Ralph Mazitschek

13.1k citations

150 papers · 10.1k indexed · 4 hit papers · h-index 49

Impact in

Molecular Biology top 0.5%
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Chemical Synthesis and Analysis
Oncology top 1%
- Peptidase Inhibition and Analysis

Papers in

Aging 3
Molecular Biology 115
- Histone Deacetylase Inhibitors Research 56
- Protein Degradation and Inhibitors 34
- Ubiquitin and proteasome pathways 16
- Epigenetics and DNA Methylation 11

Co-authors: James E. Bradner Stephen J. Haggarty Athanassios Giannis Ralph Weissleder Scott A. Hilderbrand Umut Özcan Mario Andrés Salazar Hernández Edward F. Greenberg
Journals: Blood (12 papers)Angewandte Chemie International Edition (9 papers)ACS Chemical Biology (6 papers)Cell chemical biology (6 papers)Nature Communications (4 papers)
Partner nations: United States Germany United Kingdom

In The Last Decade

Ralph Mazitschek

148 papers receiving 9.9k citations

Hit Papers

align trajectories log scale

Treatment of Obesity with Celastrol 2015 · 591 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2015 Cell
2012 Blood
2010 Nature Chemical Biology
2009 Nature

Peers

Countries citing papers authored by Ralph Mazitschek

Since Specialization

Citations

This map shows the geographic impact of Ralph Mazitschek's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ralph Mazitschek with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ralph Mazitschek more than expected).

Fields of papers citing papers by Ralph Mazitschek

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ralph Mazitschek. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ralph Mazitschek. The network helps show where Ralph Mazitschek may publish in the future.

