Thomas W. Kensler

52.9k total citations · 19 hit papers
407 papers, 42.4k citations indexed

About

Thomas W. Kensler is a scholar working on Molecular Biology, Cancer Research and Plant Science. According to data from OpenAlex, Thomas W. Kensler has authored 407 papers receiving a total of 42.4k indexed citations (citations by other indexed papers that have themselves been cited), including 277 papers in Molecular Biology, 69 papers in Cancer Research and 58 papers in Plant Science. Recurrent topics in Thomas W. Kensler's work include Genomics, phytochemicals, and oxidative stress (198 papers), Glutathione Transferases and Polymorphisms (85 papers) and Carcinogens and Genotoxicity Assessment (53 papers). Thomas W. Kensler is often cited by papers focused on Genomics, phytochemicals, and oxidative stress (198 papers), Glutathione Transferases and Polymorphisms (85 papers) and Carcinogens and Genotoxicity Assessment (53 papers). Thomas W. Kensler collaborates with scholars based in United States, Japan and China. Thomas W. Kensler's co-authors include Masayuki Yamamoto, Nobunao Wakabayashi, Shyam Biswal, John D. Groopman, Mi-Kyoung Kwak, Hozumi Motohashi, Paul Talalay, Patricia A. Egner, Ken Itoh and Albena T. Dinkova‐Kostova and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Thomas W. Kensler

405 papers receiving 41.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway

2006 3.0k citations Thomas W. Kensler, Nobunao Wakabayashi et al. profile →
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

2018 1.4k citations Masayuki Yamamoto, Thomas W. Kensler et al. profile →
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

2019 1.0k citations Antonio Cuadrado, Ana I. Rojo et al. Nature Reviews Drug Discovery profile →
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.

2002 1.0k citations Rajesh K. Thimmulappa, Sorachai Srisuma et al. PubMed profile →
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

2001 928 citations Masayuki Yamamoto, Thomas W. Kensler et al. Proceedings of the National Academy of Sciences profile →
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

2004 823 citations Nobunao Wakabayashi, Albena T. Dinkova‐Kostova et al. Proceedings of the National Academy of Sciences profile →
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice

2004 740 citations Tirumalai Rangasamy, Chung Y. Cho et al. Journal of Clinical Investigation profile →
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice

2004 696 citations Tirumalai Rangasamy, Chung Y. Cho et al. Journal of Clinical Investigation profile →
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains ofHelicobacter pyloriand prevents benzo[a]pyrene-induced stomach tumors

2002 645 citations Jed W. Fahey, Thomas W. Kensler et al. Proceedings of the National Academy of Sciences profile →
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

2010 632 citations Deepti Malhotra, Nobunao Wakabayashi et al. profile →
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.

1994 613 citations Thomas W. Kensler et al. Proceedings of the National Academy of Sciences profile →
Modulation of Gene Expression by Cancer Chemopreventive Dithiolethiones through the Keap1-Nrf2 Pathway

2003 571 citations Nobunao Wakabayashi, Masayuki Yamamoto et al. profile →
Role of NRF2 in Protection Against Hyperoxic Lung Injury in Mice

2002 570 citations Thomas W. Kensler, Masayuki Yamamoto et al. profile →
K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.

1993 546 citations Thomas W. Kensler et al. PubMed profile →
The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

2009 526 citations Nobunao Wakabayashi, Thomas W. Kensler et al. profile →
Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the nrf2 Promoter

2002 516 citations Masayuki Yamamoto, Thomas W. Kensler et al. Molecular and Cellular Biology profile →
When NRF2 Talks, Who's Listening?

2010 508 citations Nobunao Wakabayashi, Thomas W. Kensler et al. profile →
Aflatoxin: A 50-Year Odyssey of Mechanistic and Translational Toxicology

2010 500 citations Thomas W. Kensler, Bill D. Roebuck et al. profile →
Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

2019 256 citations Yoko Yagishita, Jed W. Fahey et al. profile →

Peers

Countries citing papers authored by Thomas W. Kensler

Since Specialization

Citations

This map shows the geographic impact of Thomas W. Kensler's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas W. Kensler with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas W. Kensler more than expected).

Fields of papers citing papers by Thomas W. Kensler

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas W. Kensler. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas W. Kensler. The network helps show where Thomas W. Kensler may publish in the future.

