Thomas A. Milne

12.4k total citations · 6 hit papers
86 papers, 8.2k citations indexed

About

Thomas A. Milne is a scholar working on Molecular Biology, Hematology and Public Health, Environmental and Occupational Health. According to data from OpenAlex, Thomas A. Milne has authored 86 papers receiving a total of 8.2k indexed citations (citations by other indexed papers that have themselves been cited), including 68 papers in Molecular Biology, 31 papers in Hematology and 10 papers in Public Health, Environmental and Occupational Health. Recurrent topics in Thomas A. Milne's work include Genomics and Chromatin Dynamics (29 papers), Acute Myeloid Leukemia Research (26 papers) and Protein Degradation and Inhibitors (25 papers). Thomas A. Milne is often cited by papers focused on Genomics and Chromatin Dynamics (29 papers), Acute Myeloid Leukemia Research (26 papers) and Protein Degradation and Inhibitors (25 papers). Thomas A. Milne collaborates with scholars based in United Kingdom, United States and Canada. Thomas A. Milne's co-authors include C. David Allis, Jay L. Hess, Robert G. Roeder, Yali Dou, Hugh W. Brock, Joanna Wysocka, Mary Ellen Martin, Denise Gibbs, Tomek Swigut and Brian T. Chait and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Thomas A. Milne

75 papers receiving 8.1k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling

2006 886 citations Joanna Wysocka, Thomas A. Milne et al. profile →
MLL Targets SET Domain Methyltransferase Activity to Hox Gene Promoters

2002 833 citations Thomas A. Milne, Scott Briggs et al. Molecular Cell profile →
WDR5 Associates with Histone H3 Methylated at K4 and Is Essential for H3 K4 Methylation and Vertebrate Development

2005 640 citations Joanna Wysocka, Thomas A. Milne et al. Cell profile →
Regulation of MLL1 H3K4 methyltransferase activity by its core components

2006 602 citations Thomas A. Milne, Alexander J. Ruthenburg et al. profile →
Physical Association and Coordinate Function of the H3 K4 Methyltransferase MLL1 and the H4 K16 Acetyltransferase MOF

2005 532 citations Thomas A. Milne, Joanna Wysocka et al. Cell profile →
Menin Associates with a Trithorax Family Histone Methyltransferase Complex and with the Hoxc8 Locus

2004 504 citations Thomas A. Milne, Jay L. Hess et al. Molecular Cell profile →

Peers

Countries citing papers authored by Thomas A. Milne

Since Specialization

Citations

This map shows the geographic impact of Thomas A. Milne's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas A. Milne with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas A. Milne more than expected).

Fields of papers citing papers by Thomas A. Milne

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas A. Milne. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas A. Milne. The network helps show where Thomas A. Milne may publish in the future.

