Sam Chen

5.9k total citations · 5 hit papers
33 papers, 4.7k citations indexed

About

Sam Chen is a scholar working on Molecular Biology, Biomaterials and Cancer Research. According to data from OpenAlex, Sam Chen has authored 33 papers receiving a total of 4.7k indexed citations (citations by other indexed papers that have themselves been cited), including 25 papers in Molecular Biology, 6 papers in Biomaterials and 5 papers in Cancer Research. Recurrent topics in Sam Chen's work include RNA Interference and Gene Delivery (22 papers), Advanced biosensing and bioanalysis techniques (18 papers) and Lipid Membrane Structure and Behavior (8 papers). Sam Chen is often cited by papers focused on RNA Interference and Gene Delivery (22 papers), Advanced biosensing and bioanalysis techniques (18 papers) and Lipid Membrane Structure and Behavior (8 papers). Sam Chen collaborates with scholars based in Canada, Netherlands and United States. Sam Chen's co-authors include Pieter R. Cullis, Jayesh A. Kulkarni, Yuen Yi C. Tam, Roy van der Meel, Dominik Witzigmann, Ying K. Tam, Paulo J.C. Lin, Sarah B. Thomson, Blair R. Leavitt and Alex K. K. Leung and has published in prestigious journals such as Accounts of Chemical Research, ACS Nano and Nature Nanotechnology.

In The Last Decade

Sam Chen

32 papers receiving 4.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The current landscape of nucleic acid therapeutics

2021 934 citations Jayesh A. Kulkarni, Dominik Witzigmann et al. Nature Nanotechnology profile →
Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

2012 548 citations Nathan M. Belliveau, Jens Huft et al. Molecular Therapy — Nucleic Acids profile →
On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA

2018 457 citations Jayesh A. Kulkarni, Sam Chen et al. profile →
Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics

2019 376 citations Jayesh A. Kulkarni, Dominik Witzigmann et al. profile →
Lipid nanoparticle technology for therapeutic gene regulation in the liver

2020 273 citations Dominik Witzigmann, Jayesh A. Kulkarni et al. Advanced Drug Delivery Reviews profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Sam Chen Canada	23	3.9k	715	627	577	455	33	4.7k
Yuen Yi C. Tam Canada	32	3.5k 0.9×	444 0.6×	489 0.8×	478 0.8×	326 0.7×	44	4.2k
Muthusamy Jayaraman United States	21	4.8k 1.2×	606 0.8×	662 1.1×	550 1.0×	443 1.0×	34	5.7k
Steven M. Ansell United States	24	3.7k 1.0×	559 0.8×	988 1.6×	703 1.2×	505 1.1×	47	4.9k
Xucheng Hou United States	21	2.9k 0.7×	610 0.9×	486 0.8×	905 1.6×	468 1.0×	37	4.1k
Martin A. Maier United States	38	6.9k 1.8×	666 0.9×	746 1.2×	753 1.3×	709 1.6×	88	8.0k
Qiang Cheng China	37	5.4k 1.4×	1.2k 1.6×	1.2k 1.9×	850 1.5×	973 2.1×	86	6.9k
Jayesh A. Kulkarni Canada	28	5.8k 1.5×	1.1k 1.5×	1.0k 1.6×	995 1.7×	729 1.6×	47	7.2k
Lei Miao United States	20	2.9k 0.7×	934 1.3×	763 1.2×	1.4k 2.4×	501 1.1×	30	4.2k
Sean C. Semple Canada	25	3.2k 0.8×	647 0.9×	1.4k 2.2×	690 1.2×	308 0.7×	37	4.4k
Xinyao Du United States	6	2.3k 0.6×	304 0.4×	407 0.6×	411 0.7×	284 0.6×	6	2.7k

Countries citing papers authored by Sam Chen

Since Specialization

Citations

This map shows the geographic impact of Sam Chen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Sam Chen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Sam Chen more than expected).

Fields of papers citing papers by Sam Chen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Sam Chen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Sam Chen. The network helps show where Sam Chen may publish in the future.

Co-authorship network of co-authors of Sam Chen

This figure shows the co-authorship network connecting the top 25 collaborators of Sam Chen. A scholar is included among the top collaborators of Sam Chen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Sam Chen. Sam Chen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Jakubek, Zygmunt J., Sam Chen, Josh Zaifman, Yuen Yi C. Tam, & Shan Zou. (2023). Lipid Nanoparticle and Liposome Reference Materials: Assessment of Size Homogeneity and Long-Term −70 °C and 4 °C Storage Stability. Langmuir. 39(7). 2509–2519. 22 indexed citations

Chen, Sam, et al.. (2023). Microstructure and Oxidation Behavior of Fibers and Binders in Charring Ablators.

