Patrick O. Brown

169.6k total citations · 50 hit papers
272 papers, 121.0k citations indexed

About

Patrick O. Brown is a scholar working on Molecular Biology, Genetics and Virology. According to data from OpenAlex, Patrick O. Brown has authored 272 papers receiving a total of 121.0k indexed citations (citations by other indexed papers that have themselves been cited), including 204 papers in Molecular Biology, 45 papers in Genetics and 29 papers in Virology. Recurrent topics in Patrick O. Brown's work include Gene expression and cancer classification (60 papers), Genomics and Chromatin Dynamics (40 papers) and Fungal and yeast genetics research (37 papers). Patrick O. Brown is often cited by papers focused on Gene expression and cancer classification (60 papers), Genomics and Chromatin Dynamics (40 papers) and Fungal and yeast genetics research (37 papers). Patrick O. Brown collaborates with scholars based in United States, Norway and Canada. Patrick O. Brown's co-authors include David Botstein, Michael B. Eisen, Paul T. Spellman, Dari Shalon, Vishwanath R. Iyer, Joseph L. DeRisi, Matt van de Rijn, Charles M. Perou, Ronald W. Davis and Mark Schena and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Patrick O. Brown

266 papers receiving 117.3k citations

Hit Papers

Cluster analysis and display of genome-wide expression pa... 1987 2026 2000 2013 1998 2000 2001 1995 2003 4.0k 8.0k 12.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Cluster analysis and display of genome-wide expression patterns
    1998 12.7k citations Michael B. Eisen, Patrick O. Brown et al. Proceedings of the National Academy of Sciences profile →
  2. Molecular portraits of human breast tumours
    2000 11.7k citations Charles M. Perou, Thérese Sørlie et al. profile →
  3. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    2001 8.3k citations Thérese Sørlie, Charles M. Perou et al. Proceedings of the National Academy of Sciences profile →
  4. Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray
    1995 6.6k citations Dari Shalon, Patrick O. Brown et al. profile →
  5. Repeated observation of breast tumor subtypes in independent gene expression data sets
    2003 4.0k citations Thérese Sørlie, Robert Tibshirani et al. Proceedings of the National Academy of Sciences profile →
  6. Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes
    2000 3.8k citations Michael B. Eisen, David Botstein et al. Molecular Biology of the Cell profile →
  7. Comprehensive Identification of Cell Cycle–regulated Genes of the YeastSaccharomyces cerevisiaeby Microarray Hybridization
    1998 3.6k citations Vishwanath R. Iyer, Michael B. Eisen et al. Molecular Biology of the Cell profile →
  8. Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale
    1997 3.5k citations Vishwanath R. Iyer, Patrick O. Brown et al. profile →
  9. Development of the Human Infant Intestinal Microbiota
    2007 2.1k citations David A. Relman, Patrick O. Brown et al. profile →
  10. Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types
    2012 2.0k citations Patrick O. Brown et al. PLoS ONE profile →
  11. Exploring the new world of the genome with DNA microarrays
    1999 1.8k citations Patrick O. Brown, David Botstein profile →
  12. Systematic variation in gene expression patterns in human cancer cell lines
    2000 1.6k citations Douglas T. Ross, Michael B. Eisen et al. profile →
  13. The Transcriptional Program in the Response of Human Fibroblasts to Serum
    1999 1.6k citations Vishwanath R. Iyer, Michael B. Eisen et al. profile →
  14. Cell-Type Specific Features of Circular RNA Expression
