Pieter R. Cullis

54.2k total citations · 19 hit papers
331 papers, 41.4k citations indexed

About

Pieter R. Cullis is a scholar working on Molecular Biology, Biomaterials and Biomedical Engineering. According to data from OpenAlex, Pieter R. Cullis has authored 331 papers receiving a total of 41.4k indexed citations (citations by other indexed papers that have themselves been cited), including 283 papers in Molecular Biology, 71 papers in Biomaterials and 34 papers in Biomedical Engineering. Recurrent topics in Pieter R. Cullis's work include Lipid Membrane Structure and Behavior (165 papers), RNA Interference and Gene Delivery (153 papers) and Advanced biosensing and bioanalysis techniques (85 papers). Pieter R. Cullis is often cited by papers focused on Lipid Membrane Structure and Behavior (165 papers), RNA Interference and Gene Delivery (153 papers) and Advanced biosensing and bioanalysis techniques (85 papers). Pieter R. Cullis collaborates with scholars based in Canada, United States and Netherlands. Pieter R. Cullis's co-authors include Theresa M. Allen, Michael J. Hope, Ben de Kruijff, Marcel B. Bally, Jayesh A. Kulkarni, L.D. Mayer, Sam Chen, Arcadio Chonn, Roy van der Meel and Dominik Witzigmann and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Pieter R. Cullis

325 papers receiving 40.0k citations

Hit Papers

Drug Delivery Systems: Entering the Main... 1979 2026 1994 2010 2004 2012 1985 1979 1986 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Drug Delivery Systems: Entering the Mainstream
    2004 3.6k citations Pieter R. Cullis et al. profile →
  2. Liposomal drug delivery systems: From concept to clinical applications
    2012 3.6k citations Pieter R. Cullis et al. profile →
  3. Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential
    1985 1.9k citations Marcel B. Bally, Pieter R. Cullis et al. Biochimica et Biophysica Acta (BBA) - Biomembranes profile →
  4. Lipid polymorphism and the functional roles of lipids in biological membranes
    1979 1.5k citations Pieter R. Cullis et al. profile →
  5. Vesicles of variable sizes produced by a rapid extrusion procedure
    1986 1.5k citations Pieter R. Cullis et al. Biochimica et Biophysica Acta (BBA) - Biomembranes profile →
  6. The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
    2019 1.2k citations Sean C. Semple, Ying K. Tam et al. Nature Nanotechnology profile →
  7. Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**
    2012 973 citations Ying K. Tam, Pieter R. Cullis et al. profile →
  8. The current landscape of nucleic acid therapeutics
    2021 934 citations Jayesh A. Kulkarni, Dominik Witzigmann et al. Nature Nanotechnology profile →
  9. Lipid Nanoparticle Systems for Enabling Gene Therapies
    2017 842 citations Pieter R. Cullis et al. Molecular Therapy profile →
  10. Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA
    2012 548 citations Paulo J.C. Lin, Sam Chen et al. profile →
  11. On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA
    2018 457 citations Jayesh A. Kulkarni, Sam Chen et al. ACS Nano profile →
  12. Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility
    2018 411 citations Jayesh A. Kulkarni, Pieter R. Cullis et al. profile →
  13. Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics
    2019 376 citations Jayesh A. Kulkarni, Dominik Witzigmann et al. profile →
  14. Lipid nanoparticle technology for therapeutic gene regulation in the liver
    2020 273 citations Dominik Witzigmann, Jayesh A. Kulkarni et al. profile →
  15. Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery
    2019 266 citations Pieter R. Cullis, Dominik Witzigmann et al. ACS Nano profile →
  16. The 60-year evolution of lipid nanoparticles for nucleic acid delivery
    2024 191 citations Pieter R. Cullis et al. profile →
  17. Anionic Lipid Nanoparticles Preferentially Deliver mRNA to the Hepatic Reticuloendothelial System
    2022 144 citations Gabriela Arias‐Alpizar, Genc Basha et al. Advanced Materials profile →
  18. Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency
    2023 129 citations Miffy H. Y. Cheng, Jerry Leung et al. Advanced Materials profile →
  19. Direct in vivo CAR T cell engineering
    2024 52 citations Pieter R. Cullis et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Pieter R. Cullis Canada 99 29.7k 10.8k 6.9k 3.5k 3.0k 331 41.4k
Vladimir P. Torchilin United States 71 17.0k 0.6× 15.8k 1.5× 9.8k 1.4× 1.6k 0.5× 3.3k 1.1× 185 31.7k
Gert Storm Netherlands 95 13.2k 0.4× 12.6k 1.2× 9.9k 1.4× 4.2k 1.2× 1.9k 0.6× 441 30.9k
Yechezkel Barenholz Israel 78 15.0k 0.5× 8.2k 0.8× 5.4k 0.8× 2.2k 0.6× 2.3k 0.8× 346 26.8k
Theresa M. Allen Canada 74 14.5k 0.5× 11.9k 1.1× 6.3k 0.9× 1.7k 0.5× 3.2k 1.1× 200 26.6k
Leaf Huang United States 116 30.5k 1.0× 11.4k 1.1× 9.8k 1.4× 9.0k 2.6× 1.6k 0.5× 545 47.2k
Philip S. Low United States 96 15.7k 0.5× 6.1k 0.6× 7.5k 1.1× 2.4k 0.7× 2.3k 0.8× 521 36.9k
Alexander V. Kabanov United States 99 15.6k 0.5× 13.6k 1.3× 7.4k 1.1× 1.5k 0.4× 8.1k 2.7× 400 35.7k
Hiroshi Maeda Japan 62 14.4k 0.5× 18.9k 1.7× 15.8k 2.3× 2.0k 0.6× 3.5k 1.2× 244 37.4k
Demetrios Papahadjopoulos United States 82 18.2k 0.6× 7.4k 0.7× 3.9k 0.6× 1.6k 0.5× 2.0k 0.7× 178 26.2k
Francis C. Szoka United States 73 15.5k 0.5× 5.0k 0.5× 2.7k 0.4× 1.6k 0.5× 2.7k 0.9× 208 21.7k

