S. Leysen

1.1k citations

25 papers · 636 indexed · h-index 13

Impact in

Pharmacology top 10%
- Microbial Natural Products and Biosynthesis
Endocrinology top 10%

Papers in ⓘ

Endocrinology 3
Toxicology 2

Co-authors: Christian Ottmann (18 shared papers)Luc Brunsveld (13 shared papers)Chris W. Michiels (5 shared papers)Lise Vanderkelen (3 shared papers)Joris M. Van Herreweghe (3 shared papers)L. Callewaert (2 shared papers)L.‐G. Milroy (8 shared papers)Eline Sijbesma (3 shared papers)
Journals: Angewandte Chemie International Edition (3 papers)Journal of Structural Biology (2 papers)Journal of Medicinal Chemistry (2 papers)Journal of Molecular Biology (2 papers)Journal of the American Chemical Society (1 paper)
Partner nations: Netherlands United Kingdom Belgium

In The Last Decade

S. Leysen

24 papers receiving 626 citations

Peers

Countries citing papers authored by S. Leysen

Since Specialization

Citations

This map shows the geographic impact of S. Leysen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by S. Leysen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites S. Leysen more than expected).

Fields of papers citing papers by S. Leysen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by S. Leysen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by S. Leysen. The network helps show where S. Leysen may publish in the future.

Co-authors

The 25 scholars most cited alongside S. Leysen, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with S. Leysen Line = papers co-authored together S. Leysen links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 25 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR Proceedings of the National Academy of Sciences ·Loes M. Stevers, Chan Vinh Lam, S. Leysen, Femke A. Meijer, Daphne S. van Scheppingen, R.M.J.M. de Vries, Graeme W. Carlile, Lech G. Milroy, David Y. Thomas, Luc Brunsveld, Christian Ottmann	2016	117
2	Site-Directed Fragment-Based Screening for the Discovery of Protein–Protein Interaction Stabilizers Journal of the American Chemical Society ·Eline Sijbesma, Kenneth K. Hallenbeck, S. Leysen, Pim J. de Vink, Lukasz Skóra, Wolfgang Jahnke, Luc Brunsveld, Michelle R. Arkin, Christian Ottmann	2019	79
3	Guards of the great wall: bacterial lysozyme inhibitors Trends in Microbiology ·L. Callewaert, Joris M. Van Herreweghe, Lise Vanderkelen, S. Leysen, Arnout Voet, Chris W. Michiels	2012	75
4	Stabilizer‐Guided Inhibition of Protein–Protein Interactions Angewandte Chemie International Edition ·L.‐G. Milroy, Maria Bartel, Morkos A. Henen, S. Leysen, Joris M. C. Adriaans, Luc Brunsveld, Isabelle Landrieu, Christian Ottmann	2015	55
5	Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening Biochemistry ·Eline Sijbesma, Lukasz Skóra, S. Leysen, Luc Brunsveld, Uwe Koch, Peter Nußbaumer, Wolfgang Jahnke, Christian Ottmann	2017	37
6	Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists Journal of Medicinal Chemistry ·Femke A. Meijer, Richard G. Doveston, R.M.J.M. de Vries, Gaël M. Vos, Alex A.A. Vos, S. Leysen, Marcel Scheepstra, Christian Ottmann, L.‐G. Milroy, Luc Brunsveld	2019	30
7	Molecular Basis of Bacterial Defense against Host Lysozymes: X-ray Structures of Periplasmic Lysozyme Inhibitors PliI and PliC Journal of Molecular Biology ·S. Leysen, Joris M. Van Herreweghe, L. Callewaert, Michelle Heirbaut, P. Buntinx, Chris W. Michiels, Sergei V. Strelkov	2010	30
8	A Natural‐Product Switch for a Dynamic Protein Interface Angewandte Chemie International Edition ·Marcel Scheepstra, Lidia Nieto, Anna K. H. Hirsch, Sascha Fuchs, S. Leysen, Chan Vinh Lam, Leslie in het Panhuis, C. A. A. VAN BOECKEL, Hans Wienk, Rolf Boelens, Christian Ottmann, L.‐G. Milroy, Luc Brunsveld	2014	29
9	Molecular glues to stabilise protein–protein interactions Current Opinion in Chemical Biology ·Lorenzo Soini, S. Leysen, Jeremy Davis, Christian Ottmann	2022	28
10	Structural basis of bacterial defense against g-type lysozyme-based innate immunity Cellular and Molecular Life Sciences ·S. Leysen, Lise Vanderkelen, S.D. Weeks, Chris W. Michiels, Sergei V. Strelkov	2012	24
11	Accounting for observed small angle X‐ray scattering profile in the protein–protein docking server cluspro Journal of Computational Chemistry ·Bing Xia, Artem B. Mamonov, S. Leysen, Karen N. Allen, Sergei V. Strelkov, Ioannis Ch. Paschalidis, Sándor Vajda, Dima Kozakov	2015	23
12	Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor–Nuclear Receptor Related 1 Protein Dimer Activation Journal of Medicinal Chemistry ·Henrik Sundén, Anja Schäfer, Marcel Scheepstra, S. Leysen, Marcus Malo, Jian‐Nong Ma, Ethan S. Burstein, Christian Ottmann, Luc Brunsveld, Roger Olsson	2016	15
13	Structural characterization of the PliG lysozyme inhibitor family Journal of Structural Biology ·S. Leysen, Lise Vanderkelen, Kathleen Van Asten, S. Vanheuverzwijn, V. Theuwis, Chris W. Michiels, Sergei V. Strelkov	2012	12
14	Designed Spiroketal Protein Modulation Angewandte Chemie International Edition ·Marcel Scheepstra, Sebastian A. Andrei, M. Yağız Ünver, Anna K. H. Hirsch, S. Leysen, Christian Ottmann, Luc Brunsveld, L.‐G. Milroy	2017	12
15	Molecular basis and dual ligand regulation of tetrameric estrogen receptor α/14-3-3ζ protein complex Journal of Biological Chemistry ·B. Somsen, Eline Sijbesma, S. Leysen, Karolína Honzejková, Emira J. Visser, Peter J. Cossar, Tomáš Obšil, Luc Brunsveld, Christian Ottmann	2023	11
16	Identification of molecular glues of the SLP76/14-3-3 protein–protein interaction RSC Medicinal Chemistry ·Lorenzo Soini, Martin Redhead, Marta Westwood, S. Leysen, Jeremy Davis, Christian Ottmann	2021	11
17	A biophysical and structural analysis of the interaction of BLNK with 14-3-3 proteins Journal of Structural Biology ·Lorenzo Soini, S. Leysen, Jeremy Davis, Christian Ottmann	2020	10
18	Stabilizer‐Guided Inhibition of Protein–Protein Interactions Angewandte Chemie ·L.‐G. Milroy, Maria Bartel, Morkos A. Henen, S. Leysen, Joris M. C. Adriaans, Luc Brunsveld, Isabelle Landrieu, Christian Ottmann	2015	10
19	A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1 Journal of Molecular Biology ·S. Leysen, Rebecca J. Burnley, Elizabeth Rodríguez, L.‐G. Milroy, Lorenzo Soini, Carolyn J. Adamski, Larissa Nitschke, Rachel E. Davis, Tomáš Obšil, Luc Brunsveld, Tom Crabbe, Huda Y. Zoghbi, Christian Ottmann, Jeremy Davis	2021	8
20	The structure of the proteinaceous inhibitor PliI fromAeromonas hydrophilain complex with its target lysozyme Acta Crystallographica Section D Biological Crystallography ·S. Leysen, Joris M. Van Herreweghe, Kazunari Yoneda, Makoto Ogata, Taichi Usui, Tomohiro Araki, Chris W. Michiels, Sergei V. Strelkov	2015	7

