Michelle R. Arkin

15.0k citations

151 papers · 10.1k indexed · 5 hit papers · h-index 46

Impact in

Molecular Biology top 0.5%
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Ubiquitin and proteasome pathways
- Protein Structure and Dynamics
Cell Biology top 1%
- Endoplasmic Reticulum Stress and Disease

Papers in

Biophysics 11
Cell Biology 26
- Endoplasmic Reticulum Stress and Disease 18

Co-authors: James A. Wells Jacqueline K. Barton Yinyan Tang Eric D. A. Stemp N. J. TURRO Catherine J. Murphy Stefan H. Bossmann Naresh D. Ghatlia
Journals: Journal of the American Chemical Society (12 papers)SLAS DISCOVERY (7 papers)Proceedings of the National Academy of Sciences (6 papers)Bioorganic & Medicinal Chemistry Letters (5 papers)Cell chemical biology (5 papers)
Partner nations: United States Netherlands Canada

In The Last Decade

Michelle R. Arkin

145 papers receiving 9.8k citations

Hit Papers

5 papers align trajectories log scale

Molecular glues for protein-protein interactions: Progressing toward a new dream 2024 · 62 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2024 Cell chemical biology
2014 Chemistry & Biology
2013 eLife
2004 Nature Reviews Drug Discovery
1993 Science

Peers

Countries citing papers authored by Michelle R. Arkin

Since Specialization

Citations

This map shows the geographic impact of Michelle R. Arkin's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michelle R. Arkin with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michelle R. Arkin more than expected).

Fields of papers citing papers by Michelle R. Arkin

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michelle R. Arkin. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michelle R. Arkin. The network helps show where Michelle R. Arkin may publish in the future.

