David Botstein

222.5k total citations · 46 hit papers
425 papers, 163.8k citations indexed

About

David Botstein is a scholar working on Molecular Biology, Genetics and Ecology. According to data from OpenAlex, David Botstein has authored 425 papers receiving a total of 163.8k indexed citations (citations by other indexed papers that have themselves been cited), including 345 papers in Molecular Biology, 78 papers in Genetics and 59 papers in Ecology. Recurrent topics in David Botstein's work include Fungal and yeast genetics research (162 papers), RNA and protein synthesis mechanisms (59 papers) and Bacteriophages and microbial interactions (57 papers). David Botstein is often cited by papers focused on Fungal and yeast genetics research (162 papers), RNA and protein synthesis mechanisms (59 papers) and Bacteriophages and microbial interactions (57 papers). David Botstein collaborates with scholars based in United States, Germany and Canada. David Botstein's co-authors include Patrick O. Brown, Michael B. Eisen, Paul T. Spellman, Gavin Sherlock, Ronald W. Davis, Eric S. Lander, John C. Matese, Charles M. Perou, Matt van de Rijn and J. Michael Cherry and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

David Botstein

420 papers receiving 157.5k citations

Hit Papers

Gene Ontology: tool for the unification of bi... 1977 2026 1993 2009 2000 1998 2000 2001 1980 10.0k 20.0k 30.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Gene Ontology: tool for the unification of biology
    2000 30.2k citations Michael Ashburner, Catherine A. Ball et al. Nature Genetics profile →
  2. Cluster analysis and display of genome-wide expression patterns
    1998 12.7k citations Michael B. Eisen, Paul T. Spellman et al. Proceedings of the National Academy of Sciences profile →
  3. Molecular portraits of human breast tumours
    2000 11.7k citations Charles M. Perou, Thérese Sørlie et al. profile →
  4. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    2001 8.3k citations Thérese Sørlie, Charles M. Perou et al. Proceedings of the National Academy of Sciences profile →
  5. Construction of a genetic linkage map in man using restriction fragment length polymorphisms.
    1980 6.5k citations David Botstein, Ronald W. Davis et al. profile →
  6. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.
    1989 4.1k citations David Botstein et al. Genetics profile →
  7. Repeated observation of breast tumor subtypes in independent gene expression data sets
    2003 4.0k citations Thérese Sørlie, Robert Tibshirani et al. Proceedings of the National Academy of Sciences profile →
  8. Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes
    2000 3.8k citations Paul T. Spellman, Michael B. Eisen et al. profile →
  9. Comprehensive Identification of Cell Cycle–regulated Genes of the YeastSaccharomyces cerevisiaeby Microarray Hybridization
    1998 3.6k citations Paul T. Spellman, Gavin Sherlock et al. profile →
  10. Missing value estimation methods for DNA microarrays
    2001 2.8k citations Olga G. Troyanskaya, Michael Cantor et al. Bioinformatics profile →
  11. Advanced bacterial genetics
    1980 2.1k citations Ronald W. Davis, David Botstein et al. profile →
  12. Exploring the new world of the genome with DNA microarrays
    1999 1.8k citations Patrick O. Brown, David Botstein Nature Genetics profile →
  13. Systematic variation in gene expression patterns in human cancer cell lines
    2000 1.6k citations Douglas T. Ross, Michael B. Eisen et al. Nature Genetics profile →
  14. The Transcriptional Program in the Response of Human Fibroblasts to Serum
    1999 1.6k citations Vishwanath R. Iyer, Michael B. Eisen et al. Science profile →
  15. GO::TermFinder—open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes
    2004 1.5k citations David Botstein, J. Michael Cherry et al. Bioinformatics profile →
  16. The Transcriptional Program of Sporulation in Budding Yeast
    1998 1.5k citations Joseph L. DeRisi, Michael B. Eisen et al. Science profile →
  17. Two differentially regulated mRNAs with different 5′ ends encode secreted and intracellular forms of yeast invertase
    1982 1.4k citations David Botstein et al. profile →
  18. Singular value decomposition for genome-wide expression data processing and modeling
    2000 1.4k citations Patrick O. Brown, David Botstein et al. Proceedings of the National Academy of Sciences profile →
  19. Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data
    2003 1.2k citations David Botstein et al. Nature Genetics profile →
  20. Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in Tumors
    2002 1.2k citations Gavin Sherlock, Catherine A. Ball et al. profile →
  21. A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector
    1987 1.1k citations David Botstein et al. profile →
  22. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers
    1999 1.1k citations Charles M. Perou, Stefanie S. Jeffrey et al. Proceedings of the National Academy of Sciences profile →
  23. A gene expression database for the molecular pharmacology of cancer