Jakubek, Zygmunt J., et al.. (2022). Development of lipid nanoparticles and liposomes reference materials (II): cytotoxic profiles. Scientific Reports. 12(1). 18071–18071. 37 indexed citations

Kulkarni, Jayesh A., Dominik Witzigmann, Sarah B. Thomson, et al.. (2021). Author Correction: The current landscape of nucleic acid therapeutics. Nature Nanotechnology. 16(7). 841–841. 16 indexed citations

Kulkarni, Jayesh A., Dominik Witzigmann, Sarah B. Thomson, et al.. (2021). The current landscape of nucleic acid therapeutics. Nature Nanotechnology. 16(6). 630–643. 934 indexed citations breakdown →

Meel, Roy van der, Sam Chen, Josh Zaifman, et al.. (2021). Modular Lipid Nanoparticle Platform Technology for siRNA and Lipophilic Prodrug Delivery. Small. 17(37). e2103025–e2103025. 42 indexed citations

Witzigmann, Dominik, Jayesh A. Kulkarni, Jerry Leung, et al.. (2020). Lipid nanoparticle technology for therapeutic gene regulation in the liver. Advanced Drug Delivery Reviews. 159. 344–363. 273 indexed citations breakdown →

Srivannavit, Onnop, et al.. (2019). Improved Scale-Factor and Bias Stability of Ovenized Inertial Sensors in an Environmentally-Stabilized Inertial Measurement Unit (eIMU). 1–4. 8 indexed citations

Chen, Sam, Josh Zaifman, Jayesh A. Kulkarni, et al.. (2018). Dexamethasone prodrugs as potent suppressors of the immunostimulatory effects of lipid nanoparticle formulations of nucleic acids. Journal of Controlled Release. 286. 46–54. 47 indexed citations

10.

Neumann, Ursula, et al.. (2017). Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes. Molecular Metabolism. 6(10). 1161–1172. 26 indexed citations

11.

Zhang, Kaixin, Yuen Yi C. Tam, Ying K. Tam, et al.. (2016). A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo. Molecular Therapy — Nucleic Acids. 5. e348–e348. 49 indexed citations

12.

Kulkarni, Jayesh A., et al.. (2016). Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA. Nanomedicine Nanotechnology Biology and Medicine. 13(4). 1377–1387. 176 indexed citations

13.

Wang, Haitang, Yuen Yi C. Tam, Sam Chen, et al.. (2016). The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA. Molecular Therapy. 24(12). 2100–2108. 44 indexed citations

14.

Chen, Sam, Yuen Yi C. Tam, Paulo J.C. Lin, et al.. (2016). Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA. Journal of Controlled Release. 235. 236–244. 282 indexed citations

15.

Walsh, Colin, Nathan M. Belliveau, Jens Huft, et al.. (2014). Microfluidic-Based Manufacture of siRNA-Lipid Nanoparticles for Therapeutic Applications. Methods in molecular biology. 1141. 109–120. 47 indexed citations

16.

Chen, Sam, Yuen Yi C. Tam, Paulo J.C. Lin, et al.. (2014). Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration. Journal of Controlled Release. 196. 106–112. 127 indexed citations

17.

Mui, Barbara L., Ying K. Tam, Muthusamy Jayaraman, et al.. (2013). Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles. Molecular Therapy — Nucleic Acids. 2. e139–e139. 390 indexed citations

18.

Tam, Yuen Yi C., Sam Chen, & Pieter R. Cullis. (2013). Advances in Lipid Nanoparticles for siRNA Delivery. Pharmaceutics. 5(3). 498–507. 168 indexed citations

19.

Tam, Yuen Yi C., Sam Chen, Josh Zaifman, et al.. (2012). Small molecule ligands for enhanced intracellular delivery of lipid nanoparticle formulations of siRNA. Nanomedicine Nanotechnology Biology and Medicine. 9(5). 665–674. 36 indexed citations

20.

Belliveau, Nathan M., Jens Huft, Paulo J.C. Lin, et al.. (2012). Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA. Molecular Therapy — Nucleic Acids. 1. e37–e37. 548 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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