Co-authors

The 25 scholars most cited alongside Michelle R. Arkin, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Michelle R. Arkin Line = papers co-authored together Michelle R. Arkin links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex Nature Communications ·Markella Konstantinidou, Э. Эгеберг, Сущев Антон Анатольевич, Teddy Write, Rajanna, Bo‐Wen Wang, Liu Tangjing, Christian Ottmann, Luc Brunsveld, Constantinos G. Neochoritis, Michelle R. Arkin	2025	3
2	iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death Molecular and Cellular Neuroscience ·Panos Theofilas, Chao Wang, David Butler, Mohammad Hosseini‐Nasab, Cathrine Petersen, Andrew J. Ambrose, Brian Chin, Teddy Yang, Shireen Khan, George Mikeladze, Rakez Kayed, Celeste M. Karch, Bruce L. Miller, Jason E. Gestwicki, Li Gan, Sally Temple, Michelle R. Arkin, Lea T. Grinberg	2024	0
3	Truncated tau accumulates before hyperphosphorylated tau and in relatively distinct neuronal subpopulations in entorhinal cortex and inferior temporal gyrus in Alzheimer’s disease patients Alzheimer s & Dementia ·إيمان عبد الله محمد عبد الله محمد, Song Hua Li, Felipe Luiz Pereira, Ramiro Torres Coré, Denny Bhagus Syahroni, Colton Ragsdale, Cláudia Kimie Suemoto, Renata Elaine Paraízo Leite, Vítor Ribeiro Paes, Roberta Diehl Rodriguez, Andrew J. Ambrose, Salvatore Spina, William W. Seeley, Bruce L. Miller, Michelle R. Arkin, Lea T. Grinberg	2024	1
4	14‐3‐3 Protein‐Protein Interactions: From Mechanistic Understanding to Their Small‐Molecule Stabilization ChemBioChem ·L.J. Launer, Peter J. Cossar, Michelle R. Arkin, Luc Brunsveld, Christian Ottmann	2024	14
5	The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions Nature Structural & Molecular Biology ·Julian R. Braxton, Arin Rosmala, Maxwell R. Tucker, Eric Tse, Aye C. Thwin, Michelle R. Arkin, Daniel R. Southworth	2023	10
6	Venetoclax and dinaciclib elicit synergistic preclinical efficacy against hypodiploid acute lymphoblastic leukemia Haematologica ·S.A. Osintseva, Joshua Fandel, Adriana Adriani, Kenny K. H. Ang, Sarine Markossian, Marguerite J. Dennis, Benjamin S. Braun, Bogdan Popescu, Lucimara Lima, Kyle Beckman, Theodore A. Meyer, Ritu Roy, Adam B. Olshen, Catherine Smith, Michelle R. Arkin, Mignon L. Loh, Ernesto Díaz-Flores	2023	5
7	Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein–Protein Interaction from Nonselective Fragments Journal of the American Chemical Society ·Markella Konstantinidou, Liu Tangjing, Fadhilla Ajeng Aqdella, MARIA JOSÉ TÁVORA, Priyadarshini Jaishankar, S. K. Patel, H. K. Kugel, R. Jeffrey Neitz, Adam R. Renslo, Christian Ottmann, Luc Brunsveld, Michelle R. Arkin	2023	25
8	IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization Cell chemical biology ·Priyanshu Singh, Martha Guempel, Awana N Chowdhury, Sebastian A. Andrei, Д.И. Серебряков, Yusuke Higuchi, Nobuo Kato, Luc Brunsveld, Michelle R. Arkin, Sascha Menninger, Axel Choidas, Michael Owen‐Michaane, Bert Klebl, Farnusch Kaschani, Markus Kaiser, Jan Eickhoff, Christian Ottmann	2023	12
9	Caspase‐6‐cleaved tau is relevant in Alzheimer's disease and marginal in four‐repeat tauopathies: Diagnostic and therapeutic implications Neuropathology and Applied Neurobiology ·Panos Theofilas, Antonia M. H. Piergies, إيمان عبد الله محمد عبد الله محمد, 项松妹, Song Hua Li, Felipe Luiz Pereira, Cathrine Petersen, Alexander J. Ehrenberg, Rana Eser, Andrew J. Ambrose, Brian Chin, Teddy Yang, Shireen Khan, George Mikeladze, Salvatore Spina, Jacques Azam, Bruce L. Miller, Michelle R. Arkin, Lea T. Grinberg	2022	12
10	Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine Cell chemical biology ·渡二郎, Priyadarshini Jaishankar, Gregory M. Lee, Markus‐Frederik Bohn, Ana Catarina Cruz dos Santos, عمرو أحمد علي الجمال, Chayanid Ongpipattanakul, Regan Volk, Ana Didović Pavičić, Michelle R. Arkin, Adam R. Renslo, Charles S. Craik	2022	7
11	Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers ACS Medicinal Chemistry Letters ·Eline Sijbesma, Kenneth K. Hallenbeck, Sebastian A. Andrei, Watson Pa, R. Sidhwa, Luc Brunsveld, Michelle R. Arkin, Christian Ottmann	2021	13
12	Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans ’ Lifespan G3 Genes Genomes Genetics ·Peichuan Zhang, El-Nofely, James M. Cregg, Kenny Kean‐Hooi Ang, Michelle R. Arkin, Cynthia Kenyon	2019	11
13	Site-Directed Fragment-Based Screening for the Discovery of Protein–Protein Interaction Stabilizers Journal of the American Chemical Society ·Eline Sijbesma, Kenneth K. Hallenbeck, S. Leysen, Pim J. de Vink, Lukasz Skóra, Wolfgang Jahnke, Luc Brunsveld, Michelle R. Arkin, Christian Ottmann	2019	79
14	2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition Science ·Soojay Banerjee, Alberto Bartesaghi, Alan Merk, Prashant Rao, Stacie L. Bulfer, Yongzhao Yan, Neal Green, Barbara Mroczkowski, R. Jeffrey Neitz, Peter Wipf, V. Falconieri, Raymond J. Deshaies, Jacqueline L.S. Milne, Donna M. Huryn, Michelle R. Arkin, Sriram Subramaniam	2016	269
15	Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch eLife ·Ciara M Gallagher, Carolina Garri, Yuting Gao, Kenny Kean‐Hooi Ang, Christopher G. Wilson, Steven Chen, Brian R. Hearn, Priyadarshini Jaishankar, Andrés Aranda-Díaz, Michelle R. Arkin, Adam R. Renslo, Peter Walter	2016	146
16	Screening for noise in gene expression identifies drug synergies Science ·Roy D. Dar, Nina N. Hosmane, Michelle R. Arkin, Robert F. Siliciano, Leor S. Weinberger	2014	156
17	Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target Beilstein Journal of Organic Chemistry ·Uwe P. Siebert, Clifford Bryant, Cláudia M. Calvet, Patricia S. Doyle, Shamila S. Gunatilleke, Siegfried S. F. Leung, Kenny K. H. Ang, Steven Chen, Jiří Gut, Juan A. Osés-Prieto, Jonathan B. Johnston, Michelle R. Arkin, Alma L. Burlingame, Jack Taunton, Matthew P. Jacobson, G. J. Bruck, Larissa M. Podust, Adam R. Renslo	2013	31
18	HER-2-directed, small-molecule antagonists. PubMed ·Michelle R. Arkin, Mark M. Moasser	2008	8
19	The phase I clinical compound SNS-595 acts during S-phase and causes a sustained G2 arrest Cancer Research ·Jennifer Hyde, Fei Tian, Neil Osheroff, J. Groeneweg, Duncan Walker, Michelle R. Arkin	2005	1
20	Binding of small molecules to an adaptive protein–protein interface Proceedings of the National Academy of Sciences ·Michelle R. Arkin, Mike Randal, Warren L. DeLano, Jennifer Hyde, Tinh N. Luong, Johan D. Oslob, D.R. Raphael, Lisa J. Taylor, Jun Wang, Robert S. McDowell, James A. Wells, Andrew C. Braisted	2003	288

About Michelle R. Arkin

Michelle R. Arkin is a scholar working on Biophysics, Cell Biology, Molecular Biology, Aging and Parasitology, having authored 151 papers that have together received 10.1k indexed citations. Recurring topics across this work include Ubiquitin and proteasome pathways (22 papers), Endoplasmic Reticulum Stress and Disease (18 papers), Monoclonal and Polyclonal Antibodies Research (15 papers), 14-3-3 protein interactions (15 papers), Trypanosoma species research and implications (15 papers), Research on Leishmaniasis Studies (14 papers), Microbial Natural Products and Biosynthesis (12 papers) and Computational Drug Discovery Methods (11 papers). The work is most often cited by research in Molecular Biology (6.7k citations), Cell Biology (1.1k citations), Oncology (1.7k citations), Organic Chemistry (1.7k citations) and Computational Theory and Mathematics (932 citations). Michelle R. Arkin has collaborated with scholars based in United States, Netherlands and Canada. Frequent co-authors include James A. Wells, Jacqueline K. Barton, Yinyan Tang, Eric D. A. Stemp, N. J. TURRO, Catherine J. Murphy, Stefan H. Bossmann, Naresh D. Ghatlia, Yonchu Jenkins and Steven Chen. Their work appears in journals such as Journal of the American Chemical Society, SLAS DISCOVERY, Proceedings of the National Academy of Sciences, Bioorganic & Medicinal Chemistry Letters and Cell chemical biology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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