Thomas D. Madden

13.3k citations

63 papers · 7.5k indexed · 7 hit papers · h-index 34

Impact in

Biomaterials top 0.5%
- Nanoparticle-Based Drug Delivery
Molecular Biology top 1%
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Lipid Membrane Structure and Behavior

Papers in

Biomaterials 13
- Nanoparticle-Based Drug Delivery 10
Molecular Biology 50
- Lipid Membrane Structure and Behavior 27
- RNA Interference and Gene Delivery 21
- Advanced biosensing and bioanalysis techniques 14
- Photosynthetic Processes and Mechanisms 5
- Mitochondrial Function and Pathology 3

Co-authors: Pieter R. Cullis Michael J. Hope Barbara L. Mui Ying K. Tam Marcel B. Bally Muthusamy Jayaraman Xinyao Du Muthiah Manoharan
Journals: Biochimica et Biophysica Acta (BBA) - Biomembranes (6 papers)Biochemistry (5 papers)Chemistry and Physics of Lipids (5 papers)Transplantation (4 papers)Nature Communications (3 papers)
Partner nations: Canada United States United Kingdom

In The Last Decade

Thomas D. Madden

63 papers receiving 7.3k citations

Hit Papers

7 papers align trajectories log scale

A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice 2020 · 207 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2020 Molecular Therapy
2019 Nature Nanotechnology
2018 Nature Communications
2018 Journal of Controlled Release
2017 Nature Communications
2015 Journal of Controlled Release
2012 Angewandte Chemie International Edition

Peers

Countries citing papers authored by Thomas D. Madden

Since Specialization

Citations

This map shows the geographic impact of Thomas D. Madden's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas D. Madden with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas D. Madden more than expected).