Co-authors

The 25 scholars most cited alongside Ralph Mazitschek, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Ralph Mazitschek Line = papers co-authored together Ralph Mazitschek links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss Cell Metabolism ·Dongxian Guan, Yuqin Men, Alexander Bartlett, Mario Andrés Salazar Hernández, Jie Xu, Xinchi Yi, Hu-song Li, Dong Kong, Ralph Mazitschek, Umut Özcan	2024	9
2	The cyclimids: Degron-inspired cereblon binders for targeted protein degradation Cell chemical biology ·Saki Ichikawa, N. Connor Payne, Wenqing Xu, Chia‐Fu Chang, Nandini Vallavoju, Spencer Frome, Hope A. Flaxman, Ralph Mazitschek, Christina M. Woo	2024	17
3	Inhibiting the Keap1/Nrf2 Protein‐Protein Interaction with Protein‐Like Polymers Advanced Materials ·Kendal P. Carrow, H. Hamilton, Madeline P. Hopps, Yang Li, Baofu Qiao, N. Connor Payne, Matthew P. Thompson, Xiaoyu Zhang, Assa Magassa, Mara Fattah, Shivangi Agarwal, Michael P. Vincent, Marina Buyanova, Paul A. Bertin, Ralph Mazitschek, Mónica Olvera de la Cruz, Delinda A. Johnson, Jeffrey A. Johnson, Nathan C. Gianneschi	2024	16
4	Identification of a Polypeptide Inhibitor of O-GlcNAc Transferase with Picomolar Affinity Journal of the American Chemical Society ·Forrest A. Hammel, N. Connor Payne, Victoria M. Marando, Ralph Mazitschek, Suzanne Walker	2024	1
5	Nitrilase mediated mild hydrolysis of a carbon‐14 nitrile for the radiosynthesis of 4‐(7‐hydroxycarbamoyl‐[1‐¹⁴C‐heptanoyl]‐oxy)‐benzoic acid methyl ester, [¹⁴C]‐SHP‐141: A novel class I/II histone deacetylase (HDAC) inhibitor Journal of Labelled Compounds and Radiopharmaceuticals ·Sean L. Kitson, William Watters, Thomas S. Moody, Todd Chappell, Ralph Mazitschek	2023	1
6	Tiny Titans: Nanobodies as Powerful Tools for TR‐FRET Assay Development Analysis & Sensing ·N. Connor Payne, Ralph Mazitschek	2022	5
7	Resolving the deceptive isoform and complex selectivity of HDAC1/2 inhibitors Cell chemical biology ·N. Connor Payne, Ralph Mazitschek	2022	18
8	A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader Cell chemical biology ·N. Connor Payne, Semer Maksoud, Bakhos A. Tannous, Ralph Mazitschek	2022	29
9	Bright and stable luminescent probes for target engagement profiling in live cells Nature Chemical Biology ·N. Connor Payne, Alena S. Kalyakina, Kritika Singh, Mark A. Tye, Ralph Mazitschek	2021	44
10	Antifungal Activity of Gepinacin Scaffold Glycosylphosphatidylinositol Anchor Biosynthesis Inhibitors with Improved Metabolic Stability Antimicrobial Agents and Chemotherapy ·Sean D. Liston, Luke Whitesell, Catherine A. McLellan, Ralph Mazitschek, Vidmantas Petraitis, Rūta Petraitienė, Povilas Kavaliauskas, Thomas J. Walsh, Leah E. Cowen	2020	8
11	Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory ACS Chemical Neuroscience ·Wen‐Ning Zhao, Balaram Ghosh, Marshall Tyler, Jasmin Lalonde, Nadine F. Joseph, Nina Kosaric, Daniel M. Fass, Li‐Huei Tsai, Ralph Mazitschek, Stephen J. Haggarty	2018	19
12	HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy Pain ·Karen Krukowski, Jiacheng Ma, Olga Golonzhka, Geoffroy Laumet, T. Gutti, John H. van Duzer, Ralph Mazitschek, Matthew Jarpe, Cobi J. Heijnen, Annemieke Kavelaars	2017	145
13	Synthesis and biological evaluation of Santacruzamate-A based analogues Bioorganic & Medicinal Chemistry ·Rosario Randino, Patrizia Gazzerro, Ralph Mazitschek, Manuela Rodriquez	2017	8
14	Blocking HDAC3 in Bone Marrow Stromal Cells Has Direct Anti-Multiple Myeloma Effect and Modulates T Cell Function Blood ·Matthew Ho, Jiye Liu, Alireza Kalbasi, Takeshi Harada, Teru Hideshima, Paul Dowling, Yu‐Tzu Tai, Li Zhang, Kenneth Wen, Ralph Mazitschek, Amanda McCann, Kenneth C. Anderson, Peter O’Gorman, Giada Bianchi	2017	2
15	Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase Inhibitors by Multimodality Molecular Imaging in Living Subjects Cancer Research ·Carmel T. Chan, Jun Qi, William Smith, R. Paranol, Ralph Mazitschek, Nathan West, Robert E. Reeves, Gabriela Chiosis, Stuart L. Schreiber, James E. Bradner, Ramasamy Paulmurugan, Sanjiv S. Gambhir	2014	12
16	Histone Deacetylase 6 and Heat Shock Protein 90 Control the Functions of Foxp3 ⁺ T-Regulatory Cells Molecular and Cellular Biology ·Edwin F. de Zoeten, Liqing Wang, Kyle V. Butler, Ulf H. Beier, Tatiana Akimova, Hong Sai, James E. Bradner, Ralph Mazitschek, Alan P. Kozikowski, Patrick Matthias, Wayne W. Hancock	2011	217
17	Halofuginone Inhibits T _H 17 Cell Differentiation by Activating the Amino Acid Starvation Response Science ·Mark S. Sundrud, Sergei B. Koralov, Markus Feuerer, Dinis Pedro Calado, Aimee ElHed Kozhaya, Ava Rhule-Smith, Rachel E. Lefebvre, Derya Unutmaz, Ralph Mazitschek, Hanspeter Waldner, Malcolm Whitman, Tracy Keller, Anjana Rao	2009	323
18	Ubiquitin Proteasome System Stress Underlies Synergistic Killing of Ovarian Cancer Cells by Bortezomib and a Novel HDAC6 Inhibitor Clinical Cancer Research ·Martina Bazzaro, Zhenhua Lin, Antonio Santillan, Michael K. Lee, Mei‐Cheng Wang, Kwun Chuen Gary Chan, Robert E. Bristow, Ralph Mazitschek, James E. Bradner, Richard B.S. Roden	2008	107
19	Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2 European Journal of Biochemistry ·Vladimir Kirkin, Ralph Mazitschek, Jaya Krishnan, Anja Steffen, Johannes Waltenberger, Michael S. Pepper, Athanassios Giannis, Jonathan P. Sleeman	2001	2
20	Characterization of indolinones which preferentially inhibit VEGF‐C‐ and VEGF‐D‐induced activation of VEGFR‐3 rather than VEGFR‐2 European Journal of Biochemistry ·Vladimir Kirkin, Ralph Mazitschek, Jaya Krishnan, Anja Steffen, Johannes Waltenberger, Michael S. Pepper, Athanassios Giannis, Jonathan P. Sleeman	2001	88

About Ralph Mazitschek

Ralph Mazitschek is a scholar working on Aging, Molecular Biology, Oncology, Organic Chemistry and Hematology, having authored 150 papers that have together received 10.1k indexed citations. Recurring topics across this work include Histone Deacetylase Inhibitors Research (56 papers), Protein Degradation and Inhibitors (34 papers), Peptidase Inhibition and Analysis (20 papers), Ubiquitin and proteasome pathways (16 papers), Click Chemistry and Applications (14 papers), Multiple Myeloma Research and Treatments (13 papers), Malaria Research and Control (13 papers) and Epigenetics and DNA Methylation (11 papers). The work is most often cited by research in Molecular Biology (7.0k citations), Oncology (1.9k citations), Biological Psychiatry (162 citations), Aging (108 citations) and Organic Chemistry (1.7k citations). Ralph Mazitschek has collaborated with scholars based in United States, Germany and United Kingdom. Frequent co-authors include James E. Bradner, Stephen J. Haggarty, Athanassios Giannis, Ralph Weissleder, Scott A. Hilderbrand, Umut Özcan, Mario Andrés Salazar Hernández, Edward F. Greenberg, Jaemin Lee and Jun‐Li Liu. Their work appears in journals such as Blood, Angewandte Chemie International Edition, ACS Chemical Biology, Cell chemical biology and Nature Communications.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact