Ralph H. Hruban

203.9k total citations · 39 hit papers
926 papers, 93.4k citations indexed

About

Ralph H. Hruban is a scholar working on Oncology, Surgery and Cancer Research. According to data from OpenAlex, Ralph H. Hruban has authored 926 papers receiving a total of 93.4k indexed citations (citations by other indexed papers that have themselves been cited), including 657 papers in Oncology, 357 papers in Surgery and 226 papers in Cancer Research. Recurrent topics in Ralph H. Hruban's work include Pancreatic and Hepatic Oncology Research (591 papers), Cancer Genomics and Diagnostics (211 papers) and Neuroendocrine Tumor Research Advances (168 papers). Ralph H. Hruban is often cited by papers focused on Pancreatic and Hepatic Oncology Research (591 papers), Cancer Genomics and Diagnostics (211 papers) and Neuroendocrine Tumor Research Advances (168 papers). Ralph H. Hruban collaborates with scholars based in United States, Netherlands and Germany. Ralph H. Hruban's co-authors include Charles J. Yeo, Michael Goggins, John L. Cameron, Anirban Maitra, Scott E. Kern, Christopher L. Wolfgang, Christine A. Iacobuzio–Donahue, Elliot K. Fishman, Keith D. Lillemoe and Taylor A. Sohn and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Ralph H. Hruban

916 papers receiving 91.6k citations

Hit Papers

Pancreatic cancer 1993 2026 2004 2015 2011 1996 2010 2005 2003 500 1000 1.5k 2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Pancreatic cancer
    2011 2.0k citations Joseph M. Herman, Ralph H. Hruban et al. profile →
  2. DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
    1996 1.9k citations Ralph H. Hruban, Scott E. Kern et al. profile →
  3. Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    2010 1.8k citations Shinichi Yachida, Siân Jones et al. profile →
  4. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    2005 1.8k citations Sunil R. Hingorani, Ralph H. Hruban et al. Cancer Cell profile →
  5. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    2003 1.8k citations Sunil R. Hingorani, Emanuel F. Petricoin et al. Cancer Cell profile →
  6. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
    2011 1.8k citations Eric S. Calhoun, Ralph H. Hruban et al. profile →
  7. Six Hundred Fifty Consecutive Pancreaticoduodenectomies in the 1990s
    1997 1.5k citations John L. Cameron, Ralph H. Hruban et al. Annals of Surgery profile →
  8. Pancreatic cancer
    2016 1.3k citations Andrew V. Biankin, David A. Tuveson et al. profile →
  9. DAXX / ATRX , MEN1 , and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors
    2011 1.2k citations Barish H. Edil, Anirban Maitra et al. profile →
  10. 1423 Pancreaticoduodenectomies for Pancreatic Cancer: A Single-Institution Experience
    2006 1.2k citations John L. Cameron, Ralph H. Hruban et al. profile →
  11. Underlying Causes and Long-Term Survival in Patients with Initially Unexplained Cardiomyopathy
    2000 1.2k citations Ralph H. Hruban et al. profile →
  12. Gene Expression Profiles in Normal and Cancer Cells
    1997 1.0k citations Victor E. Velculescu, Scott E. Kern et al. profile →
  13. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
    1994 912 citations Ralph H. Hruban, Scott E. Kern et al. profile →
  14. Pancreatic Intraepithelial Neoplasia
    2001 842 citations Ralph H. Hruban, Volkan Adsay et al. profile →
  15. DPC4 Gene Status of the Primary Carcinoma Correlates With Patterns of Failure in Patients With Pancreatic Cancer
    2009 799 citations Christine A. Iacobuzio–Donahue, Shinichi Yachida et al. profile →
  16. Pancreaticoduodenectomy for Cancer of the Head of the Pancreas 201 Patients
    1995 771 citations John L. Cameron, Ralph H. Hruban et al. Annals of Surgery profile →
  17. An Illustrated Consensus on the Classification of Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms
    2004 761 citations Ralph H. Hruban, Volkan Adsay et al. profile →
  18. Revision of the 1990 working formulation for the classification of pulmonary allograft rejection: Lung Rejection Study Group.
    1996 724 citations Ralph H. Hruban et al. PubMed profile →
  19. Recent progress in pancreatic cancer
    2013 690 citations Christopher L. Wolfgang, Joseph M. Herman et al. profile →
  20. Intraductal Papillary Mucinous Neoplasms of the Pancreas
    2004 644 citations John L. Cameron, Ralph H. Hruban et al. Annals of Surgery profile →
  21. Prevalence of Unsuspected Pancreatic Cysts on MDCT
    2008 625 citations Alison P. Klein, Satomi Kawamoto et al. profile →
  22. Pancreaticoduodenectomy With or Without Distal Gastrectomy and Extended Retroperitoneal Lymphadenectomy for Periampullary Adenocarcinoma, Part 2
    2002 613 citations John L. Cameron, Ralph H. Hruban et al. Annals of Surgery profile →
  23. Molecular Assessment of Histopathological Staging in Squamous-Cell Carcinoma of the Head and Neck
    1995 581 citations Ralph H. Hruban et al. profile →
  24. DPC4 gene in various tumor types.
    1996 570 citations Ralph H. Hruban, Scott E. Kern et al. PubMed profile →
  25. Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene
    2009 565 citations Siân Jones, Ralph H. Hruban et al. profile →
  26. Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development
    2011 562 citations Jian Wu, Hanno Matthaei et al. Science Translational Medicine profile →
  27. Tumor-suppressive pathways in pancreatic carcinoma.
    1997 554 citations Michael Goggins, Ralph H. Hruban et al. PubMed profile →
  28. K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.
    1993 546 citations Ralph H. Hruban et al. PubMed profile →
  29. Pancreatic Cancer
    2008 538 citations Anirban Maitra, Ralph H. Hruban profile →
  30. Long-Term Outcome of Fulminant Myocarditis as Compared with Acute (Nonfulminant) Myocarditis
    2000 537 citations Ralph H. Hruban, Grover M. Hutchins et al. profile →
  31. Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia
    2012 534 citations Hanno Matthaei, Jian Wu et al. profile →
  32. International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer
    2012 525 citations Marcia Irene Canto, Ralph H. Hruban et al. profile →
  33. Association between Cigarette Smoking and Mutation of the p53 Gene in Squamous-Cell Carcinoma of the Head and Neck
    1995 506 citations Ralph H. Hruban et al. profile →
  34. Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis
    2003 504 citations Anirban Maitra, Christine A. Iacobuzio–Donahue et al. Cancer Cell profile →
  35. The incidence of p53 mutations increases with progression of head and neck cancer.
    1993 502 citations Ralph H. Hruban et al. PubMed profile →
  36. Patterns, Timing, and Predictors of Recurrence Following Pancreatectomy for Pancreatic Ductal Adenocarcinoma
    2017 477 citations Vincent P. Groot, Neda Rezaee et al. Annals of Surgery profile →
  37. Small Cell and Large Cell Neuroendocrine Carcinomas of the Pancreas are Genetically Similar and Distinct From Well-differentiated Pancreatic Neuroendocrine Tumors
    2012 380 citations Shinichi Yachida, Catherine M. White et al. profile →
  38. The High-grade (WHO G3) Pancreatic Neuroendocrine Tumor Category Is Morphologically and Biologically Heterogenous and Includes Both Well Differentiated and Poorly Differentiated Neoplasms
    2015 341 citations Olca Baştürk, Ralph H. Hruban et al. profile →
  39. Survival in Locally Advanced Pancreatic Cancer After Neoadjuvant Therapy and Surgical Resection
    2018 271 citations Vincent P. Groot, Daniel A. Laheru et al. Annals of Surgery profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Ralph H. Hruban United States 154 62.5k 31.1k 29.3k 22.6k 16.5k 926 93.4k
Eric Van Cutsem Belgium 134 70.1k 1.1× 20.7k 0.7× 16.1k 0.5× 12.4k 0.6× 8.4k 0.5× 1.2k 95.3k
Charles J. Yeo United States 115 42.3k 0.7× 29.0k 0.9× 10.8k 0.4× 8.6k 0.4× 8.4k 0.5× 579 56.1k
Adrian L. Harris United Kingdom 164 34.9k 0.6× 7.5k 0.2× 64.9k 2.2× 45.7k 2.0× 5.9k 0.4× 1.2k 109.9k
David Cunningham United Kingdom 120 42.1k 0.7× 24.5k 0.8× 12.7k 0.4× 6.5k 0.3× 4.2k 0.3× 1.2k 77.9k
Adi F. Gazdar United States 132 28.3k 0.5× 5.4k 0.2× 36.4k 1.2× 12.6k 0.6× 7.0k 0.4× 654 70.7k
Stanley R. Hamilton United States 113 34.1k 0.5× 13.5k 0.4× 21.6k 0.7× 16.8k 0.7× 4.0k 0.2× 400 67.0k
Anirban Maitra United States 115 25.8k 0.4× 8.6k 0.3× 26.6k 0.9× 14.4k 0.6× 5.5k 0.3× 564 51.1k
Mithat Gönen United States 119 26.5k 0.4× 20.8k 0.7× 8.1k 0.3× 5.8k 0.3× 6.8k 0.4× 781 60.7k
David Sidransky United States 121 25.6k 0.4× 9.1k 0.3× 40.0k 1.4× 17.1k 0.8× 3.4k 0.2× 576 66.1k
John L. Cameron United States 118 40.4k 0.6× 35.3k 1.1× 7.4k 0.3× 7.7k 0.3× 10.7k 0.6× 531 62.4k