Co-authorship network of co-authors of Thomas W. Kensler

This figure shows the co-authorship network connecting the top 25 collaborators of Thomas W. Kensler. A scholar is included among the top collaborators of Thomas W. Kensler based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Thomas W. Kensler. Thomas W. Kensler is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Randomized Phase II Clinical Trial of Sulforaphane in Former Smokers at High Risk for Lung Cancer 2025 ·Cancer Prevention Research ·Jian‐Min Yuan, Thomas W. Kensler, Sanja Đačić, Douglas J. Hartman, Renwei Wang, (unknown), (unknown), (unknown), Kimberly Fuhrer, (unknown), (unknown), Jennifer Adams‐Haduch, (unknown), Shivendra V. Singh, James G. Herman, David O. Wilson	3
2	65 Years on—Aflatoxin Biomarkers Blossoming: Whither Next? 2024 ·Toxins ·Thomas W. Kensler, David L. Eaton	10
3	Profound primary prevention of liver cancer following a natural experiment in China: A 50‐year perspective and public health implications 2024 ·International Journal of Cancer ·Jianguo Chen, Thomas W. Kensler, Jian Zhu, Yuan‐Rong Zhu, (unknown), Jianhua Lu, Alvaro Muñoz, John D. Groopman	5
4	Transcriptional Regulation of Math1 by Aryl Hydrocarbon Receptor: Effect on Math1 ⁺ Progenitor Cells in Mouse Small Intestine 2023 ·Molecular and Cellular Biology ·Yoko Yagishita, Tanvi Joshi, Thomas W. Kensler, Nobunao Wakabayashi	3
5	Forced Hepatic Expression of NRF2 or NQO1 Impedes Hepatocyte Lipid Accumulation in a Lipodystrophy Mouse Model 2023 ·International Journal of Molecular Sciences ·Nobunao Wakabayashi, Yoko Yagishita, (unknown), Thomas W. Kensler	4
6	A Point Mutation at C151 of Keap1 of Mice Abrogates NRF2 Signaling, Cytoprotection in Vitro, and Hepatoprotection in Vivo by Bardoxolone Methyl (CDDO-Me) 2023 ·Molecular Pharmacology ·(unknown), Yoko Yagishita, Tanvi Joshi, Nobunao Wakabayashi, Harini Srinivasan, Takafumi Suzuki, Masayuki Yamamoto, Thomas W. Kensler	15
7	Assessing the Validity of Normalizing Aflatoxin B1-Lysine Albumin Adduct Biomarker Measurements to Total Serum Albumin Concentration across Multiple Human Population Studies 2022 ·Toxins ·Joshua W. Smith, Derek K. Ng, Christian S. Álvarez, Patricia A. Egner, (unknown), Jianguo Chen, Thomas W. Kensler, Jill Koshiol, Alvaro Rivera‐Andrade, María F Kroker-Lobos, Manuel Ramírez‐Zea, Katherine A. McGlynn, John D. Groopman	10
8	Current Landscape of NRF2 Biomarkers in Clinical Trials 2020 ·Antioxidants ·Yoko Yagishita, (unknown), (unknown), Thomas W. Kensler	73
9	Constitutive Activation of Nrf2 in Mice Expands Enterogenesis in Small Intestine Through Negative Regulation of Math1 2020 ·Cellular and Molecular Gastroenterology and Hepatology ·Yoko Yagishita, (unknown), Thomas W. Kensler, Nobunao Wakabayashi	16
10	Serum miR‐182 is a predictive biomarker for dichotomization of risk of hepatocellular carcinoma in rats 2019 ·Molecular Carcinogenesis ·(unknown), Natalie M. Johnson, Bill D. Roebuck, Thomas W. Kensler, John D. Groopman	10
11	Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases breakdown → 2019 ·Nature Reviews Drug Discovery ·Antonio Cuadrado, Ana I. Rojo, Geoffrey Wells, John D. Hayes, (unknown), William L. Rumsey, Otis C. Attucks, Stephen Franklin, Anna–Liisa Levonen, Thomas W. Kensler, Albena T. Dinkova‐Kostova	1034
12	Nrf2 in liver toxicology 2019 ·Archives of Pharmacal Research ·Keiko Taguchi, Thomas W. Kensler	43
13	NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress–Induced DPP3–KEAP1 Interaction 2017 ·Cancer Research ·(unknown), Allen L. Alcivar, Jianglin Ma, Tzeh Keong Foo, (unknown), Amar Mahdi, Yanying Huo, Thomas W. Kensler, Michael L. Gatza, Bing Xia	148
14	Effect of Green Tea Supplements on Liver Enzyme Elevation: Results from a Randomized Intervention Study in the United States 2017 ·Cancer Prevention Research ·(unknown), Hamed Samavat, Allison M. Dostal, Renwei Wang, Carolyn J. Torkelson, Chung S. Yang, Lesley M. Butler, Thomas W. Kensler, Anna H. Wu, Mindy S. Kurzer, Jian‐Min Yuan	44
15	Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane 2016 ·Cancer Prevention Research ·Julie E. Bauman, Yan Zang, Malabika Sen, Changyou Li, Lin Wang, Patricia A. Egner, Jed W. Fahey, Daniel P. Normolle, Jennifer R. Grandis, Thomas W. Kensler, Daniel E. Johnson	85
16	Is It Time to Advance the Chemoprevention of Environmental Carcinogenesis with Microdosing Trials? 2009 ·Cancer Prevention Research ·Thomas W. Kensler, John D. Groopman	9
17	Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice 2008 ·Proceedings of the National Academy of Sciences ·Thomas E. Sussan, Tirumalai Rangasamy, David J. Blake, Deepti Malhotra, Hazim El‐Haddad, Djahida Bedja, Melinda S. Yates, Ponvijay Kombairaju, Masayuki Yamamoto, Karen T. Liby, Michael B. Sporn, Kathleen L. Gabrielson, Hunter C. Champion, Rubin M. Tuder, Thomas W. Kensler, Shyam Biswal	282
18	Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice breakdown → 2004 ·Journal of Clinical Investigation ·Tirumalai Rangasamy, Chung Y. Cho, Rajesh K. Thimmulappa, Lijie Zhen, Sorachai Srisuma, Thomas W. Kensler, Masayuki Yamamoto, Irina Petrache, Rubin M. Tuder, Shyam Biswal	696
19	Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice breakdown → 2004 ·Journal of Clinical Investigation ·Tirumalai Rangasamy, Chung Y. Cho, Rajesh K. Thimmulappa, Lijie Zhen, Sorachai Srisuma, Thomas W. Kensler, Masayuki Yamamoto, Irina Petrache, Rubin M. Tuder, Shyam Biswal	740
20	Modulation of aflatoxin metabolism, aflatoxin-N7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases. 1986 ·PubMed ·Thomas W. Kensler, Patricia A. Egner, Nancy E. Davidson, Bill D. Roebuck, (unknown), John D. Groopman	132

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