    2013 1.6k citations Mari Olsen, Patrick O. Brown et al. PLoS Genetics profile →
  15. Use of a cDNA microarray to analyse gene expression patterns in human cancer
    1996 1.5k citations Patrick O. Brown et al. profile →
  16. The Transcriptional Program of Sporulation in Budding Yeast
    1998 1.5k citations Michael B. Eisen, David Botstein et al. profile →
  17. Singular value decomposition for genome-wide expression data processing and modeling
    2000 1.4k citations Patrick O. Brown, David Botstein et al. Proceedings of the National Academy of Sciences profile →
  18. Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in Tumors
    2002 1.2k citations Catherine A. Ball, Charles M. Perou et al. Molecular Biology of the Cell profile →
  19. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers
    1999 1.1k citations Charles M. Perou, Stefanie S. Jeffrey et al. Proceedings of the National Academy of Sciences profile →
  20. A gene expression database for the molecular pharmacology of cancer
    2000 1.1k citations Douglas T. Ross, Michael B. Eisen et al. profile →
  21. Genome-wide analysis of DNA copy-number changes using cDNA microarrays
    1999 1.1k citations Jonathan R. Pollack, Charles M. Perou et al. profile →
  22. Diversity of gene expression in adenocarcinoma of the lung
    2001 1.0k citations Matt van de Rijn, Charles M. Perou et al. Proceedings of the National Academy of Sciences profile →
  23. Gene expression profiling identifies clinically relevant subtypes of prostate cancer
    2004 984 citations Julian P. T. Higgins, Matt van de Rijn et al. Proceedings of the National Academy of Sciences profile →
  24. Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors
    2002 875 citations Jonathan R. Pollack, Thérese Sørlie et al. Proceedings of the National Academy of Sciences profile →
  25. Diversity, topographic differentiation, and positional memory in human fibroblasts
    2002 867 citations Howard Y. Chang, Jen‐Tsan Chi et al. Proceedings of the National Academy of Sciences profile →
  26. Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF
    2001 841 citations Vishwanath R. Iyer, David Botstein et al. profile →
  27. [12] DNA arrays for analysis of gene expression
    1999 823 citations Michael B. Eisen, Patrick O. Brown profile →
  28. Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia
    2001 815 citations David Botstein, Patrick O. Brown et al. profile →
  29. A DNA microarray system for analyzing complex DNA samples using two-color fluorescent probe hybridization.
    1996 795 citations Dari Shalon, Steven J. Smith et al. Genome Research profile →
  30. Integration of murine leukemia virus DNA depends on mitosis.
    1993 755 citations Patrick O. Brown et al. profile →
  31. Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival
    2005 733 citations Howard Y. Chang, Dimitry S.A. Nuyten et al. Proceedings of the National Academy of Sciences profile →
  32. Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds
    2004 711 citations Howard Y. Chang, Julie B. Sneddon et al. profile →
  33. Gene Expression Patterns in Human Liver Cancers
    2002 700 citations Xin Chen, ST Cheung et al. Molecular Biology of the Cell profile →
  34. Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions
    2001 694 citations Patrick O. Brown et al. Genome biology profile →
  35. Comparative Gene Expression Profiles Following UV Exposure in Wild-Type and SOS-Deficient Escherichia coli
    2001 676 citations Patrick O. Brown et al. profile →
  36. Individuality and variation in gene expression patterns in human blood
