Lee A. Witters

23.0k citations

133 papers · 19.4k indexed · 6 hit papers · h-index 74

Impact in

Physiology top 0.1%
- Adipose Tissue and Metabolism
Molecular Biology top 0.1%
- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Peroxisome Proliferator-Activated Receptors
- PI3K/AKT/mTOR signaling in cancer

Papers in

Physiology 11
- Adipose Tissue and Metabolism 25
Clinical Biochemistry 13
- Metabolism and Genetic Disorders 13

Co-authors: Bruce E. Kemp David Stapleton Belinda J. Michell Ken I. Mitchelhill Anthony R. Means Reuben J. Shaw Nabeel Bardeesy Lewis C. Cantley
Journals: Journal of Biological Chemistry (32 papers)Biochemical and Biophysical Research Communications (13 papers)Biochemical Journal (10 papers)Archives of Biochemistry and Biophysics (7 papers)American Journal of Physiology-Endocrinology and Metabolism (7 papers)
Partner nations: United States Australia Canada

In The Last Decade

Lee A. Witters

133 papers receiving 18.9k citations

Hit Papers

6 papers align trajectories log scale

The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases 2005 · 840 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2005 Journal of Biological Chemistry
2004 Genes & Development
2004 Proceedings of the National Academy of Sciences
1999 American Journal of Physiology-Endocrinology and Metabolism
1999 FEBS Letters
1996 Journal of Biological Chemistry

Peers

Countries citing papers authored by Lee A. Witters

Since Specialization

Citations

This map shows the geographic impact of Lee A. Witters's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lee A. Witters with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lee A. Witters more than expected).

