Sean C. Semple

7.8k total citations · 1 hit paper
37 papers, 4.4k citations indexed

About

Sean C. Semple is a scholar working on Molecular Biology, Biomaterials and Immunology. According to data from OpenAlex, Sean C. Semple has authored 37 papers receiving a total of 4.4k indexed citations (citations by other indexed papers that have themselves been cited), including 32 papers in Molecular Biology, 10 papers in Biomaterials and 5 papers in Immunology. Recurrent topics in Sean C. Semple's work include RNA Interference and Gene Delivery (17 papers), Nanoparticle-Based Drug Delivery (10 papers) and Lipid Membrane Structure and Behavior (9 papers). Sean C. Semple is often cited by papers focused on RNA Interference and Gene Delivery (17 papers), Nanoparticle-Based Drug Delivery (10 papers) and Lipid Membrane Structure and Behavior (9 papers). Sean C. Semple collaborates with scholars based in Canada, United States and Italy. Sean C. Semple's co-authors include Pieter R. Cullis, Arcadio Chonn, Michael J. Hope, P.R. Cullis, Steven M. Ansell, Sandra K. Klimuk, Norbert Maurer, Ying K. Tam, Barbara L. Mui and Troy O. Harasym and has published in prestigious journals such as Journal of Biological Chemistry, Journal of Clinical Oncology and Nature Nanotechnology.

In The Last Decade

Sean C. Semple

37 papers receiving 4.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

2019 1.2k citations Akin Akinc, Martin A. Maier et al. Nature Nanotechnology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Sean C. Semple Canada	25	3.2k	1.4k	690	647	358	37	4.4k
Steven M. Ansell United States	24	3.7k 1.1×	988 0.7×	703 1.0×	559 0.9×	249 0.7×	47	4.9k
Arcadio Chonn Canada	19	2.2k 0.7×	1.4k 1.0×	493 0.7×	490 0.8×	330 0.9×	23	3.5k
Rogério Gaspar Portugal	26	1.8k 0.6×	1.5k 1.1×	569 0.8×	973 1.5×	516 1.4×	41	3.8k
Sherry Y. Wu United States	29	2.6k 0.8×	1.1k 0.8×	537 0.8×	829 1.3×	397 1.1×	66	4.4k
Martin C. Woodle United States	37	4.3k 1.3×	2.5k 1.8×	507 0.7×	1.1k 1.7×	486 1.4×	75	6.7k
Thomas J. Anchordoquy United States	38	4.1k 1.3×	936 0.7×	571 0.8×	883 1.4×	382 1.1×	86	5.4k
Hyesung Jeon South Korea	31	2.3k 0.7×	832 0.6×	340 0.5×	568 0.9×	175 0.5×	69	4.0k
Hiroto Hatakeyama Japan	41	3.6k 1.1×	1.9k 1.4×	494 0.7×	1.2k 1.9×	177 0.5×	82	4.9k
Sam Chen Canada	23	3.9k 1.2×	627 0.5×	577 0.8×	715 1.1×	156 0.4×	33	4.7k
Yuhua Weng China	27	2.8k 0.9×	482 0.3×	416 0.6×	863 1.3×	328 0.9×	65	3.9k

Countries citing papers authored by Sean C. Semple

Since Specialization

Citations

This map shows the geographic impact of Sean C. Semple's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Sean C. Semple with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Sean C. Semple more than expected).

Fields of papers citing papers by Sean C. Semple

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Sean C. Semple. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Sean C. Semple. The network helps show where Sean C. Semple may publish in the future.

Co-authorship network of co-authors of Sean C. Semple

This figure shows the co-authorship network connecting the top 25 collaborators of Sean C. Semple. A scholar is included among the top collaborators of Sean C. Semple based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Sean C. Semple. Sean C. Semple is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Parhiz, Hamideh, Vladimir V. Shuvaev, Qin Li, et al.. (2024). Physiologically based modeling of LNP-mediated delivery of mRNA in the vascular system. Molecular Therapy — Nucleic Acids. 35(2). 102175–102175. 11 indexed citations

Akinc, Akin, Martin A. Maier, Muthiah Manoharan, et al.. (2019). The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs. Nature Nanotechnology. 14(12). 1084–1087. 1160 indexed citations breakdown →

Johnston, Michael, et al.. (2007). Characterization of the drug retention and pharmacokinetic properties of liposomal nanoparticles containing dihydrosphingomyelin. Biochimica et Biophysica Acta (BBA) - Biomembranes. 1768(5). 1121–1127. 103 indexed citations

Jong, Susan de, Ghania Chikh, Laura Sekirov, et al.. (2007). Encapsulation in liposomal nanoparticles enhances the immunostimulatory, adjuvant and anti-tumor activity of subcutaneously administered CpG ODN. Cancer Immunology Immunotherapy. 56(8). 1251–1264. 98 indexed citations

