Muthusamy Jayaraman

13.0k total citations · 4 hit papers
34 papers, 5.7k citations indexed

About

Muthusamy Jayaraman is a scholar working on Molecular Biology, Organic Chemistry and Oncology. According to data from OpenAlex, Muthusamy Jayaraman has authored 34 papers receiving a total of 5.7k indexed citations (citations by other indexed papers that have themselves been cited), including 18 papers in Molecular Biology, 15 papers in Organic Chemistry and 8 papers in Oncology. Recurrent topics in Muthusamy Jayaraman's work include RNA Interference and Gene Delivery (12 papers), Synthesis of β-Lactam Compounds (11 papers) and Advanced biosensing and bioanalysis techniques (11 papers). Muthusamy Jayaraman is often cited by papers focused on RNA Interference and Gene Delivery (12 papers), Synthesis of β-Lactam Compounds (11 papers) and Advanced biosensing and bioanalysis techniques (11 papers). Muthusamy Jayaraman collaborates with scholars based in United States, India and Canada. Muthusamy Jayaraman's co-authors include Muthiah Manoharan, Martin A. Maier, Kallanthottathil G. Rajeev, Akin Akinc, Ying K. Tam, Michael J. Hope, Barbara L. Mui, Xinyao Du, Thomas D. Madden and Steven M. Ansell and has published in prestigious journals such as Journal of the American Chemical Society, Angewandte Chemie International Edition and Blood.

In The Last Decade

Muthusamy Jayaraman

32 papers receiving 5.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

2019 1.2k citations Akin Akinc, Martin A. Maier et al. Nature Nanotechnology profile →
Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

2012 1.0k citations Hyukjin Lee, Abigail K. R. Lytton‐Jean et al. Nature Nanotechnology profile →
Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

2012 973 citations Muthusamy Jayaraman, Steven M. Ansell et al. Angewandte Chemie International Edition profile →
Mechanisms and optimization of in vivo delivery of lipophilic siRNAs

2007 771 citations Christian Wolfrum, K. N. Jayaprakash et al. Nature Biotechnology profile →

Peers

Muthusamy Jayaraman

MB

CR

BIOMA

BE

OC

Steve R. Roffler Taiwan

Ikuhiko Nakase Japan

Palma Rocchi France

May C. Morris France

Valentin V. Vlassov Russia

Kun Cheng United States

Martin A. Maier United States

Hongxia Wang China

Carston R. Wagner United States

Yuanyu Huang China

Steve R. Roffler Taiwan

Muthusamy Jayaraman

3.4k ×0.7

MB

691 ×0.9

CR

1.1k ×1.7

BIOMA

905 ×1.5

BE

368 ×0.6

OC

Citations per year, relative to Muthusamy Jayaraman Muthusamy Jayaraman (= 1×) peers Steve R. Roffler

Countries citing papers authored by Muthusamy Jayaraman

Since Specialization

Citations

This map shows the geographic impact of Muthusamy Jayaraman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Muthusamy Jayaraman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Muthusamy Jayaraman more than expected).

Fields of papers citing papers by Muthusamy Jayaraman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Muthusamy Jayaraman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Muthusamy Jayaraman. The network helps show where Muthusamy Jayaraman may publish in the future.

Co-authorship network of co-authors of Muthusamy Jayaraman

This figure shows the co-authorship network connecting the top 25 collaborators of Muthusamy Jayaraman. A scholar is included among the top collaborators of Muthusamy Jayaraman based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Muthusamy Jayaraman. Muthusamy Jayaraman is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

1.

Soto, David, Juliet Crabtree, Thomas Lee, et al.. (2025). In Vivo pan CAR therapy utilizing circular RNA for treatment of autoimmune diseases. Blood. 146(Supplement 1). 104–104.

2.

Silver, Rebecca, Jeffrey W. Schindler, Changqing Sun, et al.. (2025). In Vivo pan CAR therapy utilizing circular RNA for treatment of multiple myeloma. Blood. 146(Supplement 1). 4117–4117.

3.

Crabtree, Juliet, Akinola Olumide Emmanuel, David Soto, et al.. (2024). In Vivo panCAR-Mediated Depletion of B Cells in Non-Human Primates Using a Circular (oRNA®) Anti-CD20 CAR. Blood. 144(Supplement 1). 3427–3427. 2 indexed citations

4.