Countries citing papers authored by Pieter R. Cullis

Since Specialization
Citations

This map shows the geographic impact of Pieter R. Cullis's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Pieter R. Cullis with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Pieter R. Cullis more than expected).

Fields of papers citing papers by Pieter R. Cullis

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Pieter R. Cullis. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Pieter R. Cullis. The network helps show where Pieter R. Cullis may publish in the future.

Co-authorship network of co-authors of Pieter R. Cullis

This figure shows the co-authorship network connecting the top 25 collaborators of Pieter R. Cullis. A scholar is included among the top collaborators of Pieter R. Cullis based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Pieter R. Cullis. Pieter R. Cullis is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Brimacombe, Cedric A., et al.. (2025). Rational design of lipid nanoparticles for enabling gene therapies. Molecular Therapy — Methods & Clinical Development. 33(3). 101518–101518. 2 indexed citations
2.
Wang, Siming, et al.. (2025). RNA lipid nanoparticles stabilized during nebulization through excipient selection. Nanoscale Advances. 7(14). 4480–4489. 1 indexed citations
3.
Zhang, Yao, Romain Berti, Benjamin Wang, et al.. (2024). Quantitative Visualization of Lipid Nanoparticle Fusion as a Function of Formulation and Process Parameters. ACS Nano. 18(28). 18191–18201. 15 indexed citations
4.
Basha, Genc, Karen Y. T. Chan, Dominik Witzigmann, et al.. (2022). Lipid nanoparticle-mediated silencing of osteogenic suppressor GNAS leads to osteogenic differentiation of mesenchymal stem cells in vivo. Molecular Therapy. 30(9). 3034–3051. 16 indexed citations
5.
Arias‐Alpizar, Gabriela, Genc Basha, Karen Y. T. Chan, et al.. (2022). Anionic Lipid Nanoparticles Preferentially Deliver mRNA to the Hepatic Reticuloendothelial System. Advanced Materials. 34(16). e2201095–e2201095. 144 indexed citations breakdown →
6.
Kulkarni, Jayesh A., Dominik Witzigmann, Sarah B. Thomson, et al.. (2021). Author Correction: The current landscape of nucleic acid therapeutics. Nature Nanotechnology. 16(7). 841–841. 16 indexed citations
7.
Morstein, Johannes, et al.. (2021). Optimized Photoactivatable Lipid Nanoparticles Enable Red Light Triggered Drug Release. Small. 17(21). e2008198–e2008198. 54 indexed citations
8.
Kulkarni, Jayesh A., Dominik Witzigmann, Sarah B. Thomson, et al.. (2021). The current landscape of nucleic acid therapeutics. Nature Nanotechnology. 16(6). 630–643. 934 indexed citations breakdown →
9.
Meel, Roy van der, Sam Chen, Josh Zaifman, et al.. (2021). Modular Lipid Nanoparticle Platform Technology for siRNA and Lipophilic Prodrug Delivery. Small. 17(37). e2103025–e2103025. 42 indexed citations
10.
