Ralph H. Hruban

203.9k citations

926 papers · 93.4k indexed · 39 hit papers · h-index 154

Oncology top 0.01%
Surgery top 0.01%
Molecular Biology top 0.02%
Cancer Research top 0.01%
Epidemiology top 0.02%

Co-authors: Charles J. Yeo Michael Goggins John L. Cameron Anirban Maitra Scott E. Kern Christopher L. Wolfgang Christine A. Iacobuzio–Donahue Elliot K. Fishman
Topics: Pancreatic and Hepatic Oncology Research (591 papers)Cancer Genomics and Diagnostics (211 papers)Neuroendocrine Tumor Research Advances (168 papers)
Cited by: Oncology Cancer Research Surgery
Journals: Nature Science New England Journal of Medicine
Partner nations: United States Netherlands Germany

In The Last Decade

Ralph H. Hruban

916 papers receiving 91.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Pancreatic cancer

2011 2.0k citations Audrey Vincent, Joseph M. Herman et al. profile →
DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 1.9k citations Ralph H. Hruban, Scott E. Kern et al. Science profile →
Distant metastasis occurs late during the genetic evolution of pancreatic cancer

2010 1.8k citations Shinichi Yachida, Siân Jones et al. profile →
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

2005 1.8k citations Ralph H. Hruban et al. profile →
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

2003 1.8k citations Anirban Maitra, Ralph H. Hruban et al. profile →
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

2011 1.8k citations Eric S. Calhoun, Ralph H. Hruban et al. profile →
Six Hundred Fifty Consecutive Pancreaticoduodenectomies in the 1990s

1997 1.5k citations Ralph H. Hruban et al. profile →
Pancreatic cancer

2016 1.3k citations Ralph H. Hruban et al. profile →
DAXX / ATRX , MEN1 , and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

2011 1.2k citations Yuchen Jiao, Chanjuan Shi et al. Science profile →
1423 Pancreaticoduodenectomies for Pancreatic Cancer: A Single-Institution Experience

2006 1.2k citations Ralph H. Hruban, Richard D. Schulick et al. profile →
Underlying Causes and Long-Term Survival in Patients with Initially Unexplained Cardiomyopathy

2000 1.2k citations Ralph H. Hruban et al. profile →
Gene Expression Profiles in Normal and Cancer Cells

1997 1.0k citations Victor E. Velculescu, Scott E. Kern et al. Science profile →
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

1994 912 citations Ralph H. Hruban, Scott E. Kern et al. profile →
Pancreatic Intraepithelial Neoplasia

2001 842 citations Ralph H. Hruban, Volkan Adsay et al. profile →
DPC4 Gene Status of the Primary Carcinoma Correlates With Patterns of Failure in Patients With Pancreatic Cancer

2009 799 citations Christine A. Iacobuzio–Donahue, Shinichi Yachida et al. profile →
Pancreaticoduodenectomy for Cancer of the Head of the Pancreas 201 Patients

1995 771 citations Ralph H. Hruban et al. profile →
An Illustrated Consensus on the Classification of Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms

2004 761 citations Ralph H. Hruban, David S. Klimstra et al. profile →
Revision of the 1990 working formulation for the classification of pulmonary allograft rejection: Lung Rejection Study Group.

1996 724 citations Ralph H. Hruban et al. profile →
Recent progress in pancreatic cancer

2013 690 citations Christopher L. Wolfgang, Joseph M. Herman et al. profile →
Intraductal Papillary Mucinous Neoplasms of the Pancreas

2004 644 citations Ralph H. Hruban et al. profile →
Prevalence of Unsuspected Pancreatic Cysts on MDCT

2008 625 citations Alison P. Klein, Satomi Kawamoto et al. profile →
Pancreaticoduodenectomy With or Without Distal Gastrectomy and Extended Retroperitoneal Lymphadenectomy for Periampullary Adenocarcinoma, Part 2

2002 613 citations Ralph H. Hruban et al. profile →
Molecular Assessment of Histopathological Staging in Squamous-Cell Carcinoma of the Head and Neck

1995 581 citations Ralph H. Hruban et al. profile →
DPC4 gene in various tumor types.

1996 570 citations Ralph H. Hruban, Scott E. Kern et al. profile →
Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene

2009 565 citations Siân Jones, Ralph H. Hruban et al. Science profile →
Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development

2011 562 citations Jian Wu, Hanno Matthaei et al. profile →
Tumor-suppressive pathways in pancreatic carcinoma.

