Journal of Biological Chemistry ·Johan de Rooij, Holger Rehmann, Miranda van Triest, Robbert H. Cool, Alfred Wittinghofer, Johannes L. Bos	2000	324
16	Effector Recognition by the Small GTP-binding Proteins Ras and Ral Journal of Biological Chemistry ·Bettina Bauer, Gladys Mirey, Ingrid R. Vetter, Juan A. G. Ranea, Alfonso Valencia, Alfred Wittinghofer, Jacques Camonis, Robbert H. Cool	1999	71
17	Activation of the Small GTPase Ral in Platelets Molecular and Cellular Biology ·Rob M.F. Wolthuis, Barbara Franke, Miranda van Triest, Bettina Bauer, Robbert H. Cool, Jacques Camonis, Jan‐Willem N. Akkerman, Johannes L. Bos	1998	127
18	Effects of ions on the intrinsic activities of c‐H‐ras protein p21 European Journal of Biochemistry ·Michel‐Yves Mistou, Robbert H. Cool, Andrea Parmeggiani	1992	23
19	Substitution of histidine-84 and the GTPase mechanism of elongation factor Tu Biochemistry ·Robbert H. Cool, Andrea Parmeggiani	1991	52
20	Mutagenesis of the NH2-terminal domain of elongation factor Tu Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression ·Füsun Gümü§el, Robbert H. Cool, Albert Weijland, Pieter H. Anborgh, Andrea Parmeggiani	1990	14

About Robbert H. Cool

Robbert H. Cool is a scholar working on Molecular Medicine, Molecular Biology, Immunology, Cell Biology and Genetics, having authored 84 papers that have together received 5.7k indexed citations. Recurring topics across this work include Protein Kinase Regulation and GTPase Signaling (19 papers), Bacterial Genetics and Biotechnology (16 papers), Cell death mechanisms and regulation (13 papers), Macrophage Migration Inhibitory Factor (11 papers), RNA and protein synthesis mechanisms (10 papers), RNA Interference and Gene Delivery (8 papers), Cellular transport and secretion (8 papers) and Bacterial biofilms and quorum sensing (6 papers). The work is most often cited by research in Molecular Biology (4.5k citations), Molecular Medicine (318 citations), Cell Biology (673 citations), Endocrinology (210 citations) and Physiology (177 citations). Robbert H. Cool has collaborated with scholars based in Netherlands, Germany and France. Frequent co-authors include Alfred Wittinghofer, Johannes L. Bos, Johan de Rooij, Wim J. Quax, Sebastian Nijman, Fried Zwartkruis, Mark H. G. Verheijen, Gudrun Koch, Pol Nadal‐Jimenez and Karina B. Xavier. Their work appears in journals such as Journal of Biological Chemistry, Biochemistry, European Journal of Biochemistry, FEBS Journal and Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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