Zhigaltsev, Igor V., Norbert Maurer, Robert D. Leone, et al.. (2005). Liposome-encapsulated vincristine, vinblastine and vinorelbine: A comparative study of drug loading and retention. Journal of Controlled Release. 104(1). 103–111. 156 indexed citations

Semple, Sean C., Robert D. Leone, Jinfang Wang, et al.. (2005). Optimization and Characterization of a Sphingomyelin/Cholesterol Liposome Formulation of Vinorelbine with Promising Antitumor Activity. Journal of Pharmaceutical Sciences. 94(5). 1024–1038. 86 indexed citations

Semple, Sean C., Troy O. Harasym, Kathy A. Clow, et al.. (2005). Immunogenicity and Rapid Blood Clearance of Liposomes Containing Polyethylene Glycol-Lipid Conjugates and Nucleic Acid. Journal of Pharmacology and Experimental Therapeutics. 312(3). 1020–1026. 167 indexed citations

Stuart, Darrin D., Sean C. Semple, & Theresa M. Allen. (2004). High Efficiency Entrapment of Antisense Oligonucleotides in Liposomes. Methods in enzymology on CD-ROM/Methods in enzymology. 387. 171–188. 17 indexed citations

Leonetti, Carlo, Marco Scarsella, Sean C. Semple, et al.. (2004). In vivo administration of liposomal vincristine sensitizes drug‐resistant human solid tumors. International Journal of Cancer. 110(5). 767–774. 18 indexed citations

10.

Cassinelli, Giuliana, Rosanna Supino, Valentina Zuco, et al.. (2004). Role of c-myc protein in hormone refractory prostate carcinoma: cellular response to paclitaxel. Biochemical Pharmacology. 68(5). 923–931. 15 indexed citations

11.

Semple, Sean C., Zheng Yuan, Marianne Eisenhardt, et al.. (2004). 605 Encapsulation of vinorelbine in sphingomyelin/cholesterol liposomes enhances the tumor exposure and antitumor activity of vinorelbine in human mammary and non-small cell lung cancer solid tumor models. European Journal of Cancer Supplements. 2(8). 183–183. 1 indexed citations

12.

Pastorino, Fabio, Chiara Brignole, Danilo Marimpietri, et al.. (2003). Targeted liposomal c-myc antisense oligodeoxynucleotides induce apoptosis and inhibit tumor growth and metastases in human melanoma models.. PubMed. 9(12). 4595–605. 68 indexed citations

13.

Semple, Sean C., Sandra K. Klimuk, Troy O. Harasym, et al.. (2001). Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures. Biochimica et Biophysica Acta (BBA) - Biomembranes. 1510(1-2). 152–166. 379 indexed citations

14.

Maurer, Norbert, Kim F. Wong, Holger Stark, et al.. (2001). Spontaneous Entrapment of Polynucleotides upon Electrostatic Interaction with Ethanol-Destabilized Cationic Liposomes. Biophysical Journal. 80(5). 2310–2326. 194 indexed citations

15.

Semple, Sean C., Sandra K. Klimuk, Troy O. Harasym, & Michael J. Hope. (2000). Lipid-based formulations of antisense oligonucleotides for systemic delivery applications. Methods in enzymology on CD-ROM/Methods in enzymology. 313. 322–341. 37 indexed citations

16.

Klimuk, Sandra K., Sean C. Semple, Peter Scherrer, & Michael J. Hope. (1999). Contact hypersensitivity: a simple model for the characterization of disease-site targeting by liposomes. Biochimica et Biophysica Acta (BBA) - Biomembranes. 1417(2). 191–201. 22 indexed citations

17.

Semple, Sean C., Arcadio Chonn, & Pieter R. Cullis. (1998). Interactions of liposomes and lipid-based carrier systems with blood proteins: Relation to clearance behaviour in vivo. Advanced Drug Delivery Reviews. 32(1-2). 3–17. 311 indexed citations

18.

Oja, Conrad D., Sean C. Semple, Arcadio Chonn, & Pieter R. Cullis. (1996). Influence of dose on liposome clearance: critical role of blood proteins. Biochimica et Biophysica Acta (BBA) - Biomembranes. 1281(1). 31–37. 100 indexed citations

19.

Semple, Sean C., Arcadio Chonn, & Pieter R. Cullis. (1996). Influence of Cholesterol on the Association of Plasma Proteins with Liposomes. Biochemistry. 35(8). 2521–2525. 241 indexed citations

20.

Chonn, Arcadio, Sean C. Semple, & Pieter R. Cullis. (1995). β2-Glycoprotein I Is a Major Protein Associated with Very Rapidly Cleared Liposomes in Vivo, Suggesting a Significant Role in the Immune Clearance of “Non-self” Particles. Journal of Biological Chemistry. 270(43). 25845–25849. 140 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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