John Hiscott

28.4k total citations · 4 hit papers
302 papers, 23.1k citations indexed

About

John Hiscott is a scholar working on Immunology, Molecular Biology and Oncology. According to data from OpenAlex, John Hiscott has authored 302 papers receiving a total of 23.1k indexed citations (citations by other indexed papers that have themselves been cited), including 223 papers in Immunology, 89 papers in Molecular Biology and 86 papers in Oncology. Recurrent topics in John Hiscott's work include interferon and immune responses (144 papers), NF-κB Signaling Pathways (75 papers) and Immune Response and Inflammation (66 papers). John Hiscott is often cited by papers focused on interferon and immune responses (144 papers), NF-κB Signaling Pathways (75 papers) and Immune Response and Inflammation (66 papers). John Hiscott collaborates with scholars based in Canada, United States and Italy. John Hiscott's co-authors include Rongtuan Lin, Pierre Génin, Nathalie Grandvaux, Paula M. Pitha, Benjamin R. tenOever, Yaël Mamane, Christophe Heylbroeck, Marc J. Servant, Sonia Sharma and Hakju Kwon and has published in prestigious journals such as Science, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

John Hiscott

301 papers receiving 22.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

2003 1.4k citations Sonia Sharma, Benjamin R. tenOever et al. profile →
Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation

1998 804 citations Rongtuan Lin, Paula M. Pitha et al. profile →
VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents

2003 674 citations Benjamin R. tenOever, John Hiscott et al. profile →
Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop.

1993 521 citations John Hiscott, Anne Roulston et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
John Hiscott Canada	77	15.0k	7.6k	5.3k	4.5k	4.1k	302	23.1k
Robert H. Silverman United States	71	10.8k 0.7×	10.5k 1.4×	4.4k 0.8×	4.0k 0.9×	1.7k 0.4×	252	22.3k
Masahiro Yamamoto Japan	76	20.0k 1.3×	10.2k 1.3×	3.0k 0.6×	5.8k 1.3×	4.6k 1.1×	276	29.7k
Caetano Reis e Sousa United Kingdom	85	27.4k 1.8×	9.2k 1.2×	5.1k 0.9×	5.6k 1.2×	1.8k 0.4×	150	34.9k
Glen N. Barber United States	84	19.2k 1.3×	13.5k 1.8×	5.2k 1.0×	4.9k 1.1×	2.0k 0.5×	203	29.0k
Ganes C. Sen United States	72	9.7k 0.6×	7.6k 1.0×	3.1k 0.6×	3.3k 0.7×	1.7k 0.4×	245	17.4k
Rongtuan Lin Canada	66	9.9k 0.7×	4.6k 0.6×	3.0k 0.6×	3.1k 0.7×	2.4k 0.6×	147	14.1k
Paula M. Pitha United States	66	10.9k 0.7×	4.9k 0.6×	4.8k 0.9×	3.5k 0.8×	1.8k 0.4×	221	17.6k
Paul J. Hertzog Australia	65	11.0k 0.7×	6.5k 0.9×	5.0k 0.9×	2.4k 0.5×	2.1k 0.5×	248	20.3k
William E. Paul United States	98	30.2k 2.0×	8.2k 1.1×	6.1k 1.2×	3.4k 0.7×	1.5k 0.4×	344	42.5k
Herbert C. Morse United States	81	12.1k 0.8×	8.0k 1.1×	3.6k 0.7×	2.8k 0.6×	1.4k 0.4×	437	22.8k

Countries citing papers authored by John Hiscott

Since Specialization

Citations

This map shows the geographic impact of John Hiscott's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John Hiscott with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John Hiscott more than expected).

Fields of papers citing papers by John Hiscott

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John Hiscott. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John Hiscott. The network helps show where John Hiscott may publish in the future.

Co-authorship network of co-authors of John Hiscott

This figure shows the co-authorship network connecting the top 25 collaborators of John Hiscott. A scholar is included among the top collaborators of John Hiscott based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John Hiscott. John Hiscott is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Hiscott, John, et al.. (2025). Origin and function of anti-interferon type I viral proteins. Virology. 605. 110456–110456. 1 indexed citations

Angelis, Marta De, Donatella Amatore, Paola Checconi, et al.. (2022). Influenza Virus Down-Modulates G6PD Expression and Activity to Induce Oxidative Stress and Promote Its Replication. Frontiers in Cellular and Infection Microbiology. 11. 804976–804976. 39 indexed citations

Castiello, Luciano, Alessandra Zevini, Elisabetta Vulpis, et al.. (2019). An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation. Cancer Immunology Immunotherapy. 68(9). 1479–1492. 24 indexed citations

Olagnier, David, Michela Muscolini, Carolyn B. Coyne, Michael Diamond, & John Hiscott. (2016). Mechanisms of Zika Virus Infection and Neuropathogenesis. DNA and Cell Biology. 35(8). 367–372. 42 indexed citations