Co-authorship network of co-authors of Thomas A. Milne

This figure shows the co-authorship network connecting the top 25 collaborators of Thomas A. Milne. A scholar is included among the top collaborators of Thomas A. Milne based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Thomas A. Milne. Thomas A. Milne is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement 2025 ·JACS Au ·(unknown), Shozeb Haider, Thomas A. Milne, Michael J. Booth	0
2	A genome-wide screen identifies Runx2 as a novel regulator of hematopoietic stem cell expansion and T-cell commitment 2025 ·Blood ·(unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), Elizabeth Brown, Marlies Vanden Bempt, (unknown), Joydeep Bhadury, Thomas A. Milne, Adam C. Wilkinson	0
3	Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking 2025 ·Chemical Science ·(unknown), Thomas A. Milne, Michael J. Booth	0
4	DYRK1A inhibition results in MYC and ERK activation rendering KMT2A-R acute lymphoblastic leukemia cells sensitive to BCL2 inhibition 2025 ·Leukemia ·(unknown), Gerald Wertheim, Shikha Gaur, (unknown), Joseph P. Loftus, (unknown), Anil Kumar, Srividya Swaminathan, Rahul S. Bhansali, Wayne E. Childers, Huimin Geng, Thomas A. Milne, Xianxin Hua, Kathrin M. Bernt, Thierry Besson, Junwei Shi, John D. Crispino, Martin Carroll, Sarah K. Tasian, Christian Hurtz	1
5	Harnessing BET-Bromodomain Assisted Nuclear Import for Targeted Subcellular Localization and Enhanced Efficacy of Antisense Oligonucleotides 2025 ·Journal of the American Chemical Society ·(unknown), Marta Cadeddu, Peter L. Oliver, Thomas A. Milne, Michael J. Booth	0
6	Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia 2024 ·RSC Medicinal Chemistry ·(unknown), (unknown), (unknown), Sébastien R. G. Galan, (unknown), (unknown), Carole J. R. Bataille, Thomas Jackson, (unknown), Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell	1
7	Identification of a Novel Chromatin Structure Associated with the Transcriptional Response to Menin Inhibitors in AML 2024 ·Blood ·Pablo R. Freire, (unknown), Elizabeth T. Ener, Jevon Cutler, Christian Marinaccio, (unknown), Thomas A. Milne, Scott A. Armstrong	0
8	Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell lines 2023 ·European Journal of Medicinal Chemistry ·(unknown), Sébastien R. G. Galan, (unknown), Thomas Jackson, (unknown), (unknown), (unknown), Tom S. Carter, (unknown), (unknown), (unknown), Carole J. R. Bataille, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Alan Naylor, Graham M. Wynne, Angela J. Russell	5
9	Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation 2023 ·ACS Chemical Biology ·(unknown), M. Teresa Serafini, Emma K. Grant, (unknown), (unknown), Matthias Schiedel, M.A. McDonough, (unknown), (unknown), (unknown), (unknown), Philip C. Biggin, Fernanda Duarte, Thomas A. Milne, Jacob T. Bush, Stuart J. Conway	1
10	Bispecific CAR-iNKT Immunotherapy for High Risk MLL-Rearranged Acute Lymphoblastic Leukemia 2023 ·Blood ·Hongwei Ren, Natalina Elliott, (unknown), Joe W. Cross, (unknown), (unknown), Irene Roberts, Christina Halsey, Thomas A. Milne, Anindita Roy, Anastasios Karadimitris	4
11	The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes 2020 ·Blood ·Hua Peng, Joanna Hester, (unknown), Rong Li, Bethan Psaila, Anindita Roy, Carole J. R. Bataille, Graham M. Wynne, Thomas Jackson, Thomas A. Milne, Angela J. Russell, James Davies, Irene Roberts, Fadi Issa, Suzanne M. Watt	20
12	The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia 2018 ·Nature Communications ·Akihiko Numata, Hui Si Kwok, Akira Kawasaki, Jia Li, Qiling Zhou, Jon Kerry, Touati Benoukraf, Deepak Bararia, Feng Li, Erica Ballabio, Marta Tapia, Aniruddha J. Deshpande, Robert S. Welner, Ruud Delwel, Henry Yang, Thomas A. Milne, Reshma Taneja, Daniel G. Tenen	21
13	MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome 2016 ·Cancer Cell ·Vaia Stavropoulou, (unknown), Laurent Brault, Mathijs A. Sanders, Sabine Juge, (unknown), Alexandar Tzankov, Michelina Iacovino, I‐Jun Lau, Thomas A. Milne, Hélène Royo, Michael Kyba, Peter J.M. Valk, Antoine H.F.M. Peters, Juerg Schwaller	151
14	Intragenic Enhancers Act as Alternative Promoters 2012 ·Molecular Cell ·Monika S. Kowalczyk, Jim R. Hughes, David Garrick, Magnus Lynch, Jacqueline A. Sharpe, Jacqueline A. Sloane-Stanley, Simon J. McGowan, Marco De Gobbi, (unknown), Douglas Vernimmen, Jill M. Brown, (unknown), Licio Collavin, Richard J. Gibbons, Jonathan Flint, Stephen Taylor, Veronica J. Buckle, Thomas A. Milne, W. G. Wood, Douglas R. Higgs	194
15	Multiple Interactions Recruit MLL1 and MLL1 Fusion Proteins to the HOXA9 Locus in Leukemogenesis 2010 ·Molecular Cell ·Thomas A. Milne, Jaehoon Kim, Gang Greg Wang, Sonja C. Stadler, Venkatesha Basrur, Sarah J. Whitcomb, Zhanxin Wang, Alexander J. Ruthenburg, Kojo S.J. Elenitoba‐Johnson, Robert G. Roeder, C. David Allis	169
16	Interaction of MLL Amino Terminal Sequences with Menin Is Required for Transformation 2007 ·Cancer Research ·Corrado Caslini, Zhaohai Yang, (unknown), Thomas A. Milne, Robert K. Slany, Jay L. Hess	164
17	Leukemogenic MLL Fusion Proteins Bind across a Broad Region of the Hox a9 Locus, Promoting Transcription and Multiple Histone Modifications 2005 ·Cancer Research ·Thomas A. Milne, Mary Ellen Martin, Hugh W. Brock, Robert K. Slany, Jay L. Hess	141
18	Taking LSD1 to a New High 2005 ·Cell ·Joanna Wysocka, Thomas A. Milne, C. David Allis	35
19	MLL Targets SET Domain Methyltransferase Activity to Hox Gene Promoters breakdown → 2002 ·Molecular Cell ·Thomas A. Milne, Scott Briggs, Hugh W. Brock, Mary Ellen Martin, Denise Gibbs, C. David Allis, Jay L. Hess	833
20	The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs 1999 ·Molecular and General Genetics MGG ·Thomas A. Milne, David Sinclair, Hugh W. Brock	74

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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