Michael Sinz

4.9k citations

72 papers · 2.8k indexed · h-index 29

Impact in

Pharmacology top 0.05%
- Pharmacogenetics and Drug Metabolism
- Drug-Induced Hepatotoxicity and Protection
Oncology top 2%
- Drug Transport and Resistance Mechanisms

Papers in ⓘ

Pharmacology 44
- Pharmacogenetics and Drug Metabolism 43
Oncology 30
- Drug Transport and Resistance Mechanisms 29

Co-authors: K. R. Krishna Iyer (5 shared papers)Thomas F. Woolf (5 shared papers)Rory P. Remmel (4 shared papers)Sridhar Mani (6 shared papers)Roger N. Hayes (2 shared papers)Jasminder Sahi (4 shared papers)Hongjian Zhang (4 shared papers)Sean Kim (9 shared papers)
Journals: Drug Metabolism and Disposition (16 papers)Journal of Pharmacology and Experimental Therapeutics (5 papers)Bioorganic & Medicinal Chemistry Letters (3 papers)Journal of Medicinal Chemistry (3 papers)Clinical Cancer Research (2 papers)
Partner nations: United States Germany India

In The Last Decade

Michael Sinz

71 papers receiving 2.7k citations

Peers

Countries citing papers authored by Michael Sinz

Since Specialization

Citations

This map shows the geographic impact of Michael Sinz's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael Sinz with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael Sinz more than expected).

Fields of papers citing papers by Michael Sinz

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael Sinz. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael Sinz. The network helps show where Michael Sinz may publish in the future.