Akinc, Akin, Martin A. Maier, Muthiah Manoharan, et al.. (2019). The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs. Nature Nanotechnology. 14(12). 1084–1087. 1160 indexed citations breakdown →

5.

Schlegel, Mark K., Donald J. Foster, Alexander V. Kel’in, et al.. (2017). Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA. Journal of the American Chemical Society. 139(25). 8537–8546. 62 indexed citations

6.

Rajeev, Kallanthottathil G., Jayaprakash K. Nair, Muthusamy Jayaraman, et al.. (2015). Hepatocyte‐Specific Delivery of siRNAs Conjugated to Novel Non‐nucleosidic Trivalent N‐Acetylgalactosamine Elicits Robust Gene Silencing in Vivo. ChemBioChem. 16(6). 903–908. 148 indexed citations

7.

Mui, Barbara L., Ying K. Tam, Muthusamy Jayaraman, et al.. (2013). Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles. Molecular Therapy — Nucleic Acids. 2. e139–e139. 390 indexed citations

8.

Jayaraman, Muthusamy, Steven M. Ansell, Barbara L. Mui, et al.. (2012). Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**. Angewandte Chemie International Edition. 51(34). 8529–8533. 973 indexed citations breakdown →

9.

Jayaraman, Muthusamy, et al.. (2012). An immobilized and reusable Cu(i) catalyst for metal ion-free conjugation of ligands to fully deprotected oligonucleotides through click reaction. Chemical Communications. 49(2). 184–186. 11 indexed citations

10.

Lee, Hyukjin, Abigail K. R. Lytton‐Jean, Yi Chen, et al.. (2012). Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Nature Nanotechnology. 7(6). 389–393. 1005 indexed citations breakdown →

11.

Jayaraman, Muthusamy, Steven M. Ansell, Barbara L. Mui, et al.. (2012). Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**. Angewandte Chemie. 124(34). 8657–8661. 122 indexed citations

12.

Akinc, Akin, Michael S. Goldberg, June Qin, et al.. (2009). Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver. Molecular Therapy. 17(5). 872–879. 283 indexed citations

13.

Wolfrum, Christian, K. N. Jayaprakash, Muthusamy Jayaraman, et al.. (2007). Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nature Biotechnology. 25(10). 1149–1157. 771 indexed citations breakdown →

14.

Morrell, Andrew, Muthusamy Jayaraman, Muthukaman Nagarajan, et al.. (2006). Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay. Bioorganic & Medicinal Chemistry Letters. 16(16). 4395–4399. 15 indexed citations

15.

Antony, Smitha, Glenda Kohlhagen, Muthusamy Jayaraman, et al.. (2004). Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison. Molecular Pharmacology. 67(2). 523–530. 64 indexed citations

16.

Meltzer, Peter C., Bing Wang, Zhengming Chen, et al.. (2001). Synthesis of 6- and 7- Hydroxy-8-azabicyclo[3.2.1]octanes and Their Binding Affinity for the Dopamine and Serotonin Transporters. Journal of Medicinal Chemistry. 44(16). 2619–2635. 38 indexed citations

17.

Bose, Ajay K., Muthusamy Jayaraman, Maria Teresa Batista, & M. S. MANHAS. (1998). Organic Reactions in Water: Indium Mediated Synthesis of a-Alkylidene-b-lactams. Heterocycles. 49(1). 97–97. 3 indexed citations

18.

Jayaraman, Muthusamy, Phillip E. Fanwick, & Mark Cushman. (1998). Novel Oxidative Transformation of Indenoisoquinolines to Isoquinoline-3-spiro-3‘-phthalides in the Presence of Osmium Tetraoxide and 4-Methylmorpholine N-Oxide. The Journal of Organic Chemistry. 63(17). 5736–5737. 9 indexed citations

19.

Jayaraman, Muthusamy, A.R.A.S. Deshmukh, & B. M. Bhawal. (1994). Efficient Asymmetric Synthesis of cis-4-Formyl .beta.-Lactams from L-(+)-Tartaric Acid. The Journal of Organic Chemistry. 59(4). 932–934. 34 indexed citations

20.

Jayaraman, Muthusamy, A.R.A.S. Deshmukh, & B. M. Bhawal. (1992). Remote Stereocontrol in Ketene-Imine Cycloaddition: An Efficient Asymmetric Synthesis ofcis-β-Lactams. Synlett. 1992(9). 749–750. 14 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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