1997 554 citations Michael Goggins, Ralph H. Hruban et al. profile →
K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.

1993 546 citations Ralph H. Hruban et al. profile →
Pancreatic Cancer

2008 538 citations Anirban Maitra, Ralph H. Hruban profile →
Long-Term Outcome of Fulminant Myocarditis as Compared with Acute (Nonfulminant) Myocarditis

2000 537 citations Ralph H. Hruban et al. profile →
Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia

2012 534 citations Mitsuro Kanda, Hanno Matthaei et al. profile →
International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer

2012 525 citations Marcia Irene Canto, Ralph H. Hruban et al. Gut profile →
Association between Cigarette Smoking and Mutation of the p53 Gene in Squamous-Cell Carcinoma of the Head and Neck

1995 506 citations Ralph H. Hruban et al. profile →
Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis

2003 504 citations Anirban Maitra, Christine A. Iacobuzio–Donahue et al. profile →
The incidence of p53 mutations increases with progression of head and neck cancer.

1993 502 citations Ralph H. Hruban et al. profile →
Patterns, Timing, and Predictors of Recurrence Following Pancreatectomy for Pancreatic Ductal Adenocarcinoma

2017 477 citations Neda Rezaee, Elliot K. Fishman et al. profile →
Small Cell and Large Cell Neuroendocrine Carcinomas of the Pancreas are Genetically Similar and Distinct From Well-differentiated Pancreatic Neuroendocrine Tumors

2012 380 citations Shinichi Yachida, Catherine M. White et al. profile →
The High-grade (WHO G3) Pancreatic Neuroendocrine Tumor Category Is Morphologically and Biologically Heterogenous and Includes Both Well Differentiated and Poorly Differentiated Neoplasms

2015 341 citations Olca Baştürk, Laura H. Tang et al. profile →
Survival in Locally Advanced Pancreatic Cancer After Neoadjuvant Therapy and Surgical Resection

2018 271 citations Daniel A. Laheru, Lei Zheng et al. profile →

Peers

Countries citing papers authored by Ralph H. Hruban

Since Specialization

Citations

This map shows the geographic impact of Ralph H. Hruban's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ralph H. Hruban with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ralph H. Hruban more than expected).

Fields of papers citing papers by Ralph H. Hruban

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ralph H. Hruban. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ralph H. Hruban. The network helps show where Ralph H. Hruban may publish in the future.

