Peter R. Shepherd

14.7k citations

181 papers · 10.5k indexed · 4 hit papers · h-index 51

Impact in

Molecular Biology top 0.5%
- PI3K/AKT/mTOR signaling in cancer
- Metabolism, Diabetes, and Cancer
- Protein Kinase Regulation and GTPase Signaling
Physiology top 0.5%
- Adipose Tissue and Metabolism
- Diet and metabolism studies

Papers in

Molecular Biology 138
- PI3K/AKT/mTOR signaling in cancer 63
- Metabolism, Diabetes, and Cancer 60
- Protein Kinase Regulation and GTPase Signaling 43
- Wnt/β-catenin signaling in development and cancer 13
Genetics 19
- Chronic Lymphocytic Leukemia Research 18

Co-authors: Barbara B. Kahn Dominic J. Withers Kenneth Siddle B. Nave D. Margriet Ouwens Dario R. Alessi Scott Menard Luigi Gnudi
Journals: Biochemical Journal (26 papers)Journal of Biological Chemistry (14 papers)Biochemical Society Transactions (9 papers)Biochemical and Biophysical Research Communications (8 papers)Diabetologia (7 papers)
Partner nations: New Zealand United Kingdom Australia

In The Last Decade

Peter R. Shepherd

176 papers receiving 10.3k citations

Hit Papers

align trajectories log scale

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins 2004 · 916 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2004 The Journal of Cell Biology
1999 Biochemical Journal
1999 New England Journal of Medicine
1998 Biochemical Journal

Peers

Countries citing papers authored by Peter R. Shepherd

Since Specialization

Citations

This map shows the geographic impact of Peter R. Shepherd's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Peter R. Shepherd with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Peter R. Shepherd more than expected).