    2000 1.1k citations Douglas T. Ross, Michael B. Eisen et al. Nature Genetics profile →
  24. Genome-wide analysis of DNA copy-number changes using cDNA microarrays
    1999 1.1k citations Jonathan R. Pollack, Charles M. Perou et al. Nature Genetics profile →
  25. Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease
    2003 1.1k citations David Botstein et al. Nature Genetics profile →
  26. Diversity of gene expression in adenocarcinoma of the lung
    2001 1.0k citations Olga G. Troyanskaya, Matt van de Rijn et al. Proceedings of the National Academy of Sciences profile →
  27. Gene expression profiling identifies clinically relevant subtypes of prostate cancer
    2004 984 citations Matt van de Rijn, Robert Tibshirani et al. Proceedings of the National Academy of Sciences profile →
  28. Sterile host yeasts (SHY): A eukaryotic system of biological containment for recombinant DNA experiments
    1979 930 citations David Botstein, Ronald W. Davis et al. profile →
  29. Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors
    2002 875 citations Jonathan R. Pollack, Thérese Sørlie et al. Proceedings of the National Academy of Sciences profile →
  30. Diversity, topographic differentiation, and positional memory in human fibroblasts
    2002 867 citations Matt van de Rijn, David Botstein et al. Proceedings of the National Academy of Sciences profile →
  31. Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF
    2001 841 citations Vishwanath R. Iyer, David Botstein et al. profile →
  32. Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia
    2001 815 citations Ash A. Alizadeh, David Botstein et al. profile →
  33. Advanced Bacterial Genetics: A Manual for Genetic Engineering
    1980 769 citations David Botstein, John R. Roth et al. profile →
  34. Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds
    2004 711 citations Ash A. Alizadeh, Robert B. West et al. profile →
  35. Prediction of Survival in Diffuse Large-B-Cell Lymphoma Based on the Expression of Six Genes
    2004 708 citations Ash A. Alizadeh, David Botstein et al. profile →
  36. Gene Expression Patterns in Human Liver Cancers
    2002 700 citations Matt van de Rijn, David Botstein et al. profile →
  37. DNA topoisomerase II is required at the time of mitosis in yeast
    1985 681 citations David Botstein et al. profile →
  38. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer
    1998 645 citations David Botstein et al. profile →
  39. Homozygosity Mapping: A Way to Map Human Recessive Traits with the DNA of Inbred Children
    1987 628 citations David Botstein et al. Science profile →
  40. The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery
    1988 608 citations David Botstein et al. profile →
  41. Endothelial cell diversity revealed by global expression profiling
    2003 596 citations Olga G. Troyanskaya, Matt van de Rijn et al. Proceedings of the National Academy of Sciences profile →
  42. Promoter-specific binding of Rap1 revealed by genome-wide maps of protein–DNA association
    2001 544 citations David Botstein, Patrick O. Brown et al. Nature Genetics profile →
  43. Saccharomyces genome database
    2002 531 citations Laurie Issel‐Tarver, Kara Dolinski et al. Methods in enzymology on CD-ROM/Methods in enzymology profile →
  44. Genome-wide analysis of DNA copy number variation in breast cancer using DNA microarrays
    1999 531 citations Jonathan R. Pollack, Charles M. Perou et al. Nature Genetics profile →
  45. Genetic engineering in Vivo using translocatable drug-resistance elements
    1977 491 citations John R. Roth, David Botstein et al. profile →
  46. Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations
    2013 389 citations Gregory I. Lang, David Botstein et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
David Botstein United States 150 111.9k 29.0k 22.9k 20.5k 18.2k 425 163.8k
Eric S. Lander United States 178 145.6k 1.3× 52.3k 1.8× 34.7k 1.5× 18.9k 0.9× 25.2k 1.4× 408 222.1k
Patrick O. Brown United States 137 85.4k 0.8× 14.8k 0.5× 24.6k 1.1× 20.1k 1.0× 6.4k 0.3× 272 121.0k
Matthias Mann Germany 214 150.8k 1.3× 12.0k 0.4× 14.3k 0.6× 17.3k 0.8× 10.2k 0.6× 845 215.4k
Gordon K. Smyth Australia 87 69.9k 0.6× 13.2k 0.5× 20.6k 0.9× 14.1k 0.7× 14.0k 0.8× 345 122.5k
Peer Bork Germany 151 97.1k 0.9× 15.3k 0.5× 9.5k 0.4× 7.0k 0.3× 18.8k 1.0× 524 145.9k
Wolfgang Huber Germany 72 67.0k 0.6× 12.6k 0.4× 14.6k 0.6× 7.0k 0.3× 17.8k 1.0× 249 109.8k
Douglas Hanahan United States 109 79.7k 0.7× 13.4k 0.5× 36.5k 1.6× 43.8k 2.1× 3.8k 0.2× 230 137.2k
Richard Durbin United Kingdom 78 74.7k 0.7× 42.8k 1.5× 12.1k 0.5× 4.6k 0.2× 26.9k 1.5× 169 133.8k
Steven L. Salzberg United States 96 110.2k 1.0× 24.8k 0.9× 18.8k 0.8× 5.1k 0.2× 46.6k 2.6× 244 185.4k
Minoru Kanehisa Japan 75 76.3k 0.7× 10.1k 0.4× 12.2k 0.5× 5.4k 0.3× 14.1k 0.8× 266 114.1k

Countries citing papers authored by David Botstein

Since Specialization
Citations

This map shows the geographic impact of David Botstein's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David Botstein with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David Botstein more than expected).