Fields of papers citing papers by Lee A. Witters

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lee A. Witters. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lee A. Witters. The network helps show where Lee A. Witters may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Lee A. Witters, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Lee A. Witters Line = papers co-authored together Lee A. Witters links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis Journal of Clinical Investigation ·István Vadász, Laura A. Dada, Arturo Briva, Humberto E. Trejo Bittar, Lynn C. Welch, Jiwang Chen, Péter T. Tóth, Emilia Lecuona, Lee A. Witters, Paul T. Schumacker, Navdeep S. Chandel, Werner Seeger, Jacob I. Sznajder	2008	142
2	Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance Cell Metabolism ·Kristin A. Anderson, Thomas J. Ribar, Fumin Lin, Pamela Noeldner, Michelle Green, Michael J. Muehlbauer, Lee A. Witters, Bruce E. Kemp, Anthony R. Means	2008	300
3	The AMPK γ1 R70Q mutant regulates multiple metabolic and growth pathways in neonatal cardiac myocytes American Journal of Physiology-Heart and Circulatory Physiology ·焦同梅, Lee A. Witters, Michael F. Allard, Martin E. Young, Jason R.B. Dyck	2007	6
4	Silencing the constitutive active transcription factor CREB by the LKB1‐SIK signaling cascade FEBS Journal ·Yoshiko Katoh, Hiroshi Takemori, Xing‐zi Lin, Mitsuhiro Tamura, Masaaki Muraoka, Rovshan Gurbanlı, Yuko Tsuchiya, Min Li, Junko Doi, Akira Miyauchi, Lee A. Witters, Haruki Nakamura, Mitsuhiro Okamoto	2006	132
5	Up-regulation of AMP-activated Kinase by Dysfunctional Cystic Fibrosis Transmembrane Conductance Regulator in Cystic Fibrosis Airway Epithelial Cells Mitigates Excessive Inflammation Journal of Biological Chemistry ·Kenneth R. Hallows, Adam Fitch, Christine Richardson, Paul R. Reynolds, John P. Clancy, Pierre C. Dagher, Lee A. Witters, Jay K. Kolls, Joseph M. Pilewski	2005	62
6	AMP-activated Protein Kinase β Subunit Tethers α and γ Subunits via Its C-terminal Sequence (186–270) Journal of Biological Chemistry ·Tristan J. Iseli, Mark Walter, Bryce J. W. van Denderen, Frosa Katsis, Lee A. Witters, Bruce E. Kemp, Belinda J. Michell, David Stapleton	2005	111
7	The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases Journal of Biological Chemistry ·Perera Tk, Kristin A. Anderson, Jeanne M. Franzone, Bruce E. Kemp, Anthony R. Means, Lee A. Witters Hit paper breakdown →	2005	840
8	The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress Proceedings of the National Academy of Sciences ·Reuben J. Shaw, Burhanuddin Burhanuddin, Nabeel Bardeesy, Perera Tk, Lee A. Witters, Ronald A. DePinho, Lewis C. Cantley Hit paper breakdown →	2004	1484
9	AMPK β Subunit Targets Metabolic Stress Sensing to Glycogen Current Biology ·Galina Polekhina, Irenius Raya Gara Ama, Belinda J. Michell, Bryce van Denderen, Sid Murthy, Susanne C. Feil, Ian G. Jennings, Duncan J. Campbell, Lee A. Witters, Michael W. Parker, Bruce E. Kemp, David Stapleton	2003	353
10	Insulin‐like growth factor 1 is essential for normal dendritic growth Journal of Neuroscience Research ·Clara M. Cheng, Ronald F. Mervis, Shui‐Lin Niu, Norman Salem, Lee A. Witters, Victor Tseng, Rickey R. Reinhardt, Carolyn A. Bondy	2003	128
11	The blooming of the French lilac Journal of Clinical Investigation ·Lee A. Witters	2001	9
12	Malonyl-CoA Decarboxylase Is Not a Substrate of AMP-Activated Protein Kinase in Rat Fast-Twitch Skeletal Muscle or an Islet Cell Line Archives of Biochemistry and Biophysics ·V. V. Yudovina, Michael F. Hirshman, Kei Sakamoto, Bruce E. Kemp, Stephen J. Gould, Laurie J. Goodyear, Lee A. Witters	2001	43
13	AMP-Activated Protein Kinase Is Activated by the Stimulations of Gq-Coupled Receptors Biochemical and Biophysical Research Communications ·Kazuhiro Kishi, Tomoyuki Yuasa, Asako Minami, Simpel Rani, Akifumi Hagi, Hideki Hayashi, Bruce E. Kemp, Lee A. Witters, Yousuke Ebina	2000	54
14	Cellular Distribution and Developmental Expression of AMP‐Activated Protein Kinase Isoforms in Mouse Central Nervous System Journal of Neurochemistry ·Ann M. Turnley, David Stapleton, Richard J. Mann, Lee A. Witters, Bruce E. Kemp, Perry F. Bartlett	1999	224
15	Identification of human acetyl-CoA carboxylase isozymes in tissue and in breast cancer cells International Journal of Biochemistry ·Lee A. Witters, Paulina Winiarska, J. De Grotte, Wilks Ak, Francis P. Kuhajda	1994	49
16	Hepatic 5′-AMP-Activated Protein Kinase: Zonal Distribution and Relationship to Acetyl-CoA Carboxylase Activity in Varying Nutritional States Archives of Biochemistry and Biophysics ·Lee A. Witters, Guoquan Gao, Bruce E. Kemp, Bjørn Quistorff	1994	61
17	Acetyl‐CoA carboxylase in reuber hepatoma cells: Variation in enzyme activity, insulin regulation, and cellular lipid content Journal of Cellular Biochemistry ·Abdisamed M Yousuf, Joseph L. Evans, L. VASAROS, Thomas D. Watts, Lee A. Witters	1992	17
18	Regulation of intracellular acetyl-CoA carboxylase by ATP depletors mimics the action of the 5′-AMP-activated protein kinase Biochemical and Biophysical Research Communications ·Lee A. Witters, L. VASAROS, Z Mohsenifar	1991	42
19	Hepatic zonation of insulin‐stimulated tyrosine phosphorylation FEBS Letters ·Abdisamed M Yousuf, Bjørn Quistorff, Lee A. Witters	1990	2
20	Protein phosphorylation and dephosphorylation Current Opinion in Cell Biology ·Lee A. Witters	1990	33

About Lee A. Witters

Lee A. Witters is a scholar working on Physiology, Clinical Biochemistry, Molecular Biology, Cell Biology and Physiology, having authored 133 papers that have together received 19.4k indexed citations. Recurring topics across this work include Metabolism, Diabetes, and Cancer (79 papers), Pancreatic function and diabetes (44 papers), Adipose Tissue and Metabolism (25 papers), Peroxisome Proliferator-Activated Receptors (22 papers), Mitochondrial Function and Pathology (13 papers), Metabolism and Genetic Disorders (13 papers), Biotin and Related Studies (13 papers) and Protein Kinase Regulation and GTPase Signaling (11 papers). The work is most often cited by research in Physiology (5.5k citations), Molecular Biology (14.5k citations), Physiology (753 citations), Cancer Research (2.2k citations) and Endocrinology, Diabetes and Metabolism (2.3k citations). Lee A. Witters has collaborated with scholars based in United States, Australia and Canada. Frequent co-authors include Bruce E. Kemp, David Stapleton, Belinda J. Michell, Ken I. Mitchelhill, Anthony R. Means, Reuben J. Shaw, Nabeel Bardeesy, Lewis C. Cantley, Ronald A. DePinho and Asish K. Saha. Their work appears in journals such as Journal of Biological Chemistry, Biochemical and Biophysical Research Communications, Biochemical Journal, Archives of Biochemistry and Biophysics and American Journal of Physiology-Endocrinology and Metabolism.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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