Fields of papers citing papers by Peter R. Shepherd

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Peter R. Shepherd. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Peter R. Shepherd. The network helps show where Peter R. Shepherd may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Peter R. Shepherd, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Peter R. Shepherd Line = papers co-authored together Peter R. Shepherd links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding Biochemical Journal ·郭益安, Glenn R. Masson, Woo Jung Lee, James M. Dickson, Jackie D. Kendall, Manoj Kumar Rathinaswamy, Christina M. Buchanan, Martin Middleditch, Clovis de Souza Ferreira, Julie A. Spicer, Gordon W. Rewcastle, William A. Denny, John E. Burke, Peter R. Shepherd, Roger Williams, Jack U. Flanagan	2024	1
2	A role for β‐catenin in diet‐induced skeletal muscle insulin resistance Physiological Reports ·Stewart W. C. Masson, Labé Kàlàriki Idjawaru Karajá, สุพัตรา ศรีวณิชชากร, Christopher P. Hedges, Wouter Peeters, Martin Gram, David S. Rowlands, Peter R. Shepherd, Troy L. Merry	2023	3
3	Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice Nature Aging ·Christopher P. Hedges, 理张, สุพัตรา ศรีวณิชชากร, Phillipe Marre, Tokushige Ohyama, Рафаэль Фаритович Шарафутдинов, محمدحسن پورقنبر, Jordi Boix, Marylise Personnic, Brya G. Matthews, Sunita Sinha, 龙三平, Jagdish K. Jaiswal, Kimberley M. Mellor, Anthony J. Hickey, Peter R. Shepherd, Troy L. Merry	2023	8
4	Response to BRAF-targeted Therapy Is Enhanced by Cotargeting VEGFRs or WNT/β-Catenin Signaling in BRAF-mutant Colorectal Cancer Models Molecular Cancer Therapeutics ·Khanh Bao Tran, Sharada Kolekar, 秀子阿部, G. Kasturilal, Christina M. Buchanan, Sanjeev Deva, Peter R. Shepherd	2022	7
5	Glucose regulates expression of pro-inflammatory genes, IL-1β and IL-12 , through a mechanism involving hexosamine biosynthesis pathway-dependent regulation of α-E catenin Bioscience Reports ·Labé Kàlàriki Idjawaru Karajá, Freudling, Brie Sorrenson, Peter R. Shepherd	2021	11
6	The Impact of Exogenous Insulin Input on Calculating Hepatic Clearance Parameters Journal of Diabetes Science and Technology ·Teresa Lancry de Gouveia de Albuquerque e Sousa Robalo, J. Geoffrey Chase, Jennifer L. Knopp, Jian-Ming Syu, Walter M. Booth, Troy L. Merry, Rinki Murphy, Peter R. Shepherd, I Boissevain, Paul D. Docherty	2021	2
7	β‐Catenin is required for optimal exercise‐ and contraction‐stimulated skeletal muscle glucose uptake The Journal of Physiology ·Stewart W. C. Masson, Jonathan S. T. Woodhead, Randall F. D’Souza, สุพัตรา ศรีวณิชชากร, Phillipe Marre, Liz, W. J. Hoffman, Sara Mendonça Freitas, 吴文欣, Peter R. Shepherd, Troy L. Merry	2021	11
8	The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry Diabetologia ·I Boissevain, 林济广, 嘉彦岩佐, 明郁張, 李宏言李宏言, Jian-Ming Syu, 符定慧, Tony R. Merriman, Jennifer L. Knopp, J. Geoffrey Chase, Jeremy Krebs, Rosemary M. Hall, Lindsay D. Plank, Rinki Murphy, Peter R. Shepherd, Troy L. Merry	2021	6
9	Variability in Estimated Modelled Insulin Secretion Journal of Diabetes Science and Technology ·Jian-Ming Syu, I Boissevain, Jennifer L. Knopp, J. Geoffrey Chase, Rinki Murphy, Peter R. Shepherd, Troy L. Merry	2021	1
10	Derivation of induced pluripotent stem cell lines from New Zealand donors Journal of the Royal Society of New Zealand ·Freudling, Aneta Przepiorski, Rossella Riu, Lian Feng Zhang, Veronika Sander, Brie Sorrenson, G. Kasturilal, Jennifer A. Hollywood, Janak de Zoysa, Peter R. Shepherd, Alan J. Davidson, Teresa M. Holm	2020	4
11	Prolonged treatment with a PI3K p110α inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does not affect mitochondrial function Bioscience Reports ·Christopher P. Hedges, Toan Pham, 理张, Stewart W. C. Masson, Anthony J. Hickey, Peter R. Shepherd, Troy L. Merry	2020	7
12	β-catenin regulates muscle glucose transport via actin remodelling and M-cadherin binding Molecular Metabolism ·Stewart W. C. Masson, Brie Sorrenson, Peter R. Shepherd, Troy L. Merry	2020	28
13	Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth Cancer Discovery ·Helen Pearson, Jason Li, Valérie S. Méniel, Christina M. Fennell, Paul Waring, Karen G. Montgomery, Richard J. Rebello, Kana Yamagishi, Sarah Koushyar, Luc Furic, Carleen Cullinane, Richard Clarkson, Matthew J. Smalley, Kaylene J. Simpson, Toby J. Phesse, Peter R. Shepherd, Patrick O. Humbert, Owen J. Sansom, Wayne A. Phillips	2018	78
14	Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR Bioorganic & Medicinal Chemistry ·Jackie D. Kendall, О.А. Нелень, Kit Yee Tsang, Raphaël Frédérick, Elaine S. Marshall, Ripudaman Singh, Claire L. Lill, Woo Jung Lee, Sharada Kolekar, 豊章三浦, Nada Kapidzic, 久吉飯塚, Claire Chaussade, Christina M. Buchanan, Gordon W. Rewcastle, Bruce C. Baguley, Jack U. Flanagan, Stephen M. F. Jamieson, William A. Denny, Peter R. Shepherd	2011	30
15	Correction: Adiponectin Haploinsufficiency Promotes Mammary Tumor Development in MMTV-PyVT Mice by Modulation of Phosphatase and Tensin Homolog Activities PLoS ONE ·Janice B. B. Lam, Hei‐Man Chow, Aimin Xu, Karen S.L. Lam, Jing Liu, Nai-Sum Wong, Randall T. Moon, Peter R. Shepherd, Garth J. S. Cooper, Yu Wang	2009	6
16	GSK-3β regulation in skeletal muscles by adrenaline and insulin: Evidence that PKA and PKB regulate different pools of GSK-3 Cellular Signalling ·Jørgen Jensen, Erlend O. Brennesvik, Yu‐Chiang Lai, Peter R. Shepherd	2006	53
17	Insulin Activates the α Isoform of Class II Phosphoinositide 3-Kinase Journal of Biological Chemistry ·Richard A. Brown, Jan Domin, Alexandre Arcaro, Michael D. Waterfield, Peter R. Shepherd	1999	114
18	Differential Regulation of Phosphoinositide 3-Kinase Adapter Subunit Variants by Insulin in Human Skeletal Muscle Journal of Biological Chemistry ·Peter R. Shepherd, B. Nave, Jorge Rincón, Lorraine A. Nolte, A. Paul Bevan, Kenneth Siddle, Juleen R. Zierath, Harriet Wallberg‐Henriksson	1997	50
19	Expression, Enzyme Activity, and Subcellular Localization of Mammalian Target of Rapamycin in Insulin-Responsive Cells Biochemical and Biophysical Research Communications ·Dominic J. Withers, D. Margriet Ouwens, B. Nave, Gerard C.M. van der Zon, Clara M. Alarcón, María E. Cárdenas, Joseph Heitman, J. A. Maassen, Peter R. Shepherd	1997	64
20	The role of phosphoinositide 3-kinase in insulin signalling Journal of Molecular Endocrinology ·Peter R. Shepherd, B. Nave, Stephen O’Rahilly	1996	53

About Peter R. Shepherd

Peter R. Shepherd is a scholar working on Molecular Biology, Genetics, Aging, Endocrine and Autonomic Systems and Cell Biology, having authored 181 papers that have together received 10.5k indexed citations. Recurring topics across this work include PI3K/AKT/mTOR signaling in cancer (63 papers), Metabolism, Diabetes, and Cancer (60 papers), Protein Kinase Regulation and GTPase Signaling (43 papers), Pancreatic function and diabetes (35 papers), Chronic Lymphocytic Leukemia Research (18 papers), Adipose Tissue and Metabolism (13 papers), Wnt/β-catenin signaling in development and cancer (13 papers) and Regulation of Appetite and Obesity (11 papers). The work is most often cited by research in Molecular Biology (6.7k citations), Physiology (2.4k citations), Endocrine and Autonomic Systems (598 citations), Cell Biology (1.3k citations) and Endocrinology, Diabetes and Metabolism (1.0k citations). Peter R. Shepherd has collaborated with scholars based in New Zealand, United Kingdom and Australia. Frequent co-authors include Barbara B. Kahn, Dominic J. Withers, Kenneth Siddle, B. Nave, D. Margriet Ouwens, Dario R. Alessi, Scott Menard, Luigi Gnudi, Effie Tozzo and Jørgen Jensen. Their work appears in journals such as Biochemical Journal, Journal of Biological Chemistry, Biochemical Society Transactions, Biochemical and Biophysical Research Communications and Diabetologia.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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