Douglas R. Higgs

32.6k total citations · 1 hit paper
323 papers, 21.4k citations indexed

About

Douglas R. Higgs is a scholar working on Molecular Biology, Genetics and Hematology. According to data from OpenAlex, Douglas R. Higgs has authored 323 papers receiving a total of 21.4k indexed citations (citations by other indexed papers that have themselves been cited), including 192 papers in Molecular Biology, 161 papers in Genetics and 90 papers in Hematology. Recurrent topics in Douglas R. Higgs's work include Hemoglobinopathies and Related Disorders (157 papers), Genomics and Chromatin Dynamics (82 papers) and Iron Metabolism and Disorders (66 papers). Douglas R. Higgs is often cited by papers focused on Hemoglobinopathies and Related Disorders (157 papers), Genomics and Chromatin Dynamics (82 papers) and Iron Metabolism and Disorders (66 papers). Douglas R. Higgs collaborates with scholars based in United Kingdom, United States and Jamaica. Douglas R. Higgs's co-authors include Richard J. Gibbons, D. J. Weatherall, W. G. Wood, Helena Ayyub, Jim R. Hughes, Robert D. Nicholls, Andrew P. Jarman, David Garrick, J. B. Clegg and J. B. Clegg and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Douglas R. Higgs

317 papers receiving 20.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16

1985 518 citations Robert D. Nicholls, Douglas R. Higgs et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Douglas R. Higgs United Kingdom	83	13.1k	7.7k	5.4k	5.3k	2.2k	323	21.4k
Haig H. Kazazian United States	74	17.2k 1.3×	2.8k 0.4×	5.2k 1.0×	3.4k 0.7×	731 0.3×	193	23.5k
Ad Geurts van Kessel Netherlands	63	8.0k 0.6×	2.1k 0.3×	4.8k 0.9×	2.5k 0.5×	324 0.1×	256	15.6k
Frank Costantini United States	69	17.6k 1.3×	1.5k 0.2×	5.6k 1.0×	1.3k 0.3×	1.4k 0.6×	145	24.6k
Gerd A. Blobel United States	71	13.0k 1.0×	1.7k 0.2×	1.6k 0.3×	2.0k 0.4×	899 0.4×	185	15.7k
Karl V. Voelkerding United States	32	11.2k 0.9×	1.6k 0.2×	9.8k 1.8×	1.2k 0.2×	1.1k 0.5×	86	23.1k
Margaret A. Goodell United States	74	14.5k 1.1×	5.8k 0.7×	1.9k 0.4×	6.5k 1.2×	1.6k 0.7×	217	24.7k
Michael L. Cleary United States	84	15.3k 1.2×	2.9k 0.4×	2.2k 0.4×	5.6k 1.1×	455 0.2×	206	23.2k
Peter Marynen Belgium	67	6.8k 0.5×	1.8k 0.2×	3.1k 0.6×	2.6k 0.5×	428 0.2×	289	14.9k
Argiris Efstratiadis United States	73	20.1k 1.5×	1.2k 0.2×	8.5k 1.6×	587 0.1×	1.3k 0.6×	120	29.0k
Andrew O.M. Wilkie United Kingdom	66	9.3k 0.7×	1.5k 0.2×	9.4k 1.7×	649 0.1×	570 0.3×	241	15.7k

Countries citing papers authored by Douglas R. Higgs

Since Specialization

Citations

This map shows the geographic impact of Douglas R. Higgs's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Douglas R. Higgs with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Douglas R. Higgs more than expected).

Fields of papers citing papers by Douglas R. Higgs

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Douglas R. Higgs. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Douglas R. Higgs. The network helps show where Douglas R. Higgs may publish in the future.

Co-authorship network of co-authors of Douglas R. Higgs

This figure shows the co-authorship network connecting the top 25 collaborators of Douglas R. Higgs. A scholar is included among the top collaborators of Douglas R. Higgs based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Douglas R. Higgs. Douglas R. Higgs is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Kassouf, Mira, Matthew Gosden, Maria Suciu, et al.. (2025). The α-globin super-enhancer acts in an orientation-dependent manner. Nature Communications. 16(1). 1033–1033. 5 indexed citations

Frost, Joe N., Megan R. Teh, Mohsin Badat, et al.. (2025). Ancient genomic linkage of α-globin and Nprl3 couples metabolism with erythropoiesis. Nature Communications. 16(1). 2749–2749.