About S. Leysen

S. Leysen is a scholar working on Endocrinology, Toxicology, Pharmacology, Molecular Biology and Genetics, having authored 25 papers that have together received 636 indexed citations. Recurring topics across this work include 14-3-3 protein interactions (12 papers), Ubiquitin and proteasome pathways (12 papers), Microbial Natural Products and Biosynthesis (7 papers), Estrogen and related hormone effects (4 papers), Enzyme Structure and Function (4 papers), Bacterial Genetics and Biotechnology (3 papers), Bacteriophages and microbial interactions (3 papers) and Nuclear Receptors and Signaling (3 papers). The work is most often cited by research in Pharmacology (135 citations), Endocrinology (36 citations), Molecular Biology (474 citations), Microbiology (25 citations) and Computational Theory and Mathematics (48 citations). S. Leysen has collaborated with scholars based in Netherlands, United Kingdom and Belgium. Frequent co-authors include Christian Ottmann, Luc Brunsveld, Chris W. Michiels, Lise Vanderkelen, Joris M. Van Herreweghe, L. Callewaert, L.‐G. Milroy, Eline Sijbesma, Sergei V. Strelkov and Jeremy Davis. Their work appears in journals such as Angewandte Chemie International Edition, Journal of Structural Biology, Journal of Medicinal Chemistry, Journal of Molecular Biology and Journal of the American Chemical Society.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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