Qian, Feng, Martijn A. Langereis, David Olagnier, et al.. (2014). Coxsackievirus Cloverleaf RNA Containing a 5′ Triphosphate Triggers an Antiviral Response via RIG-I Activation. PLoS ONE. 9(4). e95927–e95927. 20 indexed citations

Piya, Sujan, Ae Ran Moon, Peter I. Song, et al.. (2011). Suppression of IRF4 by IRF1, 3, and 7 in Noxa Expression Is a Necessary Event for IFN-γ–Mediated Tumor Elimination. Molecular Cancer Research. 9(10). 1356–1365. 15 indexed citations

Romieu‐Mourez, Raphaëlle, Mayra Solis, Alessandra Nardin, et al.. (2006). Distinct Roles for IFN Regulatory Factor (IRF)-3 and IRF-7 in the Activation of Antitumor Properties of Human Macrophages. Cancer Research. 66(21). 10576–10585. 66 indexed citations

Solis, Mayra, et al.. (2006). Gene expression profiling of the host response to HIV-1 B, C, or A/E infection in monocyte-derived dendritic cells. Virology. 352(1). 86–99. 23 indexed citations

Setiadi, Audi, Muriel D. David, Susan S. Chen, John Hiscott, & Wilfred A. Jefferies. (2005). Identification of Mechanisms Underlying Transporter Associated with Antigen Processing Deficiency in Metastatic Murine Carcinomas. Cancer Research. 65(16). 7485–7492. 25 indexed citations

10.

Gautier, Grégory, Martine Humbert, Florence Deauvieau, et al.. (2005). A type I interferon autocrine–paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. The Journal of Experimental Medicine. 201(9). 1435–1446. 429 indexed citations

11.

Mamane, Yaël, Martin Loignon, Jennifer C Palmer, et al.. (2005). Repression of DNA Repair Mechanisms in IRF-4-Expressing and HTLV-I-Infected T Lymphocytes. Journal of Interferon & Cytokine Research. 25(1). 43–51. 9 indexed citations

12.

Miller, Kristen L., Susan McArdle, Michael Gale, et al.. (2004). Effects of the Hepatitis C Virus Core Protein on Innate Cellular Defense Pathways. Journal of Interferon & Cytokine Research. 24(7). 391–402. 39 indexed citations

13.

Daher, Aı̈cha, Sylvie Bannwarth, Johannes Voortman, et al.. (2003). Additive Activity between the Trans -Activation Response RNA-Binding Protein, TRBP2, and Cyclin T1 on HIV Type 1 Expression and Viral Production in Murine Cells. AIDS Research and Human Retroviruses. 19(9). 767–778. 15 indexed citations

14.

Mamane, Yaël, Sonia Sharma, Nathalie Grandvaux, Eduardo Osorio-Hernández, & John Hiscott. (2002). Review: IRF-4 Activities in HTLV-I-Induced T Cell Leukemogenesis. Journal of Interferon & Cytokine Research. 22(1). 135–143. 27 indexed citations

15.

Battistini, Angela, Giulia Marsili, Marco Sgarbanti, Barbara Ensoli, & John Hiscott. (2002). Review: IRF Regulation of HIV-1 Long Terminal Repeat Activity. Journal of Interferon & Cytokine Research. 22(1). 27–37. 42 indexed citations

16.

Hiscott, John & Paula M. Pitha. (2002). Interferon Regulatory Factors: Bridging Antiviral Defense, Growth Control, and Immunoregulation. Journal of Interferon & Cytokine Research. 22(1). 3–4. 4 indexed citations

17.

Sharma, Sonia, et al.. (2000). Activation and Regulation of Interferon Regulatory Factor 4 in HTLV Type 1-Infected T Lymphocytes. AIDS Research and Human Retroviruses. 16(16). 1613–1622. 38 indexed citations

18.

Au, Wei-Chun, et al.. (1999). Lipopolysaccharide Inhibits Virus-mediated Induction of Interferon Genes by Disruption of Nuclear Transport of Interferon Regulatory Factors 3 and 7. Journal of Biological Chemistry. 274(25). 18060–18066. 17 indexed citations

19.

Conti, Lucia, John Hiscott, Maddalena Papacchini, et al.. (1997). Induction of relA(p65) and I kappa B alpha subunit expression during differentiation of human peripheral blood monocytes to macrophages.. PubMed. 8(4). 435–42. 24 indexed citations

20.

Gu, Zhengxian, et al.. (1995). Inhibition of Human Immunodeficiency Virus Type 1 Multiplication by Transforming Growth Factor β ₁ and AZT in HIV-1-Infected Myeloid Cells. Journal of Interferon & Cytokine Research. 15(10). 849–855. 5 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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