Tsang, Felice Ho‐Ching, et al.. (2024). The characteristics of CTCF binding sequences contribute to enhancer blocking activity. Nucleic Acids Research. 52(17). 10180–10193. 4 indexed citations

Camellato, Brendan, Leslie A. Mitchell, Christian Babbs, et al.. (2023). Super-enhancers include classical enhancers and facilitators to fully activate gene expression. Cell. 186(26). 5826–5839.e18. 86 indexed citations

Badat, Mohsin, Hua Peng, Siobhan Rice, et al.. (2023). Direct correction of haemoglobin E β-thalassaemia using base editors. Nature Communications. 14(1). 2238–2238. 17 indexed citations

Miyata, Masato, Nynke Gillemans, Dorit Hockman, et al.. (2020). An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells. Blood. 136(3). 269–278. 14 indexed citations

Oudelaar, A. Marieke, James Davies, Lars L. P. Hanssen, et al.. (2018). Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains. Nature Genetics. 50(12). 1744–1751. 134 indexed citations

Jeziorska, Danuta M., Robert Murray, Marco De Gobbi, et al.. (2017). DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease. Proceedings of the National Academy of Sciences. 114(36). E7526–E7535. 105 indexed citations

Hanssen, Lars L. P., Mira Kassouf, A. Marieke Oudelaar, et al.. (2017). Tissue-specific CTCF–cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo. Nature Cell Biology. 19(8). 952–961. 150 indexed citations

10.

Renella, Raffaele, Nigel Roberts, Jill M. Brown, et al.. (2011). Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1α localization in erythroblasts. Blood. 117(25). 6928–6938. 34 indexed citations

11.

Lower, Karen M., Jim R. Hughes, Marco De Gobbi, et al.. (2009). Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition. Proceedings of the National Academy of Sciences. 106(51). 21771–21776. 74 indexed citations

12.

Vernimmen, Douglas, Jacqueline A. Sharpe, Jacqueline A. Sloane-Stanley, et al.. (2009). Chromosome looping at the human α-globin locus is mediated via the major upstream regulatory element (HS −40). Blood. 114(19). 4253–4260. 71 indexed citations

13.

Muers, Mary, Jacqueline A. Sharpe, David Garrick, et al.. (2007). Defining the Cause of Skewed X-Chromosome Inactivation in X-Linked Mental Retardation by Use of a Mouse Model. The American Journal of Human Genetics. 80(6). 1138–1149. 24 indexed citations

14.

Higgs, Douglas R., David Garrick, Eduardo Anguita, et al.. (2005). Understanding α‐Globin Gene Regulation: Aiming to Improve the Management of Thalassemia. Annals of the New York Academy of Sciences. 1054(1). 92–102. 34 indexed citations

15.

Higgs, Douglas R.. (2005). alpha thalassemia as an acquired molecular defect in myelodysplasia. Haematologica. 90(11). 1441–1442.

16.

Gibbons, Richard J., Andrea Pellagatti, David Garrick, et al.. (2003). Identification of acquired somatic mutations in the gene encoding chromatin-remodeling factor ATRX in the α-thalassemia myelodysplasia syndrome (ATMDS). Nature Genetics. 34(4). 446–449. 97 indexed citations

17.

Higgs, Douglas R., et al.. (1999). The Pattern of Replication at a Human Telomeric Region (16p13.3): Its Relationship to Chromosome Structure and Gene Expression. Human Molecular Genetics. 8(8). 1373–1386. 75 indexed citations

18.

Gibbons, Richard J., David J. Picketts, Laurent Villard, & Douglas R. Higgs. (1995). Mutations in a putative global transcriptional regulator cause X-linked mental retardation with α-thalassemia (ATR-X syndrome). Cell. 80(6). 837–845. 458 indexed citations

19.

Gibbons, Richard J., Andrew O.M. Wilkie, D. J. Weatherall, & Douglas R. Higgs. (1991). A newly defined X linked mental retardation syndrome associated with alpha thalassaemia.. Journal of Medical Genetics. 28(11). 729–733. 49 indexed citations

20.

Higgs, Douglas R., Helena Ayyub, J. B. Clegg, et al.. (1985). Alpha thalassaemia in British people.. BMJ. 290(6478). 1303–1306. 31 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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