Fields of papers citing papers by David Botstein

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David Botstein. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David Botstein. The network helps show where David Botstein may publish in the future.

Co-authorship network of co-authors of David Botstein

This figure shows the co-authorship network connecting the top 25 collaborators of David Botstein. A scholar is included among the top collaborators of David Botstein based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David Botstein. David Botstein is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Turco, Gina, Christie Chang, Brianna Richardson, et al.. (2023). Global analysis of the yeast knockout phenome. Science Advances. 9(21). eadg5702–eadg5702. 17 indexed citations
2.
Arita, Yuko, Zhijian Li, Helena Friesen, et al.. (2021). A genome‐scale yeast library with inducible expression of individual genes. Molecular Systems Biology. 17(6). e10207–e10207. 35 indexed citations
3.
Gibney, Patrick A., Anqi Chen, Jonathan C. Chen, et al.. (2020). A tps1Δ persister-like state in Saccharomyces cerevisiae is regulated by MKT1. PLoS ONE. 15(5). e0233779–e0233779. 7 indexed citations
4.
Hackett, Sean R., Vito Riccardo Tomaso Zanotelli, Wenxin Xu, et al.. (2016). Systems-level analysis of mechanisms regulating yeast metabolic flux. Science. 354(6311). 206 indexed citations
5.
Silverman, Sanford J., Allegra A. Petti, Nikolai Slavov, et al.. (2010). Metabolic cycling in single yeast cells from unsynchronized steady-state populations limited on glucose or phosphate. Proceedings of the National Academy of Sciences. 107(15). 6946–6951. 69 indexed citations
6.
Lang, Gregory I., Andrew W. Murray, & David Botstein. (2009). The cost of gene expression underlies a fitness trade-off in yeast. Proceedings of the National Academy of Sciences. 106(14). 5755–5760. 119 indexed citations
7.
Boer, Viktor M., Sasan Amini, & David Botstein. (2008). Influence of genotype and nutrition on survival and metabolism of starving yeast. Proceedings of the National Academy of Sciences. 105(19). 6930–6935. 107 indexed citations
8.
Gresham, David, Douglas M. Ruderfer, Stephen C. Pratt, et al.. (2006). Genome-Wide Detection of Polymorphisms at Nucleotide Resolution with a Single DNA Microarray. Science. 311(5769). 1932–1936. 208 indexed citations
9.
Sørlie, Thérese, Charles M. Perou, Huihui Fan, et al.. (2006). Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer. Molecular Cancer Therapeutics. 5(11). 2914–2918. 97 indexed citations
10.
Botstein, David. (2004). Ira Herskowitz: 1946-2003. Genetics. 166(2). 653–660. 12 indexed citations
11.
Linn, Sabine C., Robert B. West, Jonathan R. Pollack, et al.. (2003). Gene Expression Patterns and Gene Copy Number Changes in Dermatofibrosarcoma Protuberans. American Journal Of Pathology. 163(6). 2383–2395. 107 indexed citations
12.
Pollack, Jonathan R., Matt van de Rijn, & David Botstein. (2002). Challenges in developing a molecular characterization of cancer. Seminars in Oncology. 29(3). 280–285. 9 indexed citations
13.
Troyanskaya, Olga G., Michael Cantor, Gavin Sherlock, et al.. (2001). Missing value estimation methods for DNA microarrays. Bioinformatics. 17(6). 520–525. 2794 indexed citations breakdown →
14.
Ashburner, Michael, Catherine A. Ball, Judith A. Blake, et al.. (2000). Gene Ontology: tool for the unification of biology. Nature Genetics. 25(1). 25–29. 30198 indexed citations breakdown →
15.
Perou, Charles M., Stefanie S. Jeffrey, Matt van de Rijn, et al.. (1999). Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proceedings of the National Academy of Sciences. 96(16). 9212–9217. 1087 indexed citations breakdown →
16.
Botstein, David, Ash A. Alizadeh, Joseph L. DeRisi, et al.. (1998). DNA MICROARRAYS AS "MICROSCOPES" FOR WATCHING A GENOME IN ACTION. 21. 172. 1 indexed citations
17.
Shortle, David & David Botstein. (1983). [31] Directed mutagenesis with sodium bisulfite. Methods in enzymology on CD-ROM/Methods in enzymology. 100. 457–468. 66 indexed citations
18.
Botstein, David & Ronald W. Davis. (1982). Principles and Practice of Recombinant DNA Research with Yeast. Cold Spring Harbor Monograph Archive. 607–636. 95 indexed citations
19.
Davis, Ronald W., David Botstein, & John R. Roth. (1980). Advanced bacterial genetics. 2078 indexed citations breakdown →
20.
Roberts, Jeffrey W., et al.. (1976). Transcription Termination and Regulation in Bacteriophages P22 and Lambda. Cold Spring Harbor Monograph Archive. 6. 707–718. 26 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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