Co-authors

The 25 scholars most cited alongside Michael Sinz, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Michael Sinz Line = papers co-authored together Michael Sinz links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 72 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Inactivation of Cytochrome P450 3A4 by Bergamottin, a Component of Grapefruit Juice Chemical Research in Toxicology ·Kan He, K. R. Krishna Iyer, Roger N. Hayes, Michael Sinz, Thomas F. Woolf, Paul F. Hollenberg	1998	247
2	Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole Oncogene ·Haiyan Huang, H Wang, Michael Sinz, Mary Zoeckler, Jeff L. Staudinger, Matthew R. Redinbo, Denise G. Teotico, Joseph Locker, Ganjam V. Kalpana, Sridhar Mani	2006	167
3	Pharmacokinetic Drug Interactions Involving 17??-Ethinylestradiol Clinical Pharmacokinetics ·Hongjian Zhang, Donghui Cui, Bonnie Wang, Yong–Hae Han, Praveen Balimane, Zheng Yang, Michael Sinz, A. David Rodrigues	2007	143
4	Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032) Antimicrobial Agents and Chemotherapy ·Fiona McPhee, Amy K. Sheaffer, Jacques Friborg, Dennis Hernandez, Paul Falk, Guangzhi Zhai, Steven M. LeVine, Susan Chaniewski, Fei Yu, Diana Barry, Chaoqun Chen, Min S. Lee, Kathy Mosure, Li‐Qiang Sun, Michael Sinz, Nicholas A. Meanwell, Richard J. Colonno, Jay O. Knipe, Paul M. Scola	2012	139
5	Human Pregnane X Receptor Antagonists and Agonists Define Molecular Requirements for Different Binding Sites Molecular Pharmacology ·Sean Ekins, Cheng Chang, Sridhar Mani, Matthew D. Krasowski, Erica J. Reschly, Manisha Iyer, Vladyslav Kholodovych, Ni Ai, William J. Welsh, Michael Sinz, Peter W. Swaan, Rachana Patel, Kenneth Bachmann	2007	123
6	Evaluation of 170 Xenobiotics as Transactivators of Human Pregnane X Receptor (hPXR) and Correlation to Known CYP3A4 Drug Interactions Current Drug Metabolism ·Michael Sinz, Sean Kim, Zhengrong Zhu, Taosheng Chen, Monique Anthony, Kenneth E.J. Dickinson, António Sebastião Rodrigues	2006	115
7	In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective Drug Metabolism and Disposition ·Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David D. Moore, Sharon L. Ripp, José Silva, Vikram Sinha, Michael Sinz, Andrej Skerjanec	2009	108
8	Expanding the Roles for Pregnane X Receptor in Cancer: Proliferation and Drug Resistance in Ovarian Cancer Clinical Cancer Research ·Divya Gupta, Madhukumar Venkatesh, Hongwei Wang, Sean Kim, Michael Sinz, Gary L. Goldberg, Kathleen D. Whitney, Clifford Longley, Sridhar Mani	2008	90
9	Activated Pregnenolone X-Receptor Is a Target for Ketoconazole and Its Analogs Clinical Cancer Research ·Hongwei Wang, Haiyan Huang, Hao Li, Denise G. Teotico, Michael Sinz, Sharyn D. Baker, Jeffrey L. Staudinger, Ganjam V. Kalpana, Matthew R. Redinbo, Sridhar Mani	2007	88
10	Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes Xenobiotica ·Jasminder Sahi, Geraldine A. Hamilton, Michael Sinz, Silvana P. Barros, See-Chang Huang, Lawrence J. Lesko, Edward L. LeCluyse	2000	85
11	Comparative Effects of Thiazolidinediones on in Vitro P450 Enzyme Induction and Inhibition Drug Metabolism and Disposition ·Jasminder Sahi, Christopher B. Black, Geraldine A. Hamilton, Xianxian Zheng, Summer Jolley, Kelly Rose, Darryl Gilbert, Edward L. LeCluyse, Michael Sinz	2003	83
12	Current Industrial Practices in Assessing CYP450 Enzyme Induction: Preclinical and Clinical The AAPS Journal ·Michael Sinz, Gillian Wallace, Jasminder Sahi	2008	82
13	Cytochrome P450 reaction-phenotyping: an industrial perspective Expert Opinion on Drug Metabolism & Toxicology ·Hongjian Zhang, Carl D. Davis, Michael Sinz, A. David Rodrigues	2007	82
14	Evaluation of Various Static and Dynamic Modeling Methods to Predict Clinical CYP3A Induction Using In Vitro CYP3A4 mRNA Induction Data Clinical Pharmacology & Therapeutics ·Heidi J. Einolf, L Chen, Odette A. Fahmi, Christopher R. Gibson, R. Scott Obach, Mohamad Shebley, J Silva, Michael Sinz, Jashvant D. Unadkat, L Zhang, Ping Zhao	2013	73
15	Machine Learning Methods and Docking for Predicting Human Pregnane X Receptor Activation Chemical Research in Toxicology ·Akash Khandelwal, Matthew D. Krasowski, Erica J. Reschly, Michael Sinz, Peter W. Swaan, Sean Ekins	2008	62
16	Computational Discovery of Novel Low Micromolar Human Pregnane X Receptor Antagonists Molecular Pharmacology ·Sean Ekins, Vladyslav Kholodovych, Ni Ai, Michael Sinz, J. Gál, Lajos Gera, William J. Welsh, Kenneth Bachmann, Sridhar Mani	2008	59
17	Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC–MS/MS analysis Journal of Pharmaceutical and Biomedical Analysis ·Ming Yao, Mingshe Zhu, Michael Sinz, Hongjian Zhang, W. Griffith Humphreys, A. David Rodrigues, Renke Dai	2007	56
18	Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development Drug Metabolism Reviews ·Michael Sinz	2013	54
19	Characterization of Phase I and Phase II hepatic drug metabolism activities in a panel of human liver preparations Chemico-Biological Interactions ·K. R. Krishna Iyer, Michael Sinz	1999	54
20	Correlation of High-Throughput Pregnane X Receptor (PXR) Transactivation and Binding Assays SLAS DISCOVERY ·Zhengrong Zhu, Sean Kim, Taosheng Chen, Jun-Hsiang Lin, Aneka Bell, James Bryson, Yves Dubaquié, Ning Yan, Joseph Yanchunas, Dianlin Xie, Robert H. Stoffel, Michael Sinz, Kenneth E.J. Dickinson	2004	46

About Michael Sinz

Michael Sinz is a scholar working on Pharmacology, Oncology, Pediatrics, Perinatology and Child Health, Virology and Endocrinology, Diabetes and Metabolism, having authored 72 papers that have together received 2.8k indexed citations. Recurring topics across this work include Pharmacogenetics and Drug Metabolism (43 papers), Drug Transport and Resistance Mechanisms (29 papers), Pharmacological Effects and Toxicity Studies (14 papers), Hormonal Regulation and Hypertension (12 papers), Estrogen and related hormone effects (9 papers), HIV/AIDS drug development and treatment (9 papers), Computational Drug Discovery Methods (6 papers) and Receptor Mechanisms and Signaling (5 papers). The work is most often cited by research in Pharmacology (1.6k citations), Oncology (1.1k citations), Hepatology (216 citations), Endocrinology, Diabetes and Metabolism (442 citations) and Pediatrics, Perinatology and Child Health (394 citations). Michael Sinz has collaborated with scholars based in United States, Germany and India. Frequent co-authors include K. R. Krishna Iyer, Thomas F. Woolf, Rory P. Remmel, Sridhar Mani, Roger N. Hayes, Jasminder Sahi, Hongjian Zhang, Sean Kim, Kan He and Paul F. Hollenberg. Their work appears in journals such as Drug Metabolism and Disposition, Journal of Pharmacology and Experimental Therapeutics, Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry and Clinical Cancer Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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