    2003 618 citations David A. Relman, Patrick O. Brown et al. Proceedings of the National Academy of Sciences profile →
  37. Circular RNA Is Expressed across the Eukaryotic Tree of Life
    2014 604 citations Mari Olsen, Patrick O. Brown et al. PLoS ONE profile →
  38. Endothelial cell diversity revealed by global expression profiling
    2003 596 citations Jen‐Tsan Chi, Howard Y. Chang et al. Proceedings of the National Academy of Sciences profile →
  39. Precision and functional specificity in mRNA decay
    2002 556 citations Yulei Wang, Chih Long Liu et al. Proceedings of the National Academy of Sciences profile →
  40. Promoter-specific binding of Rap1 revealed by genome-wide maps of protein–DNA association
    2001 544 citations David Botstein, Patrick O. Brown et al. profile →
  41. Extensive Association of Functionally and Cytotopically Related mRNAs with Puf Family RNA-Binding Proteins in Yeast
    2004 542 citations André P. Gerber, Daniel Herschlag et al. profile →
  42. Genome-wide analysis of mRNA translation profiles in Saccharomyces cerevisiae
    2003 535 citations Yoav Arava, Yulei Wang et al. Proceedings of the National Academy of Sciences profile →
  43. Genome-wide analysis of DNA copy number variation in breast cancer using DNA microarrays
    1999 531 citations Jonathan R. Pollack, Charles M. Perou et al. profile →
  44. Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors
    2003 530 citations Patrick O. Brown et al. Proceedings of the National Academy of Sciences profile →
  45. Autoantigen microarrays for multiplex characterization of autoantibody responses
    2002 529 citations Patrick O. Brown et al. profile →
  46. The Novel Marker, DOG1, Is Expressed Ubiquitously in Gastrointestinal Stromal Tumors Irrespective of KIT or PDGFRA Mutation Status
    2004 487 citations Robert B. West, Christopher L. Corless et al. American Journal Of Pathology profile →
  47. Drug target validation and identification of secondary drug target effects using DNA microarrays
    1998 479 citations Vishwanath R. Iyer, Hongyue Dai et al. profile →
  48. Correct integration of retroviral DNA in vitro
    1987 402 citations Patrick O. Brown et al. profile →
  49. Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein.
    1989 345 citations Patrick O. Brown et al. Proceedings of the National Academy of Sciences profile →
  50. A nucleoprotein complex mediates the integration of retroviral DNA.
    1989 325 citations Patrick O. Brown et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Patrick O. Brown United States 137 85.4k 24.6k 20.1k 14.8k 7.3k 272 121.0k
Chris Sander United States 119 69.7k 0.8× 26.3k 1.1× 13.4k 0.7× 8.3k 0.6× 10.6k 1.4× 308 93.4k
Gordon K. Smyth Australia 87 69.9k 0.8× 20.6k 0.8× 14.1k 0.7× 13.2k 0.9× 9.8k 1.3× 345 122.5k
David Botstein United States 150 111.9k 1.3× 22.9k 0.9× 20.5k 1.0× 29.0k 2.0× 8.0k 1.1× 425 163.8k
Stephen J. Elledge United States 152 76.0k 0.9× 13.9k 0.6× 27.7k 1.4× 10.1k 0.7× 2.8k 0.4× 367 93.0k
Arnold J. Levine United States 131 60.9k 0.7× 16.1k 0.7× 45.8k 2.3× 11.6k 0.8× 4.8k 0.7× 443 90.7k
Jill P. Mesirov United States 55 51.9k 0.6× 15.2k 0.6× 11.9k 0.6× 7.5k 0.5× 9.8k 1.3× 137 80.1k
Douglas Hanahan United States 109 79.7k 0.9× 36.5k 1.5× 43.8k 2.2× 13.4k 0.9× 12.6k 1.7× 230 137.2k
Wolfgang Huber Germany 72 67.0k 0.8× 14.6k 0.6× 7.0k 0.4× 12.6k 0.8× 5.2k 0.7× 249 109.8k
Todd R. Golub United States 111 77.0k 0.9× 27.5k 1.1× 18.8k 0.9× 7.3k 0.5× 13.7k 1.9× 229 113.9k
Minoru Kanehisa Japan 75 76.3k 0.9× 12.2k 0.5× 5.4k 0.3× 10.1k 0.7× 7.0k 1.0× 266 114.1k