Co-authorship network of co-authors of Ralph H. Hruban

This figure shows the co-authorship network connecting the top 25 collaborators of Ralph H. Hruban. A scholar is included among the top collaborators of Ralph H. Hruban based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ralph H. Hruban. Ralph H. Hruban is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Radiomics machine learning algorithm facilitates detection of small pancreatic neuroendocrine tumors on CT 2024 ·Diagnostic and Interventional Imaging ·(unknown),(unknown),Javad Azadi,Sheila Sheth,Satomi Kawamoto,Ammar A. Javed,Florent Tixier,Ralph H. Hruban,Elliot K. Fishman,Linda C. Chu	9
2	Performance of explainable artificial intelligence in guiding the management of patients with a pancreatic cyst 2024 ·Pancreatology ·Juan Lavista Ferres,Felipe Oviedo,Caleb Robinson,Linda C. Chu,Satomi Kawamoto,Elham Afghani,Jin He,Alison P. Klein,(unknown),Christopher L. Wolfgang,Ammar A. Javed,Rahul Dodhia,(unknown),Ken W Kinzler,Ralph H. Hruban,William B. Weeks,Elliot K. Fishman,Anne Marie Lennon	3
3	CRISPR-Cas9 for selective targeting of somatic mutations in pancreatic cancers 2024 ·NAR Cancer ·(unknown),(unknown),Eitan Halper‐Stromberg,(unknown),(unknown),Alyza Skaist,(unknown),(unknown),(unknown),(unknown),Hirohiko Kamiyama,Sarah J. Wheelan,Ming-Tseh Lin,Ralph H. Hruban,Chien‐Fu Hung,Michael Goldstein,Robert B. Scharpf,Nicholas J. Roberts,James R. Eshleman	3
4	Cyst Fluid Telomerase Activity Predicts the Histologic Grade of Cystic Neoplasms of the Pancreas 2016 ·Clinical Cancer Research ·Tatsuo Hata,Marco Dal Molin,Masaya Suenaga,Jun Yu,Meredith E. Pittman,Matthew J. Weiss,Marcia Irene Canto,Christopher L. Wolfgang,Anne Marie Lennon,Ralph H. Hruban,Michael Goggins	34
5	Alternative Lengthening of Telomeres in Primary Pancreatic Neuroendocrine Tumors Is Associated with Aggressive Clinical Behavior and Poor Survival 2016 ·Clinical Cancer Research ·Joo Young Kim,Jacqueline A. Brosnan‐Cashman,Soyeon An,Sung Joo Kim,Ki Byung Song,Min Sun Kim,(unknown),Dae Wook Hwang,Alan K. Meeker,Eunsil Yu,Song Cheol Kim,Ralph H. Hruban,Christopher M. Heaphy,Seung‐Mo Hong	108
6	Very Long-term Survival Following Resection for Pancreatic Cancer Is Not Explained by Commonly Mutated Genes: Results of Whole-Exome Sequencing Analysis 2015 ·Clinical Cancer Research ·Marco Dal Molin,Ming Zhang,Roeland F. de Wilde,Niki A. Ottenhof,Neda Rezaee,Christopher L. Wolfgang,Amanda L. Blackford,Bert Vogelstein,Kenneth W. Kinzler,Nickolas Papadopoulos,Ralph H. Hruban,Anirban Maitra,Laura D. Wood	74
7	Immunotherapy Converts Nonimmunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation 2014 ·Cancer Immunology Research ·Eric R. Lutz,Annie A. Wu,Elaine Bigelow,Rajni Sharma,Guanglan Mo,Kevin C. Soares,Sara Solt,(unknown),(unknown),Allison Yager,Daniel A. Laheru,Christopher L. Wolfgang,Jiang Wang,Ralph H. Hruban,Robert A. Anders,Elizabeth M. Jaffee,Lei Zheng	399
8	Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts 2012 ·Gut ·Mitsuro Kanda,Spencer Knight,Mark Topazian,Sapna Syngal,James J. Farrell,Jeffrey Lee,Ihab R. Kamel,Anne Marie Lennon,Michael Borges,Angela Young,Sho Fujiwara,(unknown),James R. Eshleman,Ralph H. Hruban,Marcia Irene Canto,Michael Goggins	119
9	miRNA Biomarkers in Cyst Fluid Augment the Diagnosis and Management of Pancreatic Cysts 2012 ·Clinical Cancer Research ·Hanno Matthaei,Dennis Wylie,(unknown),Marco Dal Molin,Jon Kemppainen,Skye C. Mayo,Christopher L. Wolfgang,Richard D. Schulick,(unknown),Bernard F. Andruss,Alex Adai,Ralph H. Hruban,Anna E. Szafranska-Schwarzbach,Anirban Maitra	126
10	Genetically Defined Subsets of Human Pancreatic Cancer Show Unique In Vitro Chemosensitivity 2012 ·Clinical Cancer Research ·Yunfeng Cui,Jacqueline A. Brosnan‐Cashman,Amanda L. Blackford,Surojit Sur,Ralph H. Hruban,Kenneth W. Kinzler,Bert Vogelstein,Anirban Maitra,Luis A. Díaz,Christine A. Iacobuzio–Donahue,James R. Eshleman	54