Fields of papers citing papers by Thomas D. Madden

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas D. Madden. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas D. Madden. The network helps show where Thomas D. Madden may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Thomas D. Madden, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Thomas D. Madden Line = papers co-authored together Thomas D. Madden links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema Nature Communications ·G. Dustler, Gábor Kovács, 土屋文子, László Bálint, Giorgi Julien, Halina Tassell, J E Earp, Barbara L. Mui, Ying K. Tam, Thomas D. Madden, Katalin Karikó, Raghu P. Kataru, Michael J. Hope, Drew Weissman, Babak J. Mehrara, Norbert Pardi, Zoltán Jakus	2021	44
2	The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs Nature Nanotechnology ·Akin Akinc, Martin A. Maier, Muthiah Manoharan, Kevin Fitzgerald, Muthusamy Jayaraman, Scott Barros, Steven M. Ansell, Xinyao Du, Michael J. Hope, Thomas D. Madden, Barbara L. Mui, Sean C. Semple, Ying K. Tam, Marco A. Ciufolini, Dominik Witzigmann, Jayesh A. Kulkarni, Roy van der Meel, Pieter R. Cullis Hit paper breakdown →	2019	1160
3	Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques Molecular Therapy — Nucleic Acids ·Norbert Pardi, Celia C. LaBranche, Guido Ferrari, Derek W. Cain, István Tombácz, Robert Parks, Hiromi Muramatsu, Barbara L. Mui, Ying K. Tam, Katalin Karikó, Patricia Polacino, Christopher Barbosa, Thomas D. Madden, Michael J. Hope, Barton F. Haynes, David C. Montefiori, Shiu-Lok Hu, Drew Weissman	2019	75
4	PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake Journal of Controlled Release ·Hamideh Parhiz, Vladimir V. Shuvaev, Norbert Pardi, Makan Khoshnejad, Raisa Y. Kiseleva, (unknown), Y. Han, Steven Tuyishime, Barbara L. Mui, Ying K. Tam, Thomas D. Madden, Michael J. Hope, Drew Weissman, Vladimir R. Muzykantov Hit paper breakdown →	2018	154
5	Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies Nature Communications ·Norbert Pardi, Kaela Parkhouse, Ericka Kirkpatrick, Meagan McMahon, Seth J. Zost, Barbara L. Mui, Ying K. Tam, Katalin Karikó, Christopher Barbosa, Thomas D. Madden, Michael J. Hope, Florian Krammer, Scott E. Hensley, Drew Weissman Hit paper breakdown →	2018	201
6	Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge Nature Communications ·Norbert Pardi, Anthony Secreto, Xiaochuan Shan, Fotini Debonera, Joshua Glover, Yanjie Yi, Hiromi Muramatsu, Houping Ni, Barbara L. Mui, Ying K. Tam, Farida Shaheen, Ronald G. Collman, Katalin Karikó, Gwenn Danet-Desnoyers, Thomas D. Madden, Michael J. Hope, Drew Weissman Hit paper breakdown →	2017	267
7	Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines npj Vaccines ·Johannes Lutz, Sandra Lazzaro, Mohamed Habbeddine, Kim E. Schmidt, Patrick Baumhof, Barbara L. Mui, Ying K. Tam, Thomas D. Madden, Michael J. Hope, Regina Heidenreich, Mariola Fotin‐Mleczek	2017	205
8	Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo** Angewandte Chemie International Edition ·Muthusamy Jayaraman, Steven M. Ansell, Barbara L. Mui, Ying K. Tam, Jianxin Chen, Xinyao Du, David Butler, A.I. BAZHAL, Shigeo Matsuda, MASAYOSHI TSUGE, Kallanthottathil G. Rajeev, Ismail M. Hafez, Akin Akinc, Martin A. Maier, Mark A. Tracy, Pieter R. Cullis, Thomas D. Madden, Muthiah Manoharan, Michael J. Hope Hit paper breakdown →	2012	973
9	The Liposomal Formulation of Doxorubicin Methods in enzymology on CD-ROM/Methods in enzymology ·Sheela A. Abraham, Dawn Waterhouse, Lawrence D. Mayer, Pieter R. Cullis, Thomas D. Madden, Marcel B. Bally	2005	338
10	Separation of Liposomes from Plasma Components Using Fast Protein Liquid Chromatography Analytical Biochemistry ·Nawar Younis Hussain, Amir F. Ayyobi, P. Haydn Pritchard, Thomas D. Madden	1999	8
11	Biophysical and antigenic characterization of gonococcal protein I incorporated into liposomes Vaccine ·Y Wang, Milan S. Blake, Thomas D. Madden	1997	8
12	LIPOSOMAL CYCLOSPORINE Transplantation ·Takashi Ajihara, Nawar Younis Hussain, Margaretha Lutzhoft, Mark Meloche, Thomas D. Madden	1995	1
13	Influence of transbilayer area asymmetry on the morphology of large unilamellar vesicles Biophysical Journal ·Barbara L. Mui, Jürgen Döbereiner, Thomas D. Madden, P.R. Cullis	1995	110
14	Transmembrane distribution of lipophilic cations in response to an electrochemical potential in reconstituted cytochromec oxidase vesicles and in vesicles exhibiting a potassium ion diffusion potential Journal of Bioenergetics and Biomembranes ·Thomas D. Madden, Thomas E. Redelmeier	1994	8
15	Osmotic properties of large unilamellar vesicles prepared by extrusion Biophysical Journal ·Barbara L. Mui, Pieter R. Cullis, Evan Evans, Thomas D. Madden	1993	188
16	Incorporation of amphotericin B into large unilamellar vesicles composed of phosphatidylcholine and phosphatidylglycerol Chemistry and Physics of Lipids ·Thomas D. Madden, A S Janoff, Pieter R. Cullis	1990	25
17	Protection of liposomes during dehydration or freezing Chemistry and Physics of Lipids ·Paul Richard Harrigan, Thomas D. Madden, Pieter R. Cullis	1990	98
18	The accumulation of drugs within large unilamellar vesicles exhibiting a proton gradient: a survey Chemistry and Physics of Lipids ·Thomas D. Madden, Paul Richard Harrigan, Faiq Afkari Primadika, Marcel B. Bally, Lawrence D. Mayer, T.E. Redelmeier, Helen Loughrey, Colin Tilcock, Lawrence W. Reinish, Pieter R. Cullis	1990	199
19	Protein reconstitution: Methodologies and applications International Journal of Biochemistry ·Thomas D. Madden	1988	4
20	Spontaneous vesiculation of large multilamellar vesicles composed of saturated phosphatidylcholine and phosphatidylglycerol mixtures Biochemistry ·Thomas D. Madden, Colin Tilcock, (unknown), Pieter R. Cullis	1988	21

About Thomas D. Madden

Thomas D. Madden is a scholar working on Biomaterials, Molecular Biology, Virology, Transplantation and Spectroscopy, having authored 63 papers that have together received 7.5k indexed citations. Recurring topics across this work include Lipid Membrane Structure and Behavior (27 papers), RNA Interference and Gene Delivery (21 papers), Advanced biosensing and bioanalysis techniques (14 papers), Nanoparticle-Based Drug Delivery (10 papers), Photosynthetic Processes and Mechanisms (5 papers), Photoreceptor and optogenetics research (4 papers), Mass Spectrometry Techniques and Applications (4 papers) and Mitochondrial Function and Pathology (3 papers). The work is most often cited by research in Biomaterials (1.4k citations), Molecular Biology (5.6k citations), Pharmaceutical Science (372 citations), Infectious Diseases (1.1k citations) and Immunology (1.1k citations). Thomas D. Madden has collaborated with scholars based in Canada, United States and United Kingdom. Frequent co-authors include Pieter R. Cullis, Michael J. Hope, Barbara L. Mui, Ying K. Tam, Marcel B. Bally, Muthusamy Jayaraman, Xinyao Du, Muthiah Manoharan, Steven M. Ansell and Martin A. Maier. Their work appears in journals such as Biochimica et Biophysica Acta (BBA) - Biomembranes, Biochemistry, Chemistry and Physics of Lipids, Transplantation and Nature Communications.

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