Kulkarni, Jayesh A., Sarah B. Thomson, Josh Zaifman, et al.. (2020). Spontaneous, solvent-free entrapment of siRNA within lipid nanoparticles. Nanoscale. 12(47). 23959–23966. 49 indexed citations
11.
Ramishetti, Srinivas, Ranit Kedmi, Meir Goldsmith, et al.. (2015). Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles. ACS Nano. 9(7). 6706–6716. 160 indexed citations
12.
Yamamoto, Yoshiaki, Paulo J.C. Lin, Eliana Beraldi, et al.. (2015). siRNA Lipid Nanoparticle Potently Silences Clusterin and Delays Progression When Combined with Androgen Receptor Cotargeting in Enzalutamide-Resistant Prostate Cancer. Clinical Cancer Research. 21(21). 4845–4855. 57 indexed citations
13.
Raney, Sam G., Laura Sekirov, Ghania Chikh, et al.. (2008). The effect of circulation lifetime and drug-to-lipid ratio of intravenously administered lipid nanoparticles on the biodistribution and immunostimulatory activity of encapsulated CpG-ODN. Journal of drug targeting. 16(7-8). 564–577. 5 indexed citations
14.
Deitcher, Steven R., Pieter R. Cullis, May Q. Wong, & Gavin Choy. (2007). Vinorelbine liposomes injection results in greater tumor drug exposure compared to conventional vinorelbine in tumor-bearing nude mice. Molecular Cancer Therapeutics. 6. 3 indexed citations
15.
Fenske, David B. & Pieter R. Cullis. (2005). Entrapment of Small Molecules and Nucleic Acid–Based Drugs in Liposomes. Methods in enzymology on CD-ROM/Methods in enzymology. 391. 7–40. 53 indexed citations
16.
Chen, Tao, Deirdre P. McIntosh, Jung Soo Kim, et al.. (2004). Alkylated derivatives of poly(ethylacrylic acid) can be inserted into preformed liposomes and trigger pH-dependent intracellular delivery of liposomal contents. Molecular Membrane Biology. 21(6). 385–393. 24 indexed citations
17.
Chonn, Arcadio, Sean C. Semple, & Pieter R. Cullis. (1995). β2-Glycoprotein I Is a Major Protein Associated with Very Rapidly Cleared Liposomes in Vivo, Suggesting a Significant Role in the Immune Clearance of “Non-self” Particles. Journal of Biological Chemistry. 270(43). 25845–25849. 140 indexed citations
18.
Harrigan, Paul Richard, et al.. (1993). Accumulation of doxorubicin and other lipophilic amines into large unilamellar vesicles in response to transmembrane pH gradients. Biochimica et Biophysica Acta (BBA) - Biomembranes. 1149(2). 329–338. 152 indexed citations
19.
Loughrey, Helen, Lewis S. L. Choi, Pieter R. Cullis, & Marcel B. Bally. (1990). Optimized procedures for the coupling of proteins to liposomes. Journal of Immunological Methods. 132(1). 25–35. 55 indexed citations
20.
Tilcock, Colin, et al.. (1989). Detection of surface charge-related properties in model membrane systems by aqueous two-phase partition. Biochimica et Biophysica Acta (BBA) - Biomembranes. 986(1). 167–171. 7 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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