11	Genome-Wide Somatic Copy Number Alterations in Low-Grade PanINs and IPMNs from Individuals with a Family History of Pancreatic Cancer 2012 ·Clinical Cancer Research ·Seung‐Mo Hong,Audrey Vincent,Mitsuro Kanda,(unknown),Noriyuki Omura,Michael Borges,Alison P. Klein,Marcia Irene Canto,Ralph H. Hruban,Michael Goggins	45
12	Clinical Significance of the Genetic Landscape of Pancreatic Cancer and Implications for Identification of Potential Long-term Survivors 2012 ·Clinical Cancer Research ·Shinichi Yachida,Catherine M. White,Yoshiki Naito,Yi Zhong,Jacqueline A. Brosnan‐Cashman,Anne M. Macgregor‐Das,Richard A. Morgan,Tyler Saunders,Daniel A. Laheru,Joseph M. Herman,Ralph H. Hruban,Alison P. Klein,Siân Jones,Victor E. Velculescu,Christopher L. Wolfgang,Christine A. Iacobuzio–Donahue	199
13	Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma 2011 ·Science ·Chetan Bettegowda,Nishant Agrawal,Yuchen Jiao,Mark Sausen,Laura D. Wood,Ralph H. Hruban,Fausto J. Rodríguez,Daniel P. Cahill,Roger E. McLendon,Gregory J. Riggins,Victor E. Velculescu,Sueli Mieko Oba‐Shinjo,Suely Kazue Nagahashi Marie,Bert Vogelstein,Darell D. Bigner,Hai Yan,Nickolas Papadopoulos,Kenneth W. Kinzler	370
14	DAXX / ATRX , MEN1 , and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumorsbreakdown → 2011 ·Science ·Yuchen Jiao,Chanjuan Shi,Barish H. Edil,Roeland F. de Wilde,David S. Klimstra,Anirban Maitra,Richard D. Schulick,Laura H. Tang,Christopher L. Wolfgang,Michael A. Choti,Victor E. Velculescu,Luis A. Díaz,Bert Vogelstein,Kenneth W. Kinzler,Ralph H. Hruban,Nickolas Papadopoulos	1244
15	Genome-Wide CpG Island Profiling of Intraductal Papillary Mucinous Neoplasms of the Pancreas 2011 ·Clinical Cancer Research ·Seung‐Mo Hong,Noriyuki Omura,Audrey Vincent,Ang Li,Spencer Knight,Jun Yu,Ralph H. Hruban,Michael Goggins	57
16	MicroRNA Alterations of Pancreatic Intraepithelial Neoplasias 2011 ·Clinical Cancer Research ·Jun Yu,Ang Li,Seung‐Mo Hong,Ralph H. Hruban,Michael Goggins	174
17	Mutant proteins as cancer-specific biomarkers 2011 ·Proceedings of the National Academy of Sciences ·Qing Wang,Raghothama Chaerkady,Jian Wu,Hee Jung Hwang,Nikolaos G. Papadopoulos,Levy Kopelovich,Anirban Maitra,Hanno Matthaei,James R. Eshleman,Ralph H. Hruban,Kenneth W. Kinzler,Akhilesh Pandey,Bert Vogelstein	128
18	Synthetic Triterpenoids Prolong Survival in a Transgenic Mouse Model of Pancreatic Cancer 2010 ·Cancer Prevention Research ·Karen T. Liby,Darlene B. Royce,Renee Risingsong,Charlotte R. Williams,Anirban Maitra,Ralph H. Hruban,Michael B. Sporn	78
19	Identifying Allelic Loss and Homozygous Deletions in Pancreatic Cancer without Matched Normals Using High-Density Single-Nucleotide Polymorphism Arrays 2006 ·Cancer Research ·Eric S. Calhoun,Tomáš Hucl,Eike Gallmeier,Kristen M. West,Dan E. Arking,Anirban Maitra,Christine A. Iacobuzio–Donahue,Aravinda Chakravarti,Ralph H. Hruban,Scott E. Kern	66
20	Neuropathology 2005 ·Modern Pathology ·Hui Zhang,Olca Baştürk,Marini Othman,Said Khayyata,Anirban Maitra,Ralph H. Hruban,Volkan Adsay,(unknown)	0

About Ralph H. Hruban

Ralph H. Hruban is a scholar working on Oncology, Cancer Research and Surgery, having authored 926 papers that have together received 93.4k indexed citations. Recurring topics across this work include Pancreatic and Hepatic Oncology Research (591 papers), Cancer Genomics and Diagnostics (211 papers) and Neuroendocrine Tumor Research Advances (168 papers). The work is most often cited by research in Oncology (62.5k citations), Cancer Research (22.6k citations) and Surgery (31.1k citations). Ralph H. Hruban has collaborated with scholars based in United States, Netherlands and Germany. Frequent co-authors include Charles J. Yeo, Michael Goggins, John L. Cameron, Anirban Maitra, Scott E. Kern, Christopher L. Wolfgang, Christine A. Iacobuzio–Donahue, Elliot K. Fishman, Keith D. Lillemoe and Taylor A. Sohn. Their work appears in journals such as Nature, Science and New England Journal of Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact