Lea Sistonen

14.9k citations

137 papers · 11.8k indexed · 4 hit papers · h-index 58

Impact in

Aging top 0.1%
- Genetics, Aging, and Longevity in Model Organisms
Cell Biology top 0.2%
- Endoplasmic Reticulum Stress and Disease

Papers in

Aging 20
- Genetics, Aging, and Longevity in Model Organisms 20
Physical and Theoretical Chemistry 25
- thermodynamics and calorimetric analyses 25

Co-authors: Richard I. Morimoto Julius Anckar Malin Åkerfelt Lila Pirkkala Päivi Nykänen Kevin D. Sarge Kari Alitalo Anniina Vihervaara
Journals: Molecular and Cellular Biology (14 papers)Journal of Biological Chemistry (12 papers)Cell Stress and Chaperones (8 papers)Proceedings of the National Academy of Sciences (8 papers)FEBS Journal (5 papers)
Partner nations: Finland United States France

In The Last Decade

Lea Sistonen

135 papers receiving 11.5k citations

Hit Papers

align trajectories log scale

Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease 2011 · 582 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2011 Annual Review of Biochemistry
2010 Nature Reviews Molecular Cell Biology
2009 Science
2001 The FASEB Journal

Peers

Countries citing papers authored by Lea Sistonen

Since Specialization

Citations

This map shows the geographic impact of Lea Sistonen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lea Sistonen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lea Sistonen more than expected).

Fields of papers citing papers by Lea Sistonen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lea Sistonen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lea Sistonen. The network helps show where Lea Sistonen may publish in the future.

Co-authors

The 25 scholars most cited alongside Lea Sistonen, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Lea Sistonen Line = papers co-authored together Lea Sistonen links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	A guide to heat shock factors as multifunctional transcriptional regulators FEBS Journal ·收正金, J. Oleksyn, Lea Sistonen, Eva Henriksson	2025	2
2	Proteomic profiling identifies a direct interaction between heat shock transcription factor 2 and the focal adhesion adapter talin‐1 FEBS Journal ·J. Oleksyn, 收正金, Mohammed A Alhendy, Rosemarie E. Gough, Lars Ferencz, Arlene Opina, Benjamin T. Goult, Susumu Y. Imanishi, Lea Sistonen, Eva Henriksson	2024	4
3	Comprehensive analysis of human tissues reveals unique expression and localization patterns of HSF1 and HSF2 Cell Stress and Chaperones ·Jenny Joutsen, R.B.C. Copsey, 박찬호, Reijo Sironen, Jaana M. Hartikainen, Lea Sistonen	2024	8
4	HSFs drive transcription of distinct genes and enhancers during oxidative stress and heat shock Nucleic Acids Research ·M. Schmidt, Mikael C. Puustinen, J. Oleksyn, Anniina Vihervaara, Lea Sistonen	2022	23
5	Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer Nature Communications ·de Palacio Espanña A, Irantzu Gorroño‐Etxebarria, Malin Åkerfelt, Mikael C. Puustinen, Lea Sistonen, Matthias Nees, Alexander W. Braune, Jonathan Waxman, Robert Kypta	2018	84
6	Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells Proceedings of the National Academy of Sciences ·Anniina Vihervaara, Baladevamiśrakṛtā, Agomo Chimere, Aydın Akçan, Alexandra N. Elsing, Pia Roos‐Mattjus, Lea Sistonen	2013	125
7	Heterotrimerization of Heat-Shock Factors 1 and 2 Provides a Transcriptional Switch in Response to Distinct Stimuli Molecular Biology of the Cell ·Ralph Chill, Johanna Björk, Malin Åkerfelt, Tarsilah Tarsilah, Alexeï Grichine, Claire Vourc’h, Caroline Jolly, Tiina A. Salminen, Yvonne Nymalm, Lea Sistonen	2009	124
8	Fever-Like Hyperthermia Controls T Lymphocyte Persistence by Inducing Degradation of Cellular FLIPshort The Journal of Immunology ·Annika Meinander, M.A. Starnikov, Aura Kaunisto, Minna Poukkula, Lea Sistonen, John Eriksson	2007	22
9	Inhibition of DNA Binding by Differential Sumoylation of Heat Shock Factors Molecular and Cellular Biology ·Julius Anckar, Ville Hietakangas, Konstantin Denessiouk, Dennis J. Thiele, Mark S. Johnson, Lea Sistonen	2006	91
10	The ubiquitin‐proteasome pathway Annals of Medicine ·Pia Roos‐Mattjus, Lea Sistonen	2004	145
11	Enhanced intracellular replication of Salmonella enteritidis in HLA–B27–expressing human monocytic cells: Dependency on glutamic acid at position 45 in the B pocket of HLA–B27 Arthritis & Rheumatism ·陆逐, Kaisa M. Heiskanen, Ramy S. Nada, Monica DeLay, Robert A. Colbert, Lea Sistonen, Kaisa Granfors	2004	45
12	Phosphorylation of Serine 303 Is a Prerequisite for the Stress-Inducible SUMO Modification of Heat Shock Factor 1 Molecular and Cellular Biology ·Ville Hietakangas, Johanna K. Ahlskog, Rudolf Steiert, S. WIETHOLTER, Niko Sahlberg, Carina I. Holmberg, Andrey Mikhailov, Jorma J. Palvimo, Lila Pirkkala, Lea Sistonen	2003	254
13	Primary chondrocytes resist hydrostatic pressure-induced stress while primary synovial cells and fibroblasts show modified Hsp70 response Osteoarthritis and Cartilage ·Kai Kaarniranta, Carina I. Holmberg, Mikko J. Lammi, John Eriksson, Lea Sistonen, Heikki J. Helminen	2001	36
14	Disruption of Heat Shock Factor 1 Reveals an Essential Role in the Ubiquitin Proteolytic Pathway Molecular and Cellular Biology ·Lila Pirkkala, Tero-Pekka Alastalo, Xiaoxia Zuo, Ivor J. Benjamin, Lea Sistonen	2000	99
15	Heat shock factor 2 is activated during mouse heart development The International Journal of Developmental Biology ·Minna Eriksson, E. J. Jokinen, Lea Sistonen, Sirpa Leppä	2000	41
16	Heat Shock Response - Pathophysiological Implications Annals of Medicine ·Sirpa Leppä, Lea Sistonen	1997	89
17	Downregulation of the early genomic growth factor response in neu oncogene-transformed cells. PubMed ·Lea Sistonen, Päivi J. Koskinen, Heikki Lehväslaiho, Laura Lehtola, R Bravo, Kari Alitalo	1990	7
18	Receptor Downregulation and DNA Synthesis Are Modulated by EGF and TPA in Cells Expressing an EGFR/neu Chimera Growth Factors ·Laura Lehtola, Amita Coutinho, Lea Sistonen, Laura Beguinot, Kari Alitalo	1989	5
19	A chimeric EGF-R-neu proto-oncogene allows EGF to regulate neu tyrosine kinase and cell transformation. The EMBO Journal ·Heikki Lehväslaiho, Laura Lehtola, Lea Sistonen, Kari Alitalo	1989	79
20	Enhanced jun Gene Expression Is an Early Genomic Response to Transforming Growth Factor β Stimulation Molecular and Cellular Biology ·Liisa Pertovaara, Lea Sistonen, Timothy J. Bos, Peter K. Vogt, Jorma Keski‐Oja, Kari Alitalo	1989	40

About Lea Sistonen

Lea Sistonen is a scholar working on Aging, Physical and Theoretical Chemistry, Cell Biology, Molecular Biology and Oncology, having authored 137 papers that have together received 11.8k indexed citations. Recurring topics across this work include Heat shock proteins research (82 papers), Endoplasmic Reticulum Stress and Disease (31 papers), thermodynamics and calorimetric analyses (25 papers), Genetics, Aging, and Longevity in Model Organisms (20 papers), Ubiquitin and proteasome pathways (12 papers), Physiological and biochemical adaptations (11 papers), RNA Research and Splicing (11 papers) and Genomics and Chromatin Dynamics (7 papers). The work is most often cited by research in Aging (1.3k citations), Cell Biology (2.6k citations), Physical and Theoretical Chemistry (1.3k citations), Molecular Biology (9.5k citations) and Geriatrics and Gerontology (212 citations). Lea Sistonen has collaborated with scholars based in Finland, United States and France. Frequent co-authors include Richard I. Morimoto, Julius Anckar, Malin Åkerfelt, Lila Pirkkala, Päivi Nykänen, Kevin D. Sarge, Kari Alitalo, Anniina Vihervaara, John Eriksson and Ville Hietakangas. Their work appears in journals such as Molecular and Cellular Biology, Journal of Biological Chemistry, Cell Stress and Chaperones, Proceedings of the National Academy of Sciences and FEBS Journal.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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