Countries citing papers authored by Patrick O. Brown

Since Specialization
Citations

This map shows the geographic impact of Patrick O. Brown's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Patrick O. Brown with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Patrick O. Brown more than expected).

Fields of papers citing papers by Patrick O. Brown

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Patrick O. Brown. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Patrick O. Brown. The network helps show where Patrick O. Brown may publish in the future.

Co-authorship network of co-authors of Patrick O. Brown

This figure shows the co-authorship network connecting the top 25 collaborators of Patrick O. Brown. A scholar is included among the top collaborators of Patrick O. Brown based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Patrick O. Brown. Patrick O. Brown is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Isobe, Taichi, Shigeo Hisamori, Daniel J. Hogan, et al.. (2014). miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway. eLife. 3. 155 indexed citations
2.
3.
Rubins, Kathleen, Lisa E. Hensley, David A. Relman, & Patrick O. Brown. (2011). Stunned Silence: Gene Expression Programs in Human Cells Infected with Monkeypox or Vaccinia Virus. PLoS ONE. 6(1). e15615–e15615. 78 indexed citations
4.
Rubins, Kathleen, Lisa E. Hensley, George W. Bell, et al.. (2008). Comparative Analysis of Viral Gene Expression Programs during Poxvirus Infection: A Transcriptional Map of the Vaccinia and Monkeypox Genomes. PLoS ONE. 3(7). e2628–e2628. 55 indexed citations
5.
Hurowitz, Evan H., Iddo Drori, Victoria Stodden, David L. Donoho, & Patrick O. Brown. (2007). Virtual Northern Analysis of the Human Genome. PLoS ONE. 2(5). e460–e460. 11 indexed citations
6.
Rubins, Kathleen, Lisa E. Hensley, Victoria Wahl‐Jensen, et al.. (2007). The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever. Genome biology. 8(8). R174–R174. 80 indexed citations
7.
Sneddon, Julie B., Hanson H. Zhen, Kelli Montgomery, et al.. (2006). Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. Proceedings of the National Academy of Sciences. 103(40). 14842–14847. 235 indexed citations
8.
Gerber, André P., Stefan Luschnig, Mark A. Krasnow, Patrick O. Brown, & Daniel Herschlag. (2006). Genome-wide identification of mRNAs associated with the translational regulator PUMILIO in Drosophila melanogaster. Proceedings of the National Academy of Sciences. 103(12). 4487–4492. 236 indexed citations
9.
Rinn, John L., et al.. (2006). Anatomic Demarcation by Positional Variation in Fibroblast Gene Expression Programs. PLoS Genetics. 2(7). e119–e119. 371 indexed citations
10.
Chang, Howard Y., Dimitry S.A. Nuyten, Julie B. Sneddon, et al.. (2005). Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. Proceedings of the National Academy of Sciences. 102(10). 3738–3743. 733 indexed citations breakdown →
11.
West, Robert B., Christopher L. Corless, Xin Chen, et al.. (2004). The Novel Marker, DOG1, Is Expressed Ubiquitously in Gastrointestinal Stromal Tumors Irrespective of KIT or PDGFRA Mutation Status. American Journal Of Pathology. 165(1). 107–113. 487 indexed citations breakdown →
12.
Arava, Yoav, Yulei Wang, John D. Storey, et al.. (2003). Genome-wide analysis of mRNA translation profiles in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences. 100(7). 3889–3894. 535 indexed citations breakdown →
13.
Shepard, Kelly A., André P. Gerber, Ashwini Jambhekar, et al.. (2003). Widespread cytoplasmic mRNA transport in yeast: Identification of 22 bud-localized transcripts using DNA microarray analysis. Proceedings of the National Academy of Sciences. 100(20). 11429–11434. 238 indexed citations
14.
Chi, Jen‐Tsan, et al.. (2003). Genomewide view of gene silencing by small interfering RNAs. Proceedings of the National Academy of Sciences. 100(11). 6343–6346. 220 indexed citations
15.
Iacobuzio–Donahue, Christine A., Anirban Maitra, Mari Olsen, et al.. (2003). Exploration of Global Gene Expression Patterns in Pancreatic Adenocarcinoma Using cDNA Microarrays. American Journal Of Pathology. 162(4). 1151–1162. 394 indexed citations
16.
Linn, Sabine C., Robert B. West, Jonathan R. Pollack, et al.. (2003). Gene Expression Patterns and Gene Copy Number Changes in Dermatofibrosarcoma Protuberans. American Journal Of Pathology. 163(6). 2383–2395. 107 indexed citations
17.
Chen, Xin, ST Cheung, Samuel So, et al.. (2002). Gene Expression Patterns in Human Liver Cancers. Molecular Biology of the Cell. 13(6). 1929–1939. 700 indexed citations breakdown →
18.
Reid, Juliet, Vishwanath R. Iyer, Patrick O. Brown, & Kevin Struhl. (2000). Coordinate Regulation of Yeast Ribosomal Protein Genes Is Associated with Targeted Recruitment of Esa1 Histone Acetylase. Molecular Cell. 6(6). 1297–1307. 245 indexed citations
19.
Perou, Charles M., Stefanie S. Jeffrey, Matt van de Rijn, et al.. (1999). Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proceedings of the National Academy of Sciences. 96(16). 9212–9217. 1087 indexed citations breakdown →
20.
Shalon, Dari, Steven J. Smith, & Patrick O. Brown. (1996). A DNA microarray system for analyzing complex DNA samples using two-color fluorescent probe hybridization.. Genome Research. 6(7). 639–645. 795 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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