Countries citing papers authored by Ralph H. Hruban

Since Specialization
Citations

This map shows the geographic impact of Ralph H. Hruban's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ralph H. Hruban with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ralph H. Hruban more than expected).

Fields of papers citing papers by Ralph H. Hruban

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ralph H. Hruban. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ralph H. Hruban. The network helps show where Ralph H. Hruban may publish in the future.

Co-authorship network of co-authors of Ralph H. Hruban

This figure shows the co-authorship network connecting the top 25 collaborators of Ralph H. Hruban. A scholar is included among the top collaborators of Ralph H. Hruban based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ralph H. Hruban. Ralph H. Hruban is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Azadi, Javad, Sheila Sheth, Satomi Kawamoto, et al.. (2024). Radiomics machine learning algorithm facilitates detection of small pancreatic neuroendocrine tumors on CT. Diagnostic and Interventional Imaging. 106(1). 28–40. 9 indexed citations
2.
Kiemen, Ashley, Mohamad Dbouk, Azarakhsh Baghdadi, et al.. (2024). Magnetic Resonance Imaging–Based Assessment of Pancreatic Fat Strongly Correlates With Histology-Based Assessment of Pancreas Composition. Pancreas. 53(2). e180–e186. 4 indexed citations
3.
Ferres, Juan Lavista, Felipe Oviedo, Caleb Robinson, et al.. (2024). Performance of explainable artificial intelligence in guiding the management of patients with a pancreatic cyst. Pancreatology. 24(7). 1182–1191. 3 indexed citations
4.
Fujikura, Kohei, Danielle Hutchings, Alicia M. Braxton, et al.. (2020). Intraductal pancreatic cancer is less responsive than cancer in the stroma to neoadjuvant chemotherapy. Modern Pathology. 33(10). 2026–2034. 10 indexed citations
5.
Groot, Vincent P., Neda Rezaee, Wenchuan Wu, et al.. (2017). Patterns, Timing, and Predictors of Recurrence Following Pancreatectomy for Pancreatic Ductal Adenocarcinoma. Annals of Surgery. 267(5). 936–945. 477 indexed citations breakdown →
6.
Hata, Tatsuo, Marco Dal Molin, Seung‐Mo Hong, et al.. (2017). Predicting the Grade of Dysplasia of Pancreatic Cystic Neoplasms Using Cyst Fluid DNA Methylation Markers. Clinical Cancer Research. 23(14). 3935–3944. 59 indexed citations
7.
Childs, Erica J., Kari G. Chaffee, Steven Gallinger, et al.. (2016). Association of Common Susceptibility Variants of Pancreatic Cancer in Higher-Risk Patients: A PACGENE Study. Cancer Epidemiology Biomarkers & Prevention. 25(7). 1185–1191. 22 indexed citations
8.
Hata, Tatsuo, Marco Dal Molin, Masaya Suenaga, et al.. (2016). Cyst Fluid Telomerase Activity Predicts the Histologic Grade of Cystic Neoplasms of the Pancreas. Clinical Cancer Research. 22(20). 5141–5151. 34 indexed citations
9.
Kim, Haeryoung, Burcu Saka, Spencer Knight, et al.. (2014). Having Pancreatic Cancer with Tumoral Loss of ATM and Normal TP53 Protein Expression Is Associated with a Poorer Prognosis. Clinical Cancer Research. 20(7). 1865–1872. 70 indexed citations
10.
Li, Ang, Jun Yu, Haeryoung Kim, et al.. (2013). MicroRNA Array Analysis Finds Elevated Serum miR-1290 Accurately Distinguishes Patients with Low-Stage Pancreatic Cancer from Healthy and Disease Controls. Clinical Cancer Research. 19(13). 3600–3610. 244 indexed citations
11.
Kinde, Isaac, Enrico Munari, Sheila F. Faraj, et al.. (2013). TERT Promoter Mutations Occur Early in Urothelial Neoplasia and Are Biomarkers of Early Disease and Disease Recurrence in Urine. Cancer Research. 73(24). 7162–7167. 200 indexed citations
12.
Yachida, Shinichi, Catherine M. White, Yoshiki Naito, et al.. (2012). Clinical Significance of the Genetic Landscape of Pancreatic Cancer and Implications for Identification of Potential Long-term Survivors. Clinical Cancer Research. 18(22). 6339–6347. 199 indexed citations
13.
Wu, Jian, Hanno Matthaei, Anirban Maitra, et al.. (2011). Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development. Science Translational Medicine. 3(92). 92ra66–92ra66. 562 indexed citations breakdown →
14.
Garrido‐Laguna, Ignacio, Maria Uson, N.V. Rajeshkumar, et al.. (2011). Tumor Engraftment in Nude Mice and Enrichment in Stroma- Related Gene Pathways Predict Poor Survival and Resistance to Gemcitabine in Patients with Pancreatic Cancer. Clinical Cancer Research. 17(17). 5793–5800. 179 indexed citations
15.
Liby, Karen T., Darlene B. Royce, Renee Risingsong, et al.. (2010). Synthetic Triterpenoids Prolong Survival in a Transgenic Mouse Model of Pancreatic Cancer. Cancer Prevention Research. 3(11). 1427–1434. 78 indexed citations
16.
Calhoun, Eric S., Tomáš Hucl, Eike Gallmeier, et al.. (2006). Identifying Allelic Loss and Homozygous Deletions in Pancreatic Cancer without Matched Normals Using High-Density Single-Nucleotide Polymorphism Arrays. Cancer Research. 66(16). 7920–7928. 66 indexed citations
17.
Zhang, Hui, Olca Baştürk, Marini Othman, et al.. (2005). Neuropathology. Modern Pathology. 18. 291–296.
18.
Prasad, Nijaguna B., Andrew V. Biankin, Noriyoshi Fukushima, et al.. (2005). Gene Expression Profiles in Pancreatic Intraepithelial Neoplasia Reflect the Effects of Hedgehog Signaling on Pancreatic Ductal Epithelial Cells. Cancer Research. 65(5). 1619–1626. 186 indexed citations
19.
Hingorani, Sunil R., Emanuel F. Petricoin, Anirban Maitra, et al.. (2003). Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 4(6). 437–450. 1774 indexed citations breakdown →
20.
Hruban, Ralph H., W. E. Beschorner, William A. Baumgartner, et al.. (1991). Accelerated arteriosclerosis in heart transplant recipients: an immunopathology study of 22 transplanted hearts.. PubMed. 23(1 Pt 2). 1